The role of the Src family kinase Lyn in the immunomodulatory activities of cathelicidin peptide LL-37 on monocytic cells.

abstract：:Human immunodeficiency virus infects different cell types including CD4+ lymphocytes and monocyte-derived macrophages (MDMs). We have examined the activity of the HIV-1 Tat inhibitors Ro-5-3335 and Ro-24-7429 in cultured human peripheral MDMs. Monocytes were isolated from HIV-seronegative donors by gradient centrifuga...

journal_title：Journal of leukocyte biology

authors： Dunne AL,Siregar H,Mills J,Crowe SM

更新日期：1994-09-01 00:00:00

abstract：:New tools are required to expedite the development of an effective vaccine against the blood-stage infection with the human malaria parasite Plasmodium falciparum. This work describes the assessment of the ADRB assay in a mouse model, characterizing the functional interaction between antimalarial serum antibodies and ...

journal_title：Journal of leukocyte biology

authors： Llewellyn D,de Cassan SC,Williams AR,Douglas AD,Forbes EK,Adame-Gallegos JR,Shi J,Pleass RJ,Draper SJ

更新日期：2014-02-01 00:00:00

abstract：:Patients with head and neck squamous cell carcinoma (HNSCC) have increased levels of immune-suppressive peripheral blood CD34+ cells. This study showed that the peripheral blood CD34+ cells of HNSCC patients are capable of differentiating into dendritic cells. Because CD34+ cells can differentiate through several path...

journal_title：Journal of leukocyte biology

authors： Lathers DM,Lubbers E,Wright MA,Young MR

更新日期：1999-05-01 00:00:00

abstract：:Murine peritoneal exudate cells (PEC) pre-exposed to bacterial lipopolysaccharide (LPS) show augmented nitric oxide (NO) production by LPS restimulation, in contrast to LPS tolerance with reduced production of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6). Significant amounts of interferon-gamma (IF...

journal_title：Journal of leukocyte biology

authors： Tominaga K,Saito S,Matsuura M,Funatogawa K,Matsumura H,Nakano M

更新日期：1999-12-01 00:00:00

abstract：:Human immunodeficiency virus type-1 (HIV-1)-associated dementia (HAD) is a neurodegenerative disease characterized by HIV infection and replication in brain tissue. HIV-1-infected monocytes overexpress inflammatory molecules that facilitate their entry into the brain. Prostanoids are lipid mediators of inflammation th...

journal_title：Journal of leukocyte biology

authors： Pereira CF,Boven LA,Middel J,Verhoef J,Nottet HS

更新日期：2000-09-01 00:00:00

abstract：:Glucocorticoids, such as dexamethasone (Dex), are used clinically in the treatment of various inflammatory diseases. Dex acts by inhibiting the expression of inflammatory mediators, such as tumor necrosis factor alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1). It is surprising that Dex enhances bacter...

journal_title：Journal of leukocyte biology

authors： Reddy KV,Bhattacharjee G,Schabbauer G,Hollis A,Kempf K,Tencati M,O'Connell M,Guha M,Mackman N

更新日期：2004-07-01 00:00:00

abstract：:An increase in intracellular calcium concentration is one of the major initial steps in B cell activation following antigen receptor (BCR) ligation. We show herein that in C57BL/6 murine B lymphocytes and in model cell lines, BCR-mediated calcium ion (Ca(2+)) influx occurs via highly selective Ca(2+) release-activated...

journal_title：Journal of leukocyte biology

authors： Lyubchenko T,Nielsen JP,Miller SM,Liubchenko GA,Holers VM

更新日期：2009-02-01 00:00:00

abstract：:Macrophages play an important role in effector mechanisms of various chronic inflammatory diseases. We studied the effect of gluten, the agent inducing celiac disease, and other food antigens on the activation of macrophages. Nitric oxide (NO) and cytokine production were followed as markers of activation, using cultu...

journal_title：Journal of leukocyte biology

authors： Tucková L,Flegelová Z,Tlaskalová-Hogenová H,Zídek Z

更新日期：2000-03-01 00:00:00

abstract：:In this study, we examined the expression of nerve growth factor (NGF) and its receptors in mouse macrophages and the mechanisms involved in the effect of NGF on tumor necrosis factor (TNF)-alpha production. Macrophages expressed NGF and the NGF receptors TrkA and p75. Treatment of J744 cells or peritoneal macrophages...

journal_title：Journal of leukocyte biology

authors： Barouch R,Kazimirsky G,Appel E,Brodie C

更新日期：2001-06-01 00:00:00

abstract：:ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation. However, in addition to vascular endothelial cells, ICAM-1 expression is also robustly induced on epithelial and immune cells in response to inflammatory sti...

journal_title：Journal of leukocyte biology

authors： Bui TM,Wiesolek HL,Sumagin R

更新日期：2020-09-01 00:00:00

abstract：:Neutrophil activation is a multistep process. In vitro activation of neutrophils with semiphysiological activators is optimal only after preactivation or priming with cytokines, chemotaxins, and/or bacterial products. Until now, no antibodies have been developed that can distinguish between resting and (cytokine) prim...

