Phosphoinositide3-kinase regulates actin polymerization during delayed phagocytosis of Helicobacter pylori.

abstract：:C1qR(P) is a type I cell surface glycoprotein that has been shown to enhance ingestion of suboptimally opsonized targets by phagocytes in vitro. In this study, we developed and characterized polyclonal antibodies to study the tissue distribution of this receptor targeted to either the N- or C-terminal portion of the m...

journal_title：Journal of leukocyte biology

authors： Fonseca MI,Carpenter PM,Park M,Palmarini G,Nelson EL,Tenner AJ

更新日期：2001-11-01 00:00:00

abstract：:Extracellular ATP mediates a diverse array of biological responses in many cell types and tissues, including immune cells. We have demonstrated that ATP induces purinergic receptor P2X(7) mediated membrane permeabilization, apoptosis, and cytokine expression in murine mast cells (MCs). Here, we report that MCs deficie...

journal_title：Journal of leukocyte biology

authors： Bulanova E,Budagian V,Orinska Z,Koch-Nolte F,Haag F,Bulfone-Paus S

更新日期：2009-04-01 00:00:00

abstract：:Mycobacterium avium complex (MAC) is a significant cause of opportunistic infection in patients with acquired immunodeficiency syndrome. Although the major route of entry of MAC is via the gastrointestinal tract, MAC can infect humans through the respiratory tract and eventually encounter alveolar macrophages within t...

journal_title：Journal of leukocyte biology

authors： Lopez JP,Clark E,Shepherd VL

更新日期：2003-10-01 00:00:00

abstract：:Both humoral and cellular immune responses are inducible by inoculation of naked plasmid DNA encoding a polypeptide antigen. This new vaccination protocol, known as genetic immunization, has been used to initiate protective immunity against a variety of infectious pathogens and tumors in experimental animals. Dendriti...

journal_title：Journal of leukocyte biology

authors： Takashima A,Morita A

更新日期：1999-08-01 00:00:00

abstract：:Complex syndromes such as atherosclerosis and type 2 diabetes are disorders that are associated with inflammatory processes involving innate and adaptive immunity. Emerging knowledge about the pathological consequences of immune imbalances in a wide range of disease settings is expected to help to identify novel thera...

journal_title：Journal of leukocyte biology

authors： Rose B,Herder C,Löffler H,Kolb H,Martin S

更新日期：2004-04-01 00:00:00

abstract：:HL-60 cells are promyelocytic leukemia cells that respond to culture conditions with differentiation into granulocytelike or macrophagelike phagocytes. O2 metabolism is critical to the microbicidal function of phagocytic cells. O2 metabolism was studied in HL-60 cells differentiated with dimethylsulfoxide (Me2SO) and ...

journal_title：Journal of leukocyte biology

authors： Thompson BY,Sivam G,Britigan BE,Rosen GM,Cohen MS

更新日期：1988-02-01 00:00:00

abstract：:Recent studies have revealed that aloe emodin (AE), a natural compound from the root and rhizome of Rheum palmatum L., exhibits significant pharmacologic activities. However, the pharmacologic relevance of the compound, particularly for cardiovascular disease, remains largely unknown. Here, we hypothesized that AE cou...

journal_title：Journal of leukocyte biology

authors： Zhang Y,Song Z,Huang S,Zhu L,Liu T,Shu H,Wang L,Huang Y,Chen Y

更新日期：2020-12-01 00:00:00

abstract：:Enhancer of zeste homolog 2 (EZH2) is aberrantly expressed or mutated in multiple types of cancer cells and plays an oncogenic role in tumorigenesis and development in most cancers. Results from pilot clinical studies have implied that EZH2 inhibitors have therapeutic potential against some cancers. However, the exact...

journal_title：Journal of leukocyte biology

authors： Shao FF,Chen BJ,Wu GQ

更新日期：2020-10-11 00:00:00

abstract：:During the development of immune responses to pathogens, self-antigens, or environmental allergens, naive CD4(+) T cells differentiate into subsets of effector cells including Th1, Th2, and Th17 cells. The differentiation into these subsets is controlled by specific transcription factors. The activity of these effecto...

journal_title：Journal of leukocyte biology

authors： Chapoval S,Dasgupta P,Dorsey NJ,Keegan AD

更新日期：2010-06-01 00:00:00

abstract：:Secreted IgM (sIgM) is a multifunctional evolutionary conserved antibody that is critical for the maintenance of tissue homeostasis as well as the development of fully protective humoral responses to pathogens. Constitutive secretion of self- and polyreactive natural IgM, produced mainly by B-1 cells, provides a circu...

journal_title：Journal of leukocyte biology

authors： Blandino R,Baumgarth N

更新日期：2019-11-01 00:00:00

abstract：:We studied the tissue distribution of CD6(+) lymphocytes and cells expressing the CD6 ligand (also known as activated leukocyte cell adhesion molecule CD166) in calves by immunohistochemistry using an anti-bovine CD6 monoclonal antibody (mAb), a human CD6 (huCD6)-immunoglobulin G1 fusion protein (huCD6-Ig), and an ant...

