The effect of adenovirus-specific antibodies on adenoviral vector-induced, transgene product-specific T cell responses.

Abstract:

:In this study, we tested the effect of neutralizing Abs to different serotypes of E1-deleted Ad vectors on the immunogenicity of the homologous Ad vector or a vector derived from a heterologous serotype. Our results showed that, as expected, even low titers of passively transferred neutralizing Abs significantly reduced the homologous vectors' ability to elicit transgene-specific CD8(+) T cell responses. In addition, Abs changed the fate of transgene product-specific CD8(+) T cells by promoting their transition into the central memory cell pool, which resulted in markedly enhanced expansion of transgene product-specific CD8(+) T cells after a boost with a heterologous Ad vector. Non-neutralizing Abs specific to a distinct Ad serotype had no effect on the magnitude of transgene product-specific CD8(+) T cells induced by a heterologous Ad vector, nor did such Abs promote induction of more resting memory CD8(+) T cells. These results show that Abs to an Ad vaccine carrier affect not only the magnitude but also the profile of a vector-induced CD8(+) T cell response.

journal_name

J Leukoc Biol

authors

Small JC,Haut LH,Bian A,Ertl HC

doi

10.1189/jlb.1A0813-451RR

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

821-31

issue

5

eissn

0741-5400

issn

1938-3673

pii

jlb.1A0813-451RR

journal_volume

96

pub_type

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