Leukocytes of the intestinal muscularis: their phenotype and isolation.

abstract：:CD137, a member of the TNF receptor family, and its ligand are expressed on T lymphocytes and antigen-presenting cells (APC), respectively. During interaction with APC, T lymphocytes receive a potent, costimulatory signal through CD137. Reverse signaling has been demonstrated for the CD137 ligand, which causes activat...

journal_title：Journal of leukocyte biology

authors： Pauly S,Broll K,Wittmann M,Giegerich G,Schwarz H

更新日期：2002-07-01 00:00:00

abstract：:We have shown that losartan, a selective inhibitor of AT1 receptors for angiotensin II (AII), inhibits the binding of [3H]fMLP to neutrophil receptors (FPR). Here, we analyze, in Wistar rats, the effect of losartan on neutrophil recruitment in the lung triggered by fMLP. We found that i.v. infusion of losartan (0.4-20...

journal_title：Journal of leukocyte biology

authors： Raiden S,Pereyra Y,Nahmod V,Alvarez C,Castello L,Giordano M,Geffner J

更新日期：2000-11-01 00:00:00

abstract：:Mast cell activation requires Cl(-) flux, which maintains the driving force for entry of extracellular calcium and initiates release of mediators such as histamine. However, chloride channel expression in mast cells has been poorly understood. For the first time, reverse transcriptase-polymerase chain reaction shows t...

journal_title：Journal of leukocyte biology

authors： Kulka M,Gilchrist M,Duszyk M,Befus AD

更新日期：2002-01-01 00:00:00

abstract：:Although mouse models of inflammatory skin diseases such as psoriasis and atopic dermatitis fail to completely phenocopy disease in humans, they provide invaluable tools to examine the molecular and cellular mechanisms responsible for the epidermal hyperplasia, inflammation, and excess angiogenesis observed in human d...

journal_title：Journal of leukocyte biology

authors： Voskas D,Babichev Y,Ling LS,Alami J,Shaked Y,Kerbel RS,Ciruna B,Dumont DJ

更新日期：2008-07-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) has been shown to induce the production of interstitial collagenase by fibroblasts and chondrocytes. We investigated the role of TNF-alpha in collagenase gene expression by U937 monocyte/macrophage cells. Transcription of the TNF-alpha gene was observed after 0.5 h of phorbol my...

journal_title：Journal of leukocyte biology

authors： Callaghan MM,Lovis RM,Rammohan C,Lu Y,Pope RM

更新日期：1996-01-01 00:00:00

abstract：:There are conflicting data on the effect of bacterial lipopolysaccharides (LPS) on the function of human neutrophils. The present study was designed to examine the relationship between chemical composition and the modulatory effect of LPS on human neutrophil function. LPS was extracted from five strains of Pseudomonas...

journal_title：Journal of leukocyte biology

authors： Kharazmi A,Fomsgaard A,Conrad RS,Galanos C,Høiby N

更新日期：1991-01-01 00:00:00

abstract：:Clostridioides difficile (C. difficile) is the major cause of hospital-acquired gastrointestinal infections in individuals following antibiotics treatment. The pathogenesis of C. difficile infection (CDI) is mediated mainly by the production of toxins that induce tissue damage and host inflammatory responses. While in...

journal_title：Journal of leukocyte biology

authors： Hernández Del Pino RE,Barbero AM,Español LÁ,Morro LS,Pasquinelli V

更新日期：2020-08-23 00:00:00

abstract：:During inflammatory and immunological responses, leukocytes respond to external stimuli by altering the stability of cytokine and cytokine receptor messages. Change in message stability is an effective mechanism for rapidly regulating steady state levels of mRNA. Cytokine messages containing A-U-rich elements located ...

journal_title：Journal of leukocyte biology

authors： Xu L,Rahimpour R,Ran L,Kong C,Biragyn A,Andrews J,Devries M,Wang JM,Kelvin DJ

更新日期：1997-11-01 00:00:00

abstract：:CD137 ligand (CD137L) is expressed on APCs and crosslinks CD137, a powerful costimulatory molecule on T cells during cognate interactions, and thereby greatly enhances immune responses. We report that CD137 can be transferred from activated T cells and from tumor cells that express CD137 to other cells via trogocytosi...

journal_title：Journal of leukocyte biology

authors： Shao Z,Harfuddin Z,Pang WL,Nickles E,Koh LK,Schwarz H

更新日期：2015-05-01 00:00:00

abstract：:The immune system is armed with a broad range of receptors to detect and initiate the elimination of bacterial pathogens. Inflammasomes are molecular platforms that sense a diverse range of microbial insults to develop appropriate host response. In that context, noncanonical inflammasome arose as a sensor for Gram-neg...

journal_title：Journal of leukocyte biology

authors： Gomes MTR,Cerqueira DM,Guimarães ES,Campos PC,Oliveira SC

更新日期：2019-09-01 00:00:00

abstract：:To assess the effect of hypoxemia on the responses of polymorphonuclear neutrophils (PMN) during an inflammatory response, rats were maintained in a low F1O2 atmosphere (9% O2) or room air for 12 h before intrathoracic injection of carrageenin or intradermal injections of agonists. After 4 h, hypoxemic rats had 50% mo...

