At the Bedside: Innate immunity as an immunotherapy tool for hematological malignancies.

abstract：:GCs are widely prescribed to treat inflammatory disorders and autoimmune and allergic diseases. Their anti-inflammatory and immunosuppressive effects may be related, in part, to their ability to control the maturation and functions of DCs. Here, we report that GCs inhibit the maturation of human CD34-DCs induced by th...

journal_title：Journal of leukocyte biology

authors： Larangé A,Antonios D,Pallardy M,Kerdine-Römer S

更新日期：2012-01-01 00:00:00

abstract：:The pathogenesis of CRC remains to be further understood. This study was designed to elucidate the role of Foxp3+IL-17+ T cells in the pathogenesis of CRC. Surgically removed CRC tissue was collected from 12 patients with CRC. The frequency and cytokine profile of Foxp3+IL-17+ T cells in CRC were examined by flow cyto...

journal_title：Journal of leukocyte biology

authors： Yang S,Wang B,Guan C,Wu B,Cai C,Wang M,Zhang B,Liu T,Yang P

更新日期：2011-01-01 00:00:00

abstract：:The objective of this study was to find the role of LncRNA SNHG12 in the regulation of hypertensive vascular endothelial injury. LncRNA SNHG12 and miR-25-3p expression were detected by quantitative RT-PCR. Protein levels of Sirtuin 6 (SIRT6), endothelial cell (EC) senescence markers p16 and p21, and EC marker CD31 wer...

journal_title：Journal of leukocyte biology

authors： Qian W,Zheng ZQ,Nie JG,Liu LJ,Meng XZ,Sun H,Xiao FM,Kang T

更新日期：2021-01-19 00:00:00

abstract：:Azurocidin is a multifunctional endotoxin-binding serine protease homolog synthesized during the promyelocytic stage of neutrophil development. To characterize the biosynthesis and processing of azurocidin, cDNA encoding human preproazurocidin was stably transfected to the rat basophilic leukemia cell line RBL-1 and t...

journal_title：Journal of leukocyte biology

authors： Lindmark A,Garwicz D,Rasmussen PB,Flodgaard H,Gullberg U

更新日期：1999-10-01 00:00:00

abstract：:Modifying the fatty acid composition of macrophages through diet can significantly alter some of their functions, such as tumoricidal capacity and tumor necrosis factor alpha (TNF-alpha) production. The mechanism of that modification, however, is unknown. In this report, we provide evidence that fatty acids added to m...

journal_title：Journal of leukocyte biology

authors： Hubbard NE,Lim D,Somers SD,Erickson KL

更新日期：1993-08-01 00:00:00

abstract：:A wealth of scientific and clinical evidence during the past few years has lent credence to the idea that key components of the host immune effector mechanisms can be targeted to boost current tuberculosis (TB) treatment and control patient relapse. These host-directed strategies not only accelerate the clearance of p...

journal_title：Journal of leukocyte biology

authors： Cheng CY,Böhme J,Singhal A

更新日期：2018-02-01 00:00:00

abstract：:An anti-macrophage monoclonal antibody designated TRPM-3 was produced using thioglycollate-elicited rat peritoneal macrophages as immunogen. By the immunoperoxidase method, TRPM-3 was found to be specific for certain macrophage populations, such as marginal zone macrophages and marginal metallophils of the spleen, sin...

journal_title：Journal of leukocyte biology

authors： Takeya M,Hsiao L,Takahashi K

更新日期：1987-03-01 00:00:00

abstract：:It is well established that the cytokine IL-12 and the transcription factor STAT4, an essential part of the IL-12 signaling pathway, are critical components of the Th1 differentiation process in T cells. In response to pathogenic stimuli, this process causes T cells to proliferate rapidly and secrete high amounts of t...

journal_title：Journal of leukocyte biology

authors： Schaller M,Ito T,Allen RM,Kroetz D,Kittan N,Ptaschinski C,Cavassani K,Carson WF 4th,Godessart N,Grembecka J,Cierpicki T,Dou Y,Kunkel SL

更新日期：2015-10-01 00:00:00

abstract：:The persistent infection caused by hepatitis C virus (HCV) is presumably explained by a deficient immune response to the infection, but the basis for the inefficiency of immune-mediated virus eradication is not known in detail. This study addresses mechanisms of relevance to dysfunction of cytotoxic lymphocytes in HCV...

journal_title：Journal of leukocyte biology

authors： Thorén F,Romero A,Lindh M,Dahlgren C,Hellstrand K

更新日期：2004-12-01 00:00:00

abstract：:Human chorionic gonadotrophin (hCG) is a hormone produced during pregnancy and present at the implantation site and in the maternal blood. Pregnancy has been proposed to represent a controlled state of inflammation at an early stage at the implantation site and later, systemically extended to the maternal circulation....

journal_title：Journal of leukocyte biology

authors： Wan H,Coppens JM,van Helden-Meeuwsen CG,Leenen PJ,van Rooijen N,Khan NA,Kiekens RC,Benner R,Versnel MA

