当前位置： SCI文献检索 > JOURNAL OF LEUKOCYTE BIOLOGY期刊下所有文献 > Statins alter neutrophil migration by modulating cellular Rho activity--a potential mechanism for statins-mediated pleotropic effects?

Statins alter neutrophil migration by modulating cellular Rho activity--a potential mechanism for statins-mediated pleotropic effects?

Abstract：

:The ability of neutrophils to sense and migrate toward damaged tissue is a vital component of the innate immune response. Paradoxically, this same migration serves as the hallmark of a number of inflammatory conditions, including ischemic reperfusion injury, atherosclerosis, arthritis, and Crohn's disease. More recent evidence suggests that neutrophil infiltration into the cardiac allograft following transplantation is a contributing factor in allograft rejection. We have demonstrated previously a positive correlation between the degree of neutrophil migration and subsequent rejection grades in a cohort of cardiac transplant recipients. Intracellular signaling pathways that are intimately involved in neutrophil migration thus offer potential targets of manipulation in the treatment of such conditions. 3-hydroxy-3-methylyglutaryl-coenzyme A reductase inhibitors or statins are emerging as potential anti-inflammatory agents and have a proven survival benefit in the transplant population. Yet, little is known about their ability to modulate neutrophil function and their subsequent mechanism of action. We demonstrate here that pravastatin, simvastatin, and atorvastatin significantly reduce neutrophil transendothelial migration toward the chemoattractant fMLP. This effect is independent of any change in neutrophil adhesion or adhesion molecule expression but is related to the ability of statins to reduce fMLP-induced Rho activity in neutrophils. This was confirmed by the ability of the Rho precursor geranylgeranyl pyrophosphate to rescue the statin-mediated reduction in neutrophil transendothelial migration. Understanding the mechanisms of action of statins in the neutrophil allows for their use in targeting excessive migration in inappropriate inflammatory conditions.

journal_name

J Leukoc Biol

journal_title

Journal of leukocyte biology

authors

Maher BM,Dhonnchu TN,Burke JP,Soo A,Wood AE,Watson RW

doi

10.1189/jlb.0608382

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

186-93

issue

1

eissn

0741-5400

issn

1938-3673

pii

jlb.0608382

journal_volume

85

pub_type

杂志文章

相关文献

JOURNAL OF LEUKOCYTE BIOLOGY文献大全
  • Cytokine responses of bovine dendritic cells and T cells following exposure to live or inactivated bovine respiratory syncytial virus.

    abstract：:We compared the effects of live or inactivated bovine respiratory syncytial virus (BRSV) on cytokine production by bovine monocyte-derived dendritic cells (MoDC). We also investigated the response of resting memory CD4(+) T cells to MoDC exposed to both viral preparations. Although BRSV did not appear to replicate in ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：

    authors： Werling D,Collins RA,Taylor G,Howard CJ

    更新日期：2002-08-01 00:00:00

  • Influence of interleukin-2 infusion on cell cycle kinetics in the Walker-256 carcinosarcoma.

    abstract：:The effect of recombinant human interleukin-2 (IL-2) on tumor cell cycle kinetics was evaluated in rats bearing the Walker-256 carcinosarcoma. Seven days after implantation, tumor-bearing rats were infused intravenously with IL-2 at a dose of 500 mg/kg body weight or 5% dextrose for 6 h. Tumor cell mean DNA synthesis ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.55.2.241

    authors： Wan JM,Bistrian BR,Figoni MA,Istfan NW

    更新日期：1994-02-01 00:00:00

  • Dissociation between the translocation and the activation of Akt in fMLP-stimulated human neutrophils--effect of prostaglandin E2.

