Recombinant human IL-7 administration in mice affects colony-forming units-spleen and lymphoid precursor cell localization and accelerates engraftment of bone marrow transplants.

Abstract:

:Murine reconstitution assays were used to investigate the effects of recombinant human interleukin-7 (rhIL-7) on myeloid and lymphoid precursors and on bone marrow engraftment. Reconstitution with bone marrow from rhIL-7-treated mice results in a 3.4-fold decrease in total colony-forming unit-spleen (CFU-S) activity (day 9) and an 18.1- and 11.9-fold decrease in its ability to generate thymocytes and splenic B lineage cells, respectively. In contrast, after reconstitution with splenocytes from rhIL-7-treated mice, CFU-S activity increased 23.6-fold (day 9) and the thymocyte and splenic B lineage cell regenerative capacity increased by 4.0- and 3.2-fold, respectively. In addition, CD43low+, B220low+ cells that contain pre-pro-B cells and pro-B cells were expanded two- to threefold and Ig mu-, B220+, CD2- and Ig mu-, B220+, CD2+ B lineage cells were expanded approximately 10-fold and 10- to 45-fold (depending on the tissue examined), respectively, after rhIL-7 treatment. Administration of rhIL-7 to irradiated mice transplanted with bone marrow resulted in accelerated T cell and B cell reconstitution by up to 2-4 weeks. Thus, rhIL-7 administration affects the distribution of myeloid and lymphoid precursors. Moreover, rhIL-7 administration accelerates murine bone marrow cell engraftment and therefore may be useful in reducing the engraftment time in bone marrow transplant patients.

journal_name

J Leukoc Biol

authors

Boerman OC,Gregorio TA,Grzegorzewski KJ,Faltynek CR,Kenny JJ,Wiltrout RH,Komschlies KL

doi

10.1002/jlb.58.2.151

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

151-8

issue

2

eissn

0741-5400

issn

1938-3673

journal_volume

58

pub_type

杂志文章
  • Nitric oxide induces murine thymocyte apoptosis by oxidative injury and a p53-dependent mechanism.

    abstract::Previously, we showed that NO induces thymocyte apoptosis via a caspase-1-dependent mechanism [(1) ]. In the present study, we investigated the role of heme oxygenase, catalase, bax, and p53 in this process. The NO donor, S-nitroso-N-acetyl penicillamine (SNAP), induced DNA fragmentation in thymocytes in a time- and c...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Gordon SA,Abou-Jaoude W,Hoffman RA,McCarthy SA,Kim YM,Zhou X,Zhang XR,Simmons RL,Chen Y,Schall L,Ford HR

    更新日期:2001-07-01 00:00:00

  • Role of neutrophil proteinase 3 and mast cell chymase in chemerin proteolytic regulation.

    abstract::Chemerin is a potent chemotactic factor that was identified recently as the ligand of ChemR23, a G protein-coupled receptor expressed by mononuclear phagocytes, dendritic cells (DCs), and NK cells. Chemerin is synthesized as a secreted precursor, prochemerin, which is poorly active on ChemR23. However, prochemerin can...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0508322

    authors: Guillabert A,Wittamer V,Bondue B,Godot V,Imbault V,Parmentier M,Communi D

    更新日期:2008-12-01 00:00:00

  • How neutrophils resist shear stress at blood vessel walls: molecular mechanisms, subcellular structures, and cell-cell interactions.

    abstract::Neutrophils are the first cells arriving at sites of tissue injury or infection to combat invading pathogens. Successful neutrophil recruitment to sites of inflammation highly depends on specific molecular mechanisms, fine-tuning the received information into signaling pathways and converting them into well-described ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1189/jlb.3MR0117-026RR

    authors: Begandt D,Thome S,Sperandio M,Walzog B

    更新日期:2017-09-01 00:00:00

  • Functional characterization of podia formation in normal and malignant hematopoietic cells.

    abstract::Hematopoietic cells extend multiple podia of yet unknown function. Our morphological studies using scanning electron microscopy and functional studies using time-lapse video microscopy suggest that podia formed by CD34+ hematopoietic stem cells (HSC) on the bone marrow stroma component fibronectin are characteristic o...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Fruehauf S,Srbic K,Seggewiss R,Topaly J,Ho AD

    更新日期:2002-03-01 00:00:00

  • Leukocyte subsets and neutrophil function after short-term spaceflight.

    abstract::Changes in leukocyte subpopulations and function after spaceflight have been observed but the mechanisms underlying these changes are not well defined. This study investigated the effects of short-term spaceflight (8-15 days) on circulating leukocyte subsets, stress hormones, immunoglobulin levels, and neutrophil func...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.65.2.179

    authors: Stowe RP,Sams CF,Mehta SK,Kaur I,Jones ML,Feeback DL,Pierson DL

    更新日期:1999-02-01 00:00:00

  • Technical advance: Langerhans cells derived from a human cell line in a full-thickness skin equivalent undergo allergen-induced maturation and migration.

