AGE-modified albumin containing infusion solutions boosts septicaemia and inflammation in experimental peritonitis.

abstract：:uNK cells differ from cNK cells, as they produce angiogenic molecules critical for normal implantation site development. We evaluated heterogeneity among DBA(+)uNK cells for Prf, Gzma, and Vegfa. Ctsd and Srgn expression was used to assign intracellular sorting of these molecules on gd7, -9, and -14. Vegfa was present...

journal_title：Journal of leukocyte biology

authors： Lima PD,Croy BA,Degaki KY,Tayade C,Yamada AT

更新日期：2012-07-01 00:00:00

abstract：:Galectin-1 (Gal-1) is a beta-galactoside-binding protein endowed with anti-inflammatory properties. The purpose of this study was to investigate the effects of endogenous and exogenous Gal-1 on neutrophil recruitment onto TNF-treated endothelium. The effect of human recombinant (hr)Gal-1 on markers of neutrophil activ...

journal_title：Journal of leukocyte biology

authors： Cooper D,Norling LV,Perretti M

更新日期：2008-06-01 00:00:00

abstract：:We studied the tissue distribution of CD6(+) lymphocytes and cells expressing the CD6 ligand (also known as activated leukocyte cell adhesion molecule CD166) in calves by immunohistochemistry using an anti-bovine CD6 monoclonal antibody (mAb), a human CD6 (huCD6)-immunoglobulin G1 fusion protein (huCD6-Ig), and an ant...

journal_title：Journal of leukocyte biology

authors： Konno A,Ahn JS,Kitamura H,Hamilton MJ,Gebe JA,Aruffo A,Davis WC

更新日期：2001-06-01 00:00:00

abstract：:Sepsis represents uncontrolled inflammation due to an infection. Cold-inducible RNA-binding protein (CIRP) is a stress-induced damage-associated molecular pattern (DAMP). A subset of neutrophils expressing ICAM-1+ neutrophils was previously shown to produce high levels of reactive oxygen species. The role of CIRP for ...

journal_title：Journal of leukocyte biology

authors： Ode Y,Aziz M,Wang P

更新日期：2018-04-01 00:00:00

abstract：:Life stress is a major risk factor in the onset and exacerbation of mast cell-associated diseases, including allergy/anaphylaxis, asthma, and irritable bowel syndrome. Although it is known that mast cells are highly activated upon stressful events, the mechanisms by which stress modulates mast cell function and diseas...

journal_title：Journal of leukocyte biology

authors： Ayyadurai S,Gibson AJ,D'Costa S,Overman EL,Sommerville LJ,Poopal AC,Mackey E,Li Y,Moeser AJ

更新日期：2017-12-01 00:00:00

abstract：:In HIV-1-infected monocytes and monocytoid cell lines, viral expression can be observed as high-level production, restricted (chronic low-level) expression, and latency (no viral expression). Interleukin-13 (IL-13) and IL-4, which have remarkedly similar deactivating effects on inflammatory monocyte functions, were st...

journal_title：Journal of leukocyte biology

authors： Mikovits JA,Meyers AM,Ortaldo JR,Minty A,Caput D,Ferrara P,Ruscetti FW

更新日期：1994-09-01 00:00:00

abstract：:Neutrophils are important mediators of the innate immune defense and of the host response to a physical trauma. Because aberrant infiltration of injured sites by neutrophils was shown to cause adverse effects after trauma, we investigated how neutrophil infiltration could be modulated at the cellular level. Our data i...

journal_title：Journal of leukocyte biology

authors： Wille C,Eiseler T,Langenberger ST,Richter J,Mizuno K,Radermacher P,Knippschild U,Huber-Lang M,Seufferlein T,Paschke S

更新日期：2018-09-01 00:00:00

abstract：:Ketorolac tromethamine, a new nonsteroidal anti-inflammatory agent of the pyrrolo-pyrrole group, was assayed for inhibitory effects on polymorphonuclear leukocytes (PMN) in a variety of systems. Ketorolac inhibited PMN superoxide anion generation, lysozyme release, myeloperoxidase release, adherence to plastic surface...

journal_title：Journal of leukocyte biology

authors： Hyers TM,Tricomi SM,Liao JJ

更新日期：1992-05-01 00:00:00

abstract：:In resident mouse peritoneal macrophages, group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) mediates arachidonic acid (AA) release and eicosanoid production in response to diverse agonists such as A23187, phorbol myristate acetate, zymosan, and the enterotoxin, okadaic acid (OA). cPLA(2)alpha is regulated by phosp...

journal_title：Journal of leukocyte biology

authors： Tucker DE,Gijón MA,Spencer DM,Qiu ZH,Gelb MH,Leslie CC

更新日期：2008-09-01 00:00:00

abstract：:Although HDPs were originally hypothesized to act as antimicrobial agents, they also have been shown to broadly modulate the immune response through the activation of different cell types. We recently developed a series of novel, synthetic peptides, termed IDRs, which are conceptually based on a natural HDP, bovine ba...

