EBI2 in splenic and local immune responses and in autoimmunity.

abstract：:DCs orchestrate immune responses contributing to the pattern of response developed. In cancer, DCs may play a dysfunctional role in the induction of CD4(+)CD25(+)Foxp3(+) Tregs, contributing to immune evasion. We show here that Mo-DCs from breast cancer patients show an altered phenotype and induce preferentially Treg...

journal_title：Journal of leukocyte biology

authors： Ramos RN,Chin LS,Dos Santos AP,Bergami-Santos PC,Laginha F,Barbuto JA

更新日期：2012-09-01 00:00:00

abstract：:Cationic antimicrobial protein of M(r) 37 kDa (CAP37) is a multifunctional protein isolated from the granules of human neutrophils, which has important implications in host defense and inflammation. CAP37 was initially recognized for its strong antibiotic activity against Gram-negative bacteria and was viewed as a com...

journal_title：Journal of leukocyte biology

authors： Pereira HA

更新日期：1995-06-01 00:00:00

abstract：:Macrophages activated for tumor cell killing by bacterial lipopolysaccharide (LPS) were shown to lose their cytolytic activity if exposed to physiological levels of prostaglandin E2 (PGE2). Increasing the LPS stimulus more than 100-fold over the amount needed to activate the cells did not substantially increase their ...

journal_title：Journal of leukocyte biology

authors： Russell SW,Pace JL

更新日期：1984-03-01 00:00:00

abstract：:We investigated the pathogenesis of lung injury in sepsis (septic adult respiratory distress syndrome) by focusing on the functional changes of alveolar macrophages (AMs). Sepsis was induced in male WK rats by cecal ligation and puncture. Histological examination of the lungs from this experimental model revealed edem...

journal_title：Journal of leukocyte biology

authors： Goya T,Abe M,Shimura H,Torisu M

更新日期：1992-08-01 00:00:00

abstract：:Attempts to analyze bone marrow-derived macrophages (BMDM) by flow cytometry have been prohibited because of their high autofluorescence. Using an autofluorescence reduction method of Steinkamp and Stewart to reduce the autofluorescence of BMDM, we were able to examine several macrophage populations for their expressi...

journal_title：Journal of leukocyte biology

authors： Malley A,Stewart CC,Stewart SJ,Waldbeser L,Bradley LM,Shiigi SM

更新日期：1988-06-01 00:00:00

abstract：:The human polyomavirus JCV lytically infects oligodendrocytes of immunosuppressed individuals leading to the fatal demyelinating disease termed progressive multifocal leukoencephalopathy (PML). Dementia, hemiparesis, and hemianopsia are the predominant presenting signs of PML. Asymptomatic JCV infection is common worl...

journal_title：Journal of leukocyte biology

authors： Jensen PN,Major EO

更新日期：1999-04-01 00:00:00

abstract：:The ganglioside composition of endotoxin-responsive C3H/HeN murine peritoneal macrophages is known to undergo dramatic changes in vivo in response to intraperitoneal lipopolysaccharides (LPS), unlike endotoxin-hyporesponsive C3H/HeJ macrophages. To better investigate the mechanism behind LPS-induced macrophage ganglio...

journal_title：Journal of leukocyte biology

authors： Berenson CS,Yohe HC,Ryan JL

更新日期：1989-03-01 00:00:00

abstract：:The specific binding of human polymorphonuclear leukocytes (PMN) to antibody-coated target cells was characterized by flow cytometry. PMN were labeled with phycoerythrin-E (PE) via a granulocyte-specific monoclonal antibody (leu-M1) and mixed with fluorescein isothiocyanate-labeled K562 tumor cells sensitized with rab...

journal_title：Journal of leukocyte biology

authors： van Kessel KP,van Strijp JA,van der Tol ME,van Kats-Renaud HJ,Thijssen RM,Fluit AC,Verhoef J

更新日期：1989-11-01 00:00:00

abstract：:Bacterial and viral infections cause high rates of morbidity and mortality in premature newborns. In the setting of viral infection, pDCs play a key role as strong producers of IFN-α upon TLR9 activation. We analyzed pDC frequency, phenotype, morphology, and function in CB of preterm and term newborns in comparison wi...

journal_title：Journal of leukocyte biology

authors： Schüller SS,Sadeghi K,Wisgrill L,Dangl A,Diesner SC,Prusa AR,Klebermasz-Schrehof K,Greber-Platzer S,Neumüller J,Helmer H,Husslein P,Pollak A,Spittler A,Förster-Waldl E

更新日期：2013-05-01 00:00:00

abstract：:Human immunodeficiency virus infects different cell types including CD4+ lymphocytes and monocyte-derived macrophages (MDMs). We have examined the activity of the HIV-1 Tat inhibitors Ro-5-3335 and Ro-24-7429 in cultured human peripheral MDMs. Monocytes were isolated from HIV-seronegative donors by gradient centrifuga...

