Increase in the rat blood leukocyte counts induced by PAF-acether is suppressed by general anesthesia.

abstract：:Dichloromethylene diphosphonate (MDPCl2) encapsulated in multilamellar liposomes was selectively incorporated by macrophages, immediately transferred to lysosomes, then released from liposomes into lysosomes by enzymatic digestion of the liposomal lipid layers. From 4 h after ingesting liposome-encapsulated MDPCL2 mur...

journal_title：Journal of leukocyte biology

authors： Naito M,Nagai H,Kawano S,Umezu H,Zhu H,Moriyama H,Yamamoto T,Takatsuka H,Takei Y

更新日期：1996-09-01 00:00:00

abstract：:A protein with interleukin 1 (IL-1) activity was obtained from the human acute monocytic leukemia cell line (THP-1) and purified by ultrafiltration, Ultrogel AcA54 chromatography, isoelectric focusing, and discontinuous polyacrylamide gel electrophoresis. Like the pI 6.8 species of IL-1 from human peripheral blood mon...

journal_title：Journal of leukocyte biology

authors： Krakauer T

更新日期：1985-05-01 00:00:00

abstract：:In newborn infants, the innate cellular system plays a crucial role in the first line of defense against pathogens. Neutrophils are the most abundant leukocytes, and their response to the commonly encountered nosocomial bacterial (Gram positive) infection in newborns remains largely unclear. In this study, a genome-wi...

journal_title：Journal of leukocyte biology

authors： Fong ON,Chan KY,Leung KT,Lam HS,Cheung HM,Leung TY,Li K,Ng PC

更新日期：2014-01-01 00:00:00

abstract：:Colorectal cancer is the second most common cause of cancer-related death. Novel prognostic factors should be identified and validated to refine the present tumor-node-metastasis system. The presence of immune cells infiltrating colorectal cancers is a common phenomenon. However, the current belief is that clinically ...

journal_title：Journal of leukocyte biology

authors： Pagès F,Galon J,Fridman WH

更新日期：2008-10-01 00:00:00

abstract：:Discussion on the impact of blood leukocytes accumulating at the borders of the central nervous system on the development of neuropathic pain. ...

journal_title：Journal of leukocyte biology

authors： Pinho-Ribeiro FA

更新日期：2019-09-01 00:00:00

abstract：:Both humoral and cellular immune responses are inducible by inoculation of naked plasmid DNA encoding a polypeptide antigen. This new vaccination protocol, known as genetic immunization, has been used to initiate protective immunity against a variety of infectious pathogens and tumors in experimental animals. Dendriti...

journal_title：Journal of leukocyte biology

authors： Takashima A,Morita A

更新日期：1999-08-01 00:00:00

abstract：:In this study, we have investigated the expression of phospholipase C-beta2 during the course of granulocytic differentiation of normal and malignant progenitors. As a model system, we used the NB4 cell line, a reliable in vitro model for the study of acute promyelocytic leukemia (APL), a variety of acute myeloid leuk...

journal_title：Journal of leukocyte biology

authors： Bertagnolo V,Marchisio M,Pierpaoli S,Colamussi ML,Brugnoli F,Visani G,Zauli G,Capitani S

更新日期：2002-06-01 00:00:00

abstract：:The neuropathogenesis of HIV-1 encephalitis and its associated dementia revolves around sustained viral replication in cells of mononuclear phagocyte origin (brain macrophages, multinucleated giant cells, and microglia). Macrophage secretory factors play important roles in facilitating monocyte trafficking into the br...

journal_title：Journal of leukocyte biology

authors： Persidsky Y,Gendelman HE

更新日期：1997-07-01 00:00:00

abstract：:PGE(2) and other cAMP-elevating agents are known to down-regulate most functions stimulated by fMLP in human polymorphonuclear neutrophils. We reported previously that the inhibitory potential of PGE(2) resides in its capacity to suppress fMLP-stimulated PI-3Kgamma activation via the PGE(2) receptor EP(2) and hence, t...

journal_title：Journal of leukocyte biology

authors： Burelout C,Naccache PH,Bourgoin SG

更新日期：2007-06-01 00:00:00

abstract：:Virulent Legionella pneumophila replicate readily in thioglycollate-elicited peritoneal macrophages from genetically permissive A/J mice, but avirulent L. pneumophila do not. The production of cytokines by macrophages infected with L. pneumophila has been studied, but the correlation of bacterial virulence with immune...

journal_title：Journal of leukocyte biology

authors： McHugh SL,Yamamoto Y,Klein TW,Friedman H

更新日期：2000-06-01 00:00:00

abstract：:CD11c, a member of the leukointegrin family, is expressed prominently on tissue macrophages and dendritic cells and binds to complement fragment (iC3b), provisional matrix molecules (fibrinogen), and the Ig superfamily cell adhesion molecule, ICAM-1. CD11c has been proposed to function in phagocytosis, cell migration,...

