Abstract:
:Cyclophilin A (CypA), a peptidylprolyl cis-trans isomerase, is a ubiquitous and multifunctional protein. In addition to its role as a host-cell receptor for cyclosporine A, CypA has diverse functions in inflammatory conditions and diseases. CypA secreted in response to inflammatory stimuli binds to the cell surface via its receptor CD147 and induces secretion of various inflammatory cytokines. However, silencing and inhibition of either CypA or CD147 inhibits inflammatory cytokine expression and inflammation. This report reviews the literature related to the mechanism of CypA-dependent cytokine secretion and discusses this factor as a possible therapeutic target in inflammatory diseases.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Dawar FU,Xiong Y,Khattak MNK,Li J,Lin L,Mei Jdoi
10.1189/jlb.3RU0317-090RRsubject
Has Abstractpub_date
2017-10-01 00:00:00pages
989-992issue
4eissn
0741-5400issn
1938-3673pii
jlb.3RU0317-090RRjournal_volume
102pub_type
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