Monitoring of neutrophil priming in whole blood by antibodies isolated from a synthetic phage antibody library.

abstract：:Impairments in the respiratory burst and stimulus-response coupling were studied with respect to the increased rate of cell replication that occurred in HL60 cells during repetitive passages in cell culture. During a 45-week period of culture, HL60 cells developed a progressive increase in rate of replication. Concomi...

journal_title：Journal of leukocyte biology

authors： Hadjokas N,Bayer C,Nielson CP

更新日期：1992-08-01 00:00:00

abstract：:Adherence of monocytes to extracellular matrix components is critical for their accumulation at sites of infection. To gain insight into the factors that regulate monocyte recruitment, we have studied monocyte adherence with regard to the regulatory effects of bacterial lipopolysaccharide (LPS) and the mechanisms invo...

journal_title：Journal of leukocyte biology

authors： Owen CA,Campbell EJ,Stockley RA

更新日期：1992-04-01 00:00:00

abstract：:Genomic, transcriptomic and proteomic databases indicate that the N-terminal 322 residues encoded by the presumptive LOC100996504 gene, which is adjacent to the ARHGEF18 guanine nucleotide exchange factor gene on chromosome 19, constitute the N-terminal portion of a 1361-residue isoform of ARHGEF18, dubbed LOCGEF-X3. ...

journal_title：Journal of leukocyte biology

authors： Turton KB,Wilkerson EM,Hebert AS,Fogerty FJ,Schira HM,Botros FE,Coon JJ,Mosher DF

更新日期：2018-07-01 00:00:00

abstract：:TLRs mediate host defense against microbial pathogens by eliciting production of inflammatory mediators and activating expression of MHC, adhesion, and costimulatory molecules. Endotoxin tolerance limits excessive TLR-driven inflammation during sepsis and reprograms macrophage responses to LPS, decreasing expression o...

journal_title：Journal of leukocyte biology

authors： Xiong Y,Medvedev AE

更新日期：2011-12-01 00:00:00

abstract：:Toll-like receptor 2 (TLR2) and -4 mediate signals from a great variety of bacterial gut products, giving the host a panel of microbe-recognizing receptors. Under homeostatic conditions, TLRs act as protective receptors of the intestinal epithelium. When homeostasis is disrupted in diseases such as inflammatory bowel ...

journal_title：Journal of leukocyte biology

authors： Gomariz RP,Arranz A,Abad C,Torroba M,Martinez C,Rosignoli F,Garcia-Gómez M,Leceta J,Juarranz Y

更新日期：2005-08-01 00:00:00

abstract：:The role of JNK in neutrophil chemotaxis and killing of microbial pathogens remains unclear. Using a recently described cell-permeable peptide inhibitor of the JNK pathway, based on the JBD of JIP-1, coupled to the protein transduction domain of HIV-TAT (TAT-JIP), in association with control peptides, we demonstrate t...

journal_title：Journal of leukocyte biology

authors： Yeh MC,Mukaro V,Hii CS,Ferrante A

更新日期：2010-05-01 00:00:00

abstract：:Group B streptococcal (GBS) infections are associated with high morbidity and mortality. The molecular pathways mediating the pathophysiological events in GBS infection are not fully delineated. Cyclooxygenases (COX) are the enzymes that convert arachidonate to active eicosanoids. To identify the effects of GBS on eic...

journal_title：Journal of leukocyte biology

authors： Maloney CG,Thompson SD,Hill HR,Bohnsack JF,McIntyre TM,Zimmerman GA

更新日期：2000-05-01 00:00:00

abstract：:The human lysozyme (LZM) gene is highly methylated in LZM-nonexpressor immature myeloid and in nonmyeloid cells and unmethylated only in LZM-expressing cells. Extended methylation analyses of the CpG-poor 5' flanking region and of the exon 4 CpG island (both containing Alu elements) of the LZM gene were now performed....

journal_title：Journal of leukocyte biology

authors： Claus R,Fliegauf M,Stock M,Duque JA,Kolanczyk M,Lübbert M

更新日期：2006-12-01 00:00:00

abstract：:Binding of a potent chemotactic formyl tetrapeptide, formylmethionyl-leucyl-phenylalanyl-phenylalanine (fMet-Leu-Phe-Phe), to the formyl peptide receptors on the rabbit neutrophil was assessed by two approaches. A tritiated preparation of fMet-Leu-Phe-Phe was used for direct binding studies, whereas indirect studies c...

journal_title：Journal of leukocyte biology

authors： Kermode JC,Muthukumaraswamy N,Freer RJ

更新日期：1988-05-01 00:00:00

abstract：:Neutrophil accumulation and plasma leakage induced in rabbit skin by neutrophil-activating peptide-1 (NAP-1, a 72 amino acid peptide produced by monocytes and a variety of tissue cells), E. coli endotoxin, and interleukin-1 (IL-1) were compared. Neutrophil accumulation at sites injected with NAP-1 was intense, rapid, ...