更新日期：2009-08-01 00:00:00

abstract：:We compared the effects of live or inactivated bovine respiratory syncytial virus (BRSV) on cytokine production by bovine monocyte-derived dendritic cells (MoDC). We also investigated the response of resting memory CD4(+) T cells to MoDC exposed to both viral preparations. Although BRSV did not appear to replicate in ...

journal_title：Journal of leukocyte biology

authors： Werling D,Collins RA,Taylor G,Howard CJ

更新日期：2002-08-01 00:00:00

abstract：:GenBank entries for mouse Il33 reveal the existence of two transcripts, Il33a and Il33b, with different 5'UTRs but coding for the same protein. We investigated expression of these transcripts in different mouse organs and cell types in basal and inflammatory conditions. Il33a and Il33b mRNAs start with different nonco...

journal_title：Journal of leukocyte biology

authors： Talabot-Ayer D,Calo N,Vigne S,Lamacchia C,Gabay C,Palmer G

更新日期：2012-01-01 00:00:00

abstract：:We have shown previously that the cellular proteins 47b and 71/73 could be used to construct phenotypes that distinguish among bone marrow culture-derived (BMCD) macrophages that were either unstimulated or primed by gamma interferon or fully activated for tumor cell killing by gamma interferon in combination with lip...

journal_title：Journal of leukocyte biology

authors： MacKay RJ,Russell SW

更新日期：1987-09-01 00:00:00

abstract：:As part of a study to identify novel genes associated with macrophage activation, we have cloned a new member of the transforming growth factor beta (TGF-beta) superfamily designated macrophage inhibitory cytokine 1 (MIC-1). MIC-1 is synthesized as a 62-kDa intracellular protein, which, after cleavage by a furin like ...

journal_title：Journal of leukocyte biology

authors： Fairlie WD,Moore AG,Bauskin AR,Russell PK,Zhang HP,Breit SN

更新日期：1999-01-01 00:00:00

abstract：:Antagonism of ROS signaling can inhibit cell apoptosis and autophagy, thus favoring the maintenance and expansion of hematopoietic stem cells. Alpha lipoic acid (ALA), a small antioxidant molecule, affects cell apoptosis by lowering the ROS level. In this study, we show that ALA promoted production of human pluripoten...

journal_title：Journal of leukocyte biology

authors： Dong Y,Bai J,Zhang Y,Zhou Y,Pan X,Li X,Zhou Q,Chen Y,Lai M,Mao B,Bian G,Feng J,Xie F,Chen B,Nakahata T,Zhang Y,Ma F

更新日期：2020-12-01 00:00:00

abstract：:We have sought to elucidate the responses of human peripheral blood neutrophils to antigenic surfaces complexed with human specific IgA antibodies obtained either as myeloma proteins that recognize staphylococcal alpha-toxin, or from the serum of patients with subacute bacterial endocarditis due to Streptococcus mutan...

journal_title：Journal of leukocyte biology

authors： Nikolova EB,Russell MW

更新日期：1995-06-01 00:00:00

abstract：:A sensitive in vitro assay for generation of human leukocytic pyrogen has been used to study the pathogenesis of fever accompanying administration of human alpha-interferon. Unlike other potent pyrogens, two recombinant interferon preparations tested over a wide concentration range did not stimulate release of leukocy...

journal_title：Journal of leukocyte biology

authors： Ackerman SK,Hochstein HD,Zoon K,Browne W,Rivera E,Elisberg B

更新日期：1984-07-01 00:00:00

abstract：:Previously, we demonstrated the stimulus-specific ability of platelet lysate or release products to inhibit neutrophil functions in response to f-met-leu-phe (fMLP) or phorbol myristate acetate (PMA). The present study further characterizes these activities and identifies one of the platelet inhibitors of neutrophil s...

journal_title：Journal of leukocyte biology

authors： McGarrity ST,Stephenson AH,Hyers TM,Webster RO

更新日期：1988-11-01 00:00:00

abstract：:Human CD4+CD25+ regulatory T (T(R)) cells express the transcription factor forkhead box p3 (FOXP3) and have potent immunosuppressive properties. While naturally occurring T(R) cells develop in the thymus, adaptive T(R) cells develop in the periphery from naive CD4+ T cells. Adaptive T(R) cells may express cyclooxygena...

journal_title：Journal of leukocyte biology

authors： Mahic M,Yaqub S,Bryn T,Henjum K,Eide DM,Torgersen KM,Aandahl EM,Taskén K

更新日期：2008-05-01 00:00:00

abstract：:The field of innate immunity is witnessing a paradigm shift regarding "memory" and "programming" dynamics. Past studies of innate leukocytes characterized them as first responders to danger signals with no memory. However, recent findings suggest that innate leukocytes, such as monocytes and neutrophils, are capable o...

