CD4+/CD8+ double-positive T cells: more than just a developmental stage?

abstract：:Glucocorticoids (GC) are potent anti-inflammatory and immunosuppressive agents that act on a variety of immune cells, including T cells, monocytes/macrophages, osteoclasts, and dendritic cells (DC). However, the mechanism(s) by which GC exert anti-inflammatory effects is still largely unknown. It is already well known...

journal_title：Journal of leukocyte biology

authors： Kim KD,Choe YK,Choe IS,Lim JS

更新日期：2001-03-01 00:00:00

abstract：:Subcutaneous injection of recombinant human interleukin-2 (rhuIL-2) at 10(2)-10(4) U/mouse induced delayed (48 h) accumulation of mononuclear leukocytes with diffuse granulocytes, including eosinophils. Subcutaneous local infusion of rhuIL-2 or recombinant murine IL-2 (10(2)-10(4) U/mouse) via implanted Alzet miniosmo...

journal_title：Journal of leukocyte biology

authors： Dunn CJ,Hardee MM,Fidler SF,Shields SK,Chosay JG

更新日期：1996-07-01 00:00:00

abstract：:An epithelial cell line, IT-45R1, has been established from a thymus of normal Wistar rat and was found to produce growth factor which stimulated the proliferation of bone marrow cells. This growth factor induced the formation of colonies composed of macrophages, granulocytes, or both, in semi-solid medium and stimula...

journal_title：Journal of leukocyte biology

authors： Nanno M,Takahashi T,Sakata T,Horikawa T,Sako T,Suzuki R,Itoh T,Kumagai K

更新日期：1991-12-01 00:00:00

abstract：:The oxidative burst of polymorphonuclear neutrophils (PMN) and their ability to inhibit Paracoccidioides brasiliensis growth was studied in susceptible (B10.A) and resistant (A/J) mice. The cells were obtained after subcutaneous inoculation in air pouches, yielding highly pure PMN preparations; the number of cells was...

journal_title：Journal of leukocyte biology

authors： Meloni-Bruneri LH,Campa A,Abdalla DS,Calich VL,Lenzi HL,Burger E

更新日期：1996-04-01 00:00:00

abstract：:Genomic, transcriptomic and proteomic databases indicate that the N-terminal 322 residues encoded by the presumptive LOC100996504 gene, which is adjacent to the ARHGEF18 guanine nucleotide exchange factor gene on chromosome 19, constitute the N-terminal portion of a 1361-residue isoform of ARHGEF18, dubbed LOCGEF-X3. ...

journal_title：Journal of leukocyte biology

authors： Turton KB,Wilkerson EM,Hebert AS,Fogerty FJ,Schira HM,Botros FE,Coon JJ,Mosher DF

更新日期：2018-07-01 00:00:00

abstract：:MRL/fas(lpr) mice, which undergo a systemic autoimmune disease with similarities to systemic lupus erythematosus (SLE), display reduced pathology and prolonged survival if rendered deficient in ICAM-1. However, it remains unclear whether this is a result of the ability of ICAM-1 to promote the immune response or media...

journal_title：Journal of leukocyte biology

authors： Norman MU,James WG,Hickey MJ

更新日期：2008-07-01 00:00:00

abstract：:PI(3)Kγ is thought to mediate leukocyte migration to injured tissues and may be important in the pathogenesis of various T-lymphocyte-dependent pathologies, including autoimmune and inflammatory diseases. The present study evaluated the relevance of PI(3)Kγ in donor cells for the pathogenesis of acute GVHD using a mod...

journal_title：Journal of leukocyte biology

authors： Castor MG,Rezende BM,Bernardes PT,Vieira AT,Vieira EL,Arantes RM,Souza DG,Silva TA,Teixeira MM,Pinho V

更新日期：2011-06-01 00:00:00

abstract：:Neutrophil's responses to G protein-coupled chemoattractants are highly dependent on store-operated calcium (Ca(2+)) entry (SOCE). Platelet-activating factor (PAF), a primary chemoattractant, simultaneously increases cytosolic-free Ca(2+), intracellular pH (pH(i)), ERK1/2, and Akt/protein kinase B (PKB) phosphorylatio...

journal_title：Journal of leukocyte biology

authors： Sandoval AJ,Riquelme JP,Carretta MD,Hancke JL,Hidalgo MA,Burgos RA

更新日期：2007-11-01 00:00:00

abstract：:During highly active antiretroviral therapy (HAART), HIV-1 can still persist in circulating, resting CD4+ T lymphocytes, lymph node mononuclear cells, and seminal cells of patients despite sustained suppression of plasma viremia to undetectable levels. Sanctuary sites where antiretroviral drug penetration is not optim...

journal_title：Journal of leukocyte biology

authors： Crowe SM,Sonza S

更新日期：2000-09-01 00:00:00

abstract：:Many intracellular signals, such as host danger-associated molecules and bacterial toxins during infection, elicit inflammasome activation. However, the mechanical environment in tissues may also influence the sensitivity of various inflammasomes to activation. The cellular mechanical environment is determined by the ...

