Antibody ligation of murine Ly-6G induces neutropenia, blood flow cessation, and death via complement-dependent and independent mechanisms.

abstract：:In this study, we demonstrate that freshly adherent bovine monocytes release tumor necrosis factor-alpha (TNF-alpha) in response to stimulation with bacterial lipopolysaccharide (LPS). TNF-alpha was detected using actinomycin D-treated WEHI-164 murine fibrosarcoma cells as targets in an 18 hr cytotoxicity assay. Doses...

journal_title：Journal of leukocyte biology

authors： Adams JL,Czuprynski CJ

更新日期：1990-12-01 00:00:00

abstract：:Multiple mechanisms are used by the human immunodeficiency virus type 1 (HIV-1) to interfere with host-cell immune effector functions. The 27-kD Nef protein has been shown to down-modulate specific genes of the major histocompatibility complex class I (MHC-I) on the surface of infected primary T cells, facilitating th...

journal_title：Journal of leukocyte biology

authors： Brown A,Gartner S,Kawano T,Benoit N,Cheng-Mayer C

更新日期：2005-09-01 00:00:00

abstract：:Emerging evidence suggests that the innate immune system, comprised of Toll-like receptors (TLRs) and their associated molecules, plays a pivotal role in the regulation of intestinal inflammation and in the response to invading pathogens. Although TLRs are thought to have predominantly beneficial effects in pathogen r...

journal_title：Journal of leukocyte biology

authors： Gribar SC,Anand RJ,Sodhi CP,Hackam DJ

更新日期：2008-03-01 00:00:00

abstract：:The germinal center (GC) is a dynamic structure formed by proliferating B cells in the follicles of secondary lymphoid organs during T cell-dependent antibody responses to exogenous antigens. GC is composed by a dark zone, enriched in proliferating centroblasts (CBs), and a light zone where CBs migrate and transform i...

journal_title：Journal of leukocyte biology

authors： Ferretti E,Ponzoni M,Doglioni C,Pistoia V

更新日期：2016-11-01 00:00:00

abstract：:The current results provide direct evidence for a role of tissue macrophages (M phi) in natural immunity and support the use of immunomodulators to enhance antiviral resistance in immunocompromised individuals. In this study, macrophages (M phi) in the spleen and liver were eliminated by intravenous (i.v.) injection o...

journal_title：Journal of leukocyte biology

authors： Pinto AJ,Stewart D,van Rooijen N,Morahan PS

更新日期：1991-06-01 00:00:00

abstract：:Extracellular vesicles (EVs) are nanosized particles that have emerged as mediators for intercellular communication in physiologic and pathologic conditions. EVs carry signaling information on their bilipid membrane as well as cargo within, allowing them to perform a wide range of biologic processes and contribute to ...

journal_title：Journal of leukocyte biology

authors： Lam KCK,Lam MKN,Chim CS,Chan GCF,Li JCB

更新日期：2020-11-01 00:00:00

abstract：:Monocytes and macrophages differentiate from progenitor cells under the influence of colony-stimulating factors. Genome-scale data have enabled the identification of the set of genes that distinguishes macrophages from other cell types and the ways in which thousands of genes are regulated in response to pathogen chal...

journal_title：Journal of leukocyte biology

authors： Hume DA

更新日期：2012-09-01 00:00:00

abstract：:Cytohesin-1 and ARNO are guanine nucleotide-exchange factors (GEFs) for ADP-ribosylation factor (Arf). Here, we show that ARNO is expressed in HL-60 cells and established that granulocytic differentiation induced with Me2SO stimulated cytohesin-1 but not ARNO expression. Cytohesin-1 levels in HL-60 granulocytes were s...

journal_title：Journal of leukocyte biology

authors： Bourgoin SG,Houle MG,Singh IN,Harbour D,Gagnon S,Morris AJ,Brindley DN

更新日期：2002-04-01 00:00:00

abstract：:Scaffolding molecules bind simultaneously and link together various components of signal-transduction pathways. Grb2-associated binder 2 (Gab2) is a scaffolding protein required for FcgammaR-initiated allergic responses in mast cells and FcgammaR-mediated phagocytosis in macrophages, where it links IgE and IgG recepto...

journal_title：Journal of leukocyte biology

authors： Zompi S,Gu H,Colucci F

更新日期：2004-10-01 00:00:00

abstract：:Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated molecular pattern. Neutrophils present in the mononuclear cell fraction of Ficoll gradient separation are called low-density neutrophils (LDNs). Here we report the novel role of eCIRP on LDNs' heterogeneity in sepsis. Sepsis was induced in...

