It takes nerve to tell T and B cells what to do.

abstract：:Macrophage activation by IFN-gamma results in a cascade of gene expression. To identify genes activated in mouse peritoneal macrophages by IFN-gamma, we created a cDNA subtraction library of IFN-gamma-induced genes. We have isolated from this subtraction library a novel cDNA clone, called Mg21, whose mRNA is absent in...

journal_title：Journal of leukocyte biology

authors： Lafuse WP,Brown D,Castle L,Zwilling BS

更新日期：1995-03-01 00:00:00

abstract：:IL-17 has been associated with selected inflammatory and autoimmune diseases. We characterized the expression of this proinflammatory cytokine following HSV-1 corneal infection and investigated whether IL-17R signaling modulated the host response to the viral pathogen at early time-points postinfection. IL-17 was elev...

journal_title：Journal of leukocyte biology

authors： Molesworth-Kenyon SJ,Yin R,Oakes JE,Lausch RN

更新日期：2008-02-01 00:00:00

abstract：:Complex syndromes such as atherosclerosis and type 2 diabetes are disorders that are associated with inflammatory processes involving innate and adaptive immunity. Emerging knowledge about the pathological consequences of immune imbalances in a wide range of disease settings is expected to help to identify novel thera...

journal_title：Journal of leukocyte biology

authors： Rose B,Herder C,Löffler H,Kolb H,Martin S

更新日期：2004-04-01 00:00:00

abstract：:Hybridoma cell lines were produced by fusion of SP2/0 murine myeloma cell line with the spleen cells of Wister rats which were immunized with IgG2a-binding protein isolated from the detergent lysate of a murine macrophagelike cell line, P388D1, by affinity chromatography on IgG-Sepharose 4B. A monoclonal clone (design...

journal_title：Journal of leukocyte biology

authors： Kagami M,Funatsu Y,Suzuki T

更新日期：1989-04-01 00:00:00

abstract：:Emerging evidence has revealed that noradrenaline (NA), the main neurotransmitter of the sympathetic nervous system (SNS), regulates a variety of immune functions via binding to adrenergic receptors present on immune cells. In this study, we examined the role of NA in the regulation of neutrophil functions. Neutrophil...

journal_title：Journal of leukocyte biology

authors： Nicholls AJ,Wen SW,Hall P,Hickey MJ,Wong CHY

更新日期：2018-02-01 00:00:00

abstract：:Inflammation alters hematopoiesis, often by decreasing erythropoiesis and enhancing myeloid output. The mechanisms behind these changes and how the BM stroma contributes to this process are active areas of research. In this study, we examine these questions in the setting of murine Toxoplasma gondii infection. Our dat...

journal_title：Journal of leukocyte biology

authors： Chou DB,Sworder B,Bouladoux N,Roy CN,Uchida AM,Grigg M,Robey PG,Belkaid Y

更新日期：2012-07-01 00:00:00

abstract：:Mac-1 (CD11b/CD18) is known to be involved in neutrophil (PMN) adhesion to endothelial cells and extracellular matrix. Although antibodies to CD 18 are being tested for therapy in humans, their role in PMN migration through the extracellular matrix is unknown. We used direct visualization to quantify PMN motility thro...

journal_title：Journal of leukocyte biology

authors： Saltzman WM,Livingston TL,Parkhurst MR

更新日期：1999-03-01 00:00:00

abstract：:Glucosamine, an amino monosaccharide naturally occurring in the connective and cartilage tissues, contributes to maintaining the strength, flexibility, and elasticity of these tissues. In recent years, glucosamine has been used widely to treat osteoarthritis in humans and animal models. Neutrophils, which usually func...

journal_title：Journal of leukocyte biology

authors： Hua J,Sakamoto K,Nagaoka I

更新日期：2002-04-01 00:00:00

abstract：:Neutrophils kill invading pathogens by AMPs, including cathelicidins, ROS, and NETs. The human pathogen Staphylococcus aureus exhibits enhanced resistance to neutrophil AMPs, including the murine cathelicidin CRAMP, in part, as a result of alanylation of teichoic acids by the dlt operon. In this study, we took advanta...

journal_title：Journal of leukocyte biology

authors： Jann NJ,Schmaler M,Kristian SA,Radek KA,Gallo RL,Nizet V,Peschel A,Landmann R

更新日期：2009-11-01 00:00:00

abstract：:Monocytes and macrophages differentiate from progenitor cells under the influence of colony-stimulating factors. Genome-scale data have enabled the identification of the set of genes that distinguishes macrophages from other cell types and the ways in which thousands of genes are regulated in response to pathogen chal...

journal_title：Journal of leukocyte biology

authors： Hume DA

更新日期：2012-09-01 00:00:00

abstract：:Breaking the long-held paradigm that primary B cells are not phagocytic, several studies have demonstrated recently that B cells from fish, amphibians, and reptilians have a significant phagocytic capacity. Whether such capacity has remained conserved in certain mammalian B cell subsets is presently an enigma. Here, w...