journal_title：Journal of leukocyte biology

authors： Colditz IG,Zwahlen RD,Baggiolini M

更新日期：1990-08-01 00:00:00

abstract：:Human alveolar macrophages (AMO) have been investigated for their ability to produce three monokines, tumor necrosis factor-alpha (TNF), macrophage colony stimulating factor (CSF-1), and interleukin 1-beta (IL-1). No TNF activity was found in supernatants of unstimulated AMO cultured for 20 h, although TNF mRNA was de...

journal_title：Journal of leukocyte biology

authors： Becker S,Devlin RB,Haskill JS

更新日期：1989-04-01 00:00:00

abstract：:The airway epithelial cell of the lower respiratory tract is the primary host target cell for respiratory syncytial virus (RSV) infection. To estimate whether infected epithelial cells contribute to the inflammatory host response observed during the acute infection phase we analyzed the cell surface expression of inte...

journal_title：Journal of leukocyte biology

authors： Arnold R,Konig W

更新日期：1996-12-01 00:00:00

abstract：:Respiratory complications occur frequently in individuals living with human immunodeficiency-1 virus (HIV) infection, and there is evidence that HIV-related oxidative stress impairs alveolar macrophage immune function. We hypothesized that nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a master transcription fact...

journal_title：Journal of leukocyte biology

authors： Staitieh BS,Ding L,Neveu WA,Spearman P,Guidot DM,Fan X

更新日期：2017-08-01 00:00:00

abstract：:In this study, we tested the effect of neutralizing Abs to different serotypes of E1-deleted Ad vectors on the immunogenicity of the homologous Ad vector or a vector derived from a heterologous serotype. Our results showed that, as expected, even low titers of passively transferred neutralizing Abs significantly reduc...

journal_title：Journal of leukocyte biology

authors： Small JC,Haut LH,Bian A,Ertl HC

更新日期：2014-11-01 00:00:00

abstract：:To test whether reduced immune responsiveness in early life may be related to the immaturity of neonatal antigen-presenting cells, we comparatively assessed the phenotypic and functional characteristics of dendritic epidermal leukocytes (DEL) and epidermal Langerhans cells (LC) in newborn (NB) and adult mice, respecti...

journal_title：Journal of leukocyte biology

authors： Chang-Rodriguez S,Ecker R,Stingl G,Elbe-Bürger A

更新日期：2004-09-01 00:00:00

abstract：:We show that interleukin-18 is constitutively produced by dendritic cells; synthesis and secretion are poorly affected by maturative stimuli. Challenge of dendritic cells with autologous anti-tetanus toxoid T lymphocytes results in a secretory switch, with induction of secretion of biologically active interleukin-18 a...

journal_title：Journal of leukocyte biology

authors： Gardella S,Andrei C,Costigliolo S,Poggi A,Zocchi MR,Rubartelli A

更新日期：1999-08-01 00:00:00

abstract：:The agent(s) and mechanism(s) responsible for suppression of neutrophil chemotaxis in association with major thermal injury have not been identified. We have proposed that the reduced random motility characterizing patients' cells may contribute to their generalized chemotactic dysfunction. Here we report that actin p...

journal_title：Journal of leukocyte biology

authors： Hasslen SR,Ahrenholz DH,Solem LD,Nelson RD

更新日期：1992-11-01 00:00:00

abstract：:It has been reported recently that granulocyte-colony stimulating factor (G-CSF) is degraded upon exposure to human neutrophil elastase (HNE), and this has a negative effect on the ability of the cytokine to promote the in vitro proliferation and maturation of CD34+ cells. This has important implications on the possib...

journal_title：Journal of leukocyte biology

authors： Carter CR,Whitmore KM,Thorpe R

更新日期：2004-03-01 00:00:00

abstract：:In this study, we examined the expression of nerve growth factor (NGF) and its receptors in mouse macrophages and the mechanisms involved in the effect of NGF on tumor necrosis factor (TNF)-alpha production. Macrophages expressed NGF and the NGF receptors TrkA and p75. Treatment of J744 cells or peritoneal macrophages...

journal_title：Journal of leukocyte biology

authors： Barouch R,Kazimirsky G,Appel E,Brodie C

更新日期：2001-06-01 00:00:00

abstract：:The key role of TRAF6 in TLR signaling pathways is well known. More recent evidence has implicated TRAF3 as another TRAF family member important to certain TLR responses of myeloid cells. Previous studies demonstrate that TRAF3 functions are highly context-dependent, displaying receptor and cell-type specificity. We t...