    abstract::In this report, the construction of a functional, immunocompetent, full-thickness skin equivalent (SE) is described, consisting of an epidermal compartment containing keratinocytes, melanocytes, and human LCs derived from the MUTZ-3 cell line (MUTZ-LC) and a fibroblast-populated dermal compartment. The CD1a(+)Langerin...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0610374

    authors: Ouwehand K,Spiekstra SW,Waaijman T,Scheper RJ,de Gruijl TD,Gibbs S

    更新日期:2011-11-01 00:00:00

  • Levamisole causes differential cytokine expression by elicited mouse peritoneal macrophages.

    abstract::Thioglycolate-elicited peritoneal macrophages from normal C57B1/6J mice were examined in vitro for bacterial lipopolysaccharide (LPS)-stimulated interleukin-1 (IL-1), IL-6, and tumor necrosis factor (TNF) production. Macrophages from mice administered a single oral dose of levamisole (3 mg/kg) 1 to 4 days prior to mac...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.52.3.349

    authors: Kimball ES,Schneider CR,Fisher MC,Clark MC

    更新日期:1992-09-01 00:00:00

  • The human monocyte-like cell line THP-1 expresses Fc gamma RI and Fc gamma RII.

    abstract::THP-1 cells are a monocyte-like cell line derived from a patient with acute monocytic leukemia and unlike other leukemic cell lines has a normal diploid karyotype. We have characterized Fc gamma R expression on this cell line by flow cytometry, radiolabeled IgG1 and monoclonal antibody (mAb) binding assays, and bioche...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.49.6.556

    authors: Fleit HB,Kobasiuk CD

    更新日期:1991-06-01 00:00:00

  • Osteopontin augments CD3-mediated interferon-gamma and CD40 ligand expression by T cells, which results in IL-12 production from peripheral blood mononuclear cells.

    abstract::Osteopontin is an RGD-containing bone matrix protein with cytokine-like functions that is associated with early stages of Th1-mediated diseases. Although the function of osteopontin in these responses is unknown, it is expressed by activated T cells and macrophages and can costimulate T cell proliferation. Studies hav...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: O'Regan AW,Hayden JM,Berman JS

    更新日期:2000-10-01 00:00:00

  • Lessons from a double-transgenic neutrophil approach to induce antiproteinase 3 antibody-mediated vasculitis in mice.

    abstract::ANCA to either PR3 or MPO are found in patients with necrotizing vasculitis and glomerulonephritis. ANCA binding to their target antigens on neutrophils and subsequent neutrophil activation are pivotal disease mechanisms that lead to vascular inflammation and necrosis. ANCA interaction with PR3 is more complex than wi...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.5A0116-037R

    authors: Schreiber A,Eulenberg-Gustavus C,Bergmann A,Jerke U,Kettritz R

    更新日期:2016-12-01 00:00:00

  • Leukosialin (CD43) behavior during adhesion of human monocytic THP-1 cells to red blood cells.

    abstract::To understand the modulation and the behavior of glycocalyx elements during adhesion, we explored one of its components, the CD43 molecule, on human monocytic THP-1 cells exposed to cytokine stimulation and its redistribution during heterotypic adhesion to opsonized erythrocytes. First we demonstrated by immunofluores...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.61.5.609

    authors: Soler M,Merant C,Servant C,Fraterno M,Allasia C,Lissitzky JC,Bongrand P,Foa C

    更新日期:1997-05-01 00:00:00

  • Induction of cyclooxygenase-2 expression during HIV-1-infected monocyte-derived macrophage and human brain microvascular endothelial cell interactions.

    abstract::Human immunodeficiency virus type-1 (HIV-1)-associated dementia (HAD) is a neurodegenerative disease characterized by HIV infection and replication in brain tissue. HIV-1-infected monocytes overexpress inflammatory molecules that facilitate their entry into the brain. Prostanoids are lipid mediators of inflammation th...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Pereira CF,Boven LA,Middel J,Verhoef J,Nottet HS

    更新日期:2000-09-01 00:00:00

  • Immune regulation by peripheral suppressor T cells induced upon homotypic T cell/T cell interactions.

    abstract::We have shown previously that homotypic interaction of resting memory CD4 T cells with activated T cells induces the production of cytokines with immunoregulatory potential (IL-10, IL-4) from the former. Here, we analyzed the effector functions of these T cells stimulated by homotypic T cell interaction. T cells induc...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0310122

    authors: Thümmler K,Leipe J,Ramming A,Schulze-Koops H,Skapenko A

    更新日期:2010-11-01 00:00:00

  • Innate immune system regulation of nuclear hormone receptors in metabolic diseases.

