Abstract:
:Notch signaling plays a preeminent role during development in not only regulating cell fate decisions, but it can also influence growth and survival of progenitor cells. In the immune system, Notch is required for the maintenance of hematopoietic stem cells and in directing T- versus B-lineage commitment. In this review, I will summarize some of the recent findings relating to the function of Notch in the immune system during lymphocyte development and in the generation and function of mature cells.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Hoyne GFdoi
10.1189/jlb.0303089subject
Has Abstractpub_date
2003-12-01 00:00:00pages
971-81issue
6eissn
0741-5400issn
1938-3673pii
jlb.0303089journal_volume
74pub_type
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journal_title:Journal of leukocyte biology
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journal_title:Journal of leukocyte biology
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journal_title:Journal of leukocyte biology
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journal_title:Journal of leukocyte biology
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