Recombinant human IL-7 administration in mice affects colony-forming units-spleen and lymphoid precursor cell localization and accelerates engraftment of bone marrow transplants.


:Murine reconstitution assays were used to investigate the effects of recombinant human interleukin-7 (rhIL-7) on myeloid and lymphoid precursors and on bone marrow engraftment. Reconstitution with bone marrow from rhIL-7-treated mice results in a 3.4-fold decrease in total colony-forming unit-spleen (CFU-S) activity (day 9) and an 18.1- and 11.9-fold decrease in its ability to generate thymocytes and splenic B lineage cells, respectively. In contrast, after reconstitution with splenocytes from rhIL-7-treated mice, CFU-S activity increased 23.6-fold (day 9) and the thymocyte and splenic B lineage cell regenerative capacity increased by 4.0- and 3.2-fold, respectively. In addition, CD43low+, B220low+ cells that contain pre-pro-B cells and pro-B cells were expanded two- to threefold and Ig mu-, B220+, CD2- and Ig mu-, B220+, CD2+ B lineage cells were expanded approximately 10-fold and 10- to 45-fold (depending on the tissue examined), respectively, after rhIL-7 treatment. Administration of rhIL-7 to irradiated mice transplanted with bone marrow resulted in accelerated T cell and B cell reconstitution by up to 2-4 weeks. Thus, rhIL-7 administration affects the distribution of myeloid and lymphoid precursors. Moreover, rhIL-7 administration accelerates murine bone marrow cell engraftment and therefore may be useful in reducing the engraftment time in bone marrow transplant patients.


J Leukoc Biol


Boerman OC,Gregorio TA,Grzegorzewski KJ,Faltynek CR,Kenny JJ,Wiltrout RH,Komschlies KL




Has Abstract


1995-08-01 00:00:00












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    abstract::Previously, we showed that NO induces thymocyte apoptosis via a caspase-1-dependent mechanism [(1) ]. In the present study, we investigated the role of heme oxygenase, catalase, bax, and p53 in this process. The NO donor, S-nitroso-N-acetyl penicillamine (SNAP), induced DNA fragmentation in thymocytes in a time- and c...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Gordon SA,Abou-Jaoude W,Hoffman RA,McCarthy SA,Kim YM,Zhou X,Zhang XR,Simmons RL,Chen Y,Schall L,Ford HR

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    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Guillabert A,Wittamer V,Bondue B,Godot V,Imbault V,Parmentier M,Communi D

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    authors: Fruehauf S,Srbic K,Seggewiss R,Topaly J,Ho AD

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    pub_type: 杂志文章


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  • Osteopontin augments CD3-mediated interferon-gamma and CD40 ligand expression by T cells, which results in IL-12 production from peripheral blood mononuclear cells.

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    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: O'Regan AW,Hayden JM,Berman JS

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    journal_title:Journal of leukocyte biology

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    authors: Schreiber A,Eulenberg-Gustavus C,Bergmann A,Jerke U,Kettritz R

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    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


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    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


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    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Thümmler K,Leipe J,Ramming A,Schulze-Koops H,Skapenko A

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    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审


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    journal_title:Journal of leukocyte biology

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    authors: van Rooijen N,Sanders A

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    authors: Reumaux D,Hordijk PL,Duthilleul P,Roos D

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    journal_title:Journal of leukocyte biology

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    authors: Shiratsuchi Y,Iyoda T,Tanimoto N,Kegai D,Nagata K,Kobayashi Y

    更新日期:2007-02-01 00:00:00

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    authors: Salamone MC,Rabinovich GA,Mendiguren AK,Salamone GV,Fainboim L

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    journal_title:Journal of leukocyte biology

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    authors: Garbati MR,Hays LE,Rathbun RK,Jillette N,Chin K,Al-Dhalimy M,Agarwal A,Newell AE,Olson SB,Bagby GC Jr

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    authors: Hampton MB,Vissers MC,Winterbourn CC

    更新日期:1994-02-01 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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