Selective expansion of perforin-positive CD8+ T cells by immature dendritic cells infected with live Bacillus Calmette-Guérin mycobacteria.

abstract：:Ly-49 receptors regulate mouse natural killer cell functions. Members of the polymorphic Ly-49 multigene family recognize specific alleles of major histocompatibility complex class I (MHC I) or MHC I-like proteins. Previous studies have provided insight into the nature of Ly-49A and -C interaction with their high-affi...

journal_title：Journal of leukocyte biology

authors： Osman MS,Silver ET,Varghese JC,Chang CS,Gong DE,Audette GF,Hazes B,Kane KP

更新日期：2005-05-01 00:00:00

abstract：:Several members of the cytokine network play an important role in controlling the replication of the human immunodeficiency virus (HIV) in several experimental systems. Their effects can be categorized in the following three functional groups: (1) HIV-inductive cytokines; (2) HIV-suppressive cytokines; (3) cytokines w...

journal_title：Journal of leukocyte biology

authors： Vicenzi E,Biswas P,Mengozzi M,Poli G

更新日期：1997-07-01 00:00:00

abstract：:To determine if the release of IL-1 alpha and IL-1 beta by cultured PBMC could be independently modulated by different exogenous stimuli, we examined the effect of LPS, IFN gamma, latex beads, and indomethacin on the release of IL-1 alpha and IL-1 beta. PBMC culture supernatants were fractionated by Sephacryl-S-200 co...

journal_title：Journal of leukocyte biology

authors： Sandborg CI,Berman MA,Imfeld KL,Zaldivar F Jr,Masada MP,Kenney JS

更新日期：1989-11-01 00:00:00

abstract：:Vertebrate lectin purified from loach egg was tested for induction of tumor lysis mediated by macrophages. Loach egg lectin lysed tumor cells but not normal spleen cells in cooperation with BCG- or glucan (TAK)-elicited peritoneal macrophages of mice. Corynebacterium parvum-, OK432-, glycogen-, lipopolysaccharide-elic...

journal_title：Journal of leukocyte biology

authors： Yamazaki M,Okutomi T,Sakakibara F,Kawauchi H,Mizuno D

更新日期：1984-03-01 00:00:00

abstract：:We have identified three distinct cell phenotypes with respect to the conditions under which cells became susceptible to TNF-mediated lysis. These conditions include: 1) treatment with the protein synthesis inhibitor, cycloheximide; 2) contact with activated macrophages, and 3) infection with vaccinia virus. Whereas v...

journal_title：Journal of leukocyte biology

authors： Woods KM,Chapes SK

更新日期：1993-01-01 00:00:00

abstract：:The in vitro studies have proposed that human Th1 cells favor expression of CXCR3 or CCR5, whereas Th2 cells favor CCR3 and CCR4. In this study, the in vivo relevance of expression of these chemokine receptors on Th cells was investigated in patients with atopic dermatitis (AD) as the Th2-dominated disorder and nonato...

journal_title：Journal of leukocyte biology

authors： Yamamoto J,Adachi Y,Onoue Y,Adachi YS,Okabe Y,Itazawa T,Toyoda M,Seki T,Morohashi M,Matsushima K,Miyawaki T

更新日期：2000-10-01 00:00:00

abstract：:The membrane fusion events observed during neutrophil degranulation are important aspects of the immunoregulatory system. In an attempt to understand the regulation of granule-plasma membrane fusion, we have begun characterizing human neutrophil cytosol for fusion activity, finding that 50% of the fusogenic activity c...

journal_title：Journal of leukocyte biology

authors： Hessler RJ,Blackwood RA,Brock TG,Francis JW,Harsh DM,Smolen JE

更新日期：1998-03-01 00:00:00

abstract：:Experimental autoimmune uveoretinitis (EAU) is a T helper type 1 cell-mediated autoimmune disease, which serves as a model of human chronic uveitis. In this model, cells of a monocyte/macrophage lineage and retinal antigen (Ag)-specific T cells infiltrate into the retina and cause inflammatory lesion, where proinflamm...

journal_title：Journal of leukocyte biology

authors： Kitamei H,Iwabuchi K,Namba K,Yoshida K,Yanagawa Y,Kitaichi N,Kitamura M,Ohno S,Onoé K

更新日期：2006-06-01 00:00:00

abstract：:Neutrophils are indispensable in the innate immune defense against invading microorganisms. Neutrophils contain SVs and several subsets of granules that are essential for their function. Proteins present in neutrophil SVs and granules are synthesized during terminal granulopoiesis in the bone marrow. The heterogeneity...

journal_title：Journal of leukocyte biology

authors： Rørvig S,Østergaard O,Heegaard NH,Borregaard N

更新日期：2013-10-01 00:00:00

abstract：:Monocyte chemoattractant protein 1 (MCP-1) is likely to contribute to the macrophage infiltrate in human ovarian carcinomas. Although MCP-1 is predominantly expressed by the tumor parenchyma, macrophages accumulate at highest density in necrotic regions, which are associated with low oxygen tensions. Tumor necrosis fa...