journal_title：Journal of leukocyte biology

authors： Koenderman L,Kanters D,Maesen B,Raaijmakers J,Lammers JW,de Kruif J,Logtenberg T

更新日期：2000-07-01 00:00:00

abstract：:The immunosuppressive activity of interleukin-10 (IL-10) makes this cytokine a potentially important clinical tool to reduce inflammatory responses in various diseases. Its efficacy as a therapeutic modality is dependent on the responsiveness of immune cells. We report that macrophages from mice chronically infected w...

journal_title：Journal of leukocyte biology

authors： Avdiushko R,Hongo D,Lake-Bullock H,Kaplan A,Cohen D

更新日期：2001-10-01 00:00:00

abstract：:Ly-49 receptors regulate mouse natural killer cell functions. Members of the polymorphic Ly-49 multigene family recognize specific alleles of major histocompatibility complex class I (MHC I) or MHC I-like proteins. Previous studies have provided insight into the nature of Ly-49A and -C interaction with their high-affi...

journal_title：Journal of leukocyte biology

authors： Osman MS,Silver ET,Varghese JC,Chang CS,Gong DE,Audette GF,Hazes B,Kane KP

更新日期：2005-05-01 00:00:00

abstract：:Investigators from two different laboratories have compared several variables in the short-term macrophage-mediated cytotoxicity assays used by each group to study the role of MuIFN-gamma in macrophage activation. The findings suggest that the capacity of MuIFN-gamma to activate macrophages without the need for a seco...

journal_title：Journal of leukocyte biology

authors： Pace JL,Varesio L,Russell SW,Blasi E

更新日期：1985-04-01 00:00:00

abstract：:PI(3)Kγ is thought to mediate leukocyte migration to injured tissues and may be important in the pathogenesis of various T-lymphocyte-dependent pathologies, including autoimmune and inflammatory diseases. The present study evaluated the relevance of PI(3)Kγ in donor cells for the pathogenesis of acute GVHD using a mod...

journal_title：Journal of leukocyte biology

authors： Castor MG,Rezende BM,Bernardes PT,Vieira AT,Vieira EL,Arantes RM,Souza DG,Silva TA,Teixeira MM,Pinho V

更新日期：2011-06-01 00:00:00

abstract：:Macrophages activated for tumor cell killing by bacterial lipopolysaccharide (LPS) were shown to lose their cytolytic activity if exposed to physiological levels of prostaglandin E2 (PGE2). Increasing the LPS stimulus more than 100-fold over the amount needed to activate the cells did not substantially increase their ...

journal_title：Journal of leukocyte biology

authors： Russell SW,Pace JL

更新日期：1984-03-01 00:00:00

abstract：:The aim of this study was to test the hypothesis whether MERTK, which is up-regulated in human DCs treated with immunosuppressive agents, is directly involved in modulating T cell activation. MERTK is a member of the TAM family and contributes to regulating innate immune response to ACs by inhibiting DC activation in ...

journal_title：Journal of leukocyte biology

authors： Cabezón R,Carrera-Silva EA,Flórez-Grau G,Errasti AE,Calderón-Gómez E,Lozano JJ,España C,Ricart E,Panés J,Rothlin CV,Benítez-Ribas D

更新日期：2015-04-01 00:00:00

abstract：:Autoreactive CD4+ and CD8+ T cells directed against CNS autoantigens may play a role in the development of multiple sclerosis (MS). Identical twins share the same genetic background but not the TCR repertoire that is shaped by the encounter with self or foreign antigens. To gain insights into the interplay between MS ...

journal_title：Journal of leukocyte biology

authors： Somma P,Ristori G,Battistini L,Cannoni S,Borsellino G,Diamantini A,Salvetti M,Sorrentino R,Fiorillo MT

更新日期：2007-03-01 00:00:00

abstract：:Tumor-associated eosinophilia has been observed in numerous human cancers and several tumor models in animals; however, the details surrounding this eosinophilia remain largely undefined and anecdotal. We used a B16-F10 melanoma cell injection model to demonstrate that eosinophil infiltration of tumors occurred from t...

journal_title：Journal of leukocyte biology

authors： Cormier SA,Taranova AG,Bedient C,Nguyen T,Protheroe C,Pero R,Dimina D,Ochkur SI,O'Neill K,Colbert D,Lombari TR,Constant S,McGarry MP,Lee JJ,Lee NA

更新日期：2006-06-01 00:00:00

abstract：:Aged and protein-malnourished hosts have diminished febrile responses and increased morbidity and mortality from infection that could be due to deficiencies in the production of certain monokines. In this study, the ability of peritoneal macrophages from aged and protein-malnourished rats to produce IL-1 and TNF was e...

