当前位置： SCI文献检索 > JOURNAL OF LEUKOCYTE BIOLOGY期刊下所有文献 > Differential impact of high and low penetrance TNFRSF1A gene mutations on conventional and regulatory CD4+ T cell functions in TNFR1-associated periodic syndrome.

Differential impact of high and low penetrance TNFRSF1A gene mutations on conventional and regulatory CD4+ T cell functions in TNFR1-associated periodic syndrome.

Abstract：

:TNFR-associated periodic syndrome is an autoinflammatory disorder caused by autosomal-dominant mutations in TNFRSF1A, the gene encoding for TNFR superfamily 1A. The lack of knowledge in the field of TNFR-associated periodic syndrome biology is clear, particularly in the context of control of immune self-tolerance. We investigated how TNF-α/TNFR superfamily 1A signaling can affect T cell biology, focusing on conventional CD4(+)CD25(-) and regulatory CD4(+)CD25(+) T cell functions in patients with TNFR-associated periodic syndrome carrying either high or low penetrance TNFRSF1A mutations. Specifically, we observed that in high penetrance TNFR-associated periodic syndrome, at the molecular level, these alterations were secondary to a hyperactivation of the ERK1/2, STAT1/3/5, mammalian target of rapamycin, and NF-κB pathways in conventional T cells. In addition, these patients had a lower frequency of peripheral regulatory T cells, which also displayed a defective suppressive phenotype. These alterations were partially found in low penetrance TNFR-associated periodic syndrome, suggesting a specific link between the penetrance of the TNFRSF1A mutation and the observed T cell phenotype. Taken together, our data envision a novel role for adaptive immunity in the pathogenesis of TNFR-associated periodic syndrome involving both CD4(+) conventional T cells and Tregs, suggesting a novel mechanism of inflammation in the context of autoinflammatory disorders.

journal_name

J Leukoc Biol

journal_title

Journal of leukocyte biology

authors

Pucino V,Lucherini OM,Perna F,Obici L,Merlini G,Cattalini M,La Torre F,Maggio MC,Lepore MT,Magnotti F,Galgani M,Galeazzi M,Marone G,De Rosa V,Talarico R,Cantarini L,Matarese G

doi

10.1189/jlb.3A0915-399R

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

761-9

issue

5

eissn

0741-5400

issn

1938-3673

pii

jlb.3A0915-399R

journal_volume

99

pub_type

杂志文章

相关文献

JOURNAL OF LEUKOCYTE BIOLOGY文献大全
  • Inhibition of superantigen-induced T cell proliferation and monocyte IL-1 beta, TNF-alpha, and IL-6 production by acute ethanol treatment.

    abstract：:Alcohol use has been shown to decrease monocyte antigen presentation capacity and inflammatory cytokine production, thereby increasing susceptibility to infections. Here, we demonstrate that in vitro acute treatment of normal monocytes with pharmacological doses of ethanol can decrease superantigen [Staphylococcus ent...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.58.3.342

    authors： Szabo G,Mandrekar P,Catalano D

    更新日期：1995-09-01 00:00:00

  • Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1.

    abstract：:Interferons (IFN) and lipopolysaccharide (LPS) cause multiple changes in isoprenoid-modified proteins in murine macrophages, the most dramatic being the expression of a prenyl protein of 65 kDa. The guanylate binding proteins (GBPs) are IFN-inducible GTP-binding proteins of approximately 65 kDa that possess a CaaX mot...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.60.3.423

    authors： Nantais DE,Schwemmle M,Stickney JT,Vestal DJ,Buss JE

    更新日期：1996-09-01 00:00:00

  • HLA-A2 down-regulation on primary human macrophages infected with an M-tropic EGFP-tagged HIV-1 reporter virus.