    abstract：:PGE(2) and other cAMP-elevating agents are known to down-regulate most functions stimulated by fMLP in human polymorphonuclear neutrophils. We reported previously that the inhibitory potential of PGE(2) resides in its capacity to suppress fMLP-stimulated PI-3Kgamma activation via the PGE(2) receptor EP(2) and hence, t...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0406256

    authors： Burelout C,Naccache PH,Bourgoin SG

    更新日期：2007-06-01 00:00:00

  • Characterization of the biosynthesis, processing, and sorting of human HBP/CAP37/azurocidin.

    abstract：:Azurocidin is a multifunctional endotoxin-binding serine protease homolog synthesized during the promyelocytic stage of neutrophil development. To characterize the biosynthesis and processing of azurocidin, cDNA encoding human preproazurocidin was stably transfected to the rat basophilic leukemia cell line RBL-1 and t...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.66.4.634

    authors： Lindmark A,Garwicz D,Rasmussen PB,Flodgaard H,Gullberg U

    更新日期：1999-10-01 00:00:00

  • The inhibitory effect of secretory leukocyte protease inhibitor (SLPI) on formation of neutrophil extracellular traps.

    abstract：:Neutrophil extracellular traps (NETs), web-like DNA structures, provide efficient means of eliminating invading microorganisms but can also present a potential threat to its host because it is a likely source of autoantigens or by promoting bystander tissue damage. Therefore, it is important to identify mechanisms tha...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.4AB1114-543R

    authors： Zabieglo K,Majewski P,Majchrzak-Gorecka M,Wlodarczyk A,Grygier B,Zegar A,Kapinska-Mrowiecka M,Naskalska A,Pyrc K,Dubin A,Wahl SM,Cichy J

    更新日期：2015-07-01 00:00:00

  • Pivotal advance: peritoneal cavity B-1 B cells have phagocytic and microbicidal capacities and present phagocytosed antigen to CD4+ T cells.

    abstract：:Breaking the long-held paradigm that primary B cells are not phagocytic, several studies have demonstrated recently that B cells from fish, amphibians, and reptilians have a significant phagocytic capacity. Whether such capacity has remained conserved in certain mammalian B cell subsets is presently an enigma. Here, w...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0711372

    authors： Parra D,Rieger AM,Li J,Zhang YA,Randall LM,Hunter CA,Barreda DR,Sunyer JO

    更新日期：2012-04-01 00:00:00

  • Amplifying cancer vaccine responses by modifying pathogenic gene programs in tumor cells.

    abstract：:Immunosuppressive factors, such as vascular endothelial growth factor, transforming growth factor-beta, prostaglandin E2, interleukin (IL)-10, and IL-6, are made frequently by cancer cells. These factors, along with others, can inhibit the development and function of tumor-reactive effector T cells and the clinical re...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1189/jlb.0104016

    authors： Spaner DE

    更新日期：2004-08-01 00:00:00

  • Shedding of PECAM-1 during HIV infection: a potential role for soluble PECAM-1 in the pathogenesis of NeuroAIDS.

    abstract：:Human immunodeficiency virus (HIV) infection is characterized by viral entry into the central nervous system (CNS), which is mediated, in part, by the transmigration of HIV-infected monocytes into the brain. The elaboration of chemokines and other factors by these infected cells contributes to CNS inflammation and cog...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0405215

    authors： Eugenin EA,Gamss R,Buckner C,Buono D,Klein RS,Schoenbaum EE,Calderon TM,Berman JW

    更新日期：2006-03-01 00:00:00

  • C1qR(P), a myeloid cell receptor in blood, is predominantly expressed on endothelial cells in human tissue.

    abstract：:C1qR(P) is a type I cell surface glycoprotein that has been shown to enhance ingestion of suboptimally opsonized targets by phagocytes in vitro. In this study, we developed and characterized polyclonal antibodies to study the tissue distribution of this receptor targeted to either the N- or C-terminal portion of the m...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：

    authors： Fonseca MI,Carpenter PM,Park M,Palmarini G,Nelson EL,Tenner AJ

    更新日期：2001-11-01 00:00:00

  • Effects of in vitro exposure to arachidonic acid on TNF-alpha production by murine peritoneal macrophages.

