ATP induces P2X7 receptor-independent cytokine and chemokine expression through P2X1 and P2X3 receptors in murine mast cells.

abstract：:We have characterized the beta-adrenergic receptor binding site and the beta-adrenergic cAMP response of the HL-60 cell. The hydrophilic ligand [3H]-(-)-CGP-12177 was specifically and reversibly bound to one single class of binding sites (Kd 220 pM and Bmax 1,970 sites/cell). The adrenergic agonists inhibited the spec...

journal_title：Journal of leukocyte biology

authors： Sager G,Bang BE,Pedersen M,Aarbakke J

更新日期：1988-07-01 00:00:00

abstract：:Cytohesin-1 and ARNO are guanine nucleotide-exchange factors (GEFs) for ADP-ribosylation factor (Arf). Here, we show that ARNO is expressed in HL-60 cells and established that granulocytic differentiation induced with Me2SO stimulated cytohesin-1 but not ARNO expression. Cytohesin-1 levels in HL-60 granulocytes were s...

journal_title：Journal of leukocyte biology

authors： Bourgoin SG,Houle MG,Singh IN,Harbour D,Gagnon S,Morris AJ,Brindley DN

更新日期：2002-04-01 00:00:00

abstract：:Type I IFNs display multiple biological effects. They have a strong antiviral action, not only directly but also indirectly through activation of the immune system. They may also have actions that are deleterious for the host. The cells that produce type I IFN are mostly plasmacytoid dendritic cells (pDC), but this de...

journal_title：Journal of leukocyte biology

authors： Hosmalin A,Lebon P

更新日期：2006-11-01 00:00:00

abstract：:Epithelial and submucosal mesenchymal (SM) cells from normal human small intestine and colon could be directly infected by several strains of the human immunodeficiency virus (HIV). Macrophage-derived virus strains were more potent than the HTLVIIIB prototype strain. Persistent release of virus over several months imp...

journal_title：Journal of leukocyte biology

authors： Moyer MP,Gendelman HE

更新日期：1991-05-01 00:00:00

abstract：:Several S100 Ca(2+)-binding proteins undergo various post-translational modifications that may alter their intracellular and extracellular functions. S100A8 and S100A9, two members of this family, are particularly susceptible to oxidative modification. These proteins, abundantly expressed in neutrophils and activated ...

journal_title：Journal of leukocyte biology

authors： Lim SY,Raftery MJ,Goyette J,Hsu K,Geczy CL

更新日期：2009-09-01 00:00:00

abstract：:Blocking monoclonal antibodies (mAbs) specific to mouse interleukin-1 receptor antagonist (IL-1ra) were prepared by immunizing Armenian hamsters with recombinant mouse IL-1ra. A sensitive and specific ELISA against mouse IL-1ra was also established. In Propionibacterium acnes-induced liver injury, P. acnes induced tra...

journal_title：Journal of leukocyte biology

authors： Fujioka N,Mukaida N,Harada A,Akiyama M,Kasahara T,Kuno K,Ooi A,Mai M,Matsushima K

更新日期：1995-07-01 00:00:00

abstract：:Previously, we showed that NO induces thymocyte apoptosis via a caspase-1-dependent mechanism [(1) ]. In the present study, we investigated the role of heme oxygenase, catalase, bax, and p53 in this process. The NO donor, S-nitroso-N-acetyl penicillamine (SNAP), induced DNA fragmentation in thymocytes in a time- and c...

journal_title：Journal of leukocyte biology

authors： Gordon SA,Abou-Jaoude W,Hoffman RA,McCarthy SA,Kim YM,Zhou X,Zhang XR,Simmons RL,Chen Y,Schall L,Ford HR

更新日期：2001-07-01 00:00:00

abstract：:This short review focuses on the role of central nervous system (CNS) perivascular macrophages as targets of productive infection of the CNS. Data discussed include the importance of these cells as early targets of infection and their productive infection with AIDS. Many of the immune molecules on perivascular macroph...

journal_title：Journal of leukocyte biology

authors： Kim WK,Corey S,Alvarez X,Williams K

更新日期：2003-11-01 00:00:00

abstract：:In newborn infants, the innate cellular system plays a crucial role in the first line of defense against pathogens. Neutrophils are the most abundant leukocytes, and their response to the commonly encountered nosocomial bacterial (Gram positive) infection in newborns remains largely unclear. In this study, a genome-wi...

journal_title：Journal of leukocyte biology

authors： Fong ON,Chan KY,Leung KT,Lam HS,Cheung HM,Leung TY,Li K,Ng PC

更新日期：2014-01-01 00:00:00

abstract：:Introduction of alloantigens into the AC induces a form of immune tolerance known as ACAID, which induces antigen-specific CD8+ Tregs, contributing to ocular immune privilege by down-regulating immune responses. Recent evidence suggests IFN-γ is needed for the suppressive function of CD8+ ACAID Tregs. This study teste...