journal_title：Journal of leukocyte biology

authors： Konno A,Ahn JS,Kitamura H,Hamilton MJ,Gebe JA,Aruffo A,Davis WC

更新日期：2001-06-01 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains the leading global cause of death from an infectious agent. Mycobacteria thrive within their host Mϕs and presently, there is no animal model that permits combined in vitro and in vivo study of mycobacteria-host Mϕ interactions. Mycoba...

journal_title：Journal of leukocyte biology

authors： Popovic M,Yaparla A,Paquin-Proulx D,Koubourli DV,Webb R,Firmani M,Grayfer L

更新日期：2019-12-01 00:00:00

abstract：:We have shown previously that PCNA, a nuclear factor involved in DNA replication and repair in proliferating cells, is localized exclusively in the cytoplasm of neutrophils, where it regulates their survival. Nuclear PCNA functions are tightly linked to its ring-shaped structure, which allows PCNA to bind to numerous ...

journal_title：Journal of leukocyte biology

authors： De Chiara A,Pederzoli-Ribeil M,Mocek J,Candalh C,Mayeux P,Millet A,Witko-Sarsat V

更新日期：2013-10-01 00:00:00

abstract：:Myeloperoxidase aids in clearance of microbes by generation of peroxidase-mediated oxidants that kill leukocyte-engulfed pathogens. In this review, we will examine 1) strategies for in vitro evaluation of myeloperoxidase function and its inhibition, 2) ways to monitor generation of certain oxidant species during infla...

journal_title：Journal of leukocyte biology

authors： Huang J,Milton A,Arnold RD,Huang H,Smith F,Panizzi JR,Panizzi P

更新日期：2016-04-01 00:00:00

abstract：:Postnatal stem cells regulate the homeostasis of the majority of our tissues. They continuously generate new progenitors and mature, functional cells to replace old cells, which cannot assume the tissue function anymore and are eliminated. Blood, skin, gut mucosa, muscle, cartilage, nerves, cornea, retina, liver, and ...

journal_title：Journal of leukocyte biology

authors： Kindler V

更新日期：2005-10-01 00:00:00

abstract：:TLR agonists such as LPS and poly(I:C) induce expression of type I IFNs, such as IFN-α and -β, by macrophages. To examine the role of IFN-β in the induction of ISGs by LPS, we compared the ability of LPS to induce ISGF3 activity and ISG expression in bone marrow-derived macrophages from WT and Ifnb1(-/-) mice. We foun...

journal_title：Journal of leukocyte biology

authors： Sheikh F,Dickensheets H,Gamero AM,Vogel SN,Donnelly RP

更新日期：2014-10-01 00:00:00

abstract：:Precursors of dendritic cells (pre-DCs) arise in the bone marrow (BM), egress to the blood, and finally migrate to peripheral tissue, where they differentiate to conventional dendritic cells (cDCs). Upon their activation, antigen-bearing cDCs migrate from peripheral tissue to regional lymph nodes (LNs) in a manner dep...

journal_title：Journal of leukocyte biology

authors： Nakano H,Lyons-Cohen MR,Whitehead GS,Nakano K,Cook DN

更新日期：2017-05-01 00:00:00

abstract：:Cytokines and chemokines play an essential role in recruiting leukocytes from the circulation to the peripheral sites of inflammation by modulating cellular interactions with endothelial cell ligands and extracellular matrix (ECM). Herein, we examined regulation of T cell adhesion to ECM ligands by two major proinflam...

journal_title：Journal of leukocyte biology

authors： Ariel A,Novick D,Rubinstein M,Dinarello CA,Lider O,Hershkoviz R

更新日期：2002-07-01 00:00:00

abstract：:Genetic variation in the major histocompatibility complex (MHC) influences susceptibility and immune responses to Mycobacterium tuberculosis in mice and humans, but connections among the severity of tuberculosis (TB), dynamic changes in T cell responses to mycobacteria, and MHC genetic polymorphisms are poorly charact...

journal_title：Journal of leukocyte biology

authors： Pichugin AV,Petrovskaya SN,Apt AS

更新日期：2006-04-01 00:00:00

abstract：:Phagocytosis is the process whereby cells engulf large particles, usually over 0.5 micro m in diameter. Phagocytosis is triggered by the interaction of opsonins that cover the particle to be internalized with specific receptors on the surface of the phagocyte. The best-studied phagocytic receptors include the Fc recep...

journal_title：Journal of leukocyte biology

authors： García-García E,Rosales C

更新日期：2002-12-01 00:00:00

abstract：:Monocyte chemoattractant protein-1 (MCP-1, CCL2) is a mediator of inflammation that has been implicated in the pathogenesis of a wide variety of human diseases. CCR2, a heterotrimeric G-coupled receptor, is the only known receptor that functions at physiologic concentrations of MCP-1. Despite the importance of CCR2 in...