journal_title：Journal of leukocyte biology

authors： Negus RP,Turner L,Burke F,Balkwill FR

更新日期：1998-06-01 00:00:00

abstract：:To become competent killer cells, CD8(+) T cells require stimulation through signal transduction pathways associated with the T-cell receptor, costimulatory molecules such as CD28, and cytokine receptors such as the interleukin (IL)-2 receptor. We used wortmannin and LY294002, two inhibitors of phosphatidylinositol 3-...

journal_title：Journal of leukocyte biology

authors： Phu T,Haeryfar SM,Musgrave BL,Hoskin DW

更新日期：2001-05-01 00:00:00

abstract：:Invariant NKT (iNKT) cells are considered to be important in some autoimmune diseases including Type 1 diabetes mellitus (T1DM). So far, the published data are contradictory in regard to the role of iNKT cells in T1DM. We aimed to study iNKT cell frequency and the function of different iNKT cell subgroups in T1DM. We ...

journal_title：Journal of leukocyte biology

authors： Kis J,Engelmann P,Farkas K,Richman G,Eck S,Lolley J,Jalahej H,Borowiec M,Kent SC,Treszl A,Orban T

更新日期：2007-03-01 00:00:00

abstract：:Prion diseases are characterized by conversion of the cellular prion protein (PrP(C)) to a protease-resistant conformer, the srapie form of PrP (PrP(Sc)). Humoral immune responses to nondenatured forms of PrP(Sc) have never been fully characterized. We investigated whether production of antibodies to PrP(Sc) could occ...

journal_title：Journal of leukocyte biology

authors： Spinner DS,Kascsak RB,Lafauci G,Meeker HC,Ye X,Flory MJ,Kim JI,Schuller-Levis GB,Levis WR,Wisniewski T,Carp RI,Kascsak RJ

更新日期：2007-06-01 00:00:00

abstract：:Inbred strains of mice, notably the susceptible C57BL/6 and the resistant A/J strains of mice, were infected with a strain of Mycobacterium evium. The infection in the visceral organs of mice was then studied, and the effect of colony-stimulating factors, i.e., interleukin-3 (IL-3), granulocyte-macrophage colony-stimu...

journal_title：Journal of leukocyte biology

authors： Denis M

更新日期：1991-09-01 00:00:00

abstract：:Glucosamine, an amino monosaccharide naturally occurring in the connective and cartilage tissues, contributes to maintaining the strength, flexibility, and elasticity of these tissues. In recent years, glucosamine has been used widely to treat osteoarthritis in humans and animal models. Neutrophils, which usually func...

journal_title：Journal of leukocyte biology

authors： Hua J,Sakamoto K,Nagaoka I

更新日期：2002-04-01 00:00:00

abstract：:TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM acts to bridge TLR4 with TRIF, orchestrating the inflammatory response to pathogen challenge. We ha...

journal_title：Journal of leukocyte biology

authors： Verstak B,Stack J,Ve T,Mangan M,Hjerrild K,Jeon J,Stahl R,Latz E,Gay N,Kobe B,Bowie AG,Mansell A

更新日期：2014-09-01 00:00:00

abstract：:Exacerbations of asthma are most commonly triggered by viral infections, which amplify allergic inflammation. Cytokines released by virus-infected AECs may be important in driving this response. This review focuses on accumulating evidence in support of a role for epithelial cytokines, including IL-33, IL-25, and TSLP...

journal_title：Journal of leukocyte biology

authors： Kumar RK,Foster PS,Rosenberg HF

更新日期：2014-09-01 00:00:00

abstract：:Engagement of 2B4 (CD244) with CD48 results in activation, costimulation, or inhibition of NK cell activities, depending on the cell types and the stage of differentiation. In vivo, 2B4+ NK cells can interact with CD48+ NK cells and also with surrounding CD48+ hematopoietic cells. Similarly, CD48+ NK cells may be trig...

journal_title：Journal of leukocyte biology

authors： Kim EO,Kim N,Kim TJ,Kim K,Kim TW,Kumar V,Lee KM

更新日期：2010-10-01 00:00:00

abstract：:In this study, we test the hypothesis that cAMP, acting as an extracellular mediator, affects the physiology and function of human myeloid cells. The cAMP is a second messenger recognized as a universal regulator of several cellular functions in different organisms. Many studies have shown that extracellular cAMP exer...

journal_title：Journal of leukocyte biology

authors： Sciaraffia E,Riccomi A,Lindstedt R,Gesa V,Cirelli E,Patrizio M,De Magistris MT,Vendetti S

更新日期：2014-07-01 00:00:00

abstract：:The objective of this study was to find the role of LncRNA SNHG12 in the regulation of hypertensive vascular endothelial injury. LncRNA SNHG12 and miR-25-3p expression were detected by quantitative RT-PCR. Protein levels of Sirtuin 6 (SIRT6), endothelial cell (EC) senescence markers p16 and p21, and EC marker CD31 wer...

