Interferon fever: absence of human leukocytic pyrogen response to recombinant alpha-interferon.

abstract：:Human peritoneal macrophages (HPM) obtained via laparoscopy were examined for the presence and functional capacity of complement and Fc receptors. Between 5 and 20 ml of peritoneal fluid containing 1-2 X 10(6) macrophages/ml was available for each study. Macrophages made up 80-95% of the cells in the fluid. Fc and C3 ...

journal_title：Journal of leukocyte biology

authors： Newman SL,Becker S,Halme J

更新日期：1985-08-01 00:00:00

abstract：:The in vitro effects of 17 alpha AED, the isomer of 5-androstene-3 beta,17 beta diol (17 beta AED) on the basal growth of murine RAW 264.7, P388D1, and human HL-60 cells were investigated. 17 alpha AED treatment of RAW cells for 48 h reduced total cell number without increasing cell death as detected by trypan blue ex...

journal_title：Journal of leukocyte biology

authors： Huynh PN,Loria RM

更新日期：1997-08-01 00:00:00

abstract：:Eosinophils are traditionally associated with allergic and parasitic inflammation. More recently, eosinophils have also been shown to have roles in diverse processes including development, intestinal health, thymic selection, and B-cell survival with the majority of these insights being derived from murine models and ...

journal_title：Journal of leukocyte biology

authors： Nguyen WNT,Jacobsen EA,Finney CAM,Colarusso P,Patel KD

更新日期：2020-07-01 00:00:00

abstract：:Anti-proteinase-3 (anti-PR3) or anti-myeloperoxidase (anti-MPO) antibodies are capable of activating human neutrophils primed by TNF-alpha in vitro. We described previously the involvement of FcgammaRIIa and beta(2) integrins in this neutrophil activation. In the literature, the requirement of TNF priming has been att...

journal_title：Journal of leukocyte biology

authors： Reumaux D,Hordijk PL,Duthilleul P,Roos D

更新日期：2006-12-01 00:00:00

abstract：:Dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) C-type lectin is almost exclusively expressed at the cell surface of DC. In addition to its normal function facilitating contact of DC with T cells, DC-SIGN has been shown to bind a variety of pathogens, including Mycobacterium bovis, and HIV-1 envelope pro...

journal_title：Journal of leukocyte biology

authors： Yamakawa Y,Pennelegion C,Willcocks S,Stalker A,Machugh N,Burt D,Coffey TJ,Werling D

更新日期：2008-06-01 00:00:00

abstract：:Recombinant fusion proteins consisting of the extracellular domain of immunoregulatory proteins and the constant domain of immunoglobulin G (IgG) are a novel class of human therapeutics. IgG isoforms exert different levels of immune effector functions, such as complement lysis and antibody-dependent cell cytotoxicity ...

journal_title：Journal of leukocyte biology

authors： Taylor L,Bachler M,Duncan I,Keen S,Fallon R,Mair C,McDonald TT,Schwarz H

更新日期：2002-09-01 00:00:00

abstract：:Chemerin is a potent chemotactic factor that was identified recently as the ligand of ChemR23, a G protein-coupled receptor expressed by mononuclear phagocytes, dendritic cells (DCs), and NK cells. Chemerin is synthesized as a secreted precursor, prochemerin, which is poorly active on ChemR23. However, prochemerin can...

journal_title：Journal of leukocyte biology

authors： Guillabert A,Wittamer V,Bondue B,Godot V,Imbault V,Parmentier M,Communi D

更新日期：2008-12-01 00:00:00

abstract：:Elderly humans are more susceptible to bacterial infections because of declining immune status. We have investigated the effect of aging on neutrophil bactericidal responses, comparing neutrophil function in healthy, young (23-35 years) and elderly (>65 years) volunteers. Superoxide generation in response to fMLP was ...

journal_title：Journal of leukocyte biology

authors： Butcher SK,Chahal H,Nayak L,Sinclair A,Henriquez NV,Sapey E,O'Mahony D,Lord JM

更新日期：2001-12-01 00:00:00

abstract：:Autoreactive CD4+ and CD8+ T cells directed against CNS autoantigens may play a role in the development of multiple sclerosis (MS). Identical twins share the same genetic background but not the TCR repertoire that is shaped by the encounter with self or foreign antigens. To gain insights into the interplay between MS ...

journal_title：Journal of leukocyte biology

authors： Somma P,Ristori G,Battistini L,Cannoni S,Borsellino G,Diamantini A,Salvetti M,Sorrentino R,Fiorillo MT

更新日期：2007-03-01 00:00:00

abstract：:How regulatory T (TR) cells dampen T cell responses remains unclear. Multiple modes of action have been proposed, including cell contact-dependent and/or cytokine-dependent mechanisms. Suppression may involve direct contact between TR cells and responder T cells. Alternatively, TR cells may act on dendritic cells to r...

