RelB: an outlier in leukocyte biology.


:RelB is one of the more unusual members of the NF-κB family. This family, arguably the best known group of transcription regulators, regulates an astonishing array of cell types and biological processes. This includes regulation of cell growth, differentiation and death by apoptosis, and the development and function of the innate and adaptive-immune system. RelB is best known for its roles in lymphoid development, DC biology, and noncanonical signaling. Within the last few years, however, surprising functions of RelB have emerged. The N-terminal leucine zipper motif of RelB, a motif unique among the NF-κB family, may associate with more diverse DNA sequences than other NF-κB members. RelB is capable of direct binding to the AhR that supports the xenobiotic-detoxifying pathway. RelB can regulate the circadian rhythm by directly binding to the BMAL partner of CLOCK. Finally, RelB also couples with bioenergy NAD(+) sensor SIRT1 to integrate acute inflammation with changes in metabolism and mitochondrial bioenergetics. In this review, we will explore these unique aspects of RelB, specifically with regard to its role in immunity.


J Leukoc Biol


Millet P,McCall C,Yoza B




Has Abstract


2013-11-01 00:00:00














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    abstract::The airway epithelial cell of the lower respiratory tract is the primary host target cell for respiratory syncytial virus (RSV) infection. To estimate whether infected epithelial cells contribute to the inflammatory host response observed during the acute infection phase we analyzed the cell surface expression of inte...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Arnold R,Konig W

    更新日期:1996-12-01 00:00:00

  • Antibodies to CD18 influence neutrophil migration through extracellular matrix.

    abstract::Mac-1 (CD11b/CD18) is known to be involved in neutrophil (PMN) adhesion to endothelial cells and extracellular matrix. Although antibodies to CD 18 are being tested for therapy in humans, their role in PMN migration through the extracellular matrix is unknown. We used direct visualization to quantify PMN motility thro...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Saltzman WM,Livingston TL,Parkhurst MR

    更新日期:1999-03-01 00:00:00

  • RLR-mediated production of interferon-β by a human dendritic cell subset and its role in virus-specific immunity.

    abstract::Cytosolic RIG-I-like helicases (RLR) are PRRs involved in type I IFN production and antiviral immunity. This study focuses to the comparison of the expression, function, and signaling cascades associated to RLR in the previously identified CD14(-)DC-SIGN(+)PPARγ(low)CD1a(+) and CD14(low)DC-SIGN(+)PPARγ(high)CD1a(-) hu...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Szabo A,Bene K,Gogolák P,Réthi B,Lányi Á,Jankovich I,Dezső B,Rajnavölgyi E

    更新日期:2012-07-01 00:00:00

  • Differential presentation of tolerogenic immunoglobulin in vivo by macrophages and by a lymphoid dendritic cell-like tumor line.

    abstract::Previous work indicated that macrophages and a lymphoid dendritic cell-like tumor line, P388AD.2, possessed a differential ability to present a haptenated immunoglobulin (tolerogen) in vitro. Macrophages presented fluorescein-conjugated sheep gamma globulin (FL-SGG) and elicited B-cell unresponsiveness. In contrast, P...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Phipps RP,Illig K,Schad V,Bhimani K

    更新日期:1988-03-01 00:00:00

  • Factors mediating lipopolysaccharide-induced ganglioside expression in murine peritoneal macrophages.

    abstract::The ganglioside composition of endotoxin-responsive C3H/HeN murine peritoneal macrophages is known to undergo dramatic changes in vivo in response to intraperitoneal lipopolysaccharides (LPS), unlike endotoxin-hyporesponsive C3H/HeJ macrophages. To better investigate the mechanism behind LPS-induced macrophage ganglio...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Berenson CS,Yohe HC,Ryan JL

    更新日期:1989-03-01 00:00:00

  • Dendritic cell expression of ADAM23 governs T cell proliferation and cytokine production through the α(v)β(3) integrin receptor.

    abstract::ADAM23 is a member of the brain macrophage-derived chemokine family. Structural homology of ADAM proteins suggests their function as integrin receptors. Previous studies have linked ADAM23 as a dominant contributor to brain development and cancer metastasis. The present studies now show that ADAM23 expression on DCs p...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Elizondo DM,Andargie TE,Marshall KM,Zariwala AM,Lipscomb MW

    更新日期:2016-11-01 00:00:00

  • Characterization of macrophage subsets regulating murine natural killer cell activity.

