Role of IFN-gamma on dissociation between nitric oxide and TNF/IL-6 production by murine peritoneal cells after restimulation with bacterial lipopolysaccharide.

abstract：:Neutrophils kill invading pathogens by AMPs, including cathelicidins, ROS, and NETs. The human pathogen Staphylococcus aureus exhibits enhanced resistance to neutrophil AMPs, including the murine cathelicidin CRAMP, in part, as a result of alanylation of teichoic acids by the dlt operon. In this study, we took advanta...

journal_title：Journal of leukocyte biology

authors： Jann NJ,Schmaler M,Kristian SA,Radek KA,Gallo RL,Nizet V,Peschel A,Landmann R

更新日期：2009-11-01 00:00:00

abstract：:The Charcot-Leyden crystal (CLC) protein, a prominent cell constituent unique to eosinophils and basophils, possesses lysophospholipase activity. This activity and the extracellular deposition and formation of CLC in tissues and body fluids in association with eosinophils suggest an extracellular function for this pro...

journal_title：Journal of leukocyte biology

authors： Golightly LM,Thomas LL,Dvorak AM,Ackerman SJ

更新日期：1992-04-01 00:00:00

abstract：:In newborn infants, the innate cellular system plays a crucial role in the first line of defense against pathogens. Neutrophils are the most abundant leukocytes, and their response to the commonly encountered nosocomial bacterial (Gram positive) infection in newborns remains largely unclear. In this study, a genome-wi...

journal_title：Journal of leukocyte biology

authors： Fong ON,Chan KY,Leung KT,Lam HS,Cheung HM,Leung TY,Li K,Ng PC

更新日期：2014-01-01 00:00:00

abstract：:Aged and protein-malnourished hosts have diminished febrile responses and increased morbidity and mortality from infection that could be due to deficiencies in the production of certain monokines. In this study, the ability of peritoneal macrophages from aged and protein-malnourished rats to produce IL-1 and TNF was e...

journal_title：Journal of leukocyte biology

authors： Bradley SF,Vibhagool A,Kunkel SL,Kauffman CA

更新日期：1989-06-01 00:00:00

abstract：:Upon exposure to immune or inflammatory stimuli, dendritic cells (DC) migrate from peripheral tissues to lymphoid organs, where they present antigen. The molecular basis for the peculiar trafficking properties of DC is largely unknown. In this study, mouse DC were generated from CD34+ bone marrow precursors and cultur...

journal_title：Journal of leukocyte biology

authors： Vecchi A,Massimiliano L,Ramponi S,Luini W,Bernasconi S,Bonecchi R,Allavena P,Parmentier M,Mantovani A,Sozzani S

更新日期：1999-09-01 00:00:00

abstract：:Respiratory complications occur frequently in individuals living with human immunodeficiency-1 virus (HIV) infection, and there is evidence that HIV-related oxidative stress impairs alveolar macrophage immune function. We hypothesized that nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a master transcription fact...

journal_title：Journal of leukocyte biology

authors： Staitieh BS,Ding L,Neveu WA,Spearman P,Guidot DM,Fan X

更新日期：2017-08-01 00:00:00

abstract：:The pathogenesis of CRC remains to be further understood. This study was designed to elucidate the role of Foxp3+IL-17+ T cells in the pathogenesis of CRC. Surgically removed CRC tissue was collected from 12 patients with CRC. The frequency and cytokine profile of Foxp3+IL-17+ T cells in CRC were examined by flow cyto...

journal_title：Journal of leukocyte biology

authors： Yang S,Wang B,Guan C,Wu B,Cai C,Wang M,Zhang B,Liu T,Yang P

更新日期：2011-01-01 00:00:00

abstract：:Dendritic cell (DC) and DC-derived exosomes (EXO) have been used extensively for tumor vaccination. However, its therapeutic efficiency is limited to only production of prophylactic immunity against tumors. T cells can uptake DC-released EXO. However, the functional effect of transferred exosomal molecules on T cells ...

journal_title：Journal of leukocyte biology

authors： Hao S,Yuan J,Xiang J

更新日期：2007-10-01 00:00:00

abstract：:THP-1-derived cell lines were stably transfected with constructs encoding glycophosphatidylinositol (GPI)-anchored or transmembrane forms of human CD14. CD14 expression was associated with enhanced phagocytosis of serum (heat-inactivated)-opsonized Escherichia coli (opEc). Both the GPI-anchored and transmembrane forms...

journal_title：Journal of leukocyte biology

authors： Schiff DE,Kline L,Soldau K,Lee JD,Pugin J,Tobias PS,Ulevitch RJ

更新日期：1997-12-01 00:00:00

abstract：:A lethal human septic shock model, mouse generalized Shwartzman reaction (GSR), was elicited by two consecutive lippolysaccharide (LPS) injections (24 h apart) in which interferon-gamma (IFN-gamma) induced by interleukin (IL)-12 played a critical role in the priming phase, and tumor necrosis factor (TNF) was an import...