    abstract：:Multiple mechanisms are used by the human immunodeficiency virus type 1 (HIV-1) to interfere with host-cell immune effector functions. The 27-kD Nef protein has been shown to down-modulate specific genes of the major histocompatibility complex class I (MHC-I) on the surface of infected primary T cells, facilitating th...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0505237

    authors： Brown A,Gartner S,Kawano T,Benoit N,Cheng-Mayer C

    更新日期：2005-09-01 00:00:00

  • Activation-induced expression of CD1d antigen on mature T cells.

    abstract：:In the present study, we investigated the expression of human CD1d antigen on activated mature T cells. Expression of this glycoprotein was found to be highly regulated and dependent on PHA stimulation. Flow cytometry studies using the NOR3.2 antibody, which recognized CD1d under denaturing conditions, showed a clear ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：

    authors： Salamone MC,Rabinovich GA,Mendiguren AK,Salamone GV,Fainboim L

    更新日期：2001-02-01 00:00:00

  • The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.

    abstract：:TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM acts to bridge TLR4 with TRIF, orchestrating the inflammatory response to pathogen challenge. We ha...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.2A0913-487R

    authors： Verstak B,Stack J,Ve T,Mangan M,Hjerrild K,Jeon J,Stahl R,Latz E,Gay N,Kobe B,Bowie AG,Mansell A

    更新日期：2014-09-01 00:00:00

  • Monomeric bovine IgG2 is a potent stimulus for bovine neutrophils.

    abstract：:Bovine plasma contains factors that can stimulate bovine neutrophils. Bovine plasma at 1:1,000,000-1:1,000 dilution induced a dose-dependent superoxide production in bovine neutrophils. When bovine plasma was fractionated with a protein G column, only the IgG fraction contained induction activity. At similar concentra...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.58.2.203

    authors： Tao W,Corbett MJ,Pickett W

    更新日期：1995-08-01 00:00:00

  • p120 nucleolar-proliferating antigen is a direct target of G-CSF signaling during myeloid differentiation.

    abstract：:Granulocyte-colony stimulating factor (G-CSF) is an essential cytokine, which contributes to proliferation and differentiation of granulocyte precursor cells in the bone marrow. Despite recent progress in understanding G-CSF signaling events, the mechanisms that underlie the distinct spectrum of biological functions a...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0205066

    authors： Khanna-Gupta A,Sun H,Zibello T,Lozovatsky L,Ghosh PK,Link DC,McLemore ML,Berliner N

    更新日期：2006-05-01 00:00:00

  • DAMPs and inflammatory processes: the role of redox in the different outcomes.

    abstract：:Inflammation is deeply entangled with redox modulation. Triggering of PRRs on inflammatory cells induces ROS generation. As a consequence, activated cells mount antioxidant responses to counteract the possible harmful effects of oxidation. Therefore, when repair is completed, homeostasis is restored. Here, we describe...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1189/jlb.1008598

    authors： Carta S,Castellani P,Delfino L,Tassi S,Venè R,Rubartelli A

    更新日期：2009-09-01 00:00:00

  • Neutrophil-derived matrix metalloproteinase-9 is a potent activator of trypsinogen in acinar cells in acute pancreatitis.

    abstract：:MMPs are generally considered to regulate degradation and remodeling of the ECM. Convincing data also implicate a role for MMPs in inflammatory conditions, such as AP, although the mechanisms are not known. The aim of this study was to define the role of MMPs in regulating activation of trypsinogen and tissue damage i...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0811443

    authors： Awla D,Abdulla A,Syk I,Jeppsson B,Regnér S,Thorlacius H

    更新日期：2012-05-01 00:00:00

  • Unidirectional signaling triggered through 2B4 (CD244), not CD48, in murine NK cells.

    abstract：:Engagement of 2B4 (CD244) with CD48 results in activation, costimulation, or inhibition of NK cell activities, depending on the cell types and the stage of differentiation. In vivo, 2B4+ NK cells can interact with CD48+ NK cells and also with surrounding CD48+ hematopoietic cells. Similarly, CD48+ NK cells may be trig...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0410198

    authors： Kim EO,Kim N,Kim TJ,Kim K,Kim TW,Kumar V,Lee KM

    更新日期：2010-10-01 00:00:00

  • Interactions between HIV-infected monocytes and the extracellular matrix: HIV-infected monocytes secrete neutral metalloproteases that degrade basement membrane protein matrices.