journal_title：Journal of leukocyte biology

authors： Qian W,Zheng ZQ,Nie JG,Liu LJ,Meng XZ,Sun H,Xiao FM,Kang T

更新日期：2021-01-19 00:00:00

abstract：:Alum, aluminum-hydroxide-containing compounds, long used as adjuvants in human vaccinations, functions by ill-defined, immunostimulatory mechanisms. Antigen-free alum has been shown to act via a previously unidentified, splenic Gr1(+), IL-4-expressing myeloid cell population to stimulate early B cell priming. We demon...

journal_title：Journal of leukocyte biology

authors： Wang HB,Weller PF

更新日期：2008-04-01 00:00:00

abstract：:The CD2 receptor on T-lymphocytes plays a major part in mediating adhesive interactions via the LFA-3 ligand and in transducing signals for lymphocyte activation. In this study the expression, function, and internalization of the CD2 receptor was investigated in resting and activated murine T-cells. Surface iodination...

journal_title：Journal of leukocyte biology

authors： Abraham DJ,Bou-Gharios G,Beauchamp JR,Plater-Zyberk C,Maini RN,Olsen I

更新日期：1991-04-01 00:00:00

abstract：:We investigated the ability of the sPLA(2), known as MT-III, isolated from the viperid snake Bothrops asper, to induce LB formation in macrophages and the major cellular signaling pathways involved in this process. The effects of MT-III on ADRP localization and expression and macrophage ultrastructure were assessed. O...

journal_title：Journal of leukocyte biology

authors： Leiguez E,Zuliani JP,Cianciarullo AM,Fernandes CM,Gutiérrez JM,Teixeira C

更新日期：2011-07-01 00:00:00

abstract：:The ellipsoid-associated cells (EAC) localize on the surface of the ellipsoid. They bind the IV injected horseradish peroxidase (HRP) and bovine serum albumin (BSA), migrate to the red pulp and then enter the systemic circulation. After protein injection, the number of white blood cells increased above the normal leve...

journal_title：Journal of leukocyte biology

authors： Oláh I,Glick B,Taylor RL Jr

更新日期：1984-05-01 00:00:00

abstract：:Expression of phosphatidylserine (PS) on the surface of both macrophages and their apoptotic targets is required for efficient phagocytosis. Monocytes, the precursors of macrophages, do not express PS on their surface and do not efficiently phagocytose apoptotic cells. We report here that PS appears on the surface of ...

journal_title：Journal of leukocyte biology

authors： Callahan MK,Halleck MS,Krahling S,Henderson AJ,Williamson P,Schlegel RA

更新日期：2003-11-01 00:00:00

abstract：:Neutrophil's responses to G protein-coupled chemoattractants are highly dependent on store-operated calcium (Ca(2+)) entry (SOCE). Platelet-activating factor (PAF), a primary chemoattractant, simultaneously increases cytosolic-free Ca(2+), intracellular pH (pH(i)), ERK1/2, and Akt/protein kinase B (PKB) phosphorylatio...

journal_title：Journal of leukocyte biology

authors： Sandoval AJ,Riquelme JP,Carretta MD,Hancke JL,Hidalgo MA,Burgos RA

更新日期：2007-11-01 00:00:00

abstract：:Human neutrophils isolated from the blood were incubated in vitro for 30 min with 25 ng/ml of phorbol 12-myristate 13-acetate (PMA), a protein kinase C activator, to study its effect on the fine structure of granulocytes and on the subcellular distribution of lactoferrin (Lf). Flow cytometry analysis of the human neut...

journal_title：Journal of leukocyte biology

authors： Esaguy N,Aguas AP,Vilanova M,Silva MT

更新日期：1991-11-01 00:00:00

abstract：:In inflammatory diseases, circulating neutrophils are recruited to sites of injury. Attractant signals are provided by many different chemotactic molecules, such that blockade of one may not prevent neutrophil recruitment effectively. The Slit family of secreted proteins and their transmembrane receptor, Robo, repel a...

journal_title：Journal of leukocyte biology

authors： Tole S,Mukovozov IM,Huang YW,Magalhaes MA,Yan M,Crow MR,Liu GY,Sun CX,Durocher Y,Glogauer M,Robinson LA

更新日期：2009-12-01 00:00:00

abstract：:The tissue-fixed macrophage is a key cellular element in the initiation and regulation of inflammation. Understanding the regulation of macrophage activation may provide valuable clues to the mechanisms involved in both beneficial and deleterious effects of inflammation. The lymphokine interferon-gamma (IFN-gamma) is ...

journal_title：Journal of leukocyte biology

authors： Williams JG,Jurkovich GJ,Hahnel GB,Maier RV

更新日期：1992-12-01 00:00:00

abstract：:Group B streptococcal (GBS) infections are associated with high morbidity and mortality. The molecular pathways mediating the pathophysiological events in GBS infection are not fully delineated. Cyclooxygenases (COX) are the enzymes that convert arachidonate to active eicosanoids. To identify the effects of GBS on eic...

journal_title：Journal of leukocyte biology

authors： Maloney CG,Thompson SD,Hill HR,Bohnsack JF,McIntyre TM,Zimmerman GA

更新日期：2000-05-01 00:00:00