journal_title：Journal of leukocyte biology

authors： Dunne AL,Siregar H,Mills J,Crowe SM

更新日期：1994-09-01 00:00:00

abstract：:The immunosuppressive activity of interleukin-10 (IL-10) makes this cytokine a potentially important clinical tool to reduce inflammatory responses in various diseases. Its efficacy as a therapeutic modality is dependent on the responsiveness of immune cells. We report that macrophages from mice chronically infected w...

journal_title：Journal of leukocyte biology

authors： Avdiushko R,Hongo D,Lake-Bullock H,Kaplan A,Cohen D

更新日期：2001-10-01 00:00:00

abstract：:The role of PI-3K in leukocyte function has been studied extensively. However, the specific role of the p110gamma isoform of PI- 3K in CD4 T lymphocyte function has yet to be defined explicitly. In this study, we report that although p110gamma does not regulate antigen-dependent CD4 T cell activation and proliferation...

journal_title：Journal of leukocyte biology

authors： Thomas MS,Mitchell JS,DeNucci CC,Martin AL,Shimizu Y

更新日期：2008-09-01 00:00:00

abstract：:Antigen presentation to T lymphocytes has been characterized extensively in terms of T lymphocyte activation and eventual cell death. In contrast, little is known about the consequences of antigen presentation for the antigen-presenting cell (APC). We have determined the outcome of major histocompatibility complex cla...

journal_title：Journal of leukocyte biology

authors： Setterblad N,Blancheteau V,Delaguillaumie A,Michel F,Bécart S,Lombardi G,Acuto O,Charron D,Mooney N

更新日期：2004-06-01 00:00:00

abstract：:Neutrophils were classically described as powerful effectors of acute inflammation, and their main purpose was assumed to be restricted to pathogen killing through production of oxidants. As consequence, neutrophils also may lead to significant collateral damage to the healthy tissues, and after performing these tasks...

journal_title：Journal of leukocyte biology

authors： Mattos MS,Lopes ME,de Araujo AM,Alvarenga DM,Nakagaki BN,Mafra K,de Miranda CDM,Diniz AB,Antunes MM,Lopes MAF,Rezende RM,Menezes GB

更新日期：2020-10-01 00:00:00

abstract：:An epithelial cell line, IT-45R1, has been established from a thymus of normal Wistar rat and was found to produce growth factor which stimulated the proliferation of bone marrow cells. This growth factor induced the formation of colonies composed of macrophages, granulocytes, or both, in semi-solid medium and stimula...

journal_title：Journal of leukocyte biology

authors： Nanno M,Takahashi T,Sakata T,Horikawa T,Sako T,Suzuki R,Itoh T,Kumagai K

更新日期：1991-12-01 00:00:00

abstract：:Dichloromethylene diphosphonate (MDPCl2) encapsulated in multilamellar liposomes was selectively incorporated by macrophages, immediately transferred to lysosomes, then released from liposomes into lysosomes by enzymatic digestion of the liposomal lipid layers. From 4 h after ingesting liposome-encapsulated MDPCL2 mur...

journal_title：Journal of leukocyte biology

authors： Naito M,Nagai H,Kawano S,Umezu H,Zhu H,Moriyama H,Yamamoto T,Takatsuka H,Takei Y

更新日期：1996-09-01 00:00:00

abstract：:Previous studies about basophils and mast cells identified the ability of IgE to up-regulate FcepsilonRI expression by a process that depends on stabilization of the surface receptor by IgE. However, the mechanism of loss from the cell surface, when unoccupied, is not known. The current studies have examined whether u...

journal_title：Journal of leukocyte biology

authors： MacGlashan DW Jr

更新日期：2007-10-01 00:00:00

abstract：:Protein kinase B (Akt) is known to be involved in proinflammatory and chemotactic events in response to injury. Akt activation also leads to the induction of heme oxygenase (HO)-1. Up-regulation of HO-1 mediates potent, anti-inflammatory effects and attenuates organ injury. Although studies have shown that 17beta-estr...

journal_title：Journal of leukocyte biology

authors： Hsu JT,Kan WH,Hsieh CH,Choudhry MA,Schwacha MG,Bland KI,Chaudry IH

更新日期：2007-10-01 00:00:00

abstract：:IL-10 is a key immune-regulatory cytokine, and its gene polymorphisms correlate with severity of clinical GVHD. IL-10 is made by a variety of donor and host cells, but the functional relevance of its source and its role in the biology of acute GVHD are not well understood. We used preclinical models to examine the rel...

journal_title：Journal of leukocyte biology

authors： Tawara I,Sun Y,Liu C,Toubai T,Nieves E,Evers R,Alrubaie M,Mathewson N,Tamaki H,Reddy P

更新日期：2012-04-01 00:00:00

abstract：:Workshop cluster 1 (WC1) is a member of the scavenger receptor cysteine-rich (SRCR) superfamily that includes CD5, CD6, CD163, and M160. Bovine WC1 consists of 11 SRCR domains, a unique domain 1, and two homologous 5 SRCR domain cassettes, WC1 domains 2-6 and 7-11. The porcine orthologue of WC1 contains five SRCR doma...