journal_title：Journal of leukocyte biology

authors： Niyonsaba F,Madera L,Afacan N,Okumura K,Ogawa H,Hancock RE

更新日期：2013-07-01 00:00:00

abstract：:A lethal human septic shock model, mouse generalized Shwartzman reaction (GSR), was elicited by two consecutive lippolysaccharide (LPS) injections (24 h apart) in which interferon-gamma (IFN-gamma) induced by interleukin (IL)-12 played a critical role in the priming phase, and tumor necrosis factor (TNF) was an import...

journal_title：Journal of leukocyte biology

authors： Motegi A,Kinoshita M,Sato K,Shinomiya N,Ono S,Nonoyama S,Hiraide H,Seki S

更新日期：2006-03-01 00:00:00

abstract：:In vivo, dendritic cells (DC) form a network comprising different populations. In particular, Langerhans cells (LC) appear as a unique population of cells dependent on transforming growth factor beta(TGF-beta) for its development. In this study, we show that endogenous TGF-beta is required for the development of both ...

journal_title：Journal of leukocyte biology

authors： Caux C,Massacrier C,Dubois B,Valladeau J,Dezutter-Dambuyant C,Durand I,Schmitt D,Saeland S

更新日期：1999-11-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is one of the recently defined damage-associated molecular pattern molecules, passively released from necrotic cells and secreted by activated macrophage/monocytes. Whether cytolytic cells induce HMGB1 release from tumor cells is not known. We developed a highly sensitive method for d...

journal_title：Journal of leukocyte biology

authors： Ito N,DeMarco RA,Mailliard RB,Han J,Rabinowich H,Kalinski P,Stolz DB,Zeh HJ 3rd,Lotze MT

更新日期：2007-01-01 00:00:00

abstract：:Recent advances have led to the identification and characterization of an array of transmembrane proteases that mediate the proteolysis of various substrates (including bioactive peptides, components of the extracellular matrix, and integral proteins) and cell-cell or cell-matrix adhesion. The membrane proteases known...

journal_title：Journal of leukocyte biology

authors： Bauvois B

更新日期：2001-07-01 00:00:00

abstract：:The ellipsoid-associated cells (EAC) localize on the surface of the ellipsoid. They bind the IV injected horseradish peroxidase (HRP) and bovine serum albumin (BSA), migrate to the red pulp and then enter the systemic circulation. After protein injection, the number of white blood cells increased above the normal leve...

journal_title：Journal of leukocyte biology

authors： Oláh I,Glick B,Taylor RL Jr

更新日期：1984-05-01 00:00:00

abstract：:Polyamines naturally occur in all living beings and play an important role in the regulation of cell proliferation, differentiation, and functional stimulation of terminally differentiated cells. Our studies, using specific inhibitors of polyamine biosynthesis such as alpha-difluoromethylornithine and methylglyoxal-bi...

journal_title：Journal of leukocyte biology

authors： Messina L,Spampinato G,Arcidiacono A,Malaguarnera L,Pagano M,Kaminska B,Kaczmarek L,Messina A

更新日期：1992-12-01 00:00:00

abstract：:Apoptotic loss of CD4+ T cells has been proposed as a mechanism of T cell depletion in human immunodeficiency virus (HIV) infections resulting in immunodeficiency. The Env glycoprotein has been implicated in apoptosis of uninfected bystander cells via gp120 binding to CD4/CXC chemokine receptor 4 as well as the fusion...

journal_title：Journal of leukocyte biology

authors： Garg H,Blumenthal R

更新日期：2006-02-01 00:00:00

abstract：:In the pathogenesis of chronic inflammatory periodontal disease, neutrophils are recognized as a major cellular component from the histopathology of the periodontal lesion around teeth and from clinical cases where absence or dysfunction of neutrophils results in major periodontal destruction. Neutrophils are recruite...

journal_title：Journal of leukocyte biology

authors： Galicia JC,Benakanakere MR,Stathopoulou PG,Kinane DF

更新日期：2009-07-01 00:00:00

abstract：:The signaling adapters MyD88 and TRIF are engaged by TLRs and/or receptors of the IL-1 family and are considered important for innate immune responses that combat bacterial infections. Here, the consequences of a combined MyD88 and TRIF deficiency for the innate immune response against severe septic peritonitis was ex...

journal_title：Journal of leukocyte biology

authors： Reim D,Rossmann-Bloeck T,Jusek G,Prazeres da Costa O,Holzmann B

更新日期：2011-09-01 00:00:00

abstract：:Maturation of cells of the mononuclear phagocyte lineage from bone marrow precursors to tissue macrophages (MAC) via circulating blood monocytes (MO) is a multistep process only partially understood. Similarly, MAC differentiation can be observed if MO are cultured in vitro. In an attempt to further characterize molec...

