Impairment of human neutrophil oxidative burst by polychlorinated biphenyls: inhibition of superoxide dismutase activity.

Abstract:

:We report evidence of a novel mechanism by which polychlorinated biphenyls might act as potent inducers of inflammation. Aroclor 1242 (A1242), a polychlorinated biphenyl mixture, and 2,2',4,4'-tetrachlorobiphenyl (PCB47), a constituent of A1242 that produces the same patterns of effects, impaired the oxidative burst of human neutrophils by inhibiting the antioxidant enzyme superoxide dismutase, which converts O2- to H2O2. Pre-incubation of neutrophils with A1242 or PCB47 before stimulation with phorbol 12-myristate 13-acetate heightened the respiratory burst, producing a significant increase in intracellular O2- production along with a significant decrease in H2O2 production compared with unexposed agonist-stimulated neutrophils. This was also evident in a physiologically relevant situation in which neutrophils pre-incubated with A1242 were subsequently stimulated with a combination of N-formyl-L-methionyl-L-leucyl-L-phenylalanine and tumor necrosis factor-alpha. Incubation of bovine copper-zinc superoxide dismutase (EC 1.15.1.1) with A1242 or PCB47 in a cell-free system reversed the enzyme-mediated inhibition of 6-hydroxydopamine autoxidation, indicating that polychlorinated biphenyls inhibited superoxide dismutase activity. Low superoxide dismutase activity in neutrophils leads to imbalances between production of free radicals and antioxidant defense mechanisms, which can in turn induce tissue damage and hasten the onset of neutrophil apoptosis.

journal_name

J Leukoc Biol

authors

Narayanan PK,Carter WO,Ganey PE,Roth RA,Voytik-Harbin SL,Robinson JP

doi

10.1002/jlb.63.2.216

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

216-24

issue

2

eissn

0741-5400

issn

1938-3673

journal_volume

63

pub_type

杂志文章
  • ICAM-1 expression and low-molecular-weight G-protein activation of human bronchial epithelial cells (A549) infected with RSV.

    abstract::The airway epithelial cell of the lower respiratory tract is the primary host target cell for respiratory syncytial virus (RSV) infection. To estimate whether infected epithelial cells contribute to the inflammatory host response observed during the acute infection phase we analyzed the cell surface expression of inte...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.60.6.766

    authors: Arnold R,Konig W

    更新日期:1996-12-01 00:00:00

  • Paeoniflorin relieves LPS-induced inflammatory pain in mice by inhibiting NLRP3 inflammasome activation via transient receptor potential vanilloid 1.

    abstract::LPS has been widely used to induce inflammatory pain, attributing to production of inflammatory cytokines and sensitization of nociceptors. Paeoniflorin (PF) possesses anti-nociceptive property, but its effect on LPS-induced inflammatory pain has not been investigated. In this study, we aimed to investigate the analge...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/JLB.3MA0220-355R

    authors: Yin N,Gao Q,Tao W,Chen J,Bi J,Ding F,Wang Z

    更新日期:2020-07-01 00:00:00

  • PKC-ε pseudosubstrate and catalytic activity are necessary for membrane delivery during IgG-mediated phagocytosis.

    abstract::In RAW 264.7 cells, PKC-ε regulates FcγR-mediated phagocytosis. BMDM behave similarly; PKC-ε concentrates at phagosomes and internalization are reduced in PKC-ε⁻/⁻ cells. Two questions were asked: what is the role of PKC-ε? and what domains are necessary for PKC-ε concentration? Function was studied using BMDM and fru...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.1212634

    authors: Wood TR,Chow RY,Hanes CM,Zhang X,Kashiwagi K,Shirai Y,Trebak M,Loegering DJ,Saito N,Lennartz MR

    更新日期:2013-07-01 00:00:00

  • Activation of rat macrophages by Betafectin PGG-glucan requires cross-linking of membrane receptors distinct from complement receptor three (CR3).

    abstract::PGG-glucan (Betafectin) is a soluble, highly purified yeast (1,3)-beta-glucan with broad anti-infective and immunomodulatory activities. These studies evaluated the ability of PGG-glucan to directly elicit O2- and tumor necrosis factor alpha (TNF-alpha) production by rat leukocytes in vitro. Particulate beta-glucan st...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.64.3.337

    authors: Michalek M,Melican D,Brunke-Reese D,Langevin M,Lemerise K,Galbraith W,Patchen M,Mackin W

    更新日期:1998-09-01 00:00:00

  • ATP receptors and giant cell formation.