    abstract::The immune system modulates a number of biological processes to properly defend against pathogens. Here, we review how crosstalk between nuclear hormone receptors and the innate immune system may influence multiple biological functions during an immune response. Although nuclear hormone receptor repression of innate i...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1189/jlb.1206741

    authors: Chow EK,Razani B,Cheng G

    更新日期:2007-08-01 00:00:00

  • Elimination, blocking, and activation of macrophages: three of a kind?

    abstract::In mammals, macrophages are multifunctional cells. Apart from their scavenger role in the clearance of non-self materials such as microorganisms and altered-self materials such as apoptotic cells, senescent erythrocytes, immune complexes, and inflammatory products, they play a crucial role in the regulation of both in...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1002/jlb.62.6.702

    authors: van Rooijen N,Sanders A

    更新日期:1997-12-01 00:00:00

  • Function and regulation of the murine lymphocyte CD2 receptor.

    abstract::The CD2 receptor on T-lymphocytes plays a major part in mediating adhesive interactions via the LFA-3 ligand and in transducing signals for lymphocyte activation. In this study the expression, function, and internalization of the CD2 receptor was investigated in resting and activated murine T-cells. Surface iodination...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.49.4.329

    authors: Abraham DJ,Bou-Gharios G,Beauchamp JR,Plater-Zyberk C,Maini RN,Olsen I

    更新日期:1991-04-01 00:00:00

  • Priming by tumor necrosis factor-alpha of human neutrophil NADPH-oxidase activity induced by anti-proteinase-3 or anti-myeloperoxidase antibodies.

    abstract::Anti-proteinase-3 (anti-PR3) or anti-myeloperoxidase (anti-MPO) antibodies are capable of activating human neutrophils primed by TNF-alpha in vitro. We described previously the involvement of FcgammaRIIa and beta(2) integrins in this neutrophil activation. In the literature, the requirement of TNF priming has been att...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0304144

    authors: Reumaux D,Hordijk PL,Duthilleul P,Roos D

    更新日期:2006-12-01 00:00:00

  • Infiltrating neutrophils induce allospecific CTL in response to immunization with apoptotic cells via MCP-1 production.

    abstract::Our previous studies demonstrated that i.p. injection of late apoptotic P388 cells caused phagocytosis by macrophages and transient infiltration of neutrophils into the peritoneal cavity. As neutrophils are known to function as effectors as well as regulators in the immune response, we examined the roles of infiltrati...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0606399

    authors: Shiratsuchi Y,Iyoda T,Tanimoto N,Kegai D,Nagata K,Kobayashi Y

    更新日期:2007-02-01 00:00:00

  • Activation-induced expression of CD1d antigen on mature T cells.

    abstract::In the present study, we investigated the expression of human CD1d antigen on activated mature T cells. Expression of this glycoprotein was found to be highly regulated and dependent on PHA stimulation. Flow cytometry studies using the NOR3.2 antibody, which recognized CD1d under denaturing conditions, showed a clear ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Salamone MC,Rabinovich GA,Mendiguren AK,Salamone GV,Fainboim L

    更新日期:2001-02-01 00:00:00

  • Cytokine overproduction and crosslinker hypersensitivity are unlinked in Fanconi anemia macrophages.

    abstract::The Fanconi anemia proteins participate in a canonical pathway that repairs cross-linking agent-induced DNA damage. Cells with inactivated Fanconi anemia genes are universally hypersensitive to such agents. Fanconi anemia-deficient hematopoietic stem cells are also hypersensitive to inflammatory cytokines, and, as imp...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.3A0515-201R

    authors: Garbati MR,Hays LE,Rathbun RK,Jillette N,Chin K,Al-Dhalimy M,Agarwal A,Newell AE,Olson SB,Bagby GC Jr

    更新日期:2016-03-01 00:00:00

  • Antibodies to CD18 influence neutrophil migration through extracellular matrix.

    abstract::Mac-1 (CD11b/CD18) is known to be involved in neutrophil (PMN) adhesion to endothelial cells and extracellular matrix. Although antibodies to CD 18 are being tested for therapy in humans, their role in PMN migration through the extracellular matrix is unknown. We used direct visualization to quantify PMN motility thro...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.65.3.356

    authors: Saltzman WM,Livingston TL,Parkhurst MR

    更新日期:1999-03-01 00:00:00

  • Human monocytes respond to extracellular cAMP through A2A and A2B adenosine receptors.

