Polymorphonuclear granulocytes induce myocardial dysfunction during ischemia and in later reperfusion of hearts exposed to low-flow ischemia.

abstract：:The immunosuppressive activity of interleukin-10 (IL-10) makes this cytokine a potentially important clinical tool to reduce inflammatory responses in various diseases. Its efficacy as a therapeutic modality is dependent on the responsiveness of immune cells. We report that macrophages from mice chronically infected w...

journal_title：Journal of leukocyte biology

authors： Avdiushko R,Hongo D,Lake-Bullock H,Kaplan A,Cohen D

更新日期：2001-10-01 00:00:00

abstract：:We reported that PARP-1 exhibits differential roles in expression of inflammatory factors. Here, we show that PARP-1 deletion was associated with a significant reduction in inflammatory cell recruitment to mouse airways upon intratracheal administration of LPS. However, PARP-1 deletion exerted little effect in respons...

journal_title：Journal of leukocyte biology

authors： Zerfaoui M,Naura AS,Errami Y,Hans CP,Rezk BM,Park J,Elsegeiny W,Kim H,Lord K,Kim JG,Boulares AH

更新日期：2009-12-01 00:00:00

abstract：:The existence of an association between the brain and immunity has been documented. Data show that the nervous and immune systems communicate with one another to maintain immune homeostasis. Activated immune cells secrete cytokines that influence central nervous system activity, which in turn, activates output through...

journal_title：Journal of leukocyte biology

authors： Kin NW,Sanders VM

更新日期：2006-06-01 00:00:00

abstract：:Intravenous administration of lipopolysaccharide (LPS) to rats increased the production of nitric oxide (NO) metabolites (NOx) by blood polymorphonuclear neutrophils (PMN) in vitro. Both dexamethasone and L-NMMA, added in vitro to neutrophil cultures, inhibited the production of NO. On the other hand, the production o...

journal_title：Journal of leukocyte biology

authors： Fierro IM,Nascimento-DaSilva V,Arruda MA,Freitas MS,Plotkowski MC,Cunha FQ,Barja-Fidalgo C

更新日期：1999-04-01 00:00:00

abstract：:The germinal center (GC) is a dynamic structure formed by proliferating B cells in the follicles of secondary lymphoid organs during T cell-dependent antibody responses to exogenous antigens. GC is composed by a dark zone, enriched in proliferating centroblasts (CBs), and a light zone where CBs migrate and transform i...

journal_title：Journal of leukocyte biology

authors： Ferretti E,Ponzoni M,Doglioni C,Pistoia V

更新日期：2016-11-01 00:00:00

abstract：:The magnitude and efficacy of CD8(+) T cell memory may notably regress, especially if immune induction occurs in the absence of adequate CD4(+) help. This report demonstrates that this CD8(+) memory malfunction could be remedied if a source of cognate antigen-recognizing helper cells were provided during recall. The i...

journal_title：Journal of leukocyte biology

authors： Kumaraguru U,Banerjee K,Rouse BT

更新日期：2005-10-01 00:00:00

abstract：:The agent(s) and mechanism(s) responsible for suppression of neutrophil chemotaxis in association with major thermal injury have not been identified. We have proposed that the reduced random motility characterizing patients' cells may contribute to their generalized chemotactic dysfunction. Here we report that actin p...

journal_title：Journal of leukocyte biology

authors： Hasslen SR,Ahrenholz DH,Solem LD,Nelson RD

更新日期：1992-11-01 00:00:00

abstract：:Dysregulated Ca(2+) handling is prevalent during sepsis and postulated to perpetuate the aberrant inflammation underlying subsequent organ dysfunction and death. The signal transduction cascades mediating these processes are unknown. Here, we identify that CaMKIα mediates the Mϕ response to LPS in vitro and the inflam...

journal_title：Journal of leukocyte biology

authors： Zhang X,Guo L,Collage RD,Stripay JL,Tsung A,Lee JS,Rosengart MR

更新日期：2011-08-01 00:00:00

abstract：:The neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) is a powerful suppressor of inflammation mediated by macrophages, which express at least two receptors, melanocortin 1 and 3 receptors (MC1r and MC3r) that bind alpha-MSH. Albeit, the anti-inflammatory activity of alpha-MSH has been well documented in m...

journal_title：Journal of leukocyte biology

authors： Li D,Taylor AW

更新日期：2008-07-01 00:00:00

abstract：:The human lysozyme (LZM) gene is highly methylated in LZM-nonexpressor immature myeloid and in nonmyeloid cells and unmethylated only in LZM-expressing cells. Extended methylation analyses of the CpG-poor 5' flanking region and of the exon 4 CpG island (both containing Alu elements) of the LZM gene were now performed....

journal_title：Journal of leukocyte biology

authors： Claus R,Fliegauf M,Stock M,Duque JA,Kolanczyk M,Lübbert M

更新日期：2006-12-01 00:00:00

abstract：:New tools are required to expedite the development of an effective vaccine against the blood-stage infection with the human malaria parasite Plasmodium falciparum. This work describes the assessment of the ADRB assay in a mouse model, characterizing the functional interaction between antimalarial serum antibodies and ...