journal_title：Journal of leukocyte biology

authors： Joshi H,Morley SC

更新日期：2019-07-01 00:00:00

abstract：:Rac2 is a hematopoietic-specific Rho-GTPase that plays a stimulus-specific role in regulating reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation and other functional responses in neutrophils. In this study, rac2-/- neutrophils were shown to have significantly decreased NADPH oxidase activit...

journal_title：Journal of leukocyte biology

authors： Kim C,Dinauer MC

更新日期：2006-01-01 00:00:00

abstract：:Previously, we described a novel glycosylphosphatidyl inositol (GPI)-anchored glycoprotein (designated GPI-80) on human neutrophils and monocytes that may regulate beta(2) integrin-dependent neutrophil adherence and migration. However, the mechanism regulating beta(2) integrin remains to be clarified. To study this, w...

journal_title：Journal of leukocyte biology

authors： Yoshitake H,Takeda Y,Nitto T,Sendo F

更新日期：2002-02-01 00:00:00

abstract：:Previous work indicated that macrophages and a lymphoid dendritic cell-like tumor line, P388AD.2, possessed a differential ability to present a haptenated immunoglobulin (tolerogen) in vitro. Macrophages presented fluorescein-conjugated sheep gamma globulin (FL-SGG) and elicited B-cell unresponsiveness. In contrast, P...

journal_title：Journal of leukocyte biology

authors： Phipps RP,Illig K,Schad V,Bhimani K

更新日期：1988-03-01 00:00:00

abstract：:Neovascularization, the process of new blood vessel growth, is an important feature of many pathologic and physiologic processes. Monocytes were isolated from citrated blood buffy coat of healthy adult human donors on Ficoll-Hypaque gradients. Mononuclear cells from these gradients were fractionated on discontinuous P...

journal_title：Journal of leukocyte biology

authors： Koch AE,Polverini PJ,Leibovich SJ

更新日期：1986-02-01 00:00:00

abstract：:Th cells have long been recognized as vital components of the adaptive immune system. Until recently, CD3(+)CD4(+) Th cells were divided into cell-mediated Th1 or humoral Th2 responses. However, the Th1-Th2 hypothesis failed to accommodate the more recently described Th17 cells. Today, the major Th cell subsets includ...

journal_title：Journal of leukocyte biology

authors： Rendon JL,Choudhry MA

更新日期：2012-09-01 00:00:00

abstract：:On the surface of the macrophage, annexin A2 tetramer (A2t) serves as a docking protein or recognition element for bacterial and viral pathogens. Plasma levels of free A2t have been reported to increase following infection, although the mechanistic significance of this observation is unclear. Although annexin A2 had g...

journal_title：Journal of leukocyte biology

authors： Swisher JF,Khatri U,Feldman GM

更新日期：2007-11-01 00:00:00

abstract：:Alcohol-induced neuroinflammation is mediated by proinflammatory cytokines, including IL-1β. IL-1β production requires caspase-1 activation by inflammasomes-multiprotein complexes that are assembled in response to danger signals. We hypothesized that alcohol-induced inflammasome activation contributes to increased IL-...

journal_title：Journal of leukocyte biology

authors： Lippai D,Bala S,Petrasek J,Csak T,Levin I,Kurt-Jones EA,Szabo G

更新日期：2013-07-01 00:00:00

abstract：:Healthy donors infused with high doses of glucocorticoids [GCs; methyl-prednisolone (MP); 500 mg/day for 3 days] suffer a selective depletion of the CD14(+)CD16(+) monocytes such that these cells are reduced by 95% on day 5. In vitro studies revealed that at 11 h of culture in the presence of 10(-)(5) M MP, no depleti...

journal_title：Journal of leukocyte biology

authors： Dayyani F,Belge KU,Frankenberger M,Mack M,Berki T,Ziegler-Heitbrock L

更新日期：2003-07-01 00:00:00

abstract：:Endocytic proteolysis represents a major functional component of the major histocompatibility complex class II antigen-presentation machinery. Although transport and assembly of class II molecules in the endocytic compartment are well characterized, we lack information about the pattern of endocytic protease activity ...

journal_title：Journal of leukocyte biology

authors： Lautwein A,Kraus M,Reich M,Burster T,Brandenburg J,Overkleeft HS,Schwarz G,Kammer W,Weber E,Kalbacher H,Nordheim A,Driessen C

更新日期：2004-05-01 00:00:00

abstract：:We have shown previously that the cellular proteins 47b and 71/73 could be used to construct phenotypes that distinguish among bone marrow culture-derived (BMCD) macrophages that were either unstimulated or primed by gamma interferon or fully activated for tumor cell killing by gamma interferon in combination with lip...