journal_title：Journal of leukocyte biology

authors： Parra D,Rieger AM,Li J,Zhang YA,Randall LM,Hunter CA,Barreda DR,Sunyer JO

更新日期：2012-04-01 00:00:00

abstract：:Structurally, the monocyte chemotactic proteins MCP-1, -2, and -3 form a subfamily of the C-C or beta-chemokines. Like other chemokines, MCPs are produced by a variety of cells on stimulation with cytokines (interleukin-1, tumor necrosis factor-alpha, interferon-gamma), bacterial and viral products or mitogens. MCP-1 ...

journal_title：Journal of leukocyte biology

authors： Proost P,Wuyts A,Van Damme J

更新日期：1996-01-01 00:00:00

abstract：:This report focuses on the modulatory role of endogenous H(2)O(2) on lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-induced inducible nitric oxide synthase (NOS2) gene expression in rat peritoneal macrophages. Exogenously added H(2)O(2) was initially found to inhibit the synthesis of NOS2, which prompted us to ...

journal_title：Journal of leukocyte biology

authors： Vega A,Chacón P,Monteseirín J,El Bekay R,Alvarez M,Alba G,Conde J,Martín-Nieto J,Bedoya FJ,Pintado E,Sobrino F

更新日期：2004-06-01 00:00:00

abstract：:We have investigated the role of the purinergic P2X7 receptor in the formation of multinucleated giant cells in human monocyte/macrophage cultures stimulated with either concanavalin A or phytohemagglutinin. Macrophage fusion can be blocked by a P2X7-selective pharmacological antagonist or by a mAb directed against th...

journal_title：Journal of leukocyte biology

authors： Di Virgilio F,Falzoni S,Chiozzi P,Sanz JM,Ferrari D,Buell GN

更新日期：1999-11-01 00:00:00

abstract：:Macrophages play an important role in a wide variety of physiologic and pathologic processes. Plasticity and functional polarization are hallmarks of macrophages. Macrophages commonly exist in two distinct subsets: classically activated macrophages (M1) and alternatively activated macrophages (M2). M2b, a subtype of M...

journal_title：Journal of leukocyte biology

authors： Wang LX,Zhang SX,Wu HJ,Rong XL,Guo J

更新日期：2019-08-01 00:00:00

abstract：:IL-7R, FLT3, and CD43 are surface antigens expressed during the transition from pro-B to pre-B cells in BM. To understand interactions between their signaling pathways, we analyzed spontaneous mouse B-LBLs with dual MLV integration into Stat5a and Fiz1 or Stat5a and Hipk2. MLV integration resulted in up-regulation of ...

journal_title：Journal of leukocyte biology

authors： Tsuruyama T,Imai Y,Takeuchi H,Hiratsuka T,Maruyama Y,Kanaya K,Kaszynski R,Jin G,Okuno T,Ozeki M,Nakamura T,Takakuwa T,Manabe T,Tamaki K,Hiai H

更新日期：2010-07-01 00:00:00

abstract：:The transmembrane form of tumor necrosis factor (mTNF), expressed on activated monocytes (MO) and macrophages (MPhi), is able to induce apoptosis in human endothelial cells (EC). Apoptosis is mediated by two distinct mechanisms: direct cell contact and a yet-unidentified soluble protein, death factor X. In addition, m...

journal_title：Journal of leukocyte biology

authors： Kirchner S,Boldt S,Kolch W,Haffner S,Kazak S,Janosch P,Holler E,Andreesen R,Eissner G

更新日期：2004-02-01 00:00:00

abstract：:The brief lifespan of the polymorphonuclear neutrophil (PMN) is regulated through its capacity to undergo apoptosis, a constitutive process that is actively inhibited during sepsis. We sought to define the cellular mechanisms through which Heat Shock Protein 90 (Hsp90) prolongs the survival of inflammatory PMN. We eva...

journal_title：Journal of leukocyte biology

authors： Gupta S,Lee CM,Wang JF,Parodo J,Jia SH,Hu J,Marshall JC

更新日期：2018-05-01 00:00:00

abstract：:CXCL8 is the principal human neutrophil-attracting chemokine and a major mediator of inflammation. The chemokine exerts its neutrophil-chemotactic and neutrophil-activating activities via interaction with glycosaminoglycans (GAGs) and activation of the G protein-coupled receptors (GPCRs) CXCR1 and CXCR2. Natural CXCL8...

journal_title：Journal of leukocyte biology

authors： Metzemaekers M,Vandendriessche S,Berghmans N,Gouwy M,Proost P

更新日期：2020-06-01 00:00:00

abstract：:We have developed a method that enables the rates of phagocytosis and killing of bacteria by neutrophils to be measured in a single assay. Neutrophils were incubated with bacteria, and at specific intervals were separated from uningested bacteria by low speed centrifugation. Rates of phagocytosis and killing were calc...