journal_title：Journal of leukocyte biology

authors： Motegi A,Kinoshita M,Sato K,Shinomiya N,Ono S,Nonoyama S,Hiraide H,Seki S

更新日期：2006-03-01 00:00:00

abstract：:The localization of the adhesion protein L-selectin in human neutrophils was determined by subcellular fractionation and immunoelectron microscopy and compared with the localization of Mac-1 (alpha m beta 2) and alkaline phosphatase, the marker for secretory vesicles. L-selectin was found to be localized exclusively o...

journal_title：Journal of leukocyte biology

authors： Borregaard N,Kjeldsen L,Sengeløv H,Diamond MS,Springer TA,Anderson HC,Kishimoto TK,Bainton DF

更新日期：1994-07-01 00:00:00

abstract：:Extracellular ATP mediates a diverse array of biological responses in many cell types and tissues, including immune cells. We have demonstrated that ATP induces purinergic receptor P2X(7) mediated membrane permeabilization, apoptosis, and cytokine expression in murine mast cells (MCs). Here, we report that MCs deficie...

journal_title：Journal of leukocyte biology

authors： Bulanova E,Budagian V,Orinska Z,Koch-Nolte F,Haag F,Bulfone-Paus S

更新日期：2009-04-01 00:00:00

abstract：:Cellular lysates from PPD+ donors have been reported to transfer tuberculin reactivity to naïve recipients, but not diphtheria reactivity, and vice versa. A historically controversial topic, the terms "transfer factor" and "DLE" were used to characterize the reactivity-transferring properties of lysates. Intrigued by ...

journal_title：Journal of leukocyte biology

authors： Myles IA,Zhao M,Nardone G,Olano LR,Reckhow JD,Saleem D,Break TJ,Lionakis MS,Myers TG,Gardina PJ,Kirkpatrick CH,Holland SM,Datta SK

更新日期：2017-01-01 00:00:00

abstract：:The ability of neutrophils to sense and migrate toward damaged tissue is a vital component of the innate immune response. Paradoxically, this same migration serves as the hallmark of a number of inflammatory conditions, including ischemic reperfusion injury, atherosclerosis, arthritis, and Crohn's disease. More recent...

journal_title：Journal of leukocyte biology

authors： Maher BM,Dhonnchu TN,Burke JP,Soo A,Wood AE,Watson RW

更新日期：2009-01-01 00:00:00

abstract：:The basal presence of immunologically potent cells within the intestinal muscularis externa and their functional significance is unclear. Our aim was to investigate the basal distribution of various leukocyte populations within the rat jejunal muscularis. In addition, we sought to immunohistochemically phenotype the m...

journal_title：Journal of leukocyte biology

authors： Kalff JC,Schwarz NT,Walgenbach KJ,Schraut WH,Bauer AJ

更新日期：1998-06-01 00:00:00

abstract：:Transferrin receptor (TfR) expression is up-regulated during T cell activation after the interaction of the T cell receptor with the antigen-major histocompatibility complex and the expression of interleukin-2 (IL-2) receptor. We hypothesize that anti-TfR monoclonal antibody (mAb) will prolong allograft survival by al...

journal_title：Journal of leukocyte biology

authors： Bayer AL,Baliga P,Woodward JE

更新日期：1998-07-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains the leading global cause of death from an infectious agent. Mycobacteria thrive within their host Mϕs and presently, there is no animal model that permits combined in vitro and in vivo study of mycobacteria-host Mϕ interactions. Mycoba...

journal_title：Journal of leukocyte biology

authors： Popovic M,Yaparla A,Paquin-Proulx D,Koubourli DV,Webb R,Firmani M,Grayfer L

更新日期：2019-12-01 00:00:00

abstract：:Although endosomes, lysosomes, and phagosomes require a reductive environment for the optimal activity of disulfide reductases and other thiol-dependent enzymes, how these reductive environments are established and maintained remain unknown. Our goal in this study was to begin to elucidate the redox control systems re...

journal_title：Journal of leukocyte biology

authors： Balce DR,Greene CJ,Tailor P,Yates RM

更新日期：2016-07-01 00:00:00

abstract：:Osteopontin is an RGD-containing bone matrix protein with cytokine-like functions that is associated with early stages of Th1-mediated diseases. Although the function of osteopontin in these responses is unknown, it is expressed by activated T cells and macrophages and can costimulate T cell proliferation. Studies hav...

journal_title：Journal of leukocyte biology

authors： O'Regan AW,Hayden JM,Berman JS

更新日期：2000-10-01 00:00:00

abstract：:Leukocytes are a central cellular element of innate-immune defense in mammals. In addition to the generation of toxic oxygen radicals and nitric oxide, leukocytes express and secrete a broad array of antimicrobial proteins and peptides. In the study, an antimicrobial polypeptide was isolated and purified from human pe...

