Abstract:
:During the neoplastic progression, macrophages as well as dendritic and NK cells are attracted into the tumor site and initiate the immune response against transformed cells. They activate and present tumor antigens to T cells, which are then activated to kill tumor cells. However, tumor cells are often capable of escaping the immune machinery. As the immune surveillance is not sufficient anymore, tumor-associated macrophages contribute to tumor progression. It is notable that tumor-associated macrophages promote the proliferation of tumor cells directly by secreting growth factors. They also participate in tumor progression by acting on endothelial cells and thus promoting the neovascularization of the tumor. Tumor-associated macrophages are indeed key protagonists during angiogenesis and promote each step of the angiogenesis cascade.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Lamagna C,Aurrand-Lions M,Imhof BAdoi
10.1189/jlb.1105656subject
Has Abstractpub_date
2006-10-01 00:00:00pages
705-13issue
4eissn
0741-5400issn
1938-3673pii
jlb.1105656journal_volume
80pub_type
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