当前位置： SCI文献检索 > JOURNAL OF LEUKOCYTE BIOLOGY期刊下所有文献 > A monoclonal antibody specific for immunoglobulin A receptor triggers polymorphonuclear neutrophil superoxide release.

A monoclonal antibody specific for immunoglobulin A receptor triggers polymorphonuclear neutrophil superoxide release.

Abstract：

:An immunoglobulin M (IgM) monoclonal antibody, My43, specific for IgA Fc receptor (Fc alpha R) on human monocytes, bound to human polymorphonuclear neutrophils (PMNs) and inhibited their ability to bind IgA but not IgG. It was observed that the PMN oxidative burst was induced by both polymeric IgA and aggregated IgG, whereas IgM was without effect. The IgG-mediated oxidative burst was inhibited by anti-Fc gamma RII Fab and anti-Fc gamma RIII F(ab')2 but not by My43. Conversely, the IgA-mediated oxidative burst was inhibited by My43 but not by anti-Fc gamma RII or anti-Fc gamma RIII. When anti-Fc receptor monoclonal antibodies (mAbs) were used directly as ligands, it was observed that both anti-Fc gamma RII Fab and anti-Fc gamma RII F(ab')2 promoted the oxidative burst when cross-linked. Moreover, My43, when cross-linked with F(ab')2 antimouse IgM, also triggered the oxidative burst, whereas an IgM anti-CD15 mAb, PM81, did not stimulate function. This demonstrates that IgA receptors on PMNs are function-triggering molecules and that an anti-IgA receptor mAb may be substituted as a ligand.

journal_name

J Leukoc Biol

journal_title

Journal of leukocyte biology

authors

Shen L

doi

10.1002/jlb.51.4.373

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

373-8

issue

4

eissn

0741-5400

issn

1938-3673

journal_volume

51

pub_type

杂志文章

相关文献

JOURNAL OF LEUKOCYTE BIOLOGY文献大全
  • miR-181c-BRK1 axis plays a key role in actin cytoskeleton-dependent T cell function.

    abstract：:MicroRNAs are short endogenous noncoding RNAs that play pivotal roles in a diverse range of cellular processes. The miR-181 family is important in T cell development, proliferation, and activation. In this study, we have identified BRK1 as a potential target of miR-181c using a dual selection functional assay and have...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/JLB.1A0817-325RR

    authors： Lim SP,Ioannou N,Ramsay AG,Darling D,Gäken J,Mufti GJ

    更新日期：2018-05-01 00:00:00

  • Production and characterization of monoclonal antibodies to Fc gamma 2a-binding protein isolated from the detergent lysate of a murine macrophagelike cell line, P388D1.

    abstract：:Hybridoma cell lines were produced by fusion of SP2/0 murine myeloma cell line with the spleen cells of Wister rats which were immunized with IgG2a-binding protein isolated from the detergent lysate of a murine macrophagelike cell line, P388D1, by affinity chromatography on IgG-Sepharose 4B. A monoclonal clone (design...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.45.4.311

    authors： Kagami M,Funatsu Y,Suzuki T

    更新日期：1989-04-01 00:00:00

  • Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells.

    abstract：:4-1BB is a member of the TNFR superfamily, which contributes to the activation of signaling pathways required for the survival of activated and memory T cells. We have shown previously that TRAF1, an adaptor protein recruited to 4-1BB, is required for 4-1BB-mediated CD8 T cell survival in vivo. With the use of a prote...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.1112579

    authors： Sabbagh L,Andreeva D,Laramée GD,Oussa NA,Lew D,Bisson N,Soumounou Y,Pawson T,Watts TH

    更新日期：2013-05-01 00:00:00

  • Phenylhydrazine-induced leukocytosis in the rat.