journal_title：Journal of leukocyte biology

authors： Tremblay PB,Macari DM,Martel D,du Souich P,Barja-Fidalgo C,Marleau S

更新日期：2000-06-01 00:00:00

abstract：:SIRS is associated with lymphopenia, and prolonged lymphopenia of septic patients has been associated with increased mortality risk. We hypothesize that elevated adenosine during SIRS down-regulates Gi-coupled A1R, which signals an effect that sensitizes a cAMP-dependent lymphotoxic response. In this study, we evaluat...

journal_title：Journal of leukocyte biology

authors： Riff R,Cohen Y,Eini-Rider H,Naamani O,Mazar J,Haviv YS,Chaimovitz C,Douvdevani A

更新日期：2017-07-01 00:00:00

abstract：:The Fanconi anemia proteins participate in a canonical pathway that repairs cross-linking agent-induced DNA damage. Cells with inactivated Fanconi anemia genes are universally hypersensitive to such agents. Fanconi anemia-deficient hematopoietic stem cells are also hypersensitive to inflammatory cytokines, and, as imp...

journal_title：Journal of leukocyte biology

authors： Garbati MR,Hays LE,Rathbun RK,Jillette N,Chin K,Al-Dhalimy M,Agarwal A,Newell AE,Olson SB,Bagby GC Jr

更新日期：2016-03-01 00:00:00

abstract：:Intact cellular migration is critically important for the induction and regulation of the immune response. The Wiskott-Aldrich syndrome protein (WASP) regulates surface receptor signaling to the actin cytoskeleton in hematopoietic cells and thus plays a pivotal role in cellular locomotion. WASP deficiency causes the W...

journal_title：Journal of leukocyte biology

authors： Snapper SB,Meelu P,Nguyen D,Stockton BM,Bozza P,Alt FW,Rosen FS,von Andrian UH,Klein C

更新日期：2005-06-01 00:00:00

abstract：:IL-1 receptor-associated kinase (IRAK) 4 is a central enzyme of the TLR pathways. This study tested the hypothesis that IRAK4 kinase activity is prerequisite for regulating innate immunity during infections with intracellular bacteria. To this end, we analyzed responses of macrophages obtained from mice expressing wil...

journal_title：Journal of leukocyte biology

authors： Pattabiraman G,Murphy M,Agliano F,Karlinsey K,Medvedev AE

更新日期：2018-10-01 00:00:00

abstract：:Discussion on the impact of blood leukocytes accumulating at the borders of the central nervous system on the development of neuropathic pain. ...

journal_title：Journal of leukocyte biology

authors： Pinho-Ribeiro FA

更新日期：2019-09-01 00:00:00

abstract：:In this study, we analyzed the specific effects of transforming growth factor beta (TGF-beta1) and/or IL-4 on monocyte-derived cells. Monocytes were cultured with GM-CSF, GM-CSF/TGF-beta1, GM-CSF/IL-4, or GM-CSF/IL-4/TGF-beta1 before cell morphology, phenotype, and function were assessed. As expected, interleukin-4 is...

journal_title：Journal of leukocyte biology

authors： Guironnet G,Dezutter-Dambuyant C,Vincent C,Bechetoille N,Schmitt D,Péguet-Navarro J

更新日期：2002-05-01 00:00:00

abstract：:Cytokines of the GM-CSF family signal via the same receptor subunit (βc) and, thus, have overlapping effects on cells that express all cytokine-specific α-chains (IL-3Rα, IL-5Rα, GM-CSFRα), such as human basophils, whose rapid effector functions are similarly enhanced by IL-3, IL-5, and GM-CSF. However, previous work ...

journal_title：Journal of leukocyte biology

authors： Kämpfer SS,Odermatt A,Dahinden CA,Fux M

更新日期：2017-01-01 00:00:00

abstract：:A protein with interleukin 1 (IL-1) activity was obtained from the human acute monocytic leukemia cell line (THP-1) and purified by ultrafiltration, Ultrogel AcA54 chromatography, isoelectric focusing, and discontinuous polyacrylamide gel electrophoresis. Like the pI 6.8 species of IL-1 from human peripheral blood mon...

journal_title：Journal of leukocyte biology

authors： Krakauer T

更新日期：1985-05-01 00:00:00

abstract：:Stimulation of phagocytic leukocytes with chemotactic factors results in transient acidification, followed by alkalinization of the cytosol. Human monocytes are known to alter their functional responses to the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (fMLP) in a complex fashion as they mature in vitr...

journal_title：Journal of leukocyte biology

authors： Bernardo J,Brennan L,Brink HF,Ortiz MF,Newburger PE,Simons ER

更新日期：1993-06-01 00:00:00

abstract：:Breaking the long-held paradigm that primary B cells are not phagocytic, several studies have demonstrated recently that B cells from fish, amphibians, and reptilians have a significant phagocytic capacity. Whether such capacity has remained conserved in certain mammalian B cell subsets is presently an enigma. Here, w...

