Mechanism of glucocorticoid-induced depletion of human CD14+CD16+ monocytes.

abstract：:The interaction between CD40 on dendritic cells (DC) and its ligand CD154 has been recognized to be an important feature in the maturation of DC. Here, we were interested in the role of CD44 a surface receptor shown to mediate cell-cell adhesion and binding to Hyaluronic acid (HA). Western blot analysis of human DC st...

journal_title：Journal of leukocyte biology

authors： Termeer C,Johannsen H,Braun T,Renkl A,Ahrens T,Denfeld RW,Lappin MB,Weiss JM,Simon JC

更新日期：2001-11-01 00:00:00

abstract：:We report evidence of a novel mechanism by which polychlorinated biphenyls might act as potent inducers of inflammation. Aroclor 1242 (A1242), a polychlorinated biphenyl mixture, and 2,2',4,4'-tetrachlorobiphenyl (PCB47), a constituent of A1242 that produces the same patterns of effects, impaired the oxidative burst o...

journal_title：Journal of leukocyte biology

authors： Narayanan PK,Carter WO,Ganey PE,Roth RA,Voytik-Harbin SL,Robinson JP

更新日期：1998-02-01 00:00:00

abstract：:Primitive macrophages emerged in the sinusoidal lumen of the fetal mouse liver at 10 days of gestation before the initiation of hepatic hematopoiesis and matured into fetal macrophages. In the culture of cell suspensions from the fetal liver with LP3-conditioned medium, monocyte colonies were formed, but monocytopoies...

journal_title：Journal of leukocyte biology

authors： Naito M,Takahashi K,Nishikawa S

更新日期：1990-07-01 00:00:00

abstract：:Dendritic cells (DCs) are specialized APCs present in all tissues, including tumors. They play a major role in orchestrating immune responses and were shown to occur in various functional states in tumors. In this respect, immunogenic tumor-associated DCs (TADCs) are required to initiate and sustain T cell-dependent a...

journal_title：Journal of leukocyte biology

authors： Keirsse J,Van Damme H,Van Ginderachter JA,Laoui D

更新日期：2017-08-01 00:00:00

abstract：:Glycoprotein 130 (gp130) is a shared receptor utilized by several related cytokines, including IL-6, IL-11, IL-27, Leukemia Inhibitory Factor (LIF), Oncostatin M (OSM), Ciliary Neurotrophic Factor (CNTF), Cardiotrophin 1 (CT-1) and Cardiotrophin-like Cytokine (CLC). Gp130 plays critical roles during development and gp...

journal_title：Journal of leukocyte biology

authors： Silver JS,Hunter CA

更新日期：2010-12-01 00:00:00

abstract：:Notch signaling plays a preeminent role during development in not only regulating cell fate decisions, but it can also influence growth and survival of progenitor cells. In the immune system, Notch is required for the maintenance of hematopoietic stem cells and in directing T- versus B-lineage commitment. In this revi...

journal_title：Journal of leukocyte biology

authors： Hoyne GF

更新日期：2003-12-01 00:00:00

abstract：:The effect of selected monosaccharides on the random migration of normal adult rabbit alveolar macrophages (AM) was investigated. It was observed that 10 mM of L-fucose, L-galactose, or D-mannose stimulated AM migration 1.5-2.0 times. In addition, derivatives of L-fucose and D-mannose occupying the carbon-6 position s...

journal_title：Journal of leukocyte biology

authors： Takata I,Chida K,Gordon MR,Myrvik QN,Ricardo MJ Jr,Kucera LS

更新日期：1987-03-01 00:00:00

abstract：:The magnitude and efficacy of CD8(+) T cell memory may notably regress, especially if immune induction occurs in the absence of adequate CD4(+) help. This report demonstrates that this CD8(+) memory malfunction could be remedied if a source of cognate antigen-recognizing helper cells were provided during recall. The i...

journal_title：Journal of leukocyte biology

authors： Kumaraguru U,Banerjee K,Rouse BT

更新日期：2005-10-01 00:00:00

abstract：:Adherence of monocytes to extracellular matrix components is critical for their accumulation at sites of infection. To gain insight into the factors that regulate monocyte recruitment, we have studied monocyte adherence with regard to the regulatory effects of bacterial lipopolysaccharide (LPS) and the mechanisms invo...

journal_title：Journal of leukocyte biology

authors： Owen CA,Campbell EJ,Stockley RA

更新日期：1992-04-01 00:00:00

abstract：:Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated molecular pattern. Neutrophils present in the mononuclear cell fraction of Ficoll gradient separation are called low-density neutrophils (LDNs). Here we report the novel role of eCIRP on LDNs' heterogeneity in sepsis. Sepsis was induced in...

journal_title：Journal of leukocyte biology

authors： Takizawa S,Murao A,Ochani M,Aziz M,Wang P

更新日期：2020-10-18 00:00:00

abstract：:Pulmonary macrophages (Mphi) increase in tissue and bronchoalveolar lavage (BAL) fluid during inflammation caused by bleomycin (BLM). This study demonstrates that increasing numbers of exudate Mphi in BLM lung injury exhibit dendritic cell (DC) features. After the intratracheal administration of BLM (0.075 U), adheren...

