Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils.

abstract：:Pulmonary fibrosis is the end point of a chronic inflammatory process characterized by leukocyte recruitment and activation, fibroblast proliferation, and increased extracellular matrix production. Previous studies of models of pulmonary fibrosis have investigated the role of cytokines in the evolution of the fibrotic...

journal_title：Journal of leukocyte biology

authors： Smith RE,Strieter RM,Zhang K,Phan SH,Standiford TJ,Lukacs NW,Kunkel SL

更新日期：1995-05-01 00:00:00

abstract：:TNF is implicated in the suppression of neutrophil apoptosis during sepsis. Multiple signaling pathways are involved in TNF-mediated antiapoptotic signaling; a role for the MAP kinases (MAPK), ERK1/2, and p38 MAPK has been suggested. Antiapoptotic signaling is mediated principally through TNF receptor-1 (TNFR-1), and ...

journal_title：Journal of leukocyte biology

authors： Kilpatrick LE,Sun S,Mackie D,Baik F,Li H,Korchak HM

更新日期：2006-12-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a multifunctional cytokine that plays a pivotal role in mediating neovascularization as well as other endothelial cell alterations during inflammation. In this study, we demonstrate that human neutrophils are a source of VEGF. We observed that isolated blood neutrophils rel...

journal_title：Journal of leukocyte biology

authors： Taichman NS,Young S,Cruchley AT,Taylor P,Paleolog E

更新日期：1997-09-01 00:00:00

abstract：:An immunoglobulin M (IgM) monoclonal antibody, My43, specific for IgA Fc receptor (Fc alpha R) on human monocytes, bound to human polymorphonuclear neutrophils (PMNs) and inhibited their ability to bind IgA but not IgG. It was observed that the PMN oxidative burst was induced by both polymeric IgA and aggregated IgG, ...

journal_title：Journal of leukocyte biology

authors： Shen L

更新日期：1992-04-01 00:00:00

abstract：:The mannose receptor is a macrophage surface receptor that mediates both endocytosis and phagocytosis. Previous work has demonstrated that the prototypical Th 2 cytokine, interleukin-4 (IL-4), increases both cell-surface receptor expression and mannose receptor-mediated endocytosis, whereas the prototypical Th 1 cytok...

journal_title：Journal of leukocyte biology

authors： Raveh D,Kruskal BA,Farland J,Ezekowitz RAB

更新日期：1998-07-01 00:00:00

abstract：:Leukocytes have been implicated to be involved in the pathogenesis of IgA nephropathy (IgAN). To clarify the precise molecular mechanism of recruitment and activation of leukocytes in the subgroups of IgAN, latent, acute, and chronic types, we studied monocyte chemotactic and activating factor (MCAF/MCP-1) and interle...

journal_title：Journal of leukocyte biology

authors： Yokoyama H,Wada T,Furuichi K,Segawa C,Shimizu M,Kobayashi K,Su S,Mukaida N,Matsushima K

更新日期：1998-04-01 00:00:00

abstract：:HSA preparations for i.v. use are administered in critically ill patients. Although increasing intravascular osmotic pressure seems to be a pathophysiologically orientated treatment, clinical trials do not indicate a benefit for mortality in HSA-treated patients. Instead, there is evidence for inflammatory reactions u...

journal_title：Journal of leukocyte biology

authors： Humpert PM,Lukic IK,Thorpe SR,Hofer S,Awad EM,Andrassy M,Deemer EK,Kasper M,Schleicher E,Schwaninger M,Weigand MA,Nawroth PP,Bierhaus A

更新日期：2009-09-01 00:00:00

abstract：:Nitric oxide (NO) is a well-documented effector molecule in rodent phagocytes but its synthesis in human neutrophils has been controversial. In this study, NO production in human neutrophils activated by chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (fMLP) was measured in the presence of L-arginine (L-Ar...

journal_title：Journal of leukocyte biology

authors： Holm P,Kankaanranta H,Oja SS,Knowles RG,Moilanen E

更新日期：1999-07-01 00:00:00

abstract：:Autoreactive CD4+ and CD8+ T cells directed against CNS autoantigens may play a role in the development of multiple sclerosis (MS). Identical twins share the same genetic background but not the TCR repertoire that is shaped by the encounter with self or foreign antigens. To gain insights into the interplay between MS ...

journal_title：Journal of leukocyte biology

authors： Somma P,Ristori G,Battistini L,Cannoni S,Borsellino G,Diamantini A,Salvetti M,Sorrentino R,Fiorillo MT

更新日期：2007-03-01 00:00:00

abstract：:Neutrophil extracellular traps (NETs), web-like DNA structures, provide efficient means of eliminating invading microorganisms but can also present a potential threat to its host because it is a likely source of autoantigens or by promoting bystander tissue damage. Therefore, it is important to identify mechanisms tha...