journal_title：Journal of leukocyte biology

authors： Hampton MB,Vissers MC,Winterbourn CC

更新日期：1994-02-01 00:00:00

abstract：:The ability of neutrophils to sense and migrate toward damaged tissue is a vital component of the innate immune response. Paradoxically, this same migration serves as the hallmark of a number of inflammatory conditions, including ischemic reperfusion injury, atherosclerosis, arthritis, and Crohn's disease. More recent...

journal_title：Journal of leukocyte biology

authors： Maher BM,Dhonnchu TN,Burke JP,Soo A,Wood AE,Watson RW

更新日期：2009-01-01 00:00:00

abstract：:During inflammatory and immunological responses, leukocytes respond to external stimuli by altering the stability of cytokine and cytokine receptor messages. Change in message stability is an effective mechanism for rapidly regulating steady state levels of mRNA. Cytokine messages containing A-U-rich elements located ...

journal_title：Journal of leukocyte biology

authors： Xu L,Rahimpour R,Ran L,Kong C,Biragyn A,Andrews J,Devries M,Wang JM,Kelvin DJ

更新日期：1997-11-01 00:00:00

abstract：:Poxviruses encode a variety of immunomodulatory proteins that subvert the cytokine networks of infected hosts. Myxoma virus, a poxvirus pathogen of rabbits, expresses two distinct 35- to 40-kDa secreted glycoproteins that bind a broad spectrum of chemokines. The first of these, designated M-T7, is encoded by the T7 ge...

journal_title：Journal of leukocyte biology

authors： Lalani AS,McFadden G

更新日期：1997-11-01 00:00:00

abstract：:The Hedgehog (Hh) family of signaling molecules functions in the development of numerous tissues during embryogenesis and has also been involved in adult self-renewing tissues. Recent results have demonstrated that the different components of the Hh signaling pathway are expressed in the human thymus. In this study, w...

journal_title：Journal of leukocyte biology

authors： Varas A,Hernández-López C,Valencia J,Mattavelli S,Martínez VG,Hidalgo L,Gutiérrez-Frías C,Zapata AG,Sacedón R,Vicente A

更新日期：2008-06-01 00:00:00

abstract：:Leukocytes are a large population of cells spread within most tissues in the body. These cells may be either sessile (called as resident cells) or circulating leukocytes, which travel long journeys inside the vessels during their lifespan. Although production and maturation of these leukocytes in adults primarily occu...

journal_title：Journal of leukocyte biology

authors： Mafra K,Nakagaki BN,Castro Oliveira HM,Rezende RM,Antunes MM,Menezes GB

更新日期：2019-09-01 00:00:00

abstract：:Glucocorticoids (GC) are potent anti-inflammatory and immunosuppressive agents that act on a variety of immune cells, including T cells, monocytes/macrophages, osteoclasts, and dendritic cells (DC). However, the mechanism(s) by which GC exert anti-inflammatory effects is still largely unknown. It is already well known...

journal_title：Journal of leukocyte biology

authors： Kim KD,Choe YK,Choe IS,Lim JS

更新日期：2001-03-01 00:00:00

abstract：:Previous studies about basophils and mast cells identified the ability of IgE to up-regulate FcepsilonRI expression by a process that depends on stabilization of the surface receptor by IgE. However, the mechanism of loss from the cell surface, when unoccupied, is not known. The current studies have examined whether u...

journal_title：Journal of leukocyte biology

authors： MacGlashan DW Jr

更新日期：2007-10-01 00:00:00

abstract：:Macrophage activation is associated with increased secretion of monokines, proteases, arachidonic acid metabolites, reactive oxygen, and nitrogen intermediates and yet decreased secretion of apolipoprotein E (apo E). Although the kinetics of apo E down-regulation have been investigated, the mechanism(s) involved remai...

journal_title：Journal of leukocyte biology

authors： Zuckerman SH,O'Neal L

更新日期：1994-06-01 00:00:00

abstract：:PI(3)Kγ is thought to mediate leukocyte migration to injured tissues and may be important in the pathogenesis of various T-lymphocyte-dependent pathologies, including autoimmune and inflammatory diseases. The present study evaluated the relevance of PI(3)Kγ in donor cells for the pathogenesis of acute GVHD using a mod...

journal_title：Journal of leukocyte biology

authors： Castor MG,Rezende BM,Bernardes PT,Vieira AT,Vieira EL,Arantes RM,Souza DG,Silva TA,Teixeira MM,Pinho V

更新日期：2011-06-01 00:00:00

abstract：:The effects of B cell subsets with regulatory activity on the immune response to an allograft have evoked increasing interest. Here, we summarize the function and signaling of regulatory B cells (Bregs) and their potential effects on transplantation. These cells are able to suppress the immune system directly via liga...

journal_title：Journal of leukocyte biology

authors： Li J,Luo Y,Wang X,Feng G

更新日期：2019-04-01 00:00:00