    abstract：:Rats were injected with phenylhydrazine (PHZ) for periods of up to 6 months, during which time a marked leukocytosis was induced. The highest leukocyte counts occurred within 4-5 days following injection. An initial injection of 4 mg/100 gm body weight evoked a mean total leukocyte count of 129 X 10(3) cells/microlite...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.39.1.37

    authors： Dornfest BS,Lapin DM,Naughton BA,Adu S,Korn L,Gordon AS

    更新日期：1986-01-01 00:00:00

  • CD14+CD33+ myeloid cell-CCL11-eosinophil signature in ulcerative colitis.

    abstract：:This study tested the hypothesis that eotaxins (CCL11, CCL24, and CCL26) and IL-5 contribute to eosinophil recruitment to the intestine in UC and that intestinal macrophages are important producers of CCL11 in this disease. Peripheral blood and rectal biopsy samples were obtained from patients with active (n=18) and q...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.1212640

    authors： Lampinen M,Waddell A,Ahrens R,Carlson M,Hogan SP

    更新日期：2013-11-01 00:00:00

  • Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells.

    abstract：:Antigen presentation to T lymphocytes has been characterized extensively in terms of T lymphocyte activation and eventual cell death. In contrast, little is known about the consequences of antigen presentation for the antigen-presenting cell (APC). We have determined the outcome of major histocompatibility complex cla...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0703356

    authors： Setterblad N,Blancheteau V,Delaguillaumie A,Michel F,Bécart S,Lombardi G,Acuto O,Charron D,Mooney N

    更新日期：2004-06-01 00:00:00

  • It takes nerve to tell T and B cells what to do.

    abstract：:The existence of an association between the brain and immunity has been documented. Data show that the nervous and immune systems communicate with one another to maintain immune homeostasis. Activated immune cells secrete cytokines that influence central nervous system activity, which in turn, activates output through...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1189/jlb.1105625

    authors： Kin NW,Sanders VM

    更新日期：2006-06-01 00:00:00

  • MIC-1 is a novel TGF-beta superfamily cytokine associated with macrophage activation.

    abstract：:As part of a study to identify novel genes associated with macrophage activation, we have cloned a new member of the transforming growth factor beta (TGF-beta) superfamily designated macrophage inhibitory cytokine 1 (MIC-1). MIC-1 is synthesized as a 62-kDa intracellular protein, which, after cleavage by a furin like ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1002/jlb.65.1.2

    authors： Fairlie WD,Moore AG,Bauskin AR,Russell PK,Zhang HP,Breit SN

    更新日期：1999-01-01 00:00:00

  • HIV replication in chronically infected macrophages is not inhibited by the Tat inhibitors Ro-5-3335 and Ro-24-7429.

    abstract：:Human immunodeficiency virus infects different cell types including CD4+ lymphocytes and monocyte-derived macrophages (MDMs). We have examined the activity of the HIV-1 Tat inhibitors Ro-5-3335 and Ro-24-7429 in cultured human peripheral MDMs. Monocytes were isolated from HIV-seronegative donors by gradient centrifuga...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.56.3.369

    authors： Dunne AL,Siregar H,Mills J,Crowe SM

    更新日期：1994-09-01 00:00:00

  • Partial characterization of a mitomycin-C resistant T cell.

    abstract：:A cell resistant to concentrations of mitomycin-C associated with the inactivation of many in vitro immune responses is described. This cell is responsive to concanavalin A (Con A), poorly adherent to nylon wool, present in relatively greater numbers in lymph node than other lymphoid tissues, and is relatively radiose...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.41.1.33

    authors： Anderson RE,Standefer JC,Troup GM,Pogue LE

    更新日期：1987-01-01 00:00:00

  • Regulation of CD 163 on human macrophages: cross-linking of CD163 induces signaling and activation.