journal_title：Journal of leukocyte biology

authors： Llewellyn D,de Cassan SC,Williams AR,Douglas AD,Forbes EK,Adame-Gallegos JR,Shi J,Pleass RJ,Draper SJ

更新日期：2014-02-01 00:00:00

abstract：:The immune system in early life is regarded as immature. However, the IL-12 family member IL-23 is highly produced upon TLR stimulation by neonatal DCs. Human adult Vγ9Vδ2 T cells can be stimulated specifically via their TCR by phosphoantigens (as the pathogen-derived HMB-PP) or agents and infections that lead to thei...

journal_title：Journal of leukocyte biology

authors： Moens E,Brouwer M,Dimova T,Goldman M,Willems F,Vermijlen D

更新日期：2011-05-01 00:00:00

abstract：:Compared with CD4+25+ regulatory T cells (Tregs), the mechanisms for natural, polyclonal CD8+25+ Treg immune suppression have been significantly less studied. We previously showed that polyclonal T cells can acquire antigen-specific targeting activity through arming with exosomal peptide-MHC (pMHC). In this study, we ...

journal_title：Journal of leukocyte biology

authors： Mu C,Zhang X,Wang L,Xu A,Ahmed KA,Pang X,Chibbar R,Freywald A,Huang J,Zhu Y,Xiang J

更新日期：2017-05-01 00:00:00

abstract：:Poxviruses encode a variety of immunomodulatory proteins that subvert the cytokine networks of infected hosts. Myxoma virus, a poxvirus pathogen of rabbits, expresses two distinct 35- to 40-kDa secreted glycoproteins that bind a broad spectrum of chemokines. The first of these, designated M-T7, is encoded by the T7 ge...

journal_title：Journal of leukocyte biology

authors： Lalani AS,McFadden G

更新日期：1997-11-01 00:00:00

abstract：:In resident mouse peritoneal macrophages, group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) mediates arachidonic acid (AA) release and eicosanoid production in response to diverse agonists such as A23187, phorbol myristate acetate, zymosan, and the enterotoxin, okadaic acid (OA). cPLA(2)alpha is regulated by phosp...

journal_title：Journal of leukocyte biology

authors： Tucker DE,Gijón MA,Spencer DM,Qiu ZH,Gelb MH,Leslie CC

更新日期：2008-09-01 00:00:00

abstract：:Dendritic cells (DCs) loaded extracorporeally with antigen can be used as an adjuvant in vivo. In this work, we analyzed the migration of transferred DC and monitored the phenotype of new migrants in the draining lymph nodes. It is surprising that we found that a majority of resident DCs expressed donor MHC molecules ...

journal_title：Journal of leukocyte biology

authors： de Heusch M,Blocklet D,Egrise D,Hauquier B,Vermeersch M,Goldman S,Moser M

更新日期：2007-10-01 00:00:00

abstract：:The pathogenesis of CRC remains to be further understood. This study was designed to elucidate the role of Foxp3+IL-17+ T cells in the pathogenesis of CRC. Surgically removed CRC tissue was collected from 12 patients with CRC. The frequency and cytokine profile of Foxp3+IL-17+ T cells in CRC were examined by flow cyto...

journal_title：Journal of leukocyte biology

authors： Yang S,Wang B,Guan C,Wu B,Cai C,Wang M,Zhang B,Liu T,Yang P

更新日期：2011-01-01 00:00:00

abstract：:The seven transmembrane G protein-coupled receptor EBV-induced gene 2 (EBI2), also known as GPR183, is expressed in particular in immune cells. Activated by its endogenous ligands, which are a group of oxysterols, it functions as a chemo-attractant receptor, mediating cell migration. In coordination with other recepto...

journal_title：Journal of leukocyte biology

authors： Barington L,Wanke F,Niss Arfelt K,Holst PJ,Kurschus FC,Rosenkilde MM

更新日期：2018-08-01 00:00:00

abstract：:Recent studies have revealed that aloe emodin (AE), a natural compound from the root and rhizome of Rheum palmatum L., exhibits significant pharmacologic activities. However, the pharmacologic relevance of the compound, particularly for cardiovascular disease, remains largely unknown. Here, we hypothesized that AE cou...

journal_title：Journal of leukocyte biology

authors： Zhang Y,Song Z,Huang S,Zhu L,Liu T,Shu H,Wang L,Huang Y,Chen Y

更新日期：2020-12-01 00:00:00

abstract：:Macrophages and dendritic cells are in the front line of host defense. When they sense host invasion, they produce cytokines that alert other innate immune cells and also abet the development of an adaptive immune response. Although lipolysaccharide (LPS), peptidoglycan, unmethylated DNA, and other microbial products ...

