Abstract：
:Cationic antimicrobial protein of M(r) 37 kDa (CAP37) is a multifunctional protein isolated from the granules of human neutrophils, which has important implications in host defense and inflammation. CAP37 was initially recognized for its strong antibiotic activity against Gram-negative bacteria and was viewed as a component of the oxygen-independent killing mechanism of the neutrophil. However, we now know that CAP37 has more far reaching and important functions. It is a physiological protein released during inflammation with a high potential of regulating monocyte/macrophage functions, such as chemotaxis, increased survival, and differentiation. Recently, it has been demonstrated that CAP37 binds endotoxin. It has the structure of a serine esterase but lacks enzymatic activity. The bactericidal and endotoxin binding domains of the molecule have been delineated. The identification of functional peptides should provide new insight into the mechanisms of endotoxin binding, antimicrobial activity, and chemotaxis and in the long term provide key insights into therapies for treating infections and endotoxic shock.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Pereira HAdoi
10.1002/jlb.57.6.805subject
Has Abstractpub_date
1995-06-01 00:00:00pages
805-12issue
6eissn
0741-5400issn
1938-3673journal_volume
57pub_type
杂志文章,评审abstract：:In this study, we analyzed the specific effects of transforming growth factor beta (TGF-beta1) and/or IL-4 on monocyte-derived cells. Monocytes were cultured with GM-CSF, GM-CSF/TGF-beta1, GM-CSF/IL-4, or GM-CSF/IL-4/TGF-beta1 before cell morphology, phenotype, and function were assessed. As expected, interleukin-4 is...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：
更新日期：2002-05-01 00:00:00
abstract：:SIRS is associated with lymphopenia, and prolonged lymphopenia of septic patients has been associated with increased mortality risk. We hypothesize that elevated adenosine during SIRS down-regulates Gi-coupled A1R, which signals an effect that sensitizes a cAMP-dependent lymphotoxic response. In this study, we evaluat...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1189/jlb.3A0816-345RR
更新日期：2017-07-01 00:00:00
abstract：:An immunoglobulin M (IgM) monoclonal antibody, My43, specific for IgA Fc receptor (Fc alpha R) on human monocytes, bound to human polymorphonuclear neutrophils (PMNs) and inhibited their ability to bind IgA but not IgG. It was observed that the PMN oxidative burst was induced by both polymeric IgA and aggregated IgG, ...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1002/jlb.51.4.373
更新日期：1992-04-01 00:00:00
abstract：:Leukocyte trafficking from the blood into the tissues represents a key process during inflammation and requires multiple steps mediated by adhesion molecules and chemoattractants. Inflammation has a detrimental role in several diseases, and in such cases, the molecular mechanisms controlling leukocyte migration are po...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章,评审
doi：10.1189/jlb.0710432
更新日期：2011-04-01 00:00:00
abstract：:Recruitment of leukocytes from bloodstream to extrahematic sites is tightly regulated by a variety of adhesion molecules that are expressed on the leukocytes and the vessel walls. In this manuscript, we describe the interactions between natural killer (NK) cells and activated, autologous platelets under physiologic fl...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1189/jlb.0204106
更新日期：2004-09-01 00:00:00
abstract：:Dendritic cells (DC) are professional antigen-presenting cells that are used in vaccine approaches to cancer. Classically, mature monocyte-derived DC are generated in vitro in the presence of interleukin (IL)-4, granulocyte macrophage-colony stimulating factor, and inflammatory cytokines (G4-DC). Recently, it has been...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1189/jlb.0105052
更新日期：2005-10-01 00:00:00
abstract：:CD137, a member of the TNF receptor family, and its ligand are expressed on T lymphocytes and antigen-presenting cells (APC), respectively. During interaction with APC, T lymphocytes receive a potent, costimulatory signal through CD137. Reverse signaling has been demonstrated for the CD137 ligand, which causes activat...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
abstract：:Human skin mast cells (HSMC) in situ were examined by electron microscopy of surgical biopsy specimens obtained from a wide variety of circumstances. From these studies, it is apparent that the general ultrastructural morphology of normal HSMC is similar to that of human mast cells from other sites, except that the mo...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1002/jlb.49.2.197