journal_title：Journal of leukocyte biology

authors： Bodor J,Fehervari Z,Diamond B,Sakaguchi S

更新日期：2007-01-01 00:00:00

abstract：:Fetal alcohol spectrum disorder (FASD), which results from ethanol exposure during pregnancy, and alcohol use disorder (AUD), which includes both binge and chronic alcohol abuse, are strikingly common and costly at personal and societal levels. These disorders are associated with significant pathology, including that ...

journal_title：Journal of leukocyte biology

authors： Kane CJ,Drew PD

更新日期：2016-11-01 00:00:00

abstract：:This study tested the hypothesis that eotaxins (CCL11, CCL24, and CCL26) and IL-5 contribute to eosinophil recruitment to the intestine in UC and that intestinal macrophages are important producers of CCL11 in this disease. Peripheral blood and rectal biopsy samples were obtained from patients with active (n=18) and q...

journal_title：Journal of leukocyte biology

authors： Lampinen M,Waddell A,Ahrens R,Carlson M,Hogan SP

更新日期：2013-11-01 00:00:00

abstract：:Cathepsins (Cat) in antigen presenting cells (APC) control antigen processing as well as major histocompatibility complex class II transport and function. The set of active Cat and the subcellular architecture of the class II antigen presentation compartment are largely unknown in primary human APC, including peripher...

journal_title：Journal of leukocyte biology

authors： Greiner A,Lautwein A,Overkleeft HS,Weber E,Driessen C

更新日期：2003-02-01 00:00:00

abstract：:The receptor for urokinase plasminogen activator (uPAR; CD87) is a 50- to 65-kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed by leukocytes and tumor cells where it facilitates uPA-dependent, plasmin-mediated pericellular proteolysis during cellular invasion. Because uPAR is inducibly shed into c...

journal_title：Journal of leukocyte biology

authors： Mizukami IF,Todd RF 3rd

更新日期：1998-08-01 00:00:00

abstract：:TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM acts to bridge TLR4 with TRIF, orchestrating the inflammatory response to pathogen challenge. We ha...

journal_title：Journal of leukocyte biology

authors： Verstak B,Stack J,Ve T,Mangan M,Hjerrild K,Jeon J,Stahl R,Latz E,Gay N,Kobe B,Bowie AG,Mansell A

更新日期：2014-09-01 00:00:00

abstract：:IL-18 has a potential to up-regulate the Th1 and Th2 immune responses. It is known that IL-18, in synergy with IL-12, augments the Th1 response to bacterial infections, but it also augments the Th2 response to allergic disorders in the absence of IL-12. Although the Th1 and Th2 immune responses cross-regulate each oth...

journal_title：Journal of leukocyte biology

authors： Kinoshita M,Miyazaki H,Ono S,Seki S

更新日期：2013-05-01 00:00:00

abstract：:During inflammation the balance between cell activation and cell death is determined by the tight regulation of multiple intracellular enzyme cascades. Key regulatory steps often involve protein kinases. We show that the prototypical pro-inflammatory molecule, bacterial lipopolysaccharide, activates multiple protein k...

journal_title：Journal of leukocyte biology

authors： Lee J,Mira-Arbibe L,Ulevitch RJ

更新日期：2000-12-01 00:00:00

abstract：:The existence of an association between the brain and immunity has been documented. Data show that the nervous and immune systems communicate with one another to maintain immune homeostasis. Activated immune cells secrete cytokines that influence central nervous system activity, which in turn, activates output through...

journal_title：Journal of leukocyte biology

authors： Kin NW,Sanders VM

更新日期：2006-06-01 00:00:00

abstract：:Impairments in the respiratory burst and stimulus-response coupling were studied with respect to the increased rate of cell replication that occurred in HL60 cells during repetitive passages in cell culture. During a 45-week period of culture, HL60 cells developed a progressive increase in rate of replication. Concomi...

journal_title：Journal of leukocyte biology

authors： Hadjokas N,Bayer C,Nielson CP

更新日期：1992-08-01 00:00:00

abstract：:Macrophages and dendritic cells are in the front line of host defense. When they sense host invasion, they produce cytokines that alert other innate immune cells and also abet the development of an adaptive immune response. Although lipolysaccharide (LPS), peptidoglycan, unmethylated DNA, and other microbial products ...

journal_title：Journal of leukocyte biology

authors： Beutler B,Hoebe K,Du X,Ulevitch RJ

更新日期：2003-10-01 00:00:00

abstract：:RelB is one of the more unusual members of the NF-κB family. This family, arguably the best known group of transcription regulators, regulates an astonishing array of cell types and biological processes. This includes regulation of cell growth, differentiation and death by apoptosis, and the development and function o...