journal_title：Journal of leukocyte biology

authors： Parra D,Rieger AM,Li J,Zhang YA,Randall LM,Hunter CA,Barreda DR,Sunyer JO

更新日期：2012-04-01 00:00:00

abstract：:CXCR4 is a key co-receptor required for the infection of T-tropic HIV-1 strain of CD4+ T lymphocytes. The regulation of this chemokine receptor was therefore studied. Th2 polarized cells expressed more CXCR4 than Th1 cells. Among a panel of cytokines and stimulants, a Th2 type cytokine interleukin-4 (IL-4) selectively...

journal_title：Journal of leukocyte biology

authors： Wang J,Harada A,Matsushita S,Matsumi S,Zhang Y,Shioda T,Nagai Y,Matsushima K

更新日期：1998-11-01 00:00:00

abstract：:Vitamin B9, commonly known as folate, is an essential cofactor for one-carbon metabolism that enters cells through three major specialized transporter molecules (RFC, FR, and PCFT), which differ in expression pattern, affinity for substrate, and ligand-binding pH dependency. We now report that the expression of the fo...

journal_title：Journal of leukocyte biology

authors： Samaniego R,Palacios BS,Domiguez-Soto Á,Vidal C,Salas A,Matsuyama T,Sánchez-Torres C,de la Torre I,Miranda-Carús ME,Sánchez-Mateos P,Puig-Kröger A

更新日期：2014-05-01 00:00:00

abstract：:Besides their growth-inhibiting and differentiation-inducing properties, retinoids have been shown to exert immunomodulatory and anti-inflammatory functions by mechanisms that are not well understood. Tumor necrosis factor-alpha (TNF), a cytokine produced by mononuclear phagocytes, has been shown to be an important me...

journal_title：Journal of leukocyte biology

authors： Mehta K,McQueen T,Tucker S,Pandita R,Aggarwal BB

更新日期：1994-03-01 00:00:00

abstract：:cDNA cloning revealed the presence of two related but distinct types of human interleukin-8 (IL-8) receptors, type I (type A) and type II (type B). By immunizing rabbits with glutathione-S-transferase fused with the NH2-terminal domain of each type of IL-8 receptor, we prepared polyclonal antibodies that specifically ...

journal_title：Journal of leukocyte biology

authors： Morohashi H,Miyawaki T,Nomura H,Kuno K,Murakami S,Matsushima K,Mukaida N

更新日期：1995-01-01 00:00:00

abstract：:The ellipsoid-associated cells (EAC) localize on the surface of the ellipsoid. They bind the IV injected horseradish peroxidase (HRP) and bovine serum albumin (BSA), migrate to the red pulp and then enter the systemic circulation. After protein injection, the number of white blood cells increased above the normal leve...

journal_title：Journal of leukocyte biology

authors： Oláh I,Glick B,Taylor RL Jr

更新日期：1984-05-01 00:00:00

abstract：:Leukotriene B4 (LTB4 ) plays a prominent role in innate immunity as it induces phagocyte recruitment, the release of antimicrobial effectors, and as it potentiates the ingestion and killing of pathogens. In humans, LTB4 has a short half-life and is rapidly metabolized by leukocytes, notably into 20-OH- and 20-COOH-LTB...

journal_title：Journal of leukocyte biology

authors： Archambault AS,Poirier S,Lefebvre JS,Robichaud PP,Larose MC,Turcotte C,Martin C,Provost V,Boudreau LH,McDonald PP,Laviolette M,Surette ME,Flamand N

更新日期：2019-06-01 00:00:00

abstract：:Stimulation of the respiratory burst in phagocytes induces the formation of mixed disulfides between sulfhydryl groups of proteins and low-molecular-weight thiols. We hypothesized that this process (S-thiolation) might be involved in turning off the respiratory burst. However, induction of S-thiolation by pretreatment...

journal_title：Journal of leukocyte biology

authors： Moriguchi T,Seres T,Ravichandran V,Sasada M,Johnston RB Jr

更新日期：1996-08-01 00:00:00

abstract：:Live, but not dead Bacillus Calmette-Guérin (BCG) is partially protective against infection by Mycobacterium tuberculosis, which causes a disease with high mortality in immune compromised individuals. We have shown that uptake of BCG induces maturation of immature dendritic cells (DCs) regardless of the viability of t...

journal_title：Journal of leukocyte biology

authors： Tsunetsugu-Yokota Y,Tamura H,Tachibana M,Ogata K,Honda M,Takemori T

更新日期：2002-07-01 00:00:00

abstract：:T cell Ig and mucin domain-containing molecule 3 (Tim-3) has been found to play important roles in autoimmune diseases, but whether Tim-3-mediated engulfment of apoptotic cells is involved in systemic lupus erythematosus (SLE) remains to be elucidated. In this study, we verified the role of human Tim-3 (hTim-3) as the...

journal_title：Journal of leukocyte biology

authors： Zhao D,Guo M,Liu B,Lin Q,Xie T,Zhang Q,Jia X,Shu Q,Liang X,Gao L,Ma C

更新日期：2017-12-01 00:00:00