    abstract::We have investigated the role of the purinergic P2X7 receptor in the formation of multinucleated giant cells in human monocyte/macrophage cultures stimulated with either concanavalin A or phytohemagglutinin. Macrophage fusion can be blocked by a P2X7-selective pharmacological antagonist or by a mAb directed against th...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1002/jlb.66.5.723

    authors: Di Virgilio F,Falzoni S,Chiozzi P,Sanz JM,Ferrari D,Buell GN

    更新日期:1999-11-01 00:00:00

  • Shp1 function in myeloid cells.

    abstract::The motheaten mouse was first described in 1975 as a model of systemic inflammation and autoimmunity, as a result of immune system dysregulation. The phenotype was later ascribed to mutations in the cytoplasmic tyrosine phosphatase Shp1. This phosphatase is expressed widely throughout the hematopoietic system and has ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1189/jlb.2MR0317-105R

    authors: Abram CL,Lowell CA

    更新日期:2017-09-01 00:00:00

  • Systemic inflammatory response syndrome-related lymphopenia is associated with adenosine A1 receptor dysfunction.

    abstract::SIRS is associated with lymphopenia, and prolonged lymphopenia of septic patients has been associated with increased mortality risk. We hypothesize that elevated adenosine during SIRS down-regulates Gi-coupled A1R, which signals an effect that sensitizes a cAMP-dependent lymphotoxic response. In this study, we evaluat...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.3A0816-345RR

    authors: Riff R,Cohen Y,Eini-Rider H,Naamani O,Mazar J,Haviv YS,Chaimovitz C,Douvdevani A

    更新日期:2017-07-01 00:00:00

  • Development of laboratory and animal model systems for HIV-1 encephalitis and its associated dementia.

    abstract::The neuropathogenesis of HIV-1 encephalitis and its associated dementia revolves around sustained viral replication in cells of mononuclear phagocyte origin (brain macrophages, multinucleated giant cells, and microglia). Macrophage secretory factors play important roles in facilitating monocyte trafficking into the br...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.62.1.100

    authors: Persidsky Y,Gendelman HE

    更新日期:1997-07-01 00:00:00

  • Activation-induced expression of CD1d antigen on mature T cells.

    abstract::In the present study, we investigated the expression of human CD1d antigen on activated mature T cells. Expression of this glycoprotein was found to be highly regulated and dependent on PHA stimulation. Flow cytometry studies using the NOR3.2 antibody, which recognized CD1d under denaturing conditions, showed a clear ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: Salamone MC,Rabinovich GA,Mendiguren AK,Salamone GV,Fainboim L

    更新日期:2001-02-01 00:00:00

  • Monocyte-derived macrophages and myeloid cell lines as targets of HIV-1 replication and persistence.

    abstract::HIV infection of mononuclear phagocytes (MP), mostly as tissue macrophages, is a dominant feature in the pathogenesis of HIV disease and its progression to AIDS. Although the general mechanism of infection is not dissimilar to that of CD4+ T lymphocytes occurring via interaction of the viral envelope with CD4 and a ch...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1189/jlb.0306150

    authors: Cassol E,Alfano M,Biswas P,Poli G

    更新日期:2006-11-01 00:00:00

  • Interactions between HIV-infected monocytes and the extracellular matrix: HIV-infected monocytes secrete neutral metalloproteases that degrade basement membrane protein matrices.

    abstract::The frequency of human immunodeficiency virus (HIV)-infected monocytes that spread on a model basement membrane was about twofold greater than that of an equal number of uninfected control cells through the initial 12 to 18 h of culture. By 24 h, virtually all HIV-infected and uninfected control cells spread on the ba...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.52.2.244

    authors: Dhawan S,Toro LA,Jones BE,Meltzer MS

    更新日期:1992-08-01 00:00:00

  • Type I interferon production in HIV-infected patients.

    abstract::Type I IFNs display multiple biological effects. They have a strong antiviral action, not only directly but also indirectly through activation of the immune system. They may also have actions that are deleterious for the host. The cells that produce type I IFN are mostly plasmacytoid dendritic cells (pDC), but this de...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1189/jlb.0306154

    authors: Hosmalin A,Lebon P

    更新日期:2006-11-01 00:00:00

  • IL-12Rβ2 is critical for survival of primary Francisella tularensis LVS infection.

    abstract::Using a panel of vaccines that provided different degrees of protection, we previously identified the IL-12 receptor subunit β2 as a mediator, whose relative expression correlated with strength of protection against secondary lethal challenge of vaccinated mice with an intracellular bacterium, the LVS of Francisella t...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.1012485

    authors: Melillo AA,Foreman O,Elkins KL

    更新日期:2013-05-01 00:00:00

  • Effects of adenosine on inositol 1,4,5-trisphosphate formation and intracellular calcium changes in formyl-Met-Leu-Phe-stimulated human neutrophils.