    abstract：:The frequency of human immunodeficiency virus (HIV)-infected monocytes that spread on a model basement membrane was about twofold greater than that of an equal number of uninfected control cells through the initial 12 to 18 h of culture. By 24 h, virtually all HIV-infected and uninfected control cells spread on the ba...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.52.2.244

    authors： Dhawan S,Toro LA,Jones BE,Meltzer MS

    更新日期：1992-08-01 00:00:00

  • The essential role of the in situ immune reaction in human colorectal cancer.

    abstract：:Colorectal cancer is the second most common cause of cancer-related death. Novel prognostic factors should be identified and validated to refine the present tumor-node-metastasis system. The presence of immune cells infiltrating colorectal cancers is a common phenomenon. However, the current belief is that clinically ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.1107773

    authors： Pagès F,Galon J,Fridman WH

    更新日期：2008-10-01 00:00:00

  • Priming effect of muramyl peptides for induction by lipopolysaccharide of tumor necrosis factor production in mice.

    abstract：:Lipopolysaccharide-induced necrosis of grafted tumors was potentiated by several hydrophilic and lipophilic muramyl dipeptide (MDP) derivatives administered a few hours prior to small amounts of lipopolysaccharide (LPS) in spite of low titers of induced circulating tumor necrosis factor (TNF). However, pretreatment wi...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.47.2.164

    authors： Parant M,Parant F,Vinit MA,Jupin C,Noso Y,Chedid L

    更新日期：1990-02-01 00:00:00

  • Changes in peritoneal myeloid populations and their proinflammatory cytokine expression during infection with Listeria monocytogenes are altered in the absence of gamma/delta T cells.

    abstract：:Evidence that gamma/delta T cells play a broad, immunoregulatory role has been accumulating steadily. We show here that myeloid cells are disregulated after peritoneal infection with Listeria monocytogenes in mice lacking gamma/delta T cells. Inflammatory populations of neutrophils and monocytes recruited to the site ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.1103574

    authors： Skeen MJ,Freeman MM,Ziegler HK

    更新日期：2004-07-01 00:00:00

  • IL-4 and IL-13 have overlapping but distinct effects on HIV production in monocytes.

    abstract：:In HIV-1-infected monocytes and monocytoid cell lines, viral expression can be observed as high-level production, restricted (chronic low-level) expression, and latency (no viral expression). Interleukin-13 (IL-13) and IL-4, which have remarkedly similar deactivating effects on inflammatory monocyte functions, were st...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.56.3.340

    authors： Mikovits JA,Meyers AM,Ortaldo JR,Minty A,Caput D,Ferrara P,Ruscetti FW

    更新日期：1994-09-01 00:00:00

  • Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: Role of Cxcr2 activation and glycosaminoglycan interactions.

    abstract：:Chemokines play a crucial role in combating microbial infection by recruiting blood neutrophils to infected tissue. In mice, the chemokines Cxcl1/KC and Cxcl2/MIP2 fulfill this role. Cxcl1 and Cxcl2 exist as monomers and dimers, and exert their function by activating the Cxcr2 receptor and binding glycosaminoglycans (...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/JLB.3A0820-207R

    authors： Sawant KV,Sepuru KM,Lowry E,Penaranda B,Frevert CW,Garofalo RP,Rajarathnam K

    更新日期：2020-09-02 00:00:00

  • Interleukin-4 biases differentiation of B cells from Trypanosoma cruzi-infected mice and restrains their fratricide: role of Fas ligand down-regulation and MHC class II-transactivator up-regulation.