journal_title：Journal of leukocyte biology

authors： Tager AM,Luster AD,Leary CP,Sakamoto H,Zhao LH,Preffer F,Kradin RL

更新日期：1999-12-01 00:00:00

abstract：:p67(phox) is the paramount cytosolic regulator of the superoxide-generating Nox of phagocytes, by controlling the conformation of the catalytic component, Nox2. The initiating event of this process is a protein-protein interaction between p67(phox) and the part of Nox2 protruding into the cytosol, known as the dehydro...

journal_title：Journal of leukocyte biology

authors： Dahan I,Smith SM,Pick E

更新日期：2015-11-01 00:00:00

abstract：:Macrophages play major roles in the onset of immune responses and inflammation by inducing a variety of cytokines such as TNF and IFN-beta. The pathogen-associated molecular pattern, polyinosinic-polycytidylic acid [poly(I:C)], and LPS were used to study type-I IFN and TNF responses in human macrophages. Additionally,...

journal_title：Journal of leukocyte biology

authors： Reimer T,Brcic M,Schweizer M,Jungi TW

更新日期：2008-05-01 00:00:00

abstract：:Extracellular histones have been implicated as a cause of tissue inflammatory injury in a variety of disorders including sepsis, lung, and liver diseases. However, little is known about their interactions with neutrophils and how this might contribute to injury. Here, it is shown that histone H4 acts as neutrophil act...

journal_title：Journal of leukocyte biology

authors： Hsieh IN,Deluna X,White MR,Hartshorn KL

更新日期：2020-08-17 00:00:00

abstract：:CXC chemokines, which induce angiogenesis, have glutamine-leucine-arginine amino acid residues (ELR motif) in the amino terminus and bind CXCR2 and the Duffy antigen chemokine-binding protein. Duffy, a seven transmembrane protein that binds CXC and CC chemokines, has not been shown to couple to trimeric G proteins or ...

journal_title：Journal of leukocyte biology

authors： Du J,Luan J,Liu H,Daniel TO,Peiper S,Chen TS,Yu Y,Horton LW,Nanney LB,Strieter RM,Richmond A

更新日期：2002-01-01 00:00:00

abstract：:CD163 is a member of the group B scavenger receptor cysteine-rich (SRCR) superfamily. This study describes aspects of the tissue distribution, the regulation of expression, and signal transduction after cross-linking of this receptor at the cell surface of macrophages. CD163 showed an exclusive expression on resident ...

journal_title：Journal of leukocyte biology

authors： Van den Heuvel MM,Tensen CP,van As JH,Van den Berg TK,Fluitsma DM,Dijkstra CD,Döpp EA,Droste A,Van Gaalen FA,Sorg C,Högger P,Beelen RH

更新日期：1999-11-01 00:00:00

abstract：:A murine model of allergic bronchopulmonary aspergillosis (ABPA), developed by exposure to Aspergillus fumigatus antigens, demonstrated eosinophilia of peripheral blood (PB), bone marrow (BM), and lung. The eosinophilia was abrogated by monoclonal anti-interleukin-5 (IL-5) antibody (TRFK-5) and not by an isotype contr...

journal_title：Journal of leukocyte biology

authors： Murali PS,Kumar A,Choi H,Banasal NK,Fink JN,Kurup VP

更新日期：1993-03-01 00:00:00

abstract：:Several alterations in the expression of immune-related transcripts were identified recently in the degenerating retina of the retinoschisin knockout (Rs1h(-/Y)) mouse, including the strong expression of the adaptor protein Dap12. As Dap12 is found in leukocytes, we hypothesized that its disease-related expression may...

journal_title：Journal of leukocyte biology

authors： Weigelt K,Ernst W,Walczak Y,Ebert S,Loenhardt T,Klug M,Rehli M,Weber BH,Langmann T

更新日期：2007-12-01 00:00:00

abstract：:Angiogenesis is essential in many physiological and pathological processes and can be stimulated by many different factors. To better understand and to manipulate this process more effectively, it would be beneficial to identify molecules common to the signaling pathways stimulated by different classes of angiogenic f...

journal_title：Journal of leukocyte biology

authors： Yao M,Zhou RH,Petreaca M,Zheng L,Shyy J,Martins-Green M

更新日期：2006-09-01 00:00:00

abstract：:Recognition of Gram-positive bacteria by Toll-like receptor 2 (TLR2) induces activation of proinflammatory pathways. In mice, sensitization with the Gram-positive Propionibacterium acnes followed by a challenge with the TLR4 ligand, lipopolysaccharide (LPS), results in fulminant hepatic failure. Here, we investigated ...

journal_title：Journal of leukocyte biology

authors： Romics L Jr,Dolganiuc A,Velayudham A,Kodys K,Mandrekar P,Golenbock D,Kurt-Jones E,Szabo G

