Abstract:
:The toxicity of guanosine and deoxyguanosine in the presence or absence of the purine nucleoside phosphorylase inhibitor, 8-aminoguanosine, for malignant lymphoid cell lines and mitogen-stimulated peripheral blood lymphocytes has been studied. Deoxyguanosine inhibited the proliferation of lymphoid cells more strongly than guanosine. Addition of 100 microM 8-aminoguanosine neither enhanced nor diminished the toxicity of guanosine to the lymphoid cells. Only the toxicity of deoxyguanosine for the leukemic T cell line, MOLT 4, and the leukemic nonBnonT cell line, KM-3, was enhanced by the addition of 100 microM 8-aminoguanosine. These data suggest a possible role of purine nucleoside phosphorylase inhibitors in the treatment of lymphoproliferative disorders of the T-acute lymphoblastic leukemia (ALL) as well as the nonBnonT-ALL subclass.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
van der Kraan PM,van Zandvoort PM,De Abreu RA,Bakkeren JAdoi
10.1002/jlb.44.1.46subject
Has Abstractpub_date
1988-07-01 00:00:00pages
46-50issue
1eissn
0741-5400issn
1938-3673journal_volume
44pub_type
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