Secretory leukocyte proteinase inhibitor is a major leukocyte elastase inhibitor in human neutrophils.

abstract：:The transcription factor GATA-2 is expressed in hematopoietic stem and progenitor cells and is functionally implicated in their survival and proliferation. In the present study, we show that GATA-2 exists as an acetylated protein in immature precursor cells, KG1. GATA-2 was acetylated in vitro by p300 and GCN5. We hav...

journal_title：Journal of leukocyte biology

authors： Hayakawa F,Towatari M,Ozawa Y,Tomita A,Privalsky ML,Saito H

更新日期：2004-03-01 00:00:00

abstract：:The kinetics and regulatory mechanisms of T cell migration through the endothelium have not been fully defined. In experimental, filter-based assays in vitro, transmigration of lymphocytes takes hours, compared with minutes, in vivo. We cultured endothelial cell (EC) monolayers on filters, solid substrates, or collage...

journal_title：Journal of leukocyte biology

authors： McGettrick HM,Hunter K,Moss PA,Buckley CD,Rainger GE,Nash GB

更新日期：2009-01-01 00:00:00

abstract：:T cell Ig and mucin domain-containing molecule 3 (Tim-3) has been found to play important roles in autoimmune diseases, but whether Tim-3-mediated engulfment of apoptotic cells is involved in systemic lupus erythematosus (SLE) remains to be elucidated. In this study, we verified the role of human Tim-3 (hTim-3) as the...

journal_title：Journal of leukocyte biology

authors： Zhao D,Guo M,Liu B,Lin Q,Xie T,Zhang Q,Jia X,Shu Q,Liang X,Gao L,Ma C

更新日期：2017-12-01 00:00:00

abstract：:The immune system is armed with a broad range of receptors to detect and initiate the elimination of bacterial pathogens. Inflammasomes are molecular platforms that sense a diverse range of microbial insults to develop appropriate host response. In that context, noncanonical inflammasome arose as a sensor for Gram-neg...

journal_title：Journal of leukocyte biology

authors： Gomes MTR,Cerqueira DM,Guimarães ES,Campos PC,Oliveira SC

更新日期：2019-09-01 00:00:00

abstract：:Dendritic cells (DCs) are specialized APCs present in all tissues, including tumors. They play a major role in orchestrating immune responses and were shown to occur in various functional states in tumors. In this respect, immunogenic tumor-associated DCs (TADCs) are required to initiate and sustain T cell-dependent a...

journal_title：Journal of leukocyte biology

authors： Keirsse J,Van Damme H,Van Ginderachter JA,Laoui D

更新日期：2017-08-01 00:00:00

abstract：:Scaffolding molecules bind simultaneously and link together various components of signal-transduction pathways. Grb2-associated binder 2 (Gab2) is a scaffolding protein required for FcgammaR-initiated allergic responses in mast cells and FcgammaR-mediated phagocytosis in macrophages, where it links IgE and IgG recepto...

journal_title：Journal of leukocyte biology

authors： Zompi S,Gu H,Colucci F

更新日期：2004-10-01 00:00:00

abstract：:CXCR4 is a key co-receptor required for the infection of T-tropic HIV-1 strain of CD4+ T lymphocytes. The regulation of this chemokine receptor was therefore studied. Th2 polarized cells expressed more CXCR4 than Th1 cells. Among a panel of cytokines and stimulants, a Th2 type cytokine interleukin-4 (IL-4) selectively...

journal_title：Journal of leukocyte biology

authors： Wang J,Harada A,Matsushita S,Matsumi S,Zhang Y,Shioda T,Nagai Y,Matsushima K

更新日期：1998-11-01 00:00:00

abstract：:An immunoglobulin M (IgM) monoclonal antibody, My43, specific for IgA Fc receptor (Fc alpha R) on human monocytes, bound to human polymorphonuclear neutrophils (PMNs) and inhibited their ability to bind IgA but not IgG. It was observed that the PMN oxidative burst was induced by both polymeric IgA and aggregated IgG, ...

journal_title：Journal of leukocyte biology

authors： Shen L

更新日期：1992-04-01 00:00:00

abstract：:Over 1.4 million Americans have been diagnosed with inflammatory bowel disease (IBD), and ulcerative colitis (UC) makes up approximately half of those diagnoses. As a disease, UC cycles between periods of remission and flare, which is characterized by intense abdominal pain, increased weight loss, intestinal inflammat...

journal_title：Journal of leukocyte biology

authors： Cannon AR,Kuprys PV,Cobb AN,Ding X,Kothari AN,Kuo PC,Eberhardt JM,Hammer AM,Morris NL,Li X,Choudhry MA

更新日期：2018-09-01 00:00:00

abstract：:Glucocorticoids (GC) are potent anti-inflammatory and immunosuppressive agents that act on a variety of immune cells, including T cells, monocytes/macrophages, osteoclasts, and dendritic cells (DC). However, the mechanism(s) by which GC exert anti-inflammatory effects is still largely unknown. It is already well known...