journal_title：Journal of leukocyte biology

authors： Beutler B,Hoebe K,Du X,Ulevitch RJ

更新日期：2003-10-01 00:00:00

abstract：:TNFR-associated periodic syndrome is an autoinflammatory disorder caused by autosomal-dominant mutations in TNFRSF1A, the gene encoding for TNFR superfamily 1A. The lack of knowledge in the field of TNFR-associated periodic syndrome biology is clear, particularly in the context of control of immune self-tolerance. We ...

journal_title：Journal of leukocyte biology

authors： Pucino V,Lucherini OM,Perna F,Obici L,Merlini G,Cattalini M,La Torre F,Maggio MC,Lepore MT,Magnotti F,Galgani M,Galeazzi M,Marone G,De Rosa V,Talarico R,Cantarini L,Matarese G

更新日期：2016-05-01 00:00:00

abstract：:Clostridioides difficile (C. difficile) is the major cause of hospital-acquired gastrointestinal infections in individuals following antibiotics treatment. The pathogenesis of C. difficile infection (CDI) is mediated mainly by the production of toxins that induce tissue damage and host inflammatory responses. While in...

journal_title：Journal of leukocyte biology

authors： Hernández Del Pino RE,Barbero AM,Español LÁ,Morro LS,Pasquinelli V

更新日期：2020-08-23 00:00:00

abstract：:Activation of the microvasculature is a major component of the inflammatory response. During inflammation the vascular endothelium not only becomes more permeable to plasma proteins but also develops adhesion molecules that initiate the local immigration of leukocytes. We describe herein the in vivo changes in the thr...

journal_title：Journal of leukocyte biology

authors： Abe Y,Sugisaki K,Dannenberg AM Jr

更新日期：1996-12-01 00:00:00

abstract：:Introduction of alloantigens into the AC induces a form of immune tolerance known as ACAID, which induces antigen-specific CD8+ Tregs, contributing to ocular immune privilege by down-regulating immune responses. Recent evidence suggests IFN-γ is needed for the suppressive function of CD8+ ACAID Tregs. This study teste...

journal_title：Journal of leukocyte biology

authors： Paunicka K,Chen PW,Niederkorn JY

更新日期：2012-03-01 00:00:00

abstract：:In the present study, we investigated the expression of human CD1d antigen on activated mature T cells. Expression of this glycoprotein was found to be highly regulated and dependent on PHA stimulation. Flow cytometry studies using the NOR3.2 antibody, which recognized CD1d under denaturing conditions, showed a clear ...

journal_title：Journal of leukocyte biology

authors： Salamone MC,Rabinovich GA,Mendiguren AK,Salamone GV,Fainboim L

更新日期：2001-02-01 00:00:00

abstract：:Cyclophilin A (CypA), a peptidylprolyl cis-trans isomerase, is a ubiquitous and multifunctional protein. In addition to its role as a host-cell receptor for cyclosporine A, CypA has diverse functions in inflammatory conditions and diseases. CypA secreted in response to inflammatory stimuli binds to the cell surface vi...

journal_title：Journal of leukocyte biology

authors： Dawar FU,Xiong Y,Khattak MNK,Li J,Lin L,Mei J

更新日期：2017-10-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that accumulate during pathologic conditions, such as cancer. Patients diagnosed with advanced metastatic cancers have an average survival of 12-24 mo, a survival time that hasn't changed significantly in the past 30 yr. ...

journal_title：Journal of leukocyte biology

authors： Chesney JA,Mitchell RA,Yaddanapudi K

更新日期：2017-09-01 00:00:00

abstract：:Genomic, transcriptomic and proteomic databases indicate that the N-terminal 322 residues encoded by the presumptive LOC100996504 gene, which is adjacent to the ARHGEF18 guanine nucleotide exchange factor gene on chromosome 19, constitute the N-terminal portion of a 1361-residue isoform of ARHGEF18, dubbed LOCGEF-X3. ...

journal_title：Journal of leukocyte biology

authors： Turton KB,Wilkerson EM,Hebert AS,Fogerty FJ,Schira HM,Botros FE,Coon JJ,Mosher DF

更新日期：2018-07-01 00:00:00

abstract：:Neutrophils showed a rapid and transient adhesion to immunoglobulin G (IgG)-coated plates compared with their adhesion to bovine serum albumin (BSA)-coated plates: the adhesion reached a peak after 15 min of incubation and then gradually returned to almost the basal state in 60 min. The addition of monomeric IgG or an...

journal_title：Journal of leukocyte biology

authors： Kusunoki T,Tsuruta S,Higashi H,Hosoi S,Hata D,Sugie K,Mayumi M,Mikawa H

更新日期：1994-06-01 00:00:00

abstract：:The oxidative metabolic burst of stimulated human polymorphonuclear leukocytes (PMNs) has been evaluated by the measurement of oxygen consumption, chemiluminescence, and oxygen radicals (O2-, H2O2, OH-) derived from activation of the hexose monophosphate shunt (HMPS). PMNs from patients with chronic granulomatous dise...

journal_title：Journal of leukocyte biology

authors： Hassan NF,Campbell DE,Douglas SD

更新日期：1988-04-01 00:00:00