    abstract：:CD163 is a member of the group B scavenger receptor cysteine-rich (SRCR) superfamily. This study describes aspects of the tissue distribution, the regulation of expression, and signal transduction after cross-linking of this receptor at the cell surface of macrophages. CD163 showed an exclusive expression on resident ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.66.5.858

    authors： Van den Heuvel MM,Tensen CP,van As JH,Van den Berg TK,Fluitsma DM,Dijkstra CD,Döpp EA,Droste A,Van Gaalen FA,Sorg C,Högger P,Beelen RH

    更新日期：1999-11-01 00:00:00

  • Differential production of tumor necrosis factor, macrophage colony stimulating factor, and interleukin 1 by human alveolar macrophages.

    abstract：:Human alveolar macrophages (AMO) have been investigated for their ability to produce three monokines, tumor necrosis factor-alpha (TNF), macrophage colony stimulating factor (CSF-1), and interleukin 1-beta (IL-1). No TNF activity was found in supernatants of unstimulated AMO cultured for 20 h, although TNF mRNA was de...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：

    authors： Becker S,Devlin RB,Haskill JS

    更新日期：1989-04-01 00:00:00

  • Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase.

    abstract：:SHP-1 is a cytoplasm protein tyrosine phosphatase expressed primarily in hematopoietic cells. In the immune system, SHP-1 plays critical roles in regulation of many receptor-mediated signaling cascades, and SHP-1 deficiency in mice causes spontaneous inflammation and autoimmunity. Here, we report a unique requirement ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0409289

    authors： Zhou D,Collins CA,Wu P,Brown EJ

    更新日期：2010-05-01 00:00:00

  • Neutrophil activation in sickle cell disease.

    abstract：:Vascular occlusion is the main cause of the morbidity and mortality observed in patients with sickle cell disease (SCD). Increasing evidence indicates that (activated) neutrophils could play an important role in the initiation and propagation of vaso-occlusive processes in SCD. In this study, the activation state of n...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.66.3.411

    authors： Lard LR,Mul FP,de Haas M,Roos D,Duits AJ

    更新日期：1999-09-01 00:00:00

  • Effects of LPS-mediated bystander activation in the innate immune system.

    abstract：:LPS induces dendritic cell (DC) activation, but the precise in vivo mechanism is unclear since DCs express low levels of TLR4. Here, it is shown that DCs can be activated in response to LPS through a bystander mechanism. This result was obtained using chimeric mice reconstituted with LPS-responsive and nonresponsive b...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0406253

    authors： Yadav R,Zammit DJ,Lefrancois L,Vella AT

    更新日期：2006-12-01 00:00:00

  • Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPAR(gamma):RXR heterodimers: comparison with other polyunsaturated fatty acids.

    abstract：:There is accumulating evidence that omega-3 fatty acids may modulate immune responses. When monocytes were differentiated to dendritic cells (DCs) in the presence of docosahexaenoic acid (DHA), the expression of costimulatory and antigen presentation markers was altered in a concentration-dependent way, positively or ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.1007688

    authors： Zapata-Gonzalez F,Rueda F,Petriz J,Domingo P,Villarroya F,Diaz-Delfin J,de Madariaga MA,Domingo JC

    更新日期：2008-10-01 00:00:00

  • Infection of a murine T-cell line with a retrovirus carrying c-myc decreases the interleukin-2 cell dependence by a nonautocrine mechanism.

    abstract：:A murine interleukin-2 (IL-2)-dependent T-cell line, CTLL-2, was infected with a retrovirus carrying the mouse c-myc cDNA and the Tn-5 neogene. Transduced cells were selected in the presence of Geneticin sulfate (G418); these cells were shown to express both the endogenous and the transduced c-myc genes. The IL-2 requ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.44.6.559

    authors： Shapiro IM,Winberg G,Stefanescu I,Wigzell H,Menezes J

    更新日期：1988-12-01 00:00:00

  • Role of IFN-γ in the establishment of anterior chamber-associated immune deviation (ACAID)-induced CD8+ T regulatory cells.