journal_title：Journal of leukocyte biology

authors： Bradley SF,Vibhagool A,Kunkel SL,Kauffman CA

更新日期：1989-06-01 00:00:00

abstract：:The toxicity of guanosine and deoxyguanosine in the presence or absence of the purine nucleoside phosphorylase inhibitor, 8-aminoguanosine, for malignant lymphoid cell lines and mitogen-stimulated peripheral blood lymphocytes has been studied. Deoxyguanosine inhibited the proliferation of lymphoid cells more strongly ...

journal_title：Journal of leukocyte biology

authors： van der Kraan PM,van Zandvoort PM,De Abreu RA,Bakkeren JA

更新日期：1988-07-01 00:00:00

abstract：:Regulation of macrophage PCD plays an important role in pathogenesis of leishmaniasis. However, the precise involvement of any parasite molecule in this process remains uncertain. In the current study, in silico wide analysis demonstrated that genes in the Leishmania donovani genome are highly enriched for CpG motifs,...

journal_title：Journal of leukocyte biology

authors： Das S,Ghosh AK,Singh S,Saha B,Ganguly A,Das P

更新日期：2015-02-01 00:00:00

abstract：:Previous work has demonstrated that bleomycin can directly stimulate alveolar macrophage secretion of fibroblast growth factors and monocyte chemotactic factors. In this study, rat alveolar macrophages obtained by bronchoalveolar lavage were examined for the presence of bleomycin binding sites, which might mediate thi...

journal_title：Journal of leukocyte biology

authors： Denholm EM,Phan SH

更新日期：1990-12-01 00:00:00

abstract：:The effect of coupling C3bi to immunoglobulin G (IgG) immune complexes (IC) on their ability to produce protein tyrosine phosphorylation and activation of the mitogen-activated protein kinase (MAPK) and the Akt/protein kinase B (PKB) routes was assessed in human monocytes. Cross-linking Fc receptors for IgG activated ...

journal_title：Journal of leukocyte biology

authors： Trinidad AG,de la Puerta ML,Fernández N,Bayón Y,Crespo MS,Alonso A

更新日期：2006-05-01 00:00:00

abstract：:The oxidative metabolic burst of stimulated human polymorphonuclear leukocytes (PMNs) has been evaluated by the measurement of oxygen consumption, chemiluminescence, and oxygen radicals (O2-, H2O2, OH-) derived from activation of the hexose monophosphate shunt (HMPS). PMNs from patients with chronic granulomatous dise...

journal_title：Journal of leukocyte biology

authors： Hassan NF,Campbell DE,Douglas SD

更新日期：1988-04-01 00:00:00

abstract：:Soluble mediators and inducible cell-surface and matrix-bound molecules coordinate the cascade of events giving rise to leukocyte emigration. Knowledge of the specific mechanisms underlying the attraction of cells into a local site, however, remains sketchy. In particular, it is unclear how chemoattractants cause rapi...

journal_title：Journal of leukocyte biology

authors： Wiedermann CJ,Reinisch N,Bellmann R,Schratzberger P,Kowald E,Kähler CM

更新日期：1995-10-01 00:00:00

abstract：:The influence of ethanol (EtOH) on multiple dendritic cell (DC) subsets, in the steady state or following their mobilization in vivo, has not been characterized. Herein, generation of mouse bone marrow-derived DC (BMDC) in response to fms-like tyrosine kinase 3 ligand was inhibited by physiologically relevant concentr...

journal_title：Journal of leukocyte biology

authors： Lau AH,Abe M,Thomson AW

更新日期：2006-05-01 00:00:00

abstract：:A wealth of scientific and clinical evidence during the past few years has lent credence to the idea that key components of the host immune effector mechanisms can be targeted to boost current tuberculosis (TB) treatment and control patient relapse. These host-directed strategies not only accelerate the clearance of p...

journal_title：Journal of leukocyte biology

authors： Cheng CY,Böhme J,Singhal A

更新日期：2018-02-01 00:00:00

abstract：:Over 1.4 million Americans have been diagnosed with inflammatory bowel disease (IBD), and ulcerative colitis (UC) makes up approximately half of those diagnoses. As a disease, UC cycles between periods of remission and flare, which is characterized by intense abdominal pain, increased weight loss, intestinal inflammat...

journal_title：Journal of leukocyte biology

authors： Cannon AR,Kuprys PV,Cobb AN,Ding X,Kothari AN,Kuo PC,Eberhardt JM,Hammer AM,Morris NL,Li X,Choudhry MA

更新日期：2018-09-01 00:00:00

abstract：:When mouse peritoneal cells in early phase-inflammatory exudates were cultured in vitro, the number of polymorphonuclear leukocytes (PMNs) rapidly decreased, whereas the number of macrophages gradually increased during culture. Macrophage growth was also induced by addition of effete PMNs or their debris to macrophage...

journal_title：Journal of leukocyte biology

authors： Yui S,Yamazaki M

更新日期：1986-05-01 00:00:00