    abstract：:Modifying the fatty acid composition of macrophages through diet can significantly alter some of their functions, such as tumoricidal capacity and tumor necrosis factor alpha (TNF-alpha) production. The mechanism of that modification, however, is unknown. In this report, we provide evidence that fatty acids added to m...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.54.2.105

    authors： Hubbard NE,Lim D,Somers SD,Erickson KL

    更新日期：1993-08-01 00:00:00

  • Role of IFN-γ in the establishment of anterior chamber-associated immune deviation (ACAID)-induced CD8+ T regulatory cells.

    abstract：:Introduction of alloantigens into the AC induces a form of immune tolerance known as ACAID, which induces antigen-specific CD8+ Tregs, contributing to ocular immune privilege by down-regulating immune responses. Recent evidence suggests IFN-γ is needed for the suppressive function of CD8+ ACAID Tregs. This study teste...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0311173

    authors： Paunicka K,Chen PW,Niederkorn JY

    更新日期：2012-03-01 00:00:00

  • IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals.

    abstract：:The IL-1-related molecules, IL-1 and IL-18, can promote Th2 cytokine production by IgE/antigen-FcepsilonRI-stimulated mouse mast cells. Another IL-1-related molecule, IL-33, was identified recently as a ligand for T1/ST2. Although mouse mast cells constitutively express ST2, the effects of IL-33 on mast cell function ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0407200

    authors： Ho LH,Ohno T,Oboki K,Kajiwara N,Suto H,Iikura M,Okayama Y,Akira S,Saito H,Galli SJ,Nakae S

    更新日期：2007-12-01 00:00:00

  • Orphan nuclear receptors in T lymphocyte development.

    abstract：:Lymphocyte development is initiated from hematopoietic stem cells and can be divided into multiple phenotypically distinct stages. Transcription factors play important roles in programming the developmental process of lymphocytes. Recent studies have identified key roles of several orphan nuclear receptors in T lympho...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：

    authors： He YW

    更新日期：2002-09-01 00:00:00

  • Importance of CD44v7 isoforms for homing and seeding of hematopoietic progenitor cells.

    abstract：:The adhesion molecule CD44 consists of many isoforms of which particularly CD44v7 is of major importance in hematopoietic progenitor cell homing. An increase of progenitor cells in the periphery was observed after treating mice with a CD44v7-specific antibody, concomitant with a substantially augmented marrow-repopula...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：

    authors： Christ O,Günthert U,Haas R,Zöller M

    更新日期：2001-03-01 00:00:00

  • Hepatocyte injury during post-operative sepsis: activated neutrophils as potential mediators.

    abstract：:We evaluated the concept that the vascular entrance of both bacterial and nonbacterial particulate material could lead to hepatic parenchymal cell injury, either due to postphagocytic Kupffer cell activity or the margination of activated leukocytes in the liver. Injection of denatured, collagen-coated particles as wel...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.43.3.193

    authors： Holman JM Jr,Saba TM

    更新日期：1988-03-01 00:00:00

  • Frequencies of FoxP3+ naive T cells are related to both viral load and naive T cell proliferation responses in HIV disease.

    abstract：:HIV infection results in depletion and dysfunction of naïve CD4(+) T cells. The mechanisms underlying these deficiencies are not understood. We investigated the frequencies of CD4(+) naïve subsets in HIV disease as defined by expression of CD25 and/or FoxP3 and the relationship of these frequencies to naïve T cell pro...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.1210661

    authors： Rodriguez B,Bazdar DA,Funderburg N,Asaad R,Luciano AA,Yadavalli G,Kalayjian RC,Lederman MM,Sieg SF

    更新日期：2011-09-01 00:00:00

  • Jacalin, a lectin that inhibits in vitro HIV-1 infection, induces intracellular calcium increase via CD4 in cells lacking the CD3/TcR complex.