journal_title：Journal of leukocyte biology

authors： Millet P,McCall C,Yoza B

更新日期：2013-11-01 00:00:00

abstract：:When mouse peritoneal cells in early phase-inflammatory exudates were cultured in vitro, the number of polymorphonuclear leukocytes (PMNs) rapidly decreased, whereas the number of macrophages gradually increased during culture. Macrophage growth was also induced by addition of effete PMNs or their debris to macrophage...

journal_title：Journal of leukocyte biology

authors： Yui S,Yamazaki M

更新日期：1986-05-01 00:00:00

abstract：:CXCL8 is the principal human neutrophil-attracting chemokine and a major mediator of inflammation. The chemokine exerts its neutrophil-chemotactic and neutrophil-activating activities via interaction with glycosaminoglycans (GAGs) and activation of the G protein-coupled receptors (GPCRs) CXCR1 and CXCR2. Natural CXCL8...

journal_title：Journal of leukocyte biology

authors： Metzemaekers M,Vandendriessche S,Berghmans N,Gouwy M,Proost P

更新日期：2020-06-01 00:00:00

abstract：:The oxidative burst of polymorphonuclear neutrophils (PMN) and their ability to inhibit Paracoccidioides brasiliensis growth was studied in susceptible (B10.A) and resistant (A/J) mice. The cells were obtained after subcutaneous inoculation in air pouches, yielding highly pure PMN preparations; the number of cells was...

journal_title：Journal of leukocyte biology

authors： Meloni-Bruneri LH,Campa A,Abdalla DS,Calich VL,Lenzi HL,Burger E

更新日期：1996-04-01 00:00:00

abstract：:Alveolar macrophages from chronic obstructive pulmonary disease patients and cigarette smokers are deficient in their ability to phagocytose apoptotic bronchial epithelial cells (efferocytosis). We hypothesized that the defect is mediated via inhibition of sphingosine kinases and/or their subcellular mislocalization i...

journal_title：Journal of leukocyte biology

authors： Tran HB,Barnawi J,Ween M,Hamon R,Roscioli E,Hodge G,Reynolds PN,Pitson SM,Davies LT,Haberberger R,Hodge S

更新日期：2016-07-01 00:00:00

abstract：:Radiation-induced chimeric mice were used to study the origin of pulmonary alveolar macrophages. Unlike in other studies, these radiation chimeras were prepared by using a special fractionated irradiation regimen to minimize the killing of alveolar macrophage colony-forming cells, putative local stem cells. For this s...

journal_title：Journal of leukocyte biology

authors： Tarling JD,Lin HS,Hsu S

更新日期：1987-11-01 00:00:00

abstract：:Healthy donors infused with high doses of glucocorticoids [GCs; methyl-prednisolone (MP); 500 mg/day for 3 days] suffer a selective depletion of the CD14(+)CD16(+) monocytes such that these cells are reduced by 95% on day 5. In vitro studies revealed that at 11 h of culture in the presence of 10(-)(5) M MP, no depleti...

journal_title：Journal of leukocyte biology

authors： Dayyani F,Belge KU,Frankenberger M,Mack M,Berki T,Ziegler-Heitbrock L

更新日期：2003-07-01 00:00:00

abstract：:PI3Ks have been identified as key signaling proteins involved in many basic biologic processes in health and disease. Transgenic animals have been essential tools to study the underlying molecular mechanisms in this context and therefore, have been widely used to elucidate the role of these factors in many different s...

journal_title：Journal of leukocyte biology

authors： Schneider C,Nobs SP,Heer AK,Hirsch E,Penninger J,Siggs OM,Kopf M

更新日期：2017-02-01 00:00:00

abstract：:Maturation of cells of the mononuclear phagocyte lineage from bone marrow precursors to tissue macrophages (MAC) via circulating blood monocytes (MO) is a multistep process only partially understood. Similarly, MAC differentiation can be observed if MO are cultured in vitro. In an attempt to further characterize molec...

journal_title：Journal of leukocyte biology

authors： Krause SW,Rehli M,Kreutz M,Schwarzfischer L,Paulauskis JD,Andreesen R

更新日期：1996-10-01 00:00:00

abstract：:Alcohol-induced neuroinflammation is mediated by proinflammatory cytokines, including IL-1β. IL-1β production requires caspase-1 activation by inflammasomes-multiprotein complexes that are assembled in response to danger signals. We hypothesized that alcohol-induced inflammasome activation contributes to increased IL-...

journal_title：Journal of leukocyte biology

authors： Lippai D,Bala S,Petrasek J,Csak T,Levin I,Kurt-Jones EA,Szabo G

更新日期：2013-07-01 00:00:00