journal_title：Journal of leukocyte biology

authors： Sadhu C,Ting HJ,Lipsky B,Hensley K,Garcia-Martinez LF,Simon SI,Staunton DE

更新日期：2007-06-01 00:00:00

abstract：:The current results provide direct evidence for a role of tissue macrophages (M phi) in natural immunity and support the use of immunomodulators to enhance antiviral resistance in immunocompromised individuals. In this study, macrophages (M phi) in the spleen and liver were eliminated by intravenous (i.v.) injection o...

journal_title：Journal of leukocyte biology

authors： Pinto AJ,Stewart D,van Rooijen N,Morahan PS

更新日期：1991-06-01 00:00:00

abstract：:The tissue-fixed macrophage is a key cellular element in the initiation and regulation of inflammation. Understanding the regulation of macrophage activation may provide valuable clues to the mechanisms involved in both beneficial and deleterious effects of inflammation. The lymphokine interferon-gamma (IFN-gamma) is ...

journal_title：Journal of leukocyte biology

authors： Williams JG,Jurkovich GJ,Hahnel GB,Maier RV

更新日期：1992-12-01 00:00:00

abstract：:Retroviral infections are frequently associated with immunosuppression. Retroviral transmembrane envelope proteins (TM proteins) play an important role in this phenomenon. CKS-17, a synthetic heptadecapeptide, represents the immunosuppressive site of these retroviral TM proteins. Here we support on the further delinea...

journal_title：Journal of leukocyte biology

authors： Oostendorp RA,Schaaper WM,Post J,Meloen RH,Scheper RJ

更新日期：1992-03-01 00:00:00

abstract：:Inflammation is deeply entangled with redox modulation. Triggering of PRRs on inflammatory cells induces ROS generation. As a consequence, activated cells mount antioxidant responses to counteract the possible harmful effects of oxidation. Therefore, when repair is completed, homeostasis is restored. Here, we describe...

journal_title：Journal of leukocyte biology

authors： Carta S,Castellani P,Delfino L,Tassi S,Venè R,Rubartelli A

更新日期：2009-09-01 00:00:00

abstract：:To elucidate the differentiation mechanisms of macrophages in the murine omentum, we studied the repopulation of these cells and the expression of macrophage colony-stimulating factor (M-CSF) in the milky spots and omental tissues in mice depleted of macrophages following administration of liposome-encapsulated dichlo...

journal_title：Journal of leukocyte biology

authors： Zhu H,Naito M,Umezu H,Moriyama H,Takatsuka H,Takahashi K,Shultz LD

更新日期：1997-04-01 00:00:00

abstract：:Neonatal humans and rodents are susceptible to infection with encapsulated bacteria as a result of an inability to make antibodies to capsular polysaccharides. This is partly a result of decreased production of proinflammatory cytokines by splenic macrophages (MPhi) from neonates. In this study, we show that when stim...

journal_title：Journal of leukocyte biology

authors： Chelvarajan L,Popa D,Liu Y,Getchell TV,Stromberg AJ,Bondada S

更新日期：2007-08-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a naturally occurring growth factor produced by several cell types in response to a variety of stimuli. GM-CSF has potent stimulatory effects on the growth and maturation of hematopoietic cells and has profound effects on mature circulating effector cells. C...

journal_title：Journal of leukocyte biology

authors： Hill AD,Naama HA,Calvano SE,Daly JM

更新日期：1995-12-01 00:00:00

abstract：:mRNAs encoding inflammatory chemokines that recruit neutrophils frequently exhibit short half-lives that serve to limit their expression under inappropriate conditions but are often prolonged to ensure adequate levels during inflammatory response. Extracellular stimuli that modulate the stability of such mRNAs may be ...

journal_title：Journal of leukocyte biology

authors： Hamilton T,Li X,Novotny M,Pavicic PG Jr,Datta S,Zhao C,Hartupee J,Sun D

更新日期：2012-03-01 00:00:00

abstract：:Complex syndromes such as atherosclerosis and type 2 diabetes are disorders that are associated with inflammatory processes involving innate and adaptive immunity. Emerging knowledge about the pathological consequences of immune imbalances in a wide range of disease settings is expected to help to identify novel thera...

journal_title：Journal of leukocyte biology

authors： Rose B,Herder C,Löffler H,Kolb H,Martin S

更新日期：2004-04-01 00:00:00

abstract：:Sepsis represents uncontrolled inflammation due to an infection. Cold-inducible RNA-binding protein (CIRP) is a stress-induced damage-associated molecular pattern (DAMP). A subset of neutrophils expressing ICAM-1+ neutrophils was previously shown to produce high levels of reactive oxygen species. The role of CIRP for ...

