Abstract:
:RelB is one of the more unusual members of the NF-κB family. This family, arguably the best known group of transcription regulators, regulates an astonishing array of cell types and biological processes. This includes regulation of cell growth, differentiation and death by apoptosis, and the development and function of the innate and adaptive-immune system. RelB is best known for its roles in lymphoid development, DC biology, and noncanonical signaling. Within the last few years, however, surprising functions of RelB have emerged. The N-terminal leucine zipper motif of RelB, a motif unique among the NF-κB family, may associate with more diverse DNA sequences than other NF-κB members. RelB is capable of direct binding to the AhR that supports the xenobiotic-detoxifying pathway. RelB can regulate the circadian rhythm by directly binding to the BMAL partner of CLOCK. Finally, RelB also couples with bioenergy NAD(+) sensor SIRT1 to integrate acute inflammation with changes in metabolism and mitochondrial bioenergetics. In this review, we will explore these unique aspects of RelB, specifically with regard to its role in immunity.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Millet P,McCall C,Yoza Bdoi
10.1189/jlb.0513305subject
Has Abstractpub_date
2013-11-01 00:00:00pages
941-51issue
5eissn
0741-5400issn
1938-3673pii
jlb.0513305journal_volume
94pub_type
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1999-08-01 00:00:00
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章
doi:10.1189/jlb.1207831
更新日期:2008-06-01 00:00:00
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章,评审
doi:
更新日期:2002-10-01 00:00:00
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章
doi:10.1002/jlb.45.1.46
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章
doi:10.1002/jlb.55.6.743
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journal_title:Journal of leukocyte biology
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journal_title:Journal of leukocyte biology
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章
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journal_title:Journal of leukocyte biology
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