    abstract::In the presence of adenosine, formyl-Met-Leu-Phe-stimulated human neutrophils show a greatly diminished production of superoxide anion. Analysis of changes in levels of intracellular calcium revealed that the immediate increase (occurring within seconds) in intracellular calcium following addition of formyl-Met-Leu-Ph...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.48.3.281

    authors: Walker BA,Hagenlocker BE,Douglas VK,Ward PA

    更新日期:1990-09-01 00:00:00

  • How neutrophils resist shear stress at blood vessel walls: molecular mechanisms, subcellular structures, and cell-cell interactions.

    abstract::Neutrophils are the first cells arriving at sites of tissue injury or infection to combat invading pathogens. Successful neutrophil recruitment to sites of inflammation highly depends on specific molecular mechanisms, fine-tuning the received information into signaling pathways and converting them into well-described ...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1189/jlb.3MR0117-026RR

    authors: Begandt D,Thome S,Sperandio M,Walzog B

    更新日期:2017-09-01 00:00:00

  • Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease.

    abstract::Progressive loss of dopaminergic neurons in the substantia nigra pars compacta and their terminal connections in the striatum are central features in Parkinson's disease (PD). Emerging evidence supports the notion that microglia neuroinflammatory responses speed neurodegenerative events. We demonstrated previously tha...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0507296

    authors: Reynolds AD,Banerjee R,Liu J,Gendelman HE,Mosley RL

    更新日期:2007-11-01 00:00:00

  • The phenotype of murine wound macrophages.

    abstract::The phenotype of wound macrophages has not been studied by direct examination of these cells, yet macrophages recruited to sites of injury are described as alternatively activated macrophages, requiring IL-4 or IL-13 for phenotypic expression. This study characterized wound macrophage phenotype in the PVA sponge wound...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0409236

    authors: Daley JM,Brancato SK,Thomay AA,Reichner JS,Albina JE

    更新日期:2010-01-01 00:00:00

  • Functional regulation of GATA-2 by acetylation.

    abstract::The transcription factor GATA-2 is expressed in hematopoietic stem and progenitor cells and is functionally implicated in their survival and proliferation. In the present study, we show that GATA-2 exists as an acetylated protein in immature precursor cells, KG1. GATA-2 was acetylated in vitro by p300 and GCN5. We hav...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0603389

    authors: Hayakawa F,Towatari M,Ozawa Y,Tomita A,Privalsky ML,Saito H

    更新日期:2004-03-01 00:00:00

  • Phorbol myristate acetate induced oxidation of 2',7'-dichlorofluorescin by neutrophils from patients with chronic granulomatous disease.

    abstract::The oxidative metabolic burst of stimulated human polymorphonuclear leukocytes (PMNs) has been evaluated by the measurement of oxygen consumption, chemiluminescence, and oxygen radicals (O2-, H2O2, OH-) derived from activation of the hexose monophosphate shunt (HMPS). PMNs from patients with chronic granulomatous dise...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.43.4.317

    authors: Hassan NF,Campbell DE,Douglas SD

    更新日期:1988-04-01 00:00:00

  • TGF-β2 interfering oligonucleotides used as adjuvants for microbial vaccines.

    abstract::The success of using immune checkpoint inhibitors to treat cancers implies that inhibiting an immunosuppressive cytokine, such as TGF-β2, could be a strategy to develop novel adjuvants for microbial vaccines. To develop nucleic acid based TGF-β2 inhibitors, we designed three antisense oligonucleotides, designated as T...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/JLB.5A0420-491R

    authors: Tu L,Sun X,Yang L,Zhang T,Zhang X,Li X,Dong B,Liu Y,Yang M,Wang L,Yu Y

    更新日期:2020-11-01 00:00:00

  • Exploiting tumor-associated dendritic cell heterogeneity for novel cancer therapies.

    abstract::Dendritic cells (DCs) are specialized APCs present in all tissues, including tumors. They play a major role in orchestrating immune responses and were shown to occur in various functional states in tumors. In this respect, immunogenic tumor-associated DCs (TADCs) are required to initiate and sustain T cell-dependent a...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1189/jlb.4MR1116-466R

    authors: Keirsse J,Van Damme H,Van Ginderachter JA,Laoui D

    更新日期:2017-08-01 00:00:00

  • Granulocytes as modulators of dendritic cell function.

    abstract::Effector T cell development is directly driven by APCs, in particular, by antigen-primed dendritic cells (DCs). Depending on the pathogenic stimulus and the microenvironment, DCs induce proliferation and polarization of naive CD4+ T cells into different effector subsets, such as Th1, Th2, Th17, or regulatory T cells (...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1189/jlb.4MR0217-048RR

    authors: Breedveld A,Groot Kormelink T,van Egmond M,de Jong EC

    更新日期:2017-10-01 00:00:00

  • Epinephrine attenuates down-regulation of monocyte tumor necrosis factor receptors during human endotoxemia.