journal_title：Journal of leukocyte biology

authors： MacKay RJ,Russell SW

更新日期：1987-09-01 00:00:00

abstract：:Matrix metalloproteinases-2 and -9 (MMP-2/9) are critically involved in degradation of extracellular matrix, and their inhibition is discussed as a promising strategy against hepatic ischemia-reperfusion (I/R) injury. Here, we analyzed the role of MMP-2 and -9 for leukocyte migration and tissue injury in sham-operated...

journal_title：Journal of leukocyte biology

authors： Khandoga A,Kessler JS,Hanschen M,Khandoga AG,Burggraf D,Reichel C,Hamann GF,Enders G,Krombach F

更新日期：2006-06-01 00:00:00

abstract：:Neutrophil extracellular traps (NETs), web-like DNA structures, provide efficient means of eliminating invading microorganisms but can also present a potential threat to its host because it is a likely source of autoantigens or by promoting bystander tissue damage. Therefore, it is important to identify mechanisms tha...

journal_title：Journal of leukocyte biology

authors： Zabieglo K,Majewski P,Majchrzak-Gorecka M,Wlodarczyk A,Grygier B,Zegar A,Kapinska-Mrowiecka M,Naskalska A,Pyrc K,Dubin A,Wahl SM,Cichy J

更新日期：2015-07-01 00:00:00

abstract：:Many tumor cells are resistant to Fas-mediated killing, which has been primarily used as a mechanism to evade immune attack. In this study, we found a new action of Fas on tumors where activation of the Fas signal may force tumor cells to produce survival factors for neutrophils. Human peripheral circulating neutrophi...

journal_title：Journal of leukocyte biology

authors： Hor WS,Huang WL,Lin YS,Yang BC

更新日期：2003-03-01 00:00:00

abstract：:The objective of this study was to find the role of LncRNA SNHG12 in the regulation of hypertensive vascular endothelial injury. LncRNA SNHG12 and miR-25-3p expression were detected by quantitative RT-PCR. Protein levels of Sirtuin 6 (SIRT6), endothelial cell (EC) senescence markers p16 and p21, and EC marker CD31 wer...

journal_title：Journal of leukocyte biology

authors： Qian W,Zheng ZQ,Nie JG,Liu LJ,Meng XZ,Sun H,Xiao FM,Kang T

更新日期：2021-01-19 00:00:00

abstract：:Mature macrophages, derived in vitro from bone marrow progenitors under the influence of either macrophage colony stimulating factor (CSF-1) or granulocyte-macrophage (GM)-CSF, have been shown to differ morphologically and functionally. The data presented in this report demonstrate that macrophages derived from bone m...

journal_title：Journal of leukocyte biology

authors： Falk LA,Vogel SN

更新日期：1990-07-01 00:00:00

abstract：:The immune system is armed with a broad range of receptors to detect and initiate the elimination of bacterial pathogens. Inflammasomes are molecular platforms that sense a diverse range of microbial insults to develop appropriate host response. In that context, noncanonical inflammasome arose as a sensor for Gram-neg...

journal_title：Journal of leukocyte biology

authors： Gomes MTR,Cerqueira DM,Guimarães ES,Campos PC,Oliveira SC

更新日期：2019-09-01 00:00:00

abstract：:DCs orchestrate immune responses contributing to the pattern of response developed. In cancer, DCs may play a dysfunctional role in the induction of CD4(+)CD25(+)Foxp3(+) Tregs, contributing to immune evasion. We show here that Mo-DCs from breast cancer patients show an altered phenotype and induce preferentially Treg...

journal_title：Journal of leukocyte biology

authors： Ramos RN,Chin LS,Dos Santos AP,Bergami-Santos PC,Laginha F,Barbuto JA

更新日期：2012-09-01 00:00:00

abstract：:Ketorolac tromethamine, a new nonsteroidal anti-inflammatory agent of the pyrrolo-pyrrole group, was assayed for inhibitory effects on polymorphonuclear leukocytes (PMN) in a variety of systems. Ketorolac inhibited PMN superoxide anion generation, lysozyme release, myeloperoxidase release, adherence to plastic surface...

journal_title：Journal of leukocyte biology

authors： Hyers TM,Tricomi SM,Liao JJ

更新日期：1992-05-01 00:00:00

abstract：:The macrophage mannose receptor (MR) appears to play an important role in the binding and phagocytosis of several human pathogens, but its phagocytic property and signaling pathways have been poorly defined. The general strategy to explore such topics is to express the protein of interest in nonphagocytic cells, but i...

journal_title：Journal of leukocyte biology

authors： Le Cabec V,Emorine LJ,Toesca I,Cougoule C,Maridonneau-Parini I

更新日期：2005-06-01 00:00:00

abstract：:Endotoxin tolerance is characterized by diminished expression of inflammatory cytokines after sequential exposure to Toll-like receptor stimuli. Many mechanisms contribute to tolerance; however, chromatin remodeling appears to be the most significant regulator. The type II interferon, IFN-γ, has been recognized as bei...

journal_title：Journal of leukocyte biology

authors： Shi L,Song L,Maurer K,Sharp J,Zhang Z,Sullivan KE

更新日期：2015-10-01 00:00:00