    abstract：:Introduction of alloantigens into the AC induces a form of immune tolerance known as ACAID, which induces antigen-specific CD8+ Tregs, contributing to ocular immune privilege by down-regulating immune responses. Recent evidence suggests IFN-γ is needed for the suppressive function of CD8+ ACAID Tregs. This study teste...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.0311173

    authors： Paunicka K,Chen PW,Niederkorn JY

    更新日期：2012-03-01 00:00:00

  • CD56bright NK IL-7Rα expression negatively associates with HCV level, and IL-7-induced NK function is impaired during HCV and HIV infections.

    abstract：:Several lines of evidence support the concept that NK cells play an important role in control of hepatitis C virus (HCV) infection via cytokine secretion and cytotoxicity. IL-7 is a homeostatic cytokine with a role in T cell development, activation, proliferation, and cytokine secretion. The IL-7Rα chain [cluster of d...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.5A1116-456R

    authors： Judge CJ,Kostadinova L,Sherman KE,Butt AA,Falck-Ytter Y,Funderburg NT,Landay AL,Lederman MM,Sieg SF,Sandberg JK,Anthony DD

    更新日期：2017-07-01 00:00:00

  • The polysaccharide capsule of Cryptococcus neoformans interferes with human dendritic cell maturation and activation.

    abstract：:The ability of encapsulated and acapsular strains of Cryptococcus neoformans to activate dendritic cells (DC) derived from monocytes stimulated with granulocyte macrophage-colony stimulating factor and interleukin-4 was evaluated. Profound differences in DC response to encapsulated and acapsular C. neoformans strains ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.1002476

    authors： Vecchiarelli A,Pietrella D,Lupo P,Bistoni F,McFadden DC,Casadevall A

    更新日期：2003-09-01 00:00:00

  • CTLA4-CD80/CD86 interactions on primary mouse CD4+ T cells integrate signal-strength information to modulate activation with Concanavalin A.

    abstract：:The mechanisms by which concanavalin A (Con A), a lectin, activates T cells are poorly studied. A low dose of Con A is stimulatory for T cells, whereas a high dose of Con A results in suppression of proliferation and enhanced T cell death. The expression and functional roles of costimulatory receptors, CD28 and cytoto...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.1104644

    authors： Mukherjee S,Ahmed A,Nandi D

    更新日期：2005-07-01 00:00:00

  • CD4+/CD8+ double-positive T cells: more than just a developmental stage?

    abstract：:CD4(+)/CD8(+) DP thymocytes are a well-described T cell developmental stage within the thymus. However, once differentiated, the CD4(+) lineage or the CD8(+) lineage is generally considered to be fixed. Nevertheless, mature CD4(+)/CD8(+) DP T cells have been described in the blood and peripheral lymphoid tissues of nu...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1189/jlb.1RU0814-382

    authors： Overgaard NH,Jung JW,Steptoe RJ,Wells JW

    更新日期：2015-01-01 00:00:00

  • Adhesion to extracellular matrix proteins modulates bovine neutrophil responses to inflammatory mediators.

    abstract：:The neutrophil inflammatory response can be altered profoundly by contact with extracellular matrix proteins (ECMs). We characterized functional responses (intracellular calcium, actin polymerization, degranulation, adhesion, and oxidative burst) of bovine neutrophils adhered to selected ECM proteins [collagen IV, lam...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：

    authors： Borgquist JD,Quinn MT,Swain SD

    更新日期：2002-05-01 00:00:00

  • Characteristics of binding of a potent chemotactic formyl tetrapeptide, formylmethionyl-leucyl-phenylalanyl-phenylalanine, to the receptors on rabbit neutrophils.

