Abstract:
:Interleukin-10 (IL-10) is a potent anti-inflammatory cytokine with numerous immunomodulatory effects, including the inhibition of proinflammatory cytokine production. The mechanisms by which IL-10 exerts these effects still remain largely unknown. As there is evidence that suggests IL-10-mediated cytokine suppression requires the induction of an intermediate gene, we have used gene-chip technology to identify IL-10-inducible genes in human monocytes. We have been able to identify a total of 19 genes that are up-regulated in response to IL-10. Three of these genes had been identified previously: IL-1ra, suppressors of cytokine signaling-3, and CD163; however, the other 16 represent newly identified IL-10-responsive genes. Further analysis of the regulation of eight of these genes showed a remarkable specificity to regulation by lipopolysaccharides (LPS) and IL-10, but not by other anti-inflammatory mediators such as IL-4 and transforming growth factor-beta, suggesting that two diverse stimuli such as IL-10 and LPS may engage common signaling mechanisms.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Williams L,Jarai G,Smith A,Finan Psubject
Has Abstractpub_date
2002-10-01 00:00:00pages
800-9issue
4eissn
0741-5400issn
1938-3673journal_volume
72pub_type
杂志文章abstract::Many tumor cells are resistant to Fas-mediated killing, which has been primarily used as a mechanism to evade immune attack. In this study, we found a new action of Fas on tumors where activation of the Fas signal may force tumor cells to produce survival factors for neutrophils. Human peripheral circulating neutrophi...
journal_title:Journal of leukocyte biology
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journal_title:Journal of leukocyte biology
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journal_title:Journal of leukocyte biology
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更新日期:2004-12-01 00:00:00
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journal_title:Journal of leukocyte biology
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更新日期:2007-04-01 00:00:00
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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更新日期:2010-04-01 00:00:00
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journal_title:Journal of leukocyte biology
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doi:
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journal_title:Journal of leukocyte biology
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journal_title:Journal of leukocyte biology
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abstract::Myeloid-derived suppressor cells (MDSCs) increase in tuberculosis (TB) and may be targets for host-directed therapy (HDT). In this study, we use flow cytometry to analyze the effects of cyclooxygenase-2 inhibitors (COX-2i) on monocytic (M)-MDSCs in blood from TB patients attending a clinical trial of COX-2i. The effec...
journal_title:Journal of leukocyte biology
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更新日期:2010-08-01 00:00:00
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