journal_title：Journal of leukocyte biology

authors： Paunicka K,Chen PW,Niederkorn JY

更新日期：2012-03-01 00:00:00

abstract：:Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine with numerous immunomodulatory effects, including the inhibition of proinflammatory cytokine production. The mechanisms by which IL-10 exerts these effects still remain largely unknown. As there is evidence that suggests IL-10-mediated cytokine suppression ...

journal_title：Journal of leukocyte biology

authors： Williams L,Jarai G,Smith A,Finan P

更新日期：2002-10-01 00:00:00

abstract：:The effects of B cell subsets with regulatory activity on the immune response to an allograft have evoked increasing interest. Here, we summarize the function and signaling of regulatory B cells (Bregs) and their potential effects on transplantation. These cells are able to suppress the immune system directly via liga...

journal_title：Journal of leukocyte biology

authors： Li J,Luo Y,Wang X,Feng G

更新日期：2019-04-01 00:00:00

abstract：:Complement component C1q is a member of a family of soluble proteins called defense collagens, which are important in host defense and apoptotic cell clearance. Failure to efficiently clear apoptotic cells in the absence of C1q is associated with autoimmunity. Here, we review the literature describing a central role f...

journal_title：Journal of leukocyte biology

authors： Galvan MD,Greenlee-Wacker MC,Bohlson SS

更新日期：2012-09-01 00:00:00

abstract：:Changes in leukocyte subpopulations and function after spaceflight have been observed but the mechanisms underlying these changes are not well defined. This study investigated the effects of short-term spaceflight (8-15 days) on circulating leukocyte subsets, stress hormones, immunoglobulin levels, and neutrophil func...

journal_title：Journal of leukocyte biology

authors： Stowe RP,Sams CF,Mehta SK,Kaur I,Jones ML,Feeback DL,Pierson DL

更新日期：1999-02-01 00:00:00

abstract：:The relationship between leukocyte migration and parenchymal cell death in vivo remains poorly documented. Accordingly, cell killing in the rat mesentery, as recorded by propidium iodide staining, was investigated with an intravital approach. Superfusion of platelet-activating factor (PAF, 10(-8) M) or N-formyl-methio...

journal_title：Journal of leukocyte biology

authors： Tung DK,Bjursten LM,Zweifach BW,Schmid-Schönbein GW

更新日期：1997-08-01 00:00:00

abstract：:Immune and inflammatory cells play a critical role in the pathogenesis of atherosclerotic plaques. We have demonstrated that A2ARs inhibit foam cell formation and stimulate production of ABCA1, the primary transporter of lipoproteins. We asked whether the effects of A2ARs on foam cell formation in vitro are mediated b...

journal_title：Journal of leukocyte biology

authors： Bingham TC,Fisher EA,Parathath S,Reiss AB,Chan ES,Cronstein BN

更新日期：2010-04-01 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) against human immunodeficiency virus type 1 (HIV-1) infection dramatically suppresses viral load, leading to marked reductions in HIV-1 associated morbidity and mortality. However, infected cell reservoirs and low-level replication persist in the face of suppressive HAART, ...

journal_title：Journal of leukocyte biology

authors： Kennedy PE,Bera TK,Wang QC,Gallo M,Wagner W,Lewis MG,Berger EA,Pastan I

更新日期：2006-11-01 00:00:00

abstract：:The tissue-fixed macrophage is a key cellular element in the initiation and regulation of inflammation. Understanding the regulation of macrophage activation may provide valuable clues to the mechanisms involved in both beneficial and deleterious effects of inflammation. The lymphokine interferon-gamma (IFN-gamma) is ...

journal_title：Journal of leukocyte biology

authors： Williams JG,Jurkovich GJ,Hahnel GB,Maier RV

更新日期：1992-12-01 00:00:00

abstract：:There is growing evidence that, in addition to their role as initiators of immune responses, dendritic cells (DC) can exhibit tolerogenic properties. Immature DC deficient in cell surface costimulatory/accessory molecules can prolong organ and pancreatic islet allograft survival, whereas in vitro manipulation of DC by...

journal_title：Journal of leukocyte biology

authors： Lu L,Lee WC,Takayama T,Qian S,Gambotto A,Robbins PD,Thomson AW

更新日期：1999-08-01 00:00:00

abstract：:The human endometrium is exposed to cyclical fluctuations of ovarian-derived sex steroids resulting in proliferation, differentiation (decidualization), and menstruation. An influx of leukocytes (up to 15% macrophages) occurs during the latter stages of the menstrual cycle, including menses. We believe the endometrial...