    abstract::We examined the relationship of I-A expression by normal murine macrophages to their immunoregulatory role on natural killer cell activity. Macrophages were isolated on the basis of plastic adherence; characterized on the basis of conventional markers such as phagocytic ability, cytoplasmic non-specific esterase activ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Nelson JA,Parhar RS,Scodras JM,Lala PK

    更新日期:1990-11-01 00:00:00

  • Assessment of chemokine receptor expression by human Th1 and Th2 cells in vitro and in vivo.

    abstract::The preferential association of some chemokine receptors with human Th1 or Th2 cells has recently been reported. In this study, the expression of CCR3, CCR5, CXCR3, and CXCR4 were analyzed by flow cytometry in three distinct in vitro models of Th1/Th2 polarization, activated naive and memory T cells, and T-cell clones...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Annunziato F,Cosmi L,Galli G,Beltrame C,Romagnani P,Manetti R,Romagnani S,Maggi E

    更新日期:1999-05-01 00:00:00

  • Retinal transplantation: progress and problems in clinical application.

    abstract::There is currently no real treatment for blinding disorders that stem from the degeneration of cells in the retina and affect at least 50 million individuals worldwide. The excitement that accompanied the first studies showing the potential of retinal cell transplantation to alleviate the progress of blindness in such...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审


    authors: Lund RD,Ono SJ,Keegan DJ,Lawrence JM

    更新日期:2003-08-01 00:00:00

  • Glucan: mechanisms involved in its "radioprotective" effect.

    abstract::It has generally been accepted that most biologically derived agents that are radioprotective in the hemopoietic-syndrome dose range (eg, endotoxin, Bacillus Calmette Guerin, Corynebacterium parvum, etc) exert their beneficial properties by enhancing hemopoietic recovery and hence, by regenerating the host's ability t...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Patchen ML,D'Alesandro MM,Brook I,Blakely WF,MacVittie TJ

    更新日期:1987-08-01 00:00:00

  • The effects of 16,16-dimethyl PGE2 and phosphodiesterase inhibitors on Con A blastogenic responses and NK cytotoxic activity of mouse spleen cells.

    abstract::Prostaglandins function as down regulators of immune responses probably by increasing the concentration of intracellular cAMP. Phosphodiesterase inhibitors, which prevent the breakdown of cAMP, also increase the intracellular levels of cAMP. Prostaglandins and phosphodiesterase inhibitors have both been shown to suppr...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Ellis NK,Duffie GP,Young MR,Wepsic HT

    更新日期:1990-04-01 00:00:00

  • Chemotactic peptide enhancement of phorbol ester-induced protein kinase C activity in human neutrophils.

    abstract::Chemotactic factors and phorbol esters may act synergistically to evoke neutrophil responses, but the mechanism of such interaction is not entirely clear. We investigated the combined effects of the chemotactic peptide n-formyl-methionyl-leucyl-phenylalanine (FMLP) and phorbol myristate acetate (PMA) on protein kinase...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Gay JC,Stitt ES

    更新日期:1990-01-01 00:00:00

  • Neonatal neutrophil interaction with P-selectin: contribution of P-selectin glycoprotein ligand-1 and sialic acid.

    abstract::Previously we had determined that neonatal neutrophils had decreased interaction with monolayers expressing P-selectin compared to adult cells. In this study we examined the function of neonatal P-selectin glycoprotein ligand-1 (PSGL-1). A rabbit polyclonal antibody directed against the amino terminus of human PSGL-1 ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Tcharmtchi MH,Smith CW,Mariscalco MM

    更新日期:2000-01-01 00:00:00

  • Activation of macrophages by food antigens: enhancing effect of gluten on nitric oxide and cytokine production.

    abstract::Macrophages play an important role in effector mechanisms of various chronic inflammatory diseases. We studied the effect of gluten, the agent inducing celiac disease, and other food antigens on the activation of macrophages. Nitric oxide (NO) and cytokine production were followed as markers of activation, using cultu...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Tucková L,Flegelová Z,Tlaskalová-Hogenová H,Zídek Z

    更新日期:2000-03-01 00:00:00

  • Differential protein synthesis by murine peritoneal macrophages elicited by various stimuli.

    abstract::Protein synthetic patterns of murine peritoneal macrophages were analyzed by two-dimensional polyacrylamide gel electrophoresis (2D PAGE) of 35S methionine-labeled proteins. While the protein synthetic patterns exhibited by resident, inflammatory, and activated macrophages had numerous common features that distinguish...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Tannenbaum CS,Nurmi-McKernan L,Largen MT

