Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with MCP-1.

abstract：:The effects of brefeldin A, monensin, and the weak base NH4Cl on the biosynthesis and processing of cathepsin G and neutrophil elastase of myeloid cells were investigated. Monoblast-like U-937 cells were biosynthetically labeled with [35S]methionine, followed by subcellular fractionation, immunoprecipitation, and anal...

journal_title：Journal of leukocyte biology

authors： Lindmark A,Gullberg U,Olsson I

更新日期：1994-01-01 00:00:00

abstract：:Secreted IgM (sIgM) is a multifunctional evolutionary conserved antibody that is critical for the maintenance of tissue homeostasis as well as the development of fully protective humoral responses to pathogens. Constitutive secretion of self- and polyreactive natural IgM, produced mainly by B-1 cells, provides a circu...

journal_title：Journal of leukocyte biology

authors： Blandino R,Baumgarth N

更新日期：2019-11-01 00:00:00

abstract：:Poxviruses encode a variety of immunomodulatory proteins that subvert the cytokine networks of infected hosts. Myxoma virus, a poxvirus pathogen of rabbits, expresses two distinct 35- to 40-kDa secreted glycoproteins that bind a broad spectrum of chemokines. The first of these, designated M-T7, is encoded by the T7 ge...

journal_title：Journal of leukocyte biology

authors： Lalani AS,McFadden G

更新日期：1997-11-01 00:00:00

abstract：:Progressive loss of dopaminergic neurons in the substantia nigra pars compacta and their terminal connections in the striatum are central features in Parkinson's disease (PD). Emerging evidence supports the notion that microglia neuroinflammatory responses speed neurodegenerative events. We demonstrated previously tha...

journal_title：Journal of leukocyte biology

authors： Reynolds AD,Banerjee R,Liu J,Gendelman HE,Mosley RL

更新日期：2007-11-01 00:00:00

abstract：:Previous work has demonstrated that bleomycin can directly stimulate alveolar macrophage secretion of fibroblast growth factors and monocyte chemotactic factors. In this study, rat alveolar macrophages obtained by bronchoalveolar lavage were examined for the presence of bleomycin binding sites, which might mediate thi...

journal_title：Journal of leukocyte biology

authors： Denholm EM,Phan SH

更新日期：1990-12-01 00:00:00

abstract：:The recognition of pathogen-associated molecular patterns by TLRs triggers the activation of innate and adaptive immune responses. Flagellin, the agonist of TLR5, is expressed by prokaryotes and eukaryotes, and DNA sequences containing unmethylated CpG dinucleotides, agonists of TLR9, are present essentially in prokar...

journal_title：Journal of leukocyte biology

authors： Merlo A,Calcaterra C,Mènard S,Balsari A

更新日期：2007-09-01 00:00:00

abstract：:Type I IFNs play an important role in innate and adaptive immunity against viral infections. A novel type I IFN, namely IFN-ε, which can protect against vaginal transmission of HSV2 and Chlamydia muridarum bacterial infection, has been described in mice and humans. Nevertheless, the principle cell type and the express...

journal_title：Journal of leukocyte biology

authors： Demers A,Kang G,Ma F,Lu W,Yuan Z,Li Y,Lewis M,Kraiselburd EN,Montaner L,Li Q

更新日期：2014-12-01 00:00:00

abstract：:The immune system in early life is regarded as immature. However, the IL-12 family member IL-23 is highly produced upon TLR stimulation by neonatal DCs. Human adult Vγ9Vδ2 T cells can be stimulated specifically via their TCR by phosphoantigens (as the pathogen-derived HMB-PP) or agents and infections that lead to thei...

journal_title：Journal of leukocyte biology

authors： Moens E,Brouwer M,Dimova T,Goldman M,Willems F,Vermijlen D

更新日期：2011-05-01 00:00:00

abstract：:Although class A type I/II scavenger receptor (SR-A) is involved in numerous macrophage functions, its signaling ability remains uncertain. We used monoclonal antibodies (mAb) to specifically stimulate receptors on mouse alveolar (AMs) and peritoneal macrophages (PMs). Immobilized anti-SR-A (2F8) and anti-FcgammaR II/...

journal_title：Journal of leukocyte biology

authors： Józefowski S,Kobzik L

更新日期：2004-11-01 00:00:00

abstract：:The restriction of herpes simplex virus type 1 (HSV-1) gene expression in nonpermissive murine resident peritoneal macrophages (ResPMO) was analyzed at the level of transcription. Using nuclear run-on assays, we established that transcription of a representative gene from each HSV-1 kinetic class was initiated in both...