    abstract：:The lectin jacalin interacts with the CD4 cell surface antigen; this lectin inhibits in vitro infection by human immunodeficiency virus type 1 without preventing virus binding on the host cell. The infection process is known to involve cellular events triggered by the binding of the viral external glycoprotein gp120 t...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.56.4.521

    authors： Lafont V,Dornand J,d'Angeac AD,Monier S,Alcover A,Favero J

    更新日期：1994-10-01 00:00:00

  • Glucan: mechanisms involved in its "radioprotective" effect.

    abstract：:It has generally been accepted that most biologically derived agents that are radioprotective in the hemopoietic-syndrome dose range (eg, endotoxin, Bacillus Calmette Guerin, Corynebacterium parvum, etc) exert their beneficial properties by enhancing hemopoietic recovery and hence, by regenerating the host's ability t...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.42.2.95

    authors： Patchen ML,D'Alesandro MM,Brook I,Blakely WF,MacVittie TJ

    更新日期：1987-08-01 00:00:00

  • HIV replication and persistence in human gastrointestinal cells cultured in vitro.

    abstract：:Epithelial and submucosal mesenchymal (SM) cells from normal human small intestine and colon could be directly infected by several strains of the human immunodeficiency virus (HIV). Macrophage-derived virus strains were more potent than the HTLVIIIB prototype strain. Persistent release of virus over several months imp...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.49.5.499

    authors： Moyer MP,Gendelman HE

    更新日期：1991-05-01 00:00:00

  • Expression of both types of human interleukin-8 receptors on mature neutrophils, monocytes, and natural killer cells.

    abstract：:cDNA cloning revealed the presence of two related but distinct types of human interleukin-8 (IL-8) receptors, type I (type A) and type II (type B). By immunizing rabbits with glutathione-S-transferase fused with the NH2-terminal domain of each type of IL-8 receptor, we prepared polyclonal antibodies that specifically ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.57.1.180

    authors： Morohashi H,Miyawaki T,Nomura H,Kuno K,Murakami S,Matsushima K,Mukaida N

    更新日期：1995-01-01 00:00:00

  • IL-12Rβ2 is critical for survival of primary Francisella tularensis LVS infection.

    abstract：:Using a panel of vaccines that provided different degrees of protection, we previously identified the IL-12 receptor subunit β2 as a mediator, whose relative expression correlated with strength of protection against secondary lethal challenge of vaccinated mice with an intracellular bacterium, the LVS of Francisella t...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.1012485

    authors： Melillo AA,Foreman O,Elkins KL

    更新日期：2013-05-01 00:00:00

  • Differential expression of beta 2-integrins and cytokine production between gammadelta and alphabeta T cells in experimental autoimmune encephalomyelitis.

    abstract：:The expression of beta 2-integrins on gammadelta T cells in naïve mice or those with experimental autoimmune encephalomyelitis (EAE) remains poorly characterized. We compared beta 2-integrin expression and cytokine production between gammadelta and alphabeta T cells over the acute course of EAE. We observed that unlik...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0407263

    authors： Smith SS,Barnum SR

    更新日期：2008-01-01 00:00:00

  • LPS induces rapid IL-10 release by M-CSF-conditioned tolerogenic dendritic cell precursors.

    abstract：:Dendritic cells (DC) obtained by culturing myeloid precursors in GM-CSF undergo maturation and induce an efficient T cell response when stimulated with microbial products. DC precursors themselves also recognize microbial products, and it remains unclear how these stimulated DC precursors modulate the immune response....