更新日期：1991-02-01 00:00:00
abstract：:Previously, we demonstrated the stimulus-specific ability of platelet lysate or release products to inhibit neutrophil functions in response to f-met-leu-phe (fMLP) or phorbol myristate acetate (PMA). The present study further characterizes these activities and identifies one of the platelet inhibitors of neutrophil s...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1002/jlb.44.5.411
更新日期：1988-11-01 00:00:00
abstract：:The identification of an anti-tumor effect displayed by cells of innate immunity has opened new scenarios, not only in the field of allo-HSCT but also for nontransplanted patients with hematological malignancies or solid tumors. Donor-derived NK cells have been shown to contribute to the eradication of malignant cells...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章,评审
doi：10.1189/jlb.0613343
更新日期：2013-12-01 00:00:00
abstract：:Emerging evidence suggests that the innate immune system, comprised of Toll-like receptors (TLRs) and their associated molecules, plays a pivotal role in the regulation of intestinal inflammation and in the response to invading pathogens. Although TLRs are thought to have predominantly beneficial effects in pathogen r...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章,评审
doi：10.1189/jlb.0607358
更新日期：2008-03-01 00:00:00
abstract：:The mechanisms by which concanavalin A (Con A), a lectin, activates T cells are poorly studied. A low dose of Con A is stimulatory for T cells, whereas a high dose of Con A results in suppression of proliferation and enhanced T cell death. The expression and functional roles of costimulatory receptors, CD28 and cytoto...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1189/jlb.1104644
更新日期：2005-07-01 00:00:00
abstract：:Thimerosal is an organic mercury compound that is used as a preservative in vaccines and pharmaceutical products. Recent studies have shown a TH2-skewing effect of mercury, although the underlying mechanisms have not been identified. In this study, we investigated whether thimerosal can exercise a TH2-promoting effect...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1189/jlb.0706467
更新日期：2007-02-01 00:00:00
abstract：:NLRP3 is the most crucial member of the NLR family, as it detects the existence of pathogen invasion and self-derived molecules associated with cellular damage. Several studies have reported that excessive NLRP3 inflammasome-mediated caspase-1 activation is a key factor in the development of diseases. Recent studies h...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1189/jlb.3HI0814-371RR
更新日期：2015-05-01 00:00:00
abstract：:Reactive oxygen metabolites (ROMs) have been implicated in the pathogenesis of the inflammatory response to ischemia/reperfusion (I/R), which is exacerbated in diabetes. This study revealed an increased (P < 0.01) ROMs production in mesenteric tissue (measured using the oxidant-sensitive fluorochrome dihydrorhodamine ...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1002/jlb.66.1.59
更新日期：1999-07-01 00:00:00
abstract：:Extracellular vesicles (EVs) are nanosized particles that have emerged as mediators for intercellular communication in physiologic and pathologic conditions. EVs carry signaling information on their bilipid membrane as well as cargo within, allowing them to perform a wide range of biologic processes and contribute to ...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章,评审
doi：10.1002/JLB.3MR0420-067R
更新日期：2020-11-01 00:00:00
abstract：:In RAW 264.7 cells, PKC-ε regulates FcγR-mediated phagocytosis. BMDM behave similarly; PKC-ε concentrates at phagosomes and internalization are reduced in PKC-ε⁻/⁻ cells. Two questions were asked: what is the role of PKC-ε? and what domains are necessary for PKC-ε concentration? Function was studied using BMDM and fru...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1189/jlb.1212634
更新日期：2013-07-01 00:00:00
abstract：:An understanding of the binding specificity of leukocyte integrins is important to determine the range of ligands that interact with these receptors during inflammatory processes. In this study we show that the alpha4beta1 integrin can interact with casein and denatured albumin and promote leukocyte adhesion through t...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1002/jlb.62.3.318
更新日期：1997-09-01 00:00:00
abstract：:The human polyomavirus JCV lytically infects oligodendrocytes of immunosuppressed individuals leading to the fatal demyelinating disease termed progressive multifocal leukoencephalopathy (PML). Dementia, hemiparesis, and hemianopsia are the predominant presenting signs of PML. Asymptomatic JCV infection is common worl...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章,评审