journal_title：Journal of leukocyte biology

authors： Xie P,Poovassery J,Stunz LL,Smith SM,Schultz ML,Carlin LE,Bishop GA

更新日期：2011-12-01 00:00:00

abstract：:Secreted IgM (sIgM) is a multifunctional evolutionary conserved antibody that is critical for the maintenance of tissue homeostasis as well as the development of fully protective humoral responses to pathogens. Constitutive secretion of self- and polyreactive natural IgM, produced mainly by B-1 cells, provides a circu...

journal_title：Journal of leukocyte biology

authors： Blandino R,Baumgarth N

更新日期：2019-11-01 00:00:00

abstract：:During the neoplastic progression, macrophages as well as dendritic and NK cells are attracted into the tumor site and initiate the immune response against transformed cells. They activate and present tumor antigens to T cells, which are then activated to kill tumor cells. However, tumor cells are often capable of esc...

journal_title：Journal of leukocyte biology

authors： Lamagna C,Aurrand-Lions M,Imhof BA

更新日期：2006-10-01 00:00:00

abstract：:Blood leukocyte count alterations induced by PAF-acether in anesthetized and nonanesthetized rats were investigated. Intravenous injection of increasing amounts of PAF-acether (1.5-8 micrograms/kg) in nonanesthetized animals induced dose-dependent hemoconcentration and leukocytosis. The former was apparent within 10 m...

journal_title：Journal of leukocyte biology

authors： Bozza PT,Silva PM,Castro-Faria-Neto HC,Martins MA,Cordeiro RS

更新日期：1992-02-01 00:00:00

abstract：:Blocking monoclonal antibodies (mAbs) specific to mouse interleukin-1 receptor antagonist (IL-1ra) were prepared by immunizing Armenian hamsters with recombinant mouse IL-1ra. A sensitive and specific ELISA against mouse IL-1ra was also established. In Propionibacterium acnes-induced liver injury, P. acnes induced tra...

journal_title：Journal of leukocyte biology

authors： Fujioka N,Mukaida N,Harada A,Akiyama M,Kasahara T,Kuno K,Ooi A,Mai M,Matsushima K

更新日期：1995-07-01 00:00:00

abstract：:Treatment of mice with a monoclonal antibody (mAb) designated NIMP-R10, directed against the CD11b polypeptide of the CD18/CD11b heterodimeric type 3 complement receptor (CR3), exacerbates listeriosis by preventing myelomonocytic cells from focusing at sites of infected hepatocytes in the liver. Under these conditions...

journal_title：Journal of leukocyte biology

authors： Conlan JW,North RJ

更新日期：1992-07-01 00:00:00

abstract：:The role of NOD2 and RIP2 in inflammatory disease has been paradoxical. Whereas loss-of-function NOD2 polymorphisms cause CD, a granulomatous disease of the gastrointestinal tract, gain-of-function mutations cause EOS-a granulomatous disease primarily affecting the skin, joints, and eyes. Thus, gain-of-function mutati...

journal_title：Journal of leukocyte biology

authors： Jun JC,Cominelli F,Abbott DW

更新日期：2013-11-01 00:00:00

abstract：:The mannose receptor is a macrophage surface receptor that mediates both endocytosis and phagocytosis. Previous work has demonstrated that the prototypical Th 2 cytokine, interleukin-4 (IL-4), increases both cell-surface receptor expression and mannose receptor-mediated endocytosis, whereas the prototypical Th 1 cytok...

journal_title：Journal of leukocyte biology

authors： Raveh D,Kruskal BA,Farland J,Ezekowitz RAB

更新日期：1998-07-01 00:00:00

abstract：:Polyclonal B cell activation is not a peculiar characteristic to a particular infection, as many viruses, bacteria, and parasites induce a strong polyclonal B cell response resulting in hyper-gamma-globulinemia. Here, we discuss the different roles proposed for polyclonal B cell activation, which can be crucial for ea...

journal_title：Journal of leukocyte biology

authors： Montes CL,Acosta-Rodríguez EV,Merino MC,Bermejo DA,Gruppi A

更新日期：2007-11-01 00:00:00

abstract：:Virulent Legionella pneumophila replicate readily in thioglycollate-elicited peritoneal macrophages from genetically permissive A/J mice, but avirulent L. pneumophila do not. The production of cytokines by macrophages infected with L. pneumophila has been studied, but the correlation of bacterial virulence with immune...

journal_title：Journal of leukocyte biology

authors： McHugh SL,Yamamoto Y,Klein TW,Friedman H

更新日期：2000-06-01 00:00:00

abstract：:ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation. However, in addition to vascular endothelial cells, ICAM-1 expression is also robustly induced on epithelial and immune cells in response to inflammatory sti...

journal_title：Journal of leukocyte biology

authors： Bui TM,Wiesolek HL,Sumagin R

更新日期：2020-09-01 00:00:00