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0406267

    authors： Kwan WH,Boix C,Gougelet N,Fridman WH,Mueller CG

    更新日期：2007-07-01 00:00:00

  • In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration.

    abstract：:Eosinophil migration from circulation is controlled, in part, by chemokines through a family of G-protein-coupled chemokine receptors (CCR). Studies of human eosinophils have demonstrated that signaling through CCR3 receptors is a prominent pathway leading to chemotaxis, although several other receptor-ligand interact...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：

    authors： Borchers MT,Ansay T,DeSalle R,Daugherty BL,Shen H,Metzger M,Lee NA,Lee JJ

    更新日期：2002-06-01 00:00:00

  • The p110gamma isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites.

    abstract：:The role of PI-3K in leukocyte function has been studied extensively. However, the specific role of the p110gamma isoform of PI- 3K in CD4 T lymphocyte function has yet to be defined explicitly. In this study, we report that although p110gamma does not regulate antigen-dependent CD4 T cell activation and proliferation...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0807561

    authors： Thomas MS,Mitchell JS,DeNucci CC,Martin AL,Shimizu Y

    更新日期：2008-09-01 00:00:00

  • Time-course expression of Toll-like receptors 2 and 4 in inflammatory bowel disease and homeostatic effect of VIP.

    abstract：:Toll-like receptor 2 (TLR2) and -4 mediate signals from a great variety of bacterial gut products, giving the host a panel of microbe-recognizing receptors. Under homeostatic conditions, TLRs act as protective receptors of the intestinal epithelium. When homeostasis is disrupted in diseases such as inflammatory bowel ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.1004564

    authors： Gomariz RP,Arranz A,Abad C,Torroba M,Martinez C,Rosignoli F,Garcia-Gómez M,Leceta J,Juarranz Y

    更新日期：2005-08-01 00:00:00

  • Chemokine decoy receptor D6 mimicking trap (D6MT) prevents allosensitization and immune rejection in murine corneal allograft model.

    abstract：:Although corneal allotransplantation is performed in the immune-privileged cornea, many grafts are still rejected after transplantation. This study examined the role of chemokine receptor D6 expression in a corneal allograft rejection, investigated the modulation of D6 expression in cells, and determined the effect of...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.5A0414-233RR

    authors： Choi W,Byun YJ,Jung E,Noh H,Hajrasouliha AR,Sadrai Z,Chang E,Lee JH,Lee HK

    更新日期：2015-02-01 00:00:00

  • miR-181c-BRK1 axis plays a key role in actin cytoskeleton-dependent T cell function.

    abstract：:MicroRNAs are short endogenous noncoding RNAs that play pivotal roles in a diverse range of cellular processes. The miR-181 family is important in T cell development, proliferation, and activation. In this study, we have identified BRK1 as a potential target of miR-181c using a dual selection functional assay and have...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/JLB.1A0817-325RR

    authors： Lim SP,Ioannou N,Ramsay AG,Darling D,Gäken J,Mufti GJ

    更新日期：2018-05-01 00:00:00

  • Bcl-2 overexpression ameliorates immune complex-mediated arthritis by altering FcγRIIb expression and monocyte homeostasis.

    abstract：:RA is a chronic autoimmune disease characterized by accumulation of inflammatory cells within synovial joints. RA is associated with a failure of apoptosis of infiltrating leukocytes, thought to be a result of overexpression of prosurvival Bcl-2 proteins. Overexpression of Bcl-2 in hematopoietic cells can result in sp...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0412190

    authors： Lawlor KE,van Nieuwenhuijze A,Parker KL,Drake SF,Campbell IK,Smith SD,Vince JE,Strasser A,Wicks IP

    更新日期：2013-04-01 00:00:00

  • Selective up-regulation of phospholipase C-beta2 during granulocytic differentiation of normal and leukemic hematopoietic progenitors.

    abstract：:In this study, we have investigated the expression of phospholipase C-beta2 during the course of granulocytic differentiation of normal and malignant progenitors. As a model system, we used the NB4 cell line, a reliable in vitro model for the study of acute promyelocytic leukemia (APL), a variety of acute myeloid leuk...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：

    authors： Bertagnolo V,Marchisio M,Pierpaoli S,Colamussi ML,Brugnoli F,Visani G,Zauli G,Capitani S

    更新日期：2002-06-01 00:00:00