doi：10.1002/jlb.65.4.428
更新日期：1999-04-01 00:00:00
abstract：:Previous studies about basophils and mast cells identified the ability of IgE to up-regulate FcepsilonRI expression by a process that depends on stabilization of the surface receptor by IgE. However, the mechanism of loss from the cell surface, when unoccupied, is not known. The current studies have examined whether u...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1189/jlb.0207103
更新日期：2007-10-01 00:00:00
abstract：:The objective of this study was to find the role of LncRNA SNHG12 in the regulation of hypertensive vascular endothelial injury. LncRNA SNHG12 and miR-25-3p expression were detected by quantitative RT-PCR. Protein levels of Sirtuin 6 (SIRT6), endothelial cell (EC) senescence markers p16 and p21, and EC marker CD31 wer...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1002/JLB.1A0820-501R
更新日期：2021-01-19 00:00:00
abstract：:Phagocytosis is the process whereby cells engulf large particles, usually over 0.5 micro m in diameter. Phagocytosis is triggered by the interaction of opsonins that cover the particle to be internalized with specific receptors on the surface of the phagocyte. The best-studied phagocytic receptors include the Fc recep...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章,评审
doi：
更新日期：2002-12-01 00:00:00
abstract：:Alcohol use has been shown to decrease monocyte antigen presentation capacity and inflammatory cytokine production, thereby increasing susceptibility to infections. Here, we demonstrate that in vitro acute treatment of normal monocytes with pharmacological doses of ethanol can decrease superantigen [Staphylococcus ent...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1002/jlb.58.3.342
更新日期：1995-09-01 00:00:00
abstract：:Recombinant fusion proteins consisting of the extracellular domain of immunoregulatory proteins and the constant domain of immunoglobulin G (IgG) are a novel class of human therapeutics. IgG isoforms exert different levels of immune effector functions, such as complement lysis and antibody-dependent cell cytotoxicity ...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:CD8(+) T cells must detect foreign antigens and differentiate into effector cells to eliminate infections. But, when self-antigen is recognized instead, mechanisms of peripheral tolerance prevent acquisition of effector function to avoid autoimmunity. These distinct responses are influenced by inflammatory and regulat...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1189/jlb.1A0913-500RR
更新日期：2014-09-01 00:00:00
abstract：:Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains the leading global cause of death from an infectious agent. Mycobacteria thrive within their host Mϕs and presently, there is no animal model that permits combined in vitro and in vivo study of mycobacteria-host Mϕ interactions. Mycoba...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1002/JLB.1A0919-147R
更新日期：2019-12-01 00:00:00
abstract：:Although tumor growth enhances macrophage (m phi) cytotoxic activity by increasing their tumor necrosis factor-alpha (TNF-alpha) production, increased prostaglandin E2 (PGE2) synthesis reduces most immune responses during tumor growth. Macrophages that do not express major histocompatibility complex class II molecules...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1002/jlb.53.5.550
更新日期：1993-05-01 00:00:00
abstract：:Notch signaling plays a preeminent role during development in not only regulating cell fate decisions, but it can also influence growth and survival of progenitor cells. In the immune system, Notch is required for the maintenance of hematopoietic stem cells and in directing T- versus B-lineage commitment. In this revi...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章,评审
doi：10.1189/jlb.0303089
更新日期：2003-12-01 00:00:00
abstract：:Patients with head and neck squamous cell carcinoma (HNSCC) have increased levels of immune-suppressive peripheral blood CD34+ cells. This study showed that the peripheral blood CD34+ cells of HNSCC patients are capable of differentiating into dendritic cells. Because CD34+ cells can differentiate through several path...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1002/jlb.65.5.623
更新日期：1999-05-01 00:00:00
abstract：:Cellular lysates from PPD+ donors have been reported to transfer tuberculin reactivity to naïve recipients, but not diphtheria reactivity, and vice versa. A historically controversial topic, the terms "transfer factor" and "DLE" were used to characterize the reactivity-transferring properties of lysates. Intrigued by ...
journal_title：Journal of leukocyte biology
pub_type： 杂志文章
doi：10.1189/jlb.3A0216-082R
更新日期：2017-01-01 00:00:00