journal_title：Journal of leukocyte biology

authors： Thiruchelvam U,Dransfield I,Saunders PT,Critchley HO

更新日期：2013-02-01 00:00:00

abstract：:Transferrin receptor (TfR) expression is up-regulated during T cell activation after the interaction of the T cell receptor with the antigen-major histocompatibility complex and the expression of interleukin-2 (IL-2) receptor. We hypothesize that anti-TfR monoclonal antibody (mAb) will prolong allograft survival by al...

journal_title：Journal of leukocyte biology

authors： Bayer AL,Baliga P,Woodward JE

更新日期：1998-07-01 00:00:00

abstract：:Most staphylococci produce short α-type PSMs and about twice as long β-type PSMs that are potent leukocyte attractants and toxins. PSMs are usually secreted with the N-terminal formyl group but are only weak agonists for the leukocyte FPR1. Instead, the FPR1-related FPR2 senses PSMs efficiently and is crucial for leuk...

journal_title：Journal of leukocyte biology

authors： Kretschmer D,Rautenberg M,Linke D,Peschel A

更新日期：2015-04-01 00:00:00

abstract：:Attempts to analyze bone marrow-derived macrophages (BMDM) by flow cytometry have been prohibited because of their high autofluorescence. Using an autofluorescence reduction method of Steinkamp and Stewart to reduce the autofluorescence of BMDM, we were able to examine several macrophage populations for their expressi...

journal_title：Journal of leukocyte biology

authors： Malley A,Stewart CC,Stewart SJ,Waldbeser L,Bradley LM,Shiigi SM

更新日期：1988-06-01 00:00:00

abstract：:Several alterations in the expression of immune-related transcripts were identified recently in the degenerating retina of the retinoschisin knockout (Rs1h(-/Y)) mouse, including the strong expression of the adaptor protein Dap12. As Dap12 is found in leukocytes, we hypothesized that its disease-related expression may...

journal_title：Journal of leukocyte biology

authors： Weigelt K,Ernst W,Walczak Y,Ebert S,Loenhardt T,Klug M,Rehli M,Weber BH,Langmann T

更新日期：2007-12-01 00:00:00

abstract：:The ability of encapsulated and acapsular strains of Cryptococcus neoformans to activate dendritic cells (DC) derived from monocytes stimulated with granulocyte macrophage-colony stimulating factor and interleukin-4 was evaluated. Profound differences in DC response to encapsulated and acapsular C. neoformans strains ...

journal_title：Journal of leukocyte biology

authors： Vecchiarelli A,Pietrella D,Lupo P,Bistoni F,McFadden DC,Casadevall A

更新日期：2003-09-01 00:00:00

abstract：:GenBank entries for mouse Il33 reveal the existence of two transcripts, Il33a and Il33b, with different 5'UTRs but coding for the same protein. We investigated expression of these transcripts in different mouse organs and cell types in basal and inflammatory conditions. Il33a and Il33b mRNAs start with different nonco...

journal_title：Journal of leukocyte biology

authors： Talabot-Ayer D,Calo N,Vigne S,Lamacchia C,Gabay C,Palmer G

更新日期：2012-01-01 00:00:00

abstract：:Fluid-phase endocytosis is stimulated by H-ras-linked growth factor receptors and this stimulation requires activation of rab5. We utilized a GFP-rab5a:wt fusion protein to monitor GFP-rab5a:wt activation in living fibroblasts and in J774 macrophages. Control CHO cells that expressed GFP-rab5a:wt were cultured in seru...

journal_title：Journal of leukocyte biology

authors： Roberts RL,Barbieri MA,Ullrich J,Stahl PD

更新日期：2000-11-01 00:00:00

abstract：:Because myotonic dystrophy (MD) is an autosomal dominant multisystemic disorder affecting plasma membrane, we have studied the oxidative burst of PMNs. The PMA and fMet-Leu-Phe-stimulated superoxide generation is defective in the patient group as compared to controls: the response is both delayed and low. The kinetic ...

journal_title：Journal of leukocyte biology

authors： Mege JL,Pouget J,Capo C,Andre P,Benoliel AM,Serratrice G,Bongrand P

更新日期：1988-09-01 00:00:00

abstract：:Tissue macrophages produce several proteins of the complement system. The mechanisms that regulate this process are poorly understood. The established ability of certain prostaglandins to influence macrophage secretory activity suggests that these lipid mediators may also modulate complement production (CP). Using the...

journal_title：Journal of leukocyte biology

authors： Rediske JJ,Pickering RJ

更新日期：1985-05-01 00:00:00

abstract：:Cytokines are pivotal in the generation and resolution of the inflammatory response. The midkine/pleiotrophin (MK/PTN) family of cytokines, composed of just two members, was discovered as heparin-binding neurite outgrowth-promoting factors. Since their discovery, expression of this cytokine family has been reported in...

journal_title：Journal of leukocyte biology

authors： Sorrelle N,Dominguez ATA,Brekken RA

更新日期：2017-08-01 00:00:00