journal_title：Journal of leukocyte biology

authors： Takizawa S,Murao A,Ochani M,Aziz M,Wang P

更新日期：2020-10-18 00:00:00

abstract：:Six IgG monoclonal antibodies representing the four murine IgG isotypes were active individually in ADCC to T-lymphoma targets mediated by murine macrophages and human blood K cells. The monoclonals were directed against four antigens (Thy-1.2, H-2k, Ly 2.1, Ly 9.2). None was as effective in ADCC as allo-anti-Thy-1.2 ...

journal_title：Journal of leukocyte biology

authors： Ralph P,Nakoinz I

更新日期：1984-01-01 00:00:00

abstract：:Matrix metalloproteinases-2 and -9 (MMP-2/9) are critically involved in degradation of extracellular matrix, and their inhibition is discussed as a promising strategy against hepatic ischemia-reperfusion (I/R) injury. Here, we analyzed the role of MMP-2 and -9 for leukocyte migration and tissue injury in sham-operated...

journal_title：Journal of leukocyte biology

authors： Khandoga A,Kessler JS,Hanschen M,Khandoga AG,Burggraf D,Reichel C,Hamann GF,Enders G,Krombach F

更新日期：2006-06-01 00:00:00

abstract：:Neutrophil-induced damage to the protective epithelium has been implicated in mucosal disorders associated with hypoxia, and such damage may be initiated by epithelial-derived chemokines. Because chemokines can bind to membrane proteoglycans, we hypothesized that chemokines may associate with epithelial surfaces and a...

journal_title：Journal of leukocyte biology

authors： Furuta GT,Dzus AL,Taylor CT,Colgan SP

更新日期：2000-08-01 00:00:00

abstract：:Immunosuppressive factors, such as vascular endothelial growth factor, transforming growth factor-beta, prostaglandin E2, interleukin (IL)-10, and IL-6, are made frequently by cancer cells. These factors, along with others, can inhibit the development and function of tumor-reactive effector T cells and the clinical re...

journal_title：Journal of leukocyte biology

authors： Spaner DE

更新日期：2004-08-01 00:00:00

abstract：:Bone destruction in inflammatory osteolytic diseases including periodontitis is related to excessive activity of osteoclasts (OC), which originate from precursor cells of the myeloid lineage, termed osteoclast precursors (OCP). In contrast to ample knowledge that we currently have on mature OC, little is known about O...

journal_title：Journal of leukocyte biology

authors： Zhao Y,Li Z,Su L,Ballesteros-Tato A,Katz J,Michalek SM,Feng X,Zhang P

更新日期：2020-10-01 00:00:00

abstract：:The role of Myeloid-Derived Suppressor Cells (MDSC) in infant immune ontogeny is unknown. Here, we evaluated MDSC frequency and relationship with infant vaccine responses throughout the first year of life in a prospective cohort study. Ninety-one South African infant-mother pairs were enrolled at delivery, and blood s...

journal_title：Journal of leukocyte biology

authors： Kidzeru E,Gasper MA,Shao D,Edlefsen PT,Lejarcegui N,Havyarimana E,Urdahl K,Gantt S,Horton H,Jaspan H,Gervassi A

更新日期：2021-01-21 00:00:00

abstract：:Leukocyte trafficking from the blood into the tissues represents a key process during inflammation and requires multiple steps mediated by adhesion molecules and chemoattractants. Inflammation has a detrimental role in several diseases, and in such cases, the molecular mechanisms controlling leukocyte migration are po...

journal_title：Journal of leukocyte biology

authors： Rossi B,Angiari S,Zenaro E,Budui SL,Constantin G

更新日期：2011-04-01 00:00:00

abstract：:CD163 is the monocyte/macrophage-specific receptor for haptoglobin-hemoglobin (Hp-Hb) complexes. The cytoplasmic tail of human CD163 exists as a short tail variant and two long tail variants. Reverse transcriptase-polymerase chain reaction analysis indicated that all three CD163 variants are substantially expressed in...

journal_title：Journal of leukocyte biology

authors： Nielsen MJ,Madsen M,Møller HJ,Moestrup SK

更新日期：2006-04-01 00:00:00

abstract：:During inflammation the balance between cell activation and cell death is determined by the tight regulation of multiple intracellular enzyme cascades. Key regulatory steps often involve protein kinases. We show that the prototypical pro-inflammatory molecule, bacterial lipopolysaccharide, activates multiple protein k...

journal_title：Journal of leukocyte biology

authors： Lee J,Mira-Arbibe L,Ulevitch RJ

更新日期：2000-12-01 00:00:00

abstract：:Soluble mediators and inducible cell-surface and matrix-bound molecules coordinate the cascade of events giving rise to leukocyte emigration. Knowledge of the specific mechanisms underlying the attraction of cells into a local site, however, remains sketchy. In particular, it is unclear how chemoattractants cause rapi...