更新日期：2005-12-01 00:00:00

abstract：:It has been shown that lead (Pb) potentiates lipopolysaccharide (LPS) lethality in animals by increasing the secretion and uptake or reactivity of tumor necrosis factor-alpha (TNF-alpha). Herein we report that PbCl2 increased TNF-alpha secretion from LPS-treated human peripheral blood mononuclear cells (PBMC) in a con...

journal_title：Journal of leukocyte biology

authors： Guo TL,Mudzinski SP,Lawrence DA

更新日期：1996-06-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) has been shown to induce the production of interstitial collagenase by fibroblasts and chondrocytes. We investigated the role of TNF-alpha in collagenase gene expression by U937 monocyte/macrophage cells. Transcription of the TNF-alpha gene was observed after 0.5 h of phorbol my...

journal_title：Journal of leukocyte biology

authors： Callaghan MM,Lovis RM,Rammohan C,Lu Y,Pope RM

更新日期：1996-01-01 00:00:00

abstract：:Mutations in the gene JAGN1 were recently discovered in patients with severe congenital neutropenia (SCN). Neutrophils release neutrophil extracellular traps (NETs) consisting of decondensed chromatin decorated with various granular proteins such as neutrophil elastase and myeloperoxidase (MPO) to combat microbial inf...

journal_title：Journal of leukocyte biology

authors： Khandagale A,Lazzaretto B,Carlsson G,Sundin M,Shafeeq S,Römling U,Fadeel B

更新日期：2018-12-01 00:00:00

abstract：:A point mutation in the mouse Ncf1(m1J) gene decreases production of ROS by the phagocytic NOX2 complex. Three mRNA splice variants are expressed, but only one is expressed as a protein, although at lower levels than the WT NCF1 (also known as p47phox). Our aim was to investigate whether the mutant p47phox, lacking 8 ...

journal_title：Journal of leukocyte biology

authors： Sareila O,Jaakkola N,Olofsson P,Kelkka T,Holmdahl R

更新日期：2013-03-01 00:00:00

abstract：:In human neutrophils, TNF-elicited O(2)(-) production requires adherence and integrin activation. How this cooperative signaling between TNFRs and integrins regulates O(2)(-) generation has yet to be fully elucidated. Previously, we identified delta-PKC as a critical early regulator of TNF signaling in adherent neutro...

journal_title：Journal of leukocyte biology

authors： Kilpatrick LE,Sun S,Li H,Vary TC,Korchak HM

更新日期：2010-01-01 00:00:00

abstract：:Therapeutic manipulation of cellular apoptosis holds great promise for malignant and potentially nonmalignant diseases. A relative resistance to apoptosis in RA synovium is associated with increased expression of prosurvival Bcl-2 family members. In this study, we demonstrate that treatment of DBA/1 mice, prior to the...

journal_title：Journal of leukocyte biology

authors： Lawlor KE,Smith SD,van Nieuwenhuijze A,Huang DC,Wicks IP

更新日期：2011-10-01 00:00:00

abstract：:Exposure of lymphocytes from guinea pigs sensitized to keyhole limpet hemocyanin and of macrophages from nonsensitized animals to noncytotoxic doses of lidocaine (10(-4) to 10(-6) M) resulted in the inhibition of the production of macrophage migration inhibitory factor and of macrophage motility. The inhibition of bot...

journal_title：Journal of leukocyte biology

authors： Dickstein RA,Kiremidjian-Schumacher L,Stotzky G

更新日期：1984-11-01 00:00:00

abstract：:The immune system is armed with a broad range of receptors to detect and initiate the elimination of bacterial pathogens. Inflammasomes are molecular platforms that sense a diverse range of microbial insults to develop appropriate host response. In that context, noncanonical inflammasome arose as a sensor for Gram-neg...

journal_title：Journal of leukocyte biology

authors： Gomes MTR,Cerqueira DM,Guimarães ES,Campos PC,Oliveira SC

更新日期：2019-09-01 00:00:00

abstract：:Recombinant tissue plasminogen activator (t-PA), the only approved stroke treatment, is used for clot lysis within the occluded brain artery. Unfortunately, matrix metalloproteinase-9 (MMP-9) concentration increases after t-PA treatment and has been related to hemorrhagic transformation after ischemic stroke. Although...

journal_title：Journal of leukocyte biology

authors： Cuadrado E,Ortega L,Hernández-Guillamon M,Penalba A,Fernández-Cadenas I,Rosell A,Montaner J

更新日期：2008-07-01 00:00:00

abstract：:Although tumor growth enhances macrophage (m phi) cytotoxic activity by increasing their tumor necrosis factor-alpha (TNF-alpha) production, increased prostaglandin E2 (PGE2) synthesis reduces most immune responses during tumor growth. Macrophages that do not express major histocompatibility complex class II molecules...

journal_title：Journal of leukocyte biology

authors： Alleva DG,Burger CJ,Elgert KD

更新日期：1993-05-01 00:00:00