journal_title：Journal of leukocyte biology

authors： Feng Y,Huang N,Wu Q,Wang B

更新日期：2005-11-01 00:00:00

abstract：:Human rhinovirus (HRV)-induced respiratory infections are associated with elevated levels of IFN-gamma-inducible protein 10 (IP-10), which is an enhancer of T lymphocyte chemotaxis and correlates with symptom severity and T lymphocyte number. Increased IP-10 expression is exhibited by airway epithelial cells following...

journal_title：Journal of leukocyte biology

authors： Korpi-Steiner NL,Bates ME,Lee WM,Hall DJ,Bertics PJ

更新日期：2006-12-01 00:00:00

abstract：:C-reactive protein (CRP) is a prototypical acute-phase reactant, the humoral and plasma concentrations of which rise dramatically after tissue injury or inflammation. The effects of CRP on superoxide production and intracellular calcium mobilization by guinea pig alveolar macrophages challenged with platelet-activatin...

journal_title：Journal of leukocyte biology

authors： Földes-Filep E,Filep JG,Sirois P

更新日期：1992-01-01 00:00:00

abstract：:HIV is known to subvert cellular machinery to enhance its replication. Recently, HIV has been reported to enhance TC renin expression. We hypothesized that HIV induces and maintains high renin expression to promote its own replication in TCs. Renin enhanced HIV replication in TCs in a dose-dependent manner. (P)RR-defi...

journal_title：Journal of leukocyte biology

authors： Chandel N,Ayasolla K,Lan X,Rai P,Mikulak J,Husain M,Malhotra A,McGowan J,Singhal PC

更新日期：2014-10-01 00:00:00

abstract：:Secreted IgM (sIgM) is a multifunctional evolutionary conserved antibody that is critical for the maintenance of tissue homeostasis as well as the development of fully protective humoral responses to pathogens. Constitutive secretion of self- and polyreactive natural IgM, produced mainly by B-1 cells, provides a circu...

journal_title：Journal of leukocyte biology

authors： Blandino R,Baumgarth N

更新日期：2019-11-01 00:00:00

abstract：:CD4+CD25+ regulatory T cells play an important role in peripheral tolerance. Upon T cell receptor (TCR)-mediated activation, the cells fail to proliferate but are induced to have a suppressor function. The intracellular signaling events that lead to their responses have not been elucidated. In this study, we have exam...

journal_title：Journal of leukocyte biology

authors： Tsang JY,Camara NO,Eren E,Schneider H,Rudd C,Lombardi G,Lechler R

更新日期：2006-07-01 00:00:00

abstract：:HIV infection results in depletion and dysfunction of naïve CD4(+) T cells. The mechanisms underlying these deficiencies are not understood. We investigated the frequencies of CD4(+) naïve subsets in HIV disease as defined by expression of CD25 and/or FoxP3 and the relationship of these frequencies to naïve T cell pro...

journal_title：Journal of leukocyte biology

authors： Rodriguez B,Bazdar DA,Funderburg N,Asaad R,Luciano AA,Yadavalli G,Kalayjian RC,Lederman MM,Sieg SF

更新日期：2011-09-01 00:00:00

abstract：:Mer signaling participates in a novel inhibitory pathway in TLR activation. The purpose of the present study was to examine the role of Mer signaling in the down-regulation of TLR4 activation-driven immune responses in mice, i.t.-treated with LPS, using the specific Mer-blocking antibody. At 4 h and 24 h after LPS tre...

journal_title：Journal of leukocyte biology

authors： Lee YJ,Han JY,Byun J,Park HJ,Park EM,Chong YH,Cho MS,Kang JL

更新日期：2012-06-01 00:00:00

abstract：:Cationic antimicrobial protein of M(r) 37 kDa (CAP37) is a multifunctional protein isolated from the granules of human neutrophils, which has important implications in host defense and inflammation. CAP37 was initially recognized for its strong antibiotic activity against Gram-negative bacteria and was viewed as a com...

journal_title：Journal of leukocyte biology

authors： Pereira HA

更新日期：1995-06-01 00:00:00

abstract：:We investigated the ability of the sPLA(2), known as MT-III, isolated from the viperid snake Bothrops asper, to induce LB formation in macrophages and the major cellular signaling pathways involved in this process. The effects of MT-III on ADRP localization and expression and macrophage ultrastructure were assessed. O...

journal_title：Journal of leukocyte biology

authors： Leiguez E,Zuliani JP,Cianciarullo AM,Fernandes CM,Gutiérrez JM,Teixeira C

更新日期：2011-07-01 00:00:00

abstract：:In RAW 264.7 cells, PKC-ε regulates FcγR-mediated phagocytosis. BMDM behave similarly; PKC-ε concentrates at phagosomes and internalization are reduced in PKC-ε⁻/⁻ cells. Two questions were asked: what is the role of PKC-ε? and what domains are necessary for PKC-ε concentration? Function was studied using BMDM and fru...

journal_title：Journal of leukocyte biology

authors： Wood TR,Chow RY,Hanes CM,Zhang X,Kashiwagi K,Shirai Y,Trebak M,Loegering DJ,Saito N,Lennartz MR

更新日期：2013-07-01 00:00:00