journal_title：Journal of leukocyte biology

authors： Wu L,Morahan PS,Leary K

更新日期：1993-01-01 00:00:00

abstract：:Polymorphonuclear granulocytes (PMNs) are known to contribute to reperfusion injury of the heart. However, whether PMNs compromise myocardial function of hearts exposed to a low-flow ischemia has not been determined. Moreover, not much is known about deleterious effects of PMNs at different times during ischemia and r...

journal_title：Journal of leukocyte biology

authors： Seligmann C,Bock A,Leitsch T,Schimmer M,Simsek Y,Schultheiss HP

更新日期：2001-05-01 00:00:00

abstract：:SHP-1 is a cytoplasm protein tyrosine phosphatase expressed primarily in hematopoietic cells. In the immune system, SHP-1 plays critical roles in regulation of many receptor-mediated signaling cascades, and SHP-1 deficiency in mice causes spontaneous inflammation and autoimmunity. Here, we report a unique requirement ...

journal_title：Journal of leukocyte biology

authors： Zhou D,Collins CA,Wu P,Brown EJ

更新日期：2010-05-01 00:00:00

abstract：:Murine reconstitution assays were used to investigate the effects of recombinant human interleukin-7 (rhIL-7) on myeloid and lymphoid precursors and on bone marrow engraftment. Reconstitution with bone marrow from rhIL-7-treated mice results in a 3.4-fold decrease in total colony-forming unit-spleen (CFU-S) activity (...

journal_title：Journal of leukocyte biology

authors： Boerman OC,Gregorio TA,Grzegorzewski KJ,Faltynek CR,Kenny JJ,Wiltrout RH,Komschlies KL

更新日期：1995-08-01 00:00:00

abstract：:To determine whether monocytes can be generated from CD34+ hematopoietic progenitors in large numbers, cord blood CD34+ cells were first expanded for 3-10 days in X-VIVO 10 medium supplemented with FCS, stem cell factor (SCF), thrombopoietin (TPO), and Flt-3 Ligand (Flt-3L), and then differentiated in IMDM medium supp...

journal_title：Journal of leukocyte biology

authors： Stec M,Weglarczyk K,Baran J,Zuba E,Mytar B,Pryjma J,Zembala M

更新日期：2007-09-01 00:00:00

abstract：:Dendritic cells (DC) obtained by culturing myeloid precursors in GM-CSF undergo maturation and induce an efficient T cell response when stimulated with microbial products. DC precursors themselves also recognize microbial products, and it remains unclear how these stimulated DC precursors modulate the immune response....

journal_title：Journal of leukocyte biology

authors： Kwan WH,Boix C,Gougelet N,Fridman WH,Mueller CG

更新日期：2007-07-01 00:00:00

abstract：:Human skin mast cells (HSMC) in situ were examined by electron microscopy of surgical biopsy specimens obtained from a wide variety of circumstances. From these studies, it is apparent that the general ultrastructural morphology of normal HSMC is similar to that of human mast cells from other sites, except that the mo...

journal_title：Journal of leukocyte biology

authors： Dvorak AM,Kissell S

更新日期：1991-02-01 00:00:00

abstract：:Eosinophils are traditionally associated with allergic and parasitic inflammation. More recently, eosinophils have also been shown to have roles in diverse processes including development, intestinal health, thymic selection, and B-cell survival with the majority of these insights being derived from murine models and ...

journal_title：Journal of leukocyte biology

authors： Nguyen WNT,Jacobsen EA,Finney CAM,Colarusso P,Patel KD

更新日期：2020-07-01 00:00:00

abstract：:Discussion on Tregs that have anti-inflammatory and anti-atherogenic properties as an ideal therapeutic target to reduce fatal cardiovascular deaths following major noncardiac surgery. ...

journal_title：Journal of leukocyte biology

authors： Kyaw T,Bobik A

更新日期：2020-05-01 00:00:00

abstract：:Complex syndromes such as atherosclerosis and type 2 diabetes are disorders that are associated with inflammatory processes involving innate and adaptive immunity. Emerging knowledge about the pathological consequences of immune imbalances in a wide range of disease settings is expected to help to identify novel thera...

journal_title：Journal of leukocyte biology

authors： Rose B,Herder C,Löffler H,Kolb H,Martin S

更新日期：2004-04-01 00:00:00

abstract：:The Fc gamma receptor IIB (FcγRIIB/CD32B) was generated million years ago during evolution. It is the sole inhibitory receptor for IgG, and has long been associated with the regulation of humoral immunity and innate immune homeostasis. However, new and surprising functions of FcγRIIB are emerging. In particular, FcγRI...

journal_title：Journal of leukocyte biology

authors： Roghanian A,Stopforth RJ,Dahal LN,Cragg MS

更新日期：2018-02-06 00:00:00

abstract：:CD8(+) T cells must detect foreign antigens and differentiate into effector cells to eliminate infections. But, when self-antigen is recognized instead, mechanisms of peripheral tolerance prevent acquisition of effector function to avoid autoimmunity. These distinct responses are influenced by inflammatory and regulat...