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  • Improved host defense against septic peritonitis in mice lacking MyD88 and TRIF is linked to a normal interferon response.

    abstract::The signaling adapters MyD88 and TRIF are engaged by TLRs and/or receptors of the IL-1 family and are considered important for innate immune responses that combat bacterial infections. Here, the consequences of a combined MyD88 and TRIF deficiency for the innate immune response against severe septic peritonitis was ex...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Reim D,Rossmann-Bloeck T,Jusek G,Prazeres da Costa O,Holzmann B

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  • Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-α responses.

    abstract::TNF-α is a proinflammatory cytokine, dramatically elevated during pathogenic infection and often responsible for inflammation-induced disease pathology. SOCS proteins are inhibitors of cytokine signaling and regulators of inflammation. In this study, we found that both SOCS1 and SOCS3 were transiently induced by TNF-α...

    journal_title:Journal of leukocyte biology

    pub_type: 临床试验,杂志文章


    authors: Collins AS,Ahmed S,Napoletano S,Schroeder M,Johnston JA,Hegarty JE,O'Farrelly C,Stevenson NJ

    更新日期:2014-08-01 00:00:00

  • A new role for monoamine oxidases in the modulation of macrophage-inducible nitric oxide synthase gene expression.

    abstract::This report focuses on the modulatory role of endogenous H(2)O(2) on lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-induced inducible nitric oxide synthase (NOS2) gene expression in rat peritoneal macrophages. Exogenously added H(2)O(2) was initially found to inhibit the synthesis of NOS2, which prompted us to ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Vega A,Chacón P,Monteseirín J,El Bekay R,Alvarez M,Alba G,Conde J,Martín-Nieto J,Bedoya FJ,Pintado E,Sobrino F

    更新日期:2004-06-01 00:00:00

  • Myeloid-derived suppressor cells enhance IgE-mediated mast cell responses.

    abstract::Mast cells and MDSCs are increased by parasitic infection and tumor growth. We previously demonstrated that enhanced MDSC development in ADAM10 transgenic mice yielded resistance to Nb infection and that coculturing MDSCs and mast cells enhanced cytokine production. In the current work, we show that MDSC-mast cell coc...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Morales JK,Saleem SJ,Martin RK,Saunders BL,Barnstein BO,Faber TW,Pullen NA,Kolawole EM,Brooks KB,Norton SK,Sturgill J,Graham L,Bear HD,Urban JF Jr,Lantz CS,Conrad DH,Ryan JJ

    更新日期:2014-04-01 00:00:00

  • Histone H4 directly stimulates neutrophil activation through membrane permeabilization.

    abstract::Extracellular histones have been implicated as a cause of tissue inflammatory injury in a variety of disorders including sepsis, lung, and liver diseases. However, little is known about their interactions with neutrophils and how this might contribute to injury. Here, it is shown that histone H4 acts as neutrophil act...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Hsieh IN,Deluna X,White MR,Hartshorn KL

    更新日期:2020-08-17 00:00:00

  • poly(I:C) and LPS induce distinct IRF3 and NF-kappaB signaling during type-I IFN and TNF responses in human macrophages.

    abstract::Macrophages play major roles in the onset of immune responses and inflammation by inducing a variety of cytokines such as TNF and IFN-beta. The pathogen-associated molecular pattern, polyinosinic-polycytidylic acid [poly(I:C)], and LPS were used to study type-I IFN and TNF responses in human macrophages. Additionally,...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Reimer T,Brcic M,Schweizer M,Jungi TW

    更新日期:2008-05-01 00:00:00

  • The axonal repellent, Slit2, inhibits directional migration of circulating neutrophils.

    abstract::In inflammatory diseases, circulating neutrophils are recruited to sites of injury. Attractant signals are provided by many different chemotactic molecules, such that blockade of one may not prevent neutrophil recruitment effectively. The Slit family of secreted proteins and their transmembrane receptor, Robo, repel a...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Tole S,Mukovozov IM,Huang YW,Magalhaes MA,Yan M,Crow MR,Liu GY,Sun CX,Durocher Y,Glogauer M,Robinson LA

    更新日期:2009-12-01 00:00:00

  • LncRNA SNHG12 alleviates hypertensive vascular endothelial injury through miR-25-3p/SIRT6 pathway.