    abstract：:In the present work, we demonstrate that interleukin (IL)-4 is able to rescue B cells from Trypanosoma cruzi-infected mice, counteracting the strong apoptotic signals that these cells received in vivo. We have observed that IL-4 restrains the apoptosis of immunoglobulin (Ig)M(+) and IgG(+) B cells from infected and no...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0702353

    authors： Acosta Rodriguez EV,Zuñiga E,Montes CL,Gruppi A

    更新日期：2003-01-01 00:00:00

  • Mucosal application of plasmid-encoded IL-15 sustains a highly protective anti-Herpes simplex virus immunity.

    abstract：:In a DNA immunization against Herpes simplex virus (HSV), we examined the ability of plasmid-encoded interleukin-15 (pIL-15) to induce and maintain the mucosal B and T cell immune response. pIL-15 generated memory CD8(+) T cell responses that were threefold higher and mainly maintained in the spleen, but high levels o...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.1004621

    authors： Toka FN,Rouse BT

    更新日期：2005-07-01 00:00:00

  • Tonic protein kinase A activity maintains inactive beta2 integrins in unstimulated neutrophils by reducing myosin light-chain phosphorylation: role of myosin light-chain kinase and Rho kinase.

    abstract：:Activation of beta2 integrins is necessary for neutrophil adhesion and full activation of neutrophil effector functions. We demonstrated previously that inhibition of protein kinase A (PKA) activity in quiescent neutrophils is sufficient to increase beta2-integrin cell surface expression, affinity, and adhesion. Thus,...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0405192

    authors： Chilcoat CD,Sharief Y,Jones SL

    更新日期：2008-04-01 00:00:00

  • The bone marrow: a site of neutrophil clearance.

    abstract：:Neutrophils, an essential component of the innate immune system, are produced at a rate 10(11) cells/day and are consequently the most abundant leukocyte in the blood. These granulocytes have a relatively short half-life (6-8 h) in the blood, and as a result of the cytotoxic nature of their contents, it is critical th...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1189/jlb.0210112

    authors： Rankin SM

    更新日期：2010-08-01 00:00:00

  • Inhibition of soluble epoxide hydrolase attenuates eosinophil recruitment and food allergen-induced gastrointestinal inflammation.

    abstract：:Prevalence of food allergies in the United States is on the rise. Eosinophils are recruited to the intestinal mucosa in substantial numbers in food allergen-driven gastrointestinal (GI) inflammation. Soluble epoxide hydrolase (sEH) is known to play a pro-inflammatory role during inflammation by metabolizing anti-infla...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/JLB.3MA1017-423R

    authors： Bastan I,Ge XN,Dileepan M,Greenberg YG,Guedes AG,Hwang SH,Hammock BD,Washabau RJ,Rao SP,Sriramarao P

    更新日期：2018-07-01 00:00:00

  • Identification of a chicken "C" chemokine related to lymphotactin.

    abstract：:In this study we describe the isolation and characterization of a new chicken (Gallus gallus) chemokine. This molecule belongs to the C or gamma-chemokine family and is related to the mouse and human lymphotactin (Lptn). Mouse and human Lptn are distinguished from alpha and beta chemokines by the absence of two cystei...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.65.1.87

    authors： Rossi D,Sanchez-García J,McCormack WT,Bazan JF,Zlotnik A

    更新日期：1999-01-01 00:00:00

  • Expression of novel "LOCGEF" isoforms of ARHGEF18 in eosinophils.

    abstract：:Genomic, transcriptomic and proteomic databases indicate that the N-terminal 322 residues encoded by the presumptive LOC100996504 gene, which is adjacent to the ARHGEF18 guanine nucleotide exchange factor gene on chromosome 19, constitute the N-terminal portion of a 1361-residue isoform of ARHGEF18, dubbed LOCGEF-X3. ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/JLB.2MA1017-418RR

    authors： Turton KB,Wilkerson EM,Hebert AS,Fogerty FJ,Schira HM,Botros FE,Coon JJ,Mosher DF

    更新日期：2018-07-01 00:00:00

  • Cytokine responses of bovine dendritic cells and T cells following exposure to live or inactivated bovine respiratory syncytial virus.