journal_title：Journal of leukocyte biology

authors： Jackson SR,Yuan J,Berrien-Elliott MM,Chen CL,Meyer JM,Donlin MJ,Teague RM

更新日期：2014-09-01 00:00:00

abstract：:Inflammation-limiting nonsteroidal pain relievers magnify myocardial infarction (MI) incidences and increase re-admission events in heart failure (HF) patients. However, the molecular and cellular mechanism of this provocative adverse effect is unclear. Our goal was to determine whether carprofen (CAP) impedes splenic...

journal_title：Journal of leukocyte biology

authors： Halade GV,Kain V,Wright GM,Jadapalli JK

更新日期：2018-12-01 00:00:00

abstract：:This study addresses the role of (pro)MMP-9 overexpression in CLL cell migration. We have used primary CLL cells and CLL-derived MEC-1 cells transfected with empty (mock cells) or proMMP-9-encoding (MMP-9 cells) lentiviral vectors. The constitutive (pro)MMP-9 expression in mock cells and primary CLL cells was similar,...

journal_title：Journal of leukocyte biology

authors： Bailón E,Ugarte-Berzal E,Amigo-Jiménez I,Van den Steen P,Opdenakker G,García-Marco JA,García-Pardo A

更新日期：2014-03-11 00:00:00

abstract：:Zinc is an essential element important for growth, the nervous system, and especially the immune system. Zinc deficiency as well as levels well above normal, due to high-dose treatment, showed an impaired immune function. This review summarizes the current status of zinc's significance for leukocyte biology and health...

journal_title：Journal of leukocyte biology

authors： Wellinghausen N,Rink L

更新日期：1998-11-01 00:00:00

abstract：:Blood leukocyte count alterations induced by PAF-acether in anesthetized and nonanesthetized rats were investigated. Intravenous injection of increasing amounts of PAF-acether (1.5-8 micrograms/kg) in nonanesthetized animals induced dose-dependent hemoconcentration and leukocytosis. The former was apparent within 10 m...

journal_title：Journal of leukocyte biology

authors： Bozza PT,Silva PM,Castro-Faria-Neto HC,Martins MA,Cordeiro RS

更新日期：1992-02-01 00:00:00

abstract：:IL-17 has been associated with selected inflammatory and autoimmune diseases. We characterized the expression of this proinflammatory cytokine following HSV-1 corneal infection and investigated whether IL-17R signaling modulated the host response to the viral pathogen at early time-points postinfection. IL-17 was elev...

journal_title：Journal of leukocyte biology

authors： Molesworth-Kenyon SJ,Yin R,Oakes JE,Lausch RN

更新日期：2008-02-01 00:00:00

abstract：:Regulation of macrophage PCD plays an important role in pathogenesis of leishmaniasis. However, the precise involvement of any parasite molecule in this process remains uncertain. In the current study, in silico wide analysis demonstrated that genes in the Leishmania donovani genome are highly enriched for CpG motifs,...

journal_title：Journal of leukocyte biology

authors： Das S,Ghosh AK,Singh S,Saha B,Ganguly A,Das P

更新日期：2015-02-01 00:00:00

abstract：:The nucleosome, the basic structure of chromatin and normal product of cell apoptosis, plays a pivotal role both in the induction and the pathogenesis of systemic lupus erythematosus (SLE). Nucleosomes have been found to circulate at high levels in patients with SLE and apoptosis of lymphoid cells is increased during ...

journal_title：Journal of leukocyte biology

authors： Laderach D,Bach JF,Koutouzov S

更新日期：1998-12-01 00:00:00

abstract：:A continuing theme of work done in our laboratory involves regulation of adaptive immune response by innate cells, in general, and immuneregulation by natural killer (NK) and NKT cells, in particular. Studies include work with the lung and the eye. In addition to immune surveillance of tumor cells, the NK cell is ofte...

journal_title：Journal of leukocyte biology

authors： Stein-Streilein J,Sonoda KH,Faunce D,Zhang-Hoover J

更新日期：2000-04-01 00:00:00

abstract：:It is well established that the cytokine IL-12 and the transcription factor STAT4, an essential part of the IL-12 signaling pathway, are critical components of the Th1 differentiation process in T cells. In response to pathogenic stimuli, this process causes T cells to proliferate rapidly and secrete high amounts of t...

journal_title：Journal of leukocyte biology

authors： Schaller M,Ito T,Allen RM,Kroetz D,Kittan N,Ptaschinski C,Cavassani K,Carson WF 4th,Godessart N,Grembecka J,Cierpicki T,Dou Y,Kunkel SL

更新日期：2015-10-01 00:00:00