journal_title：Journal of leukocyte biology

authors： Lee C,Geng S,Zhang Y,Rahtes A,Li L

更新日期：2017-09-01 00:00:00

abstract：:Specific prion peptides have been shown to mimic the pathologic isoform of the prion protein (PrP) and to induce a neurotoxic effect in vitro and in vivo. As monocytic cells are thought to play a role in the transmission and pathogenesis of prion disease, the use of these peptides in regulating monocytic cell function...

journal_title：Journal of leukocyte biology

authors： Bacot SM,Lenz P,Frazier-Jessen MR,Feldman GM

更新日期：2003-07-01 00:00:00

abstract：:TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM acts to bridge TLR4 with TRIF, orchestrating the inflammatory response to pathogen challenge. We ha...

journal_title：Journal of leukocyte biology

authors： Verstak B,Stack J,Ve T,Mangan M,Hjerrild K,Jeon J,Stahl R,Latz E,Gay N,Kobe B,Bowie AG,Mansell A

更新日期：2014-09-01 00:00:00

abstract：:Monocyte chemoattractant protein-1 (MCP-1, CCL2) is a mediator of inflammation that has been implicated in the pathogenesis of a wide variety of human diseases. CCR2, a heterotrimeric G-coupled receptor, is the only known receptor that functions at physiologic concentrations of MCP-1. Despite the importance of CCR2 in...

journal_title：Journal of leukocyte biology

authors： Schecter AD,Berman AB,Yi L,Ma H,Daly CM,Soejima K,Rollins BJ,Charo IF,Taubman MB

更新日期：2004-06-01 00:00:00

abstract：:Neutrophils can attach to E-selectin under flow. Proposed ligands for E-selectin carry SLe(x)-type glycans. The leukocyte beta2 integrins are glycosylated with SLe(x). Thus, we speculated that beta2 integrins could support attachment to E-selectin. To test this hypothesis, we coated 10-microm-diameter microspheres wit...

journal_title：Journal of leukocyte biology

authors： Crutchfield KL,Shinde Patil VR,Campbell CJ,Parkos CA,Allport JR,Goetz DJ

更新日期：2000-02-01 00:00:00

abstract：:CD8(+) T cells must detect foreign antigens and differentiate into effector cells to eliminate infections. But, when self-antigen is recognized instead, mechanisms of peripheral tolerance prevent acquisition of effector function to avoid autoimmunity. These distinct responses are influenced by inflammatory and regulat...

journal_title：Journal of leukocyte biology

authors： Jackson SR,Yuan J,Berrien-Elliott MM,Chen CL,Meyer JM,Donlin MJ,Teague RM

更新日期：2014-09-01 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) against human immunodeficiency virus type 1 (HIV-1) infection dramatically suppresses viral load, leading to marked reductions in HIV-1 associated morbidity and mortality. However, infected cell reservoirs and low-level replication persist in the face of suppressive HAART, ...

journal_title：Journal of leukocyte biology

authors： Kennedy PE,Bera TK,Wang QC,Gallo M,Wagner W,Lewis MG,Berger EA,Pastan I

更新日期：2006-11-01 00:00:00

abstract：:Tissue macrophages produce several proteins of the complement system. The mechanisms that regulate this process are poorly understood. The established ability of certain prostaglandins to influence macrophage secretory activity suggests that these lipid mediators may also modulate complement production (CP). Using the...

journal_title：Journal of leukocyte biology

authors： Rediske JJ,Pickering RJ

更新日期：1985-05-01 00:00:00

abstract：:The preferential association of some chemokine receptors with human Th1 or Th2 cells has recently been reported. In this study, the expression of CCR3, CCR5, CXCR3, and CXCR4 were analyzed by flow cytometry in three distinct in vitro models of Th1/Th2 polarization, activated naive and memory T cells, and T-cell clones...

journal_title：Journal of leukocyte biology

authors： Annunziato F,Cosmi L,Galli G,Beltrame C,Romagnani P,Manetti R,Romagnani S,Maggi E

更新日期：1999-05-01 00:00:00

abstract：:Inflammation alters hematopoiesis, often by decreasing erythropoiesis and enhancing myeloid output. The mechanisms behind these changes and how the BM stroma contributes to this process are active areas of research. In this study, we examine these questions in the setting of murine Toxoplasma gondii infection. Our dat...

journal_title：Journal of leukocyte biology

authors： Chou DB,Sworder B,Bouladoux N,Roy CN,Uchida AM,Grigg M,Robey PG,Belkaid Y

更新日期：2012-07-01 00:00:00

abstract：:Because myotonic dystrophy (MD) is an autosomal dominant multisystemic disorder affecting plasma membrane, we have studied the oxidative burst of PMNs. The PMA and fMet-Leu-Phe-stimulated superoxide generation is defective in the patient group as compared to controls: the response is both delayed and low. The kinetic ...

journal_title：Journal of leukocyte biology

authors： Mege JL,Pouget J,Capo C,Andre P,Benoliel AM,Serratrice G,Bongrand P

更新日期：1988-09-01 00:00:00