journal_title：Journal of leukocyte biology

authors： Kim KD,Choe YK,Choe IS,Lim JS

更新日期：2001-03-01 00:00:00

abstract：:Virulent Legionella pneumophila replicate readily in thioglycollate-elicited peritoneal macrophages from genetically permissive A/J mice, but avirulent L. pneumophila do not. The production of cytokines by macrophages infected with L. pneumophila has been studied, but the correlation of bacterial virulence with immune...

journal_title：Journal of leukocyte biology

authors： McHugh SL,Yamamoto Y,Klein TW,Friedman H

更新日期：2000-06-01 00:00:00

abstract：:In human neutrophils, TNF-elicited O(2)(-) production requires adherence and integrin activation. How this cooperative signaling between TNFRs and integrins regulates O(2)(-) generation has yet to be fully elucidated. Previously, we identified delta-PKC as a critical early regulator of TNF signaling in adherent neutro...

journal_title：Journal of leukocyte biology

authors： Kilpatrick LE,Sun S,Li H,Vary TC,Korchak HM

更新日期：2010-01-01 00:00:00

abstract：:Secreted IgM (sIgM) is a multifunctional evolutionary conserved antibody that is critical for the maintenance of tissue homeostasis as well as the development of fully protective humoral responses to pathogens. Constitutive secretion of self- and polyreactive natural IgM, produced mainly by B-1 cells, provides a circu...

journal_title：Journal of leukocyte biology

authors： Blandino R,Baumgarth N

更新日期：2019-11-01 00:00:00

abstract：:Recently identified, angiopoietin-1 (Ang1) and -2 (Ang2) bind to the tyrosine kinase receptor Tie2 and contribute to orchestrate blood vessel formation during angiogenesis. Ang1 mediates vessel maturation and integrity by favoring the recruitment of pericytes and smooth muscle cells. Ang2, initially identified as a Ti...

journal_title：Journal of leukocyte biology

authors： Maliba R,Brkovic A,Neagoe PE,Villeneuve LR,Sirois MG

更新日期：2008-02-01 00:00:00

abstract：:Vertebrate lectin purified from loach egg was tested for induction of tumor lysis mediated by macrophages. Loach egg lectin lysed tumor cells but not normal spleen cells in cooperation with BCG- or glucan (TAK)-elicited peritoneal macrophages of mice. Corynebacterium parvum-, OK432-, glycogen-, lipopolysaccharide-elic...

journal_title：Journal of leukocyte biology

authors： Yamazaki M,Okutomi T,Sakakibara F,Kawauchi H,Mizuno D

更新日期：1984-03-01 00:00:00

abstract：:In vivo, dendritic cells (DC) reside in direct proximity to extracellular matrix (ECM) proteins. Because ECM proteins affect morphology and function of a number of cell types, this study investigated potential effects of ECM proteins on functional properties of DC. DC were generated from murine bone marrow cultures, s...

journal_title：Journal of leukocyte biology

authors： Mahnke K,Bhardwaj RS,Luger TA,Schwarz T,Grabbe S

更新日期：1996-10-01 00:00:00

abstract：:The ganglioside composition of endotoxin-responsive C3H/HeN murine peritoneal macrophages is known to undergo dramatic changes in vivo in response to intraperitoneal lipopolysaccharides (LPS), unlike endotoxin-hyporesponsive C3H/HeJ macrophages. To better investigate the mechanism behind LPS-induced macrophage ganglio...

journal_title：Journal of leukocyte biology

authors： Berenson CS,Yohe HC,Ryan JL

更新日期：1989-03-01 00:00:00

abstract：:Newborns are highly susceptible to viral infections. We hypothesized that this susceptibility could be due to a dysregulated expression of innate virus-sensing receptors, i.e., TLR3, TLR7, TLR8, and TLR9 and the cytosolic receptors retinoic acid-inducible gene I, melanoma differentiation-associated protein 5, protein ...

journal_title：Journal of leukocyte biology

authors： Slavica L,Nordström I,Karlsson MN,Valadi H,Kacerovsky M,Jacobsson B,Eriksson K

更新日期：2013-11-01 00:00:00

abstract：:Although HDPs were originally hypothesized to act as antimicrobial agents, they also have been shown to broadly modulate the immune response through the activation of different cell types. We recently developed a series of novel, synthetic peptides, termed IDRs, which are conceptually based on a natural HDP, bovine ba...

journal_title：Journal of leukocyte biology

authors： Niyonsaba F,Madera L,Afacan N,Okumura K,Ogawa H,Hancock RE

更新日期：2013-07-01 00:00:00

abstract：:TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM acts to bridge TLR4 with TRIF, orchestrating the inflammatory response to pathogen challenge. We ha...

journal_title：Journal of leukocyte biology

authors： Verstak B,Stack J,Ve T,Mangan M,Hjerrild K,Jeon J,Stahl R,Latz E,Gay N,Kobe B,Bowie AG,Mansell A