journal_title：Journal of leukocyte biology

authors： Ode Y,Aziz M,Wang P

更新日期：2018-04-01 00:00:00

abstract：:We have shown that losartan, a selective inhibitor of AT1 receptors for angiotensin II (AII), inhibits the binding of [3H]fMLP to neutrophil receptors (FPR). Here, we analyze, in Wistar rats, the effect of losartan on neutrophil recruitment in the lung triggered by fMLP. We found that i.v. infusion of losartan (0.4-20...

journal_title：Journal of leukocyte biology

authors： Raiden S,Pereyra Y,Nahmod V,Alvarez C,Castello L,Giordano M,Geffner J

更新日期：2000-11-01 00:00:00

abstract：:To determine if the release of IL-1 alpha and IL-1 beta by cultured PBMC could be independently modulated by different exogenous stimuli, we examined the effect of LPS, IFN gamma, latex beads, and indomethacin on the release of IL-1 alpha and IL-1 beta. PBMC culture supernatants were fractionated by Sephacryl-S-200 co...

journal_title：Journal of leukocyte biology

authors： Sandborg CI,Berman MA,Imfeld KL,Zaldivar F Jr,Masada MP,Kenney JS

更新日期：1989-11-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is one of the recently defined damage-associated molecular pattern molecules, passively released from necrotic cells and secreted by activated macrophage/monocytes. Whether cytolytic cells induce HMGB1 release from tumor cells is not known. We developed a highly sensitive method for d...

journal_title：Journal of leukocyte biology

authors： Ito N,DeMarco RA,Mailliard RB,Han J,Rabinowich H,Kalinski P,Stolz DB,Zeh HJ 3rd,Lotze MT

更新日期：2007-01-01 00:00:00

abstract：:Transition metals, including zinc, are essential to all living organisms. They are also toxic in high amounts, and their intracellular concentration must be tightly regulated. In this edition of JLB, Stocks et al. report that the zinc transporter, ZnT1 (SLC30A1) is induced by TLR4 activation in Mϕs, in which it contri...

journal_title：Journal of leukocyte biology

authors： Neyrolles O

更新日期：2021-02-01 00:00:00

abstract：:Endotoxin tolerance is characterized by attenuated macrophage activation to subsequent LPS challenge and can be reversed through nonspecific protein kinase C (PKC) activation, and activation by LPS within naïve cells requires the activation of the cell surface receptors CD14 and TLR4 on lipid rafts. The effect of PKC ...

journal_title：Journal of leukocyte biology

authors： Cuschieri J,Billigren J,Maier RV

更新日期：2006-12-01 00:00:00

abstract：:We investigated the ability of the sPLA(2), known as MT-III, isolated from the viperid snake Bothrops asper, to induce LB formation in macrophages and the major cellular signaling pathways involved in this process. The effects of MT-III on ADRP localization and expression and macrophage ultrastructure were assessed. O...

journal_title：Journal of leukocyte biology

authors： Leiguez E,Zuliani JP,Cianciarullo AM,Fernandes CM,Gutiérrez JM,Teixeira C

更新日期：2011-07-01 00:00:00

abstract：:Osteopontin is an RGD-containing bone matrix protein with cytokine-like functions that is associated with early stages of Th1-mediated diseases. Although the function of osteopontin in these responses is unknown, it is expressed by activated T cells and macrophages and can costimulate T cell proliferation. Studies hav...

journal_title：Journal of leukocyte biology

authors： O'Regan AW,Hayden JM,Berman JS

更新日期：2000-10-01 00:00:00

abstract：:Inflammation-limiting nonsteroidal pain relievers magnify myocardial infarction (MI) incidences and increase re-admission events in heart failure (HF) patients. However, the molecular and cellular mechanism of this provocative adverse effect is unclear. Our goal was to determine whether carprofen (CAP) impedes splenic...

journal_title：Journal of leukocyte biology

authors： Halade GV,Kain V,Wright GM,Jadapalli JK

更新日期：2018-12-01 00:00:00

abstract：:Autoreactive CD4+ and CD8+ T cells directed against CNS autoantigens may play a role in the development of multiple sclerosis (MS). Identical twins share the same genetic background but not the TCR repertoire that is shaped by the encounter with self or foreign antigens. To gain insights into the interplay between MS ...

journal_title：Journal of leukocyte biology

authors： Somma P,Ristori G,Battistini L,Cannoni S,Borsellino G,Diamantini A,Salvetti M,Sorrentino R,Fiorillo MT

更新日期：2007-03-01 00:00:00