    abstract::Epinephrine inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF) production by increasing intracellular cAMP concentrations. Because agents that increase cAMP levels can enhance TNF receptor expression in vitro, granulocyte and monocyte TNF receptors were determined by FACS-analysis in 7 normal humans...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/jlb.61.2.156

    authors: van der Poll T,Calvano SE,Kumar A,Coyle SM,Lowry SF

    更新日期:1997-02-01 00:00:00

  • The importance of the macrophage within the human endometrium.

    abstract::The human endometrium is exposed to cyclical fluctuations of ovarian-derived sex steroids resulting in proliferation, differentiation (decidualization), and menstruation. An influx of leukocytes (up to 15% macrophages) occurs during the latter stages of the menstrual cycle, including menses. We believe the endometrial...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章,评审

    doi:10.1189/jlb.0712327

    authors: Thiruchelvam U,Dransfield I,Saunders PT,Critchley HO

    更新日期:2013-02-01 00:00:00

  • CD56bright NK IL-7Rα expression negatively associates with HCV level, and IL-7-induced NK function is impaired during HCV and HIV infections.

    abstract::Several lines of evidence support the concept that NK cells play an important role in control of hepatitis C virus (HCV) infection via cytokine secretion and cytotoxicity. IL-7 is a homeostatic cytokine with a role in T cell development, activation, proliferation, and cytokine secretion. The IL-7Rα chain [cluster of d...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.5A1116-456R

    authors: Judge CJ,Kostadinova L,Sherman KE,Butt AA,Falck-Ytter Y,Funderburg NT,Landay AL,Lederman MM,Sieg SF,Sandberg JK,Anthony DD

    更新日期:2017-07-01 00:00:00

  • Decidual macrophages: key regulators of vascular remodeling in human pregnancy.

    abstract::Successful remodeling of the uterine spiral arteries is essential for a complication-free pregnancy and is best described in terms of its morphologic features. The molecular mediators and cellular sources of spiral artery remodeling are not known, although a role for uterine leukocytes has been proposed. Immunohistoch...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.1A0815-351R

    authors: Lash GE,Pitman H,Morgan HL,Innes BA,Agwu CN,Bulmer JN

    更新日期:2016-08-01 00:00:00

  • Subacute treatment of carprofen facilitate splenocardiac resolution deficit in cardiac injury.

    abstract::Inflammation-limiting nonsteroidal pain relievers magnify myocardial infarction (MI) incidences and increase re-admission events in heart failure (HF) patients. However, the molecular and cellular mechanism of this provocative adverse effect is unclear. Our goal was to determine whether carprofen (CAP) impedes splenic...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1002/JLB.3A0618-223R

    authors: Halade GV,Kain V,Wright GM,Jadapalli JK

    更新日期:2018-12-01 00:00:00

  • Activity and subcellular distribution of cathepsins in primary human monocytes.

    abstract::Cathepsins (Cat) in antigen presenting cells (APC) control antigen processing as well as major histocompatibility complex class II transport and function. The set of active Cat and the subcellular architecture of the class II antigen presentation compartment are largely unknown in primary human APC, including peripher...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0802398

    authors: Greiner A,Lautwein A,Overkleeft HS,Weber E,Driessen C

    更新日期:2003-02-01 00:00:00

  • Osteopontin augments CD3-mediated interferon-gamma and CD40 ligand expression by T cells, which results in IL-12 production from peripheral blood mononuclear cells.

    abstract::Osteopontin is an RGD-containing bone matrix protein with cytokine-like functions that is associated with early stages of Th1-mediated diseases. Although the function of osteopontin in these responses is unknown, it is expressed by activated T cells and macrophages and can costimulate T cell proliferation. Studies hav...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:

    authors: O'Regan AW,Hayden JM,Berman JS

    更新日期:2000-10-01 00:00:00

  • Impaired NADPH oxidase activity in Rac2-deficient murine neutrophils does not result from defective translocation of p47phox and p67phox and can be rescued by exogenous arachidonic acid.

    abstract::Rac2 is a hematopoietic-specific Rho-GTPase that plays a stimulus-specific role in regulating reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation and other functional responses in neutrophils. In this study, rac2-/- neutrophils were shown to have significantly decreased NADPH oxidase activit...

    journal_title:Journal of leukocyte biology

    pub_type: 杂志文章

    doi:10.1189/jlb.0705371

    authors: Kim C,Dinauer MC

    更新日期:2006-01-01 00:00:00