更新日期：2014-09-01 00:00:00

abstract：:Interferons (IFN) and lipopolysaccharide (LPS) cause multiple changes in isoprenoid-modified proteins in murine macrophages, the most dramatic being the expression of a prenyl protein of 65 kDa. The guanylate binding proteins (GBPs) are IFN-inducible GTP-binding proteins of approximately 65 kDa that possess a CaaX mot...

journal_title：Journal of leukocyte biology

authors： Nantais DE,Schwemmle M,Stickney JT,Vestal DJ,Buss JE

更新日期：1996-09-01 00:00:00

abstract：:Glycoprotein 130 (gp130) is a shared receptor utilized by several related cytokines, including IL-6, IL-11, IL-27, Leukemia Inhibitory Factor (LIF), Oncostatin M (OSM), Ciliary Neurotrophic Factor (CNTF), Cardiotrophin 1 (CT-1) and Cardiotrophin-like Cytokine (CLC). Gp130 plays critical roles during development and gp...

journal_title：Journal of leukocyte biology

authors： Silver JS,Hunter CA

更新日期：2010-12-01 00:00:00

abstract：:Radiation-induced chimeric mice were used to study the origin of pulmonary alveolar macrophages. Unlike in other studies, these radiation chimeras were prepared by using a special fractionated irradiation regimen to minimize the killing of alveolar macrophage colony-forming cells, putative local stem cells. For this s...

journal_title：Journal of leukocyte biology

authors： Tarling JD,Lin HS,Hsu S

更新日期：1987-11-01 00:00:00

abstract：:Prostaglandins function as down regulators of immune responses probably by increasing the concentration of intracellular cAMP. Phosphodiesterase inhibitors, which prevent the breakdown of cAMP, also increase the intracellular levels of cAMP. Prostaglandins and phosphodiesterase inhibitors have both been shown to suppr...

journal_title：Journal of leukocyte biology

authors： Ellis NK,Duffie GP,Young MR,Wepsic HT

更新日期：1990-04-01 00:00:00

abstract：:Neutrophils were classically described as powerful effectors of acute inflammation, and their main purpose was assumed to be restricted to pathogen killing through production of oxidants. As consequence, neutrophils also may lead to significant collateral damage to the healthy tissues, and after performing these tasks...

journal_title：Journal of leukocyte biology

authors： Mattos MS,Lopes ME,de Araujo AM,Alvarenga DM,Nakagaki BN,Mafra K,de Miranda CDM,Diniz AB,Antunes MM,Lopes MAF,Rezende RM,Menezes GB

更新日期：2020-10-01 00:00:00

abstract：:Previously, we showed that NO induces thymocyte apoptosis via a caspase-1-dependent mechanism [(1) ]. In the present study, we investigated the role of heme oxygenase, catalase, bax, and p53 in this process. The NO donor, S-nitroso-N-acetyl penicillamine (SNAP), induced DNA fragmentation in thymocytes in a time- and c...

journal_title：Journal of leukocyte biology

authors： Gordon SA,Abou-Jaoude W,Hoffman RA,McCarthy SA,Kim YM,Zhou X,Zhang XR,Simmons RL,Chen Y,Schall L,Ford HR

更新日期：2001-07-01 00:00:00

abstract：:We have shown previously that ulcerogenic (type I) strains of Helicobacter pylori (Hp) retard their entry into macrophages. However, the signaling pathways that regulate Hp phagocytosis are largely undefined. We show here that Hp strongly activated class IA phosphoinositide3-kinases (PI3Ks) in macrophages, coincident ...

journal_title：Journal of leukocyte biology

authors： Allen LA,Allgood JA,Han X,Wittine LM

更新日期：2005-07-01 00:00:00

abstract：:Changes in leukocyte subpopulations and function after spaceflight have been observed but the mechanisms underlying these changes are not well defined. This study investigated the effects of short-term spaceflight (8-15 days) on circulating leukocyte subsets, stress hormones, immunoglobulin levels, and neutrophil func...

journal_title：Journal of leukocyte biology

authors： Stowe RP,Sams CF,Mehta SK,Kaur I,Jones ML,Feeback DL,Pierson DL

更新日期：1999-02-01 00:00:00

abstract：:In the present work, we demonstrate that interleukin (IL)-4 is able to rescue B cells from Trypanosoma cruzi-infected mice, counteracting the strong apoptotic signals that these cells received in vivo. We have observed that IL-4 restrains the apoptosis of immunoglobulin (Ig)M(+) and IgG(+) B cells from infected and no...

journal_title：Journal of leukocyte biology

authors： Acosta Rodriguez EV,Zuñiga E,Montes CL,Gruppi A

更新日期：2003-01-01 00:00:00

abstract：:Underlying acquired immunity to the fungus Candida albicans is usually present in adult immunocompetent individuals and is presumed to prevent mucosal colonization progressing to symptomatic infection. Exploration of immunological events leading to Candida resistance or susceptibility has indicated the central role of...

journal_title：Journal of leukocyte biology

authors： Romani L

更新日期：2000-08-01 00:00:00