journal_title：Journal of leukocyte biology

authors： Wiedermann CJ,Reinisch N,Bellmann R,Schratzberger P,Kowald E,Kähler CM

更新日期：1995-10-01 00:00:00

abstract：:Although a number of chemokine receptors display coreceptor activities in vitro, chemokine receptor 5 (CCR5) and CXC chemokine receptor 4 (CXCR4) remain the major coreceptors used by the human immunodeficiency virus type 1 (HIV-1). In this study, we used an envelope-mediated fusion assay to demonstrate low CCR4 corece...

journal_title：Journal of leukocyte biology

authors： Agrawal L,Vanhorn-Ali Z,Alkhatib G

更新日期：2002-11-01 00:00:00

abstract：:An acute inflammatory response requires that circulating monocytes bind to and migrate across the endothelium of the vessel wall to gain access to inflamed sites. Various mediators of inflammation--cytokines and chemoattractants--have been shown to initiate and regulate the margination and extravasation of monocytes. ...

journal_title：Journal of leukocyte biology

authors： Beekhuizen H,van Furth R

更新日期：1993-10-01 00:00:00

abstract：:TLR agonists such as LPS and poly(I:C) induce expression of type I IFNs, such as IFN-α and -β, by macrophages. To examine the role of IFN-β in the induction of ISGs by LPS, we compared the ability of LPS to induce ISGF3 activity and ISG expression in bone marrow-derived macrophages from WT and Ifnb1(-/-) mice. We foun...

journal_title：Journal of leukocyte biology

authors： Sheikh F,Dickensheets H,Gamero AM,Vogel SN,Donnelly RP

更新日期：2014-10-01 00:00:00

abstract：:MΦs are important sensory cells of the innate immune system and regulate immune responses through releasing different combinations of cytokines. In this study, we examined whether cytokines released by MΦs in response to the probiotic bacterial strain GR-1 modulate the responses of DCs. The cytokine profile released b...

journal_title：Journal of leukocyte biology

authors： Martins AJ,Spanton S,Sheikh HI,Kim SO

更新日期：2011-06-01 00:00:00

abstract：:Murine reconstitution assays were used to investigate the effects of recombinant human interleukin-7 (rhIL-7) on myeloid and lymphoid precursors and on bone marrow engraftment. Reconstitution with bone marrow from rhIL-7-treated mice results in a 3.4-fold decrease in total colony-forming unit-spleen (CFU-S) activity (...

journal_title：Journal of leukocyte biology

authors： Boerman OC,Gregorio TA,Grzegorzewski KJ,Faltynek CR,Kenny JJ,Wiltrout RH,Komschlies KL

更新日期：1995-08-01 00:00:00

abstract：:Neutrophils are important mediators of the innate immune defense and of the host response to a physical trauma. Because aberrant infiltration of injured sites by neutrophils was shown to cause adverse effects after trauma, we investigated how neutrophil infiltration could be modulated at the cellular level. Our data i...

journal_title：Journal of leukocyte biology

authors： Wille C,Eiseler T,Langenberger ST,Richter J,Mizuno K,Radermacher P,Knippschild U,Huber-Lang M,Seufferlein T,Paschke S

更新日期：2018-09-01 00:00:00

abstract：:We compared the effects of live or inactivated bovine respiratory syncytial virus (BRSV) on cytokine production by bovine monocyte-derived dendritic cells (MoDC). We also investigated the response of resting memory CD4(+) T cells to MoDC exposed to both viral preparations. Although BRSV did not appear to replicate in ...

journal_title：Journal of leukocyte biology

authors： Werling D,Collins RA,Taylor G,Howard CJ

更新日期：2002-08-01 00:00:00

abstract：:2-Arachidonoyl-glycerol (2-AG) and arachidonyl-ethanolamide (AEA) are endocannabinoids that have been implicated in many physiologic disorders, including obesity, metabolic syndromes, hepatic diseases, pain, neurologic disorders, and inflammation. Their immunomodulatory effects are numerous and are not always mediated...

journal_title：Journal of leukocyte biology

authors： Turcotte C,Chouinard F,Lefebvre JS,Flamand N

更新日期：2015-06-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMN) play an important role in inflammation, immune responses, and tissue repair by secreting interleukin- 1 beta (IL-1 beta). We investigated the regulation of IL-1 beta gene expression in human PMN treated with granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF induced IL...

journal_title：Journal of leukocyte biology

authors： Fernandez MC,Walters J,Marucha P

更新日期：1996-04-01 00:00:00

abstract：:Macrophages and dendritic cells are in the front line of host defense. When they sense host invasion, they produce cytokines that alert other innate immune cells and also abet the development of an adaptive immune response. Although lipolysaccharide (LPS), peptidoglycan, unmethylated DNA, and other microbial products ...

journal_title：Journal of leukocyte biology

authors： Beutler B,Hoebe K,Du X,Ulevitch RJ

更新日期：2003-10-01 00:00:00