    abstract：:Binding of a potent chemotactic formyl tetrapeptide, formylmethionyl-leucyl-phenylalanyl-phenylalanine (fMet-Leu-Phe-Phe), to the formyl peptide receptors on the rabbit neutrophil was assessed by two approaches. A tritiated preparation of fMet-Leu-Phe-Phe was used for direct binding studies, whereas indirect studies c...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.43.5.420

    authors： Kermode JC,Muthukumaraswamy N,Freer RJ

    更新日期：1988-05-01 00:00:00

  • Changes in peritoneal myeloid populations and their proinflammatory cytokine expression during infection with Listeria monocytogenes are altered in the absence of gamma/delta T cells.

    abstract：:Evidence that gamma/delta T cells play a broad, immunoregulatory role has been accumulating steadily. We show here that myeloid cells are disregulated after peritoneal infection with Listeria monocytogenes in mice lacking gamma/delta T cells. Inflammatory populations of neutrophils and monocytes recruited to the site ...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1189/jlb.1103574

    authors： Skeen MJ,Freeman MM,Ziegler HK

    更新日期：2004-07-01 00:00:00

  • Role of IFN-gamma on dissociation between nitric oxide and TNF/IL-6 production by murine peritoneal cells after restimulation with bacterial lipopolysaccharide.

    abstract：:Murine peritoneal exudate cells (PEC) pre-exposed to bacterial lipopolysaccharide (LPS) show augmented nitric oxide (NO) production by LPS restimulation, in contrast to LPS tolerance with reduced production of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6). Significant amounts of interferon-gamma (IF...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.66.6.974

    authors： Tominaga K,Saito S,Matsuura M,Funatogawa K,Matsumura H,Nakano M

    更新日期：1999-12-01 00:00:00

  • Aspergillus fumigatus antigen induced eosinophilia in mice is abrogated by anti-IL-5 antibody.

    abstract：:A murine model of allergic bronchopulmonary aspergillosis (ABPA), developed by exposure to Aspergillus fumigatus antigens, demonstrated eosinophilia of peripheral blood (PB), bone marrow (BM), and lung. The eosinophilia was abrogated by monoclonal anti-interleukin-5 (IL-5) antibody (TRFK-5) and not by an isotype contr...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：10.1002/jlb.53.3.264

    authors： Murali PS,Kumar A,Choi H,Banasal NK,Fink JN,Kurup VP

    更新日期：1993-03-01 00:00:00

  • The immune response in autism: a new frontier for autism research.

    abstract：:Autism spectrum disorders (ASD) are part of a broad spectrum of neurodevelopmental disorders known as pervasive developmental disorders, which occur in childhood. They are characterized by impairments in social interaction, verbal and nonverbal communication and the presence of restricted and repetitive stereotyped be...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章,评审

    doi：10.1189/jlb.1205707

    authors： Ashwood P,Wills S,Van de Water J

    更新日期：2006-07-01 00:00:00

  • MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8.

    abstract：:The viral CC chemokines MC148, encoded by the poxvirus molluscum contagiosum, and viral macrophage inflammatory protein (vMIP)-I and vMIP-II, encoded by human herpesvirus 8, were probed on the murine CC receptor (CCR) 8 in parallel with human CCR8. In calcium mobilization assays, vMIP-I acted as a high-affinity agonis...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：

    authors： Lüttichau HR,Gerstoft J,Schwartz TW

    更新日期：2001-08-01 00:00:00

  • Antagonistic effects of IL-4 and TGF-beta1 on Langerhans cell-related antigen expression by human monocytes.

    abstract：:In this study, we analyzed the specific effects of transforming growth factor beta (TGF-beta1) and/or IL-4 on monocyte-derived cells. Monocytes were cultured with GM-CSF, GM-CSF/TGF-beta1, GM-CSF/IL-4, or GM-CSF/IL-4/TGF-beta1 before cell morphology, phenotype, and function were assessed. As expected, interleukin-4 is...

    journal_title：Journal of leukocyte biology

    pub_type： 杂志文章

    doi：

    authors： Guironnet G,Dezutter-Dambuyant C,Vincent C,Bechetoille N,Schmitt D,Péguet-Navarro J

    更新日期：2002-05-01 00:00:00