    abstract::The objective of this study was to find the role of LncRNA SNHG12 in the regulation of hypertensive vascular endothelial injury. LncRNA SNHG12 and miR-25-3p expression were detected by quantitative RT-PCR. Protein levels of Sirtuin 6 (SIRT6), endothelial cell (EC) senescence markers p16 and p21, and EC marker CD31 wer...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Qian W,Zheng ZQ,Nie JG,Liu LJ,Meng XZ,Sun H,Xiao FM,Kang T

    更新日期:2021-01-19 00:00:00

  • CD40 ligation and phagocytosis differently affect the differentiation of monocytes into dendritic cells.

    abstract::That monocytes can differentiate into macrophages or dendritic cells (DCs) makes them an essential link between innate and adaptive immunity. However, little is known about how interactions with pathogens or T cells influence monocyte engagement toward DCs. We approached this point in cultures where granulocyte macrop...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Rosenzwajg M,Jourquin F,Tailleux L,Gluckman JC

    更新日期:2002-12-01 00:00:00

  • Cytolytic cells induce HMGB1 release from melanoma cell lines.

    abstract::High mobility group box 1 (HMGB1) is one of the recently defined damage-associated molecular pattern molecules, passively released from necrotic cells and secreted by activated macrophage/monocytes. Whether cytolytic cells induce HMGB1 release from tumor cells is not known. We developed a highly sensitive method for d...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Ito N,DeMarco RA,Mailliard RB,Han J,Rabinowich H,Kalinski P,Stolz DB,Zeh HJ 3rd,Lotze MT

    更新日期:2007-01-01 00:00:00

  • Absence of the cystic fibrosis transmembrane regulator (Cftr) from myeloid-derived cells slows resolution of inflammation and infection.

    abstract::The absence or reduction of CFTR function causes CF and results in a pulmonary milieu characterized by bacterial colonization and unresolved inflammation. The ineffectiveness at controlling infection by species such as Pseudomonas aeruginosa suggests defects in innate immunity. Macrophages, neutrophils, and DCs have a...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Bonfield TL,Hodges CA,Cotton CU,Drumm ML

    更新日期:2012-11-01 00:00:00

  • Differential production of tumor necrosis factor, macrophage colony stimulating factor, and interleukin 1 by human alveolar macrophages.

    abstract::Human alveolar macrophages (AMO) have been investigated for their ability to produce three monokines, tumor necrosis factor-alpha (TNF), macrophage colony stimulating factor (CSF-1), and interleukin 1-beta (IL-1). No TNF activity was found in supernatants of unstimulated AMO cultured for 20 h, although TNF mRNA was de...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Becker S,Devlin RB,Haskill JS

    更新日期:1989-04-01 00:00:00

  • Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4.

    abstract::The production of IL-12 by macrophages/dendritic cells (Mphi/DC) is mediated either by a T cell-dependent pathway that is induced primarily by the interaction of CD40 ligand (CD40L) on activated T cells with CD40 on IL-12-producing cells or by a T cell-independent pathway that is induced by bacteria or bacterial produ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Takenaka H,Maruo S,Yamamoto N,Wysocka M,Ono S,Kobayashi M,Yagita H,Okumura K,Hamaoka T,Trinchieri G,Fujiwara H

    更新日期:1997-01-01 00:00:00

  • Macrophage function in murine allogeneic bone marrow radiation chimeras in the early phase after transplantation.

    abstract::We tested several of the functions of macrophages (M phi) in the early phase after allogeneic bone marrow transfer to get information about this important aspect of the nonspecific immune system in the T-cell-deficient recipient. On days 3-5 after transfer, the number of M phi was reduced in the spleen, liver, lungs, ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Roesler J,Baccarini M,Vogt B,Lohmann-Matthes ML

    更新日期:1989-08-01 00:00:00

  • Inhibition of 5-lipoxygenase-activating protein abrogates experimental liver injury: role of Kupffer cells.

    abstract::Activation of Kupffer cells is a prominent feature of necro-inflammatory liver injury. We have recently demonstrated that 5-lipoxygenase (5-LO) and its accessory protein, 5-LO-activating protein (FLAP), are essential for the survival of Kupffer cells in culture, as their inhibition drives these liver resident macropha...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章


    authors: Titos E,Clària J,Planagumà A,López-Parra M,González-Périz A,Gaya J,Miquel R,Arroyo V,Rodés J

    更新日期:2005-10-01 00:00:00