journal_title：Journal of leukocyte biology

authors： Krause SW,Rehli M,Kreutz M,Schwarzfischer L,Paulauskis JD,Andreesen R

更新日期：1996-10-01 00:00:00

abstract：:The actual level of circulating estrogen (17β-estradiol, E2) has a serious impact on regulation of diverse immune cell functions, where their classical cytoplasmic receptors, ERα and ERβ, act as nuclear transcriptional regulators of multiple target genes. There is growing evidence, however, for rapid, "non-nuclear" re...

journal_title：Journal of leukocyte biology

authors： Schneider AE,Kárpáti E,Schuszter K,Tóth EA,Kiss E,Kulcsár M,László G,Matko J

更新日期：2014-11-01 00:00:00

abstract：:Cytokines of the GM-CSF family signal via the same receptor subunit (βc) and, thus, have overlapping effects on cells that express all cytokine-specific α-chains (IL-3Rα, IL-5Rα, GM-CSFRα), such as human basophils, whose rapid effector functions are similarly enhanced by IL-3, IL-5, and GM-CSF. However, previous work ...

journal_title：Journal of leukocyte biology

authors： Kämpfer SS,Odermatt A,Dahinden CA,Fux M

更新日期：2017-01-01 00:00:00

abstract：:Angiogenesis is essential in many physiological and pathological processes and can be stimulated by many different factors. To better understand and to manipulate this process more effectively, it would be beneficial to identify molecules common to the signaling pathways stimulated by different classes of angiogenic f...

journal_title：Journal of leukocyte biology

authors： Yao M,Zhou RH,Petreaca M,Zheng L,Shyy J,Martins-Green M

更新日期：2006-09-01 00:00:00

abstract：:PI(3)Kγ is thought to mediate leukocyte migration to injured tissues and may be important in the pathogenesis of various T-lymphocyte-dependent pathologies, including autoimmune and inflammatory diseases. The present study evaluated the relevance of PI(3)Kγ in donor cells for the pathogenesis of acute GVHD using a mod...

journal_title：Journal of leukocyte biology

authors： Castor MG,Rezende BM,Bernardes PT,Vieira AT,Vieira EL,Arantes RM,Souza DG,Silva TA,Teixeira MM,Pinho V

更新日期：2011-06-01 00:00:00

abstract：:Underlying acquired immunity to the fungus Candida albicans is usually present in adult immunocompetent individuals and is presumed to prevent mucosal colonization progressing to symptomatic infection. Exploration of immunological events leading to Candida resistance or susceptibility has indicated the central role of...

journal_title：Journal of leukocyte biology

authors： Romani L

更新日期：2000-08-01 00:00:00

abstract：:The IL-1-related molecules, IL-1 and IL-18, can promote Th2 cytokine production by IgE/antigen-FcepsilonRI-stimulated mouse mast cells. Another IL-1-related molecule, IL-33, was identified recently as a ligand for T1/ST2. Although mouse mast cells constitutively express ST2, the effects of IL-33 on mast cell function ...

journal_title：Journal of leukocyte biology

authors： Ho LH,Ohno T,Oboki K,Kajiwara N,Suto H,Iikura M,Okayama Y,Akira S,Saito H,Galli SJ,Nakae S

更新日期：2007-12-01 00:00:00

abstract：:Mucosa represents the main site of pathogen/cell interactions. The two main types of cells forming the epithelial structure [epithelial cells and Langerhans cells (LC)] coordinate the first defense responses to avoid infection. To evaluate the involvement of epithelial cells in the early steps leading to a specific ad...

journal_title：Journal of leukocyte biology

authors： Cremel M,Berlier W,Hamzeh H,Cognasse F,Lawrence P,Genin C,Bernengo JC,Lambert C,Dieu-Nosjean MC,Delézay O

更新日期：2005-07-01 00:00:00

abstract：:Apoptotic leukocytes undergo cellular changes that are used as markers for "early" versus "late" stages of apoptosis. To ascertain if the order for acquisition of these changes is unique to specific hematopoietic cell types, we compared four leukocyte cell types and the following five apoptotic characteristics: MC540 ...

journal_title：Journal of leukocyte biology

authors： Hess KL,Johnson JD,Cook-Mills JM

更新日期：2001-09-01 00:00:00

abstract：:The kinetics and regulatory mechanisms of T cell migration through the endothelium have not been fully defined. In experimental, filter-based assays in vitro, transmigration of lymphocytes takes hours, compared with minutes, in vivo. We cultured endothelial cell (EC) monolayers on filters, solid substrates, or collage...

journal_title：Journal of leukocyte biology

authors： McGettrick HM,Hunter K,Moss PA,Buckley CD,Rainger GE,Nash GB

更新日期：2009-01-01 00:00:00

abstract：:How regulatory T (TR) cells dampen T cell responses remains unclear. Multiple modes of action have been proposed, including cell contact-dependent and/or cytokine-dependent mechanisms. Suppression may involve direct contact between TR cells and responder T cells. Alternatively, TR cells may act on dendritic cells to r...

journal_title：Journal of leukocyte biology

authors： Bodor J,Fehervari Z,Diamond B,Sakaguchi S

更新日期：2007-01-01 00:00:00