    abstract::In this study, we test the hypothesis that cAMP, acting as an extracellular mediator, affects the physiology and function of human myeloid cells. The cAMP is a second messenger recognized as a universal regulator of several cellular functions in different organisms. Many studies have shown that extracellular cAMP exer...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.3A0513-302RR

    authors: Sciaraffia E,Riccomi A,Lindstedt R,Gesa V,Cirelli E,Patrizio M,De Magistris MT,Vendetti S

    更新日期:2014-07-01 00:00:00

  • A single assay for measuring the rates of phagocytosis and bacterial killing by neutrophils.

    abstract::We have developed a method that enables the rates of phagocytosis and killing of bacteria by neutrophils to be measured in a single assay. Neutrophils were incubated with bacteria, and at specific intervals were separated from uningested bacteria by low speed centrifugation. Rates of phagocytosis and killing were calc...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.55.2.147

    authors: Hampton MB,Vissers MC,Winterbourn CC

    更新日期:1994-02-01 00:00:00

  • Characterization of thyroid fibrosis in a murine model of granulomatous experimental autoimmune thyroiditis.

    abstract::This study was initiated to identify and characterize thyroid fibrosis in a murine model of granulomatous experimental autoimmune thyroiditis (G-EAT) and determine if TGF-beta1 might be involved in fibrosis. G-EAT was induced by transfer of mouse thyroglobulin-sensitized spleen cells activated in vitro with thyroglobu...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Chen K,Wei Y,Sharp GC,Braley-Mullen H

    更新日期:2000-12-01 00:00:00

  • Characterization of macrophage subsets regulating murine natural killer cell activity.

    abstract::We examined the relationship of I-A expression by normal murine macrophages to their immunoregulatory role on natural killer cell activity. Macrophages were isolated on the basis of plastic adherence; characterized on the basis of conventional markers such as phagocytic ability, cytoplasmic non-specific esterase activ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.48.5.382

    authors: Nelson JA,Parhar RS,Scodras JM,Lala PK

    更新日期:1990-11-01 00:00:00

  • Frequencies of FoxP3+ naive T cells are related to both viral load and naive T cell proliferation responses in HIV disease.

    abstract::HIV infection results in depletion and dysfunction of naïve CD4(+) T cells. The mechanisms underlying these deficiencies are not understood. We investigated the frequencies of CD4(+) naïve subsets in HIV disease as defined by expression of CD25 and/or FoxP3 and the relationship of these frequencies to naïve T cell pro...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.1210661

    authors: Rodriguez B,Bazdar DA,Funderburg N,Asaad R,Luciano AA,Yadavalli G,Kalayjian RC,Lederman MM,Sieg SF

    更新日期:2011-09-01 00:00:00

  • Activation of the sympathetic nervous system modulates neutrophil function.

    abstract::Emerging evidence has revealed that noradrenaline (NA), the main neurotransmitter of the sympathetic nervous system (SNS), regulates a variety of immune functions via binding to adrenergic receptors present on immune cells. In this study, we examined the role of NA in the regulation of neutrophil functions. Neutrophil...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/JLB.3MA0517-194RR

    authors: Nicholls AJ,Wen SW,Hall P,Hickey MJ,Wong CHY

    更新日期:2018-02-01 00:00:00

  • A2A adenosine receptor stimulation decreases foam cell formation by enhancing ABCA1-dependent cholesterol efflux.

    abstract::Immune and inflammatory cells play a critical role in the pathogenesis of atherosclerotic plaques. We have demonstrated that A2ARs inhibit foam cell formation and stimulate production of ABCA1, the primary transporter of lipoproteins. We asked whether the effects of A2ARs on foam cell formation in vitro are mediated b...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0709513

    authors: Bingham TC,Fisher EA,Parathath S,Reiss AB,Chan ES,Cronstein BN

    更新日期:2010-04-01 00:00:00

  • Alcohol-induced IL-1β in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation.

    abstract::Alcohol-induced neuroinflammation is mediated by proinflammatory cytokines, including IL-1β. IL-1β production requires caspase-1 activation by inflammasomes-multiprotein complexes that are assembled in response to danger signals. We hypothesized that alcohol-induced inflammasome activation contributes to increased IL-...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.1212659

    authors: Lippai D,Bala S,Petrasek J,Csak T,Levin I,Kurt-Jones EA,Szabo G

    更新日期:2013-07-01 00:00:00

  • Combined activation of innate and T cell immunity for recognizing immunomodulatory properties of therapeutic agents.

    abstract::Complex syndromes such as atherosclerosis and type 2 diabetes are disorders that are associated with inflammatory processes involving innate and adaptive immunity. Emerging knowledge about the pathological consequences of immune imbalances in a wide range of disease settings is expected to help to identify novel thera...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.1003454

    authors: Rose B,Herder C,Löffler H,Kolb H,Martin S

    更新日期:2004-04-01 00:00:00