Abstract:
:Changes in leukocyte subpopulations and function after spaceflight have been observed but the mechanisms underlying these changes are not well defined. This study investigated the effects of short-term spaceflight (8-15 days) on circulating leukocyte subsets, stress hormones, immunoglobulin levels, and neutrophil function. At landing, a 1.5-fold increase in neutrophils was observed compared with preflight values; lymphocytes were slightly decreased, whereas the results were variable for monocytes. No significant changes were observed in plasma levels of immunoglobulins, cortisol, or adrenocorticotropic hormone. In contrast, urinary epinephrine, norepinephrine, and cortisol were significantly elevated at landing. Band neutrophils were observed in 9 of 16 astronauts. Neutrophil chemotactic assays showed a 10-fold decrease in the optimal dose response after landing. Neutrophil adhesion to endothelial cells was increased both before and after spaceflight. At landing, the expression of MAC-1 was significantly decreased while L-selectin was significantly increased. These functional alterations may be of clinical significance on long-duration space missions.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Stowe RP,Sams CF,Mehta SK,Kaur I,Jones ML,Feeback DL,Pierson DLdoi
10.1002/jlb.65.2.179subject
Has Abstractpub_date
1999-02-01 00:00:00pages
179-86issue
2eissn
0741-5400issn
1938-3673journal_volume
65pub_type
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