journal_title：Journal of leukocyte biology

authors： Schecter AD,Berman AB,Yi L,Ma H,Daly CM,Soejima K,Rollins BJ,Charo IF,Taubman MB

更新日期：2004-06-01 00:00:00

abstract：:Although corneal allotransplantation is performed in the immune-privileged cornea, many grafts are still rejected after transplantation. This study examined the role of chemokine receptor D6 expression in a corneal allograft rejection, investigated the modulation of D6 expression in cells, and determined the effect of...

journal_title：Journal of leukocyte biology

authors： Choi W,Byun YJ,Jung E,Noh H,Hajrasouliha AR,Sadrai Z,Chang E,Lee JH,Lee HK

更新日期：2015-02-01 00:00:00

abstract：:Recombinant fusion proteins consisting of the extracellular domain of immunoregulatory proteins and the constant domain of immunoglobulin G (IgG) are a novel class of human therapeutics. IgG isoforms exert different levels of immune effector functions, such as complement lysis and antibody-dependent cell cytotoxicity ...

journal_title：Journal of leukocyte biology

authors： Taylor L,Bachler M,Duncan I,Keen S,Fallon R,Mair C,McDonald TT,Schwarz H

更新日期：2002-09-01 00:00:00

abstract：:Neutrophil-induced damage to the protective epithelium has been implicated in mucosal disorders associated with hypoxia, and such damage may be initiated by epithelial-derived chemokines. Because chemokines can bind to membrane proteoglycans, we hypothesized that chemokines may associate with epithelial surfaces and a...

journal_title：Journal of leukocyte biology

authors： Furuta GT,Dzus AL,Taylor CT,Colgan SP

更新日期：2000-08-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA), a member of the immunoglobulin supergene family, is recognized by a specific 80-kd receptor on Kupffer cells and alveolar macrophages. Peritoneal macrophages were harvested from male Sprague-Dawley rats 72 h after intraperitoneal injection with thioglycolate broth and from unstimulated ...

journal_title：Journal of leukocyte biology

authors： Toth CA

更新日期：1992-05-01 00:00:00

abstract：:We reported previously that N-myc downstream-regulated gene 2 (NDRG2), a member of a new family of differentiation-related genes, is expressed specifically in dendritic cells (DC) differentiated from monocytes, CD34(+) progenitor cells, and the myelomonocytic leukemic cell line. In this study, we demonstrate that NDRG...

journal_title：Journal of leukocyte biology

authors： Choi SC,Kim KD,Kim JT,Kim JW,Lee HG,Kim JM,Jang YS,Yoon DY,Kim KI,Yang Y,Cho DH,Lim JS

更新日期：2008-01-01 00:00:00

abstract：:Although a number of chemokine receptors display coreceptor activities in vitro, chemokine receptor 5 (CCR5) and CXC chemokine receptor 4 (CXCR4) remain the major coreceptors used by the human immunodeficiency virus type 1 (HIV-1). In this study, we used an envelope-mediated fusion assay to demonstrate low CCR4 corece...

journal_title：Journal of leukocyte biology

authors： Agrawal L,Vanhorn-Ali Z,Alkhatib G

更新日期：2002-11-01 00:00:00

abstract：:Alveolar macrophages from chronic obstructive pulmonary disease patients and cigarette smokers are deficient in their ability to phagocytose apoptotic bronchial epithelial cells (efferocytosis). We hypothesized that the defect is mediated via inhibition of sphingosine kinases and/or their subcellular mislocalization i...

journal_title：Journal of leukocyte biology

authors： Tran HB,Barnawi J,Ween M,Hamon R,Roscioli E,Hodge G,Reynolds PN,Pitson SM,Davies LT,Haberberger R,Hodge S

更新日期：2016-07-01 00:00:00

abstract：:In the present study, we investigated the expression of human CD1d antigen on activated mature T cells. Expression of this glycoprotein was found to be highly regulated and dependent on PHA stimulation. Flow cytometry studies using the NOR3.2 antibody, which recognized CD1d under denaturing conditions, showed a clear ...

journal_title：Journal of leukocyte biology

authors： Salamone MC,Rabinovich GA,Mendiguren AK,Salamone GV,Fainboim L

更新日期：2001-02-01 00:00:00

abstract：:Resting microglia comprise up to 13% of the cells in human central nervous system (CNS) white matter. Their large number and dendritic morphology make them ideally suited to survey the CNS for noxious stimuli. Upon activation microglia gradually lose dendritic processes and transform into typical phagocytic macrophage...

journal_title：Journal of leukocyte biology

authors： Ulvestad E,Williams K,Bjerkvig R,Tiekotter K,Antel J,Matre R

更新日期：1994-12-01 00:00:00