journal_title：Journal of leukocyte biology

authors： Ahn JS,Konno A,Gebe JA,Aruffo A,Hamilton MJ,Park YH,Davis WC

更新日期：2002-08-01 00:00:00

abstract：:A sensitive in vitro assay for generation of human leukocytic pyrogen has been used to study the pathogenesis of fever accompanying administration of human alpha-interferon. Unlike other potent pyrogens, two recombinant interferon preparations tested over a wide concentration range did not stimulate release of leukocy...

journal_title：Journal of leukocyte biology

authors： Ackerman SK,Hochstein HD,Zoon K,Browne W,Rivera E,Elisberg B

更新日期：1984-07-01 00:00:00

abstract：:In human neutrophils, TNF-elicited O(2)(-) production requires adherence and integrin activation. How this cooperative signaling between TNFRs and integrins regulates O(2)(-) generation has yet to be fully elucidated. Previously, we identified delta-PKC as a critical early regulator of TNF signaling in adherent neutro...

journal_title：Journal of leukocyte biology

authors： Kilpatrick LE,Sun S,Li H,Vary TC,Korchak HM

更新日期：2010-01-01 00:00:00

abstract：:Genomic, transcriptomic and proteomic databases indicate that the N-terminal 322 residues encoded by the presumptive LOC100996504 gene, which is adjacent to the ARHGEF18 guanine nucleotide exchange factor gene on chromosome 19, constitute the N-terminal portion of a 1361-residue isoform of ARHGEF18, dubbed LOCGEF-X3. ...

journal_title：Journal of leukocyte biology

authors： Turton KB,Wilkerson EM,Hebert AS,Fogerty FJ,Schira HM,Botros FE,Coon JJ,Mosher DF

更新日期：2018-07-01 00:00:00

abstract：:Immunosuppression is currently the treatment of choice to attenuate the chronic deterioration of tissue function as a result of the effector mechanisms of the immunological response in transplant rejection and autoimmune diseases. However, global immunosuppression greatly increases the risk of acquiring life-threateni...

journal_title：Journal of leukocyte biology

authors： del Rio ML,Lucas CL,Buhler L,Rayat G,Rodriguez-Barbosa JI

更新日期：2010-02-01 00:00:00

abstract：:The adhesion and degranulation promoting adaptor protein (ADAP) is a multifunctional scaffold involved in many different signaling pathways that are important for the function of T cells, including the inside-out and outside-in signaling of integrins, the activation of NF-κB, and the subsequent production of proinflam...

journal_title：Journal of leukocyte biology

authors： Parzmair GP,Gereke M,Haberkorn O,Annemann M,Podlasly L,Kliche S,Reinhold A,Schraven B,Bruder D

更新日期：2017-02-01 00:00:00

abstract：:During the neoplastic progression, macrophages as well as dendritic and NK cells are attracted into the tumor site and initiate the immune response against transformed cells. They activate and present tumor antigens to T cells, which are then activated to kill tumor cells. However, tumor cells are often capable of esc...

journal_title：Journal of leukocyte biology

authors： Lamagna C,Aurrand-Lions M,Imhof BA

更新日期：2006-10-01 00:00:00

abstract：:Polyamines naturally occur in all living beings and play an important role in the regulation of cell proliferation, differentiation, and functional stimulation of terminally differentiated cells. Our studies, using specific inhibitors of polyamine biosynthesis such as alpha-difluoromethylornithine and methylglyoxal-bi...

journal_title：Journal of leukocyte biology

authors： Messina L,Spampinato G,Arcidiacono A,Malaguarnera L,Pagano M,Kaminska B,Kaczmarek L,Messina A

更新日期：1992-12-01 00:00:00

abstract：:Osteopontin is an RGD-containing bone matrix protein with cytokine-like functions that is associated with early stages of Th1-mediated diseases. Although the function of osteopontin in these responses is unknown, it is expressed by activated T cells and macrophages and can costimulate T cell proliferation. Studies hav...

journal_title：Journal of leukocyte biology

authors： O'Regan AW,Hayden JM,Berman JS

更新日期：2000-10-01 00:00:00

abstract：:The transcription factor GATA-2 is expressed in hematopoietic stem and progenitor cells and is functionally implicated in their survival and proliferation. In the present study, we show that GATA-2 exists as an acetylated protein in immature precursor cells, KG1. GATA-2 was acetylated in vitro by p300 and GCN5. We hav...

journal_title：Journal of leukocyte biology

authors： Hayakawa F,Towatari M,Ozawa Y,Tomita A,Privalsky ML,Saito H

更新日期：2004-03-01 00:00:00

abstract：:Although class A type I/II scavenger receptor (SR-A) is involved in numerous macrophage functions, its signaling ability remains uncertain. We used monoclonal antibodies (mAb) to specifically stimulate receptors on mouse alveolar (AMs) and peritoneal macrophages (PMs). Immobilized anti-SR-A (2F8) and anti-FcgammaR II/...

journal_title：Journal of leukocyte biology

authors： Józefowski S,Kobzik L

更新日期：2004-11-01 00:00:00