    abstract：:We compared the effects of live or inactivated bovine respiratory syncytial virus (BRSV) on cytokine production by bovine monocyte-derived dendritic cells (MoDC). We also investigated the response of resting memory CD4(+) T cells to MoDC exposed to both viral preparations. Although BRSV did not appear to replicate in ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：

    authors： Werling D,Collins RA,Taylor G,Howard CJ

    更新日期：2002-08-01 00:00:00

  • Differential production of IFN-alpha/beta by CSF-1- and GM-CSF-derived macrophages.

    abstract：:Mature macrophages, derived in vitro from bone marrow progenitors under the influence of either macrophage colony stimulating factor (CSF-1) or granulocyte-macrophage (GM)-CSF, have been shown to differ morphologically and functionally. The data presented in this report demonstrate that macrophages derived from bone m...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.48.1.43

    authors： Falk LA,Vogel SN

    更新日期：1990-07-01 00:00:00

  • Inhibition of neutrophil superoxide anion generation by platelet products: role of adenine nucleotides.

    abstract：:Previously, we demonstrated the stimulus-specific ability of platelet lysate or release products to inhibit neutrophil functions in response to f-met-leu-phe (fMLP) or phorbol myristate acetate (PMA). The present study further characterizes these activities and identifies one of the platelet inhibitors of neutrophil s...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.44.5.411

    authors： McGarrity ST,Stephenson AH,Hyers TM,Webster RO

    更新日期：1988-11-01 00:00:00

  • HIV infection modulates IL-1β response to LPS stimulation through a TLR4-NLRP3 pathway in human liver macrophages.

    abstract：:IL-1β is an important mediator of innate inflammatory responses and has been shown to contribute to liver injury in a number of etiologies. HIV patients have increased necroinflammation and more rapid fibrosis progression in chronic liver injury compared to non-HIV-infected patients. As the resident liver macrophage i...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/JLB.4A1018-381R

    authors： Zhang L,Mosoian A,Schwartz ME,Florman SS,Gunasekaran G,Schiano T,Fiel MI,Jiang W,Shen Q,Branch AD,Bansal MB

    更新日期：2019-04-01 00:00:00

  • Surfactant protein A enhances Mycobacterium avium ingestion but not killing by rat macrophages.

    abstract：:Mycobacterium avium complex (MAC) is a significant cause of opportunistic infection in patients with acquired immunodeficiency syndrome. Although the major route of entry of MAC is via the gastrointestinal tract, MAC can infect humans through the respiratory tract and eventually encounter alveolar macrophages within t...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0103027

    authors： Lopez JP,Clark E,Shepherd VL

    更新日期：2003-10-01 00:00:00

  • Endothelial cells enhance the human pokeweed mitogen lymphocyte response.

    abstract：:The effect of endothelial cells (EC) on lymphocyte mitogen responses was examined. Irradiated or mitomycin C treated EC were co-cultured with allogeneic peripheral blood mononuclear cells (PBM), and proliferative responses to pokeweed mitogen (PWM) and phytohemagglutinin (PHA) were assessed by 3H-thymidine incorporati...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.37.3.305

    authors： Shanahan WR Jr,Weston DM,Korn JH

    更新日期：1985-03-01 00:00:00

  • Recombinant human IL-7 administration in mice affects colony-forming units-spleen and lymphoid precursor cell localization and accelerates engraftment of bone marrow transplants.

    abstract：:Murine reconstitution assays were used to investigate the effects of recombinant human interleukin-7 (rhIL-7) on myeloid and lymphoid precursors and on bone marrow engraftment. Reconstitution with bone marrow from rhIL-7-treated mice results in a 3.4-fold decrease in total colony-forming unit-spleen (CFU-S) activity (...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.58.2.151

    authors： Boerman OC,Gregorio TA,Grzegorzewski KJ,Faltynek CR,Kenny JJ,Wiltrout RH,Komschlies KL

    更新日期：1995-08-01 00:00:00