journal_title：Journal of leukocyte biology

authors： Zabieglo K,Majewski P,Majchrzak-Gorecka M,Wlodarczyk A,Grygier B,Zegar A,Kapinska-Mrowiecka M,Naskalska A,Pyrc K,Dubin A,Wahl SM,Cichy J

更新日期：2015-07-01 00:00:00

abstract：:Quartz was injected into a hind food of BALB/c and DBA/2 mice and on days 40, 90, and 180 the progressive response ensuing in the draining popliteal lymph node (PLN) was investigated by histopathology and immunohistopathology. The area of silicotic nodules (ASN) was measured by morphometry, and, by this parameter, str...

journal_title：Journal of leukocyte biology

authors： Weirich U,Friemann J,Rehn B,Henkelüdecke U,Lammers T,Sorg C,Bruch J,Gleichmann E

更新日期：1996-02-01 00:00:00

abstract：:T helper cell type 1 (Th1)-polarizing cytokines are induced by Legionella pneumophila infection and are suppressed by pretreatment with marijuana cannabinoids (CB). Glucocorticoids and prostaglandin E2(PGE2) are also reported to suppress Th1 polarization and are induced by Delta9-tetrahydrocannabinol (THC), so their r...

journal_title：Journal of leukocyte biology

authors： Newton CA,Lu T,Nazian SJ,Perkins I,Friedman H,Klein TW

更新日期：2004-10-01 00:00:00

abstract：:On the surface of the macrophage, annexin A2 tetramer (A2t) serves as a docking protein or recognition element for bacterial and viral pathogens. Plasma levels of free A2t have been reported to increase following infection, although the mechanistic significance of this observation is unclear. Although annexin A2 had g...

journal_title：Journal of leukocyte biology

authors： Swisher JF,Khatri U,Feldman GM

更新日期：2007-11-01 00:00:00

abstract：:Neutrophils are indispensable in the innate immune defense against invading microorganisms. Neutrophils contain SVs and several subsets of granules that are essential for their function. Proteins present in neutrophil SVs and granules are synthesized during terminal granulopoiesis in the bone marrow. The heterogeneity...

journal_title：Journal of leukocyte biology

authors： Rørvig S,Østergaard O,Heegaard NH,Borregaard N

更新日期：2013-10-01 00:00:00

abstract：:Engagement of 2B4 (CD244) with CD48 results in activation, costimulation, or inhibition of NK cell activities, depending on the cell types and the stage of differentiation. In vivo, 2B4+ NK cells can interact with CD48+ NK cells and also with surrounding CD48+ hematopoietic cells. Similarly, CD48+ NK cells may be trig...

journal_title：Journal of leukocyte biology

authors： Kim EO,Kim N,Kim TJ,Kim K,Kim TW,Kumar V,Lee KM

更新日期：2010-10-01 00:00:00

abstract：:Macrophages activated for tumor cell killing by bacterial lipopolysaccharide (LPS) were shown to lose their cytolytic activity if exposed to physiological levels of prostaglandin E2 (PGE2). Increasing the LPS stimulus more than 100-fold over the amount needed to activate the cells did not substantially increase their ...

journal_title：Journal of leukocyte biology

authors： Russell SW,Pace JL

更新日期：1984-03-01 00:00:00

abstract：:Immunosuppression following infection with HIV-1 predisposes patients to a myriad of opportunistic pathogens, one of the most important of which is Mtb. Granulysin, expressed by NK cells and CTL, exhibits potent antimicrobial activity against Mtb and several other opportunistic pathogens associated with HIV-1 infectio...

journal_title：Journal of leukocyte biology

authors： Hogg AE,Bowick GC,Herzog NK,Cloyd MW,Endsley JJ

更新日期：2009-11-01 00:00:00

abstract：:SHP-1 is a cytoplasm protein tyrosine phosphatase expressed primarily in hematopoietic cells. In the immune system, SHP-1 plays critical roles in regulation of many receptor-mediated signaling cascades, and SHP-1 deficiency in mice causes spontaneous inflammation and autoimmunity. Here, we report a unique requirement ...

journal_title：Journal of leukocyte biology

authors： Zhou D,Collins CA,Wu P,Brown EJ

更新日期：2010-05-01 00:00:00

abstract：:The Fanconi anemia proteins participate in a canonical pathway that repairs cross-linking agent-induced DNA damage. Cells with inactivated Fanconi anemia genes are universally hypersensitive to such agents. Fanconi anemia-deficient hematopoietic stem cells are also hypersensitive to inflammatory cytokines, and, as imp...

journal_title：Journal of leukocyte biology

authors： Garbati MR,Hays LE,Rathbun RK,Jillette N,Chin K,Al-Dhalimy M,Agarwal A,Newell AE,Olson SB,Bagby GC Jr

更新日期：2016-03-01 00:00:00

abstract：:Seventy-kilodalton amino-terminal and 180-kDa cell-binding fibronectin fragments were used to determine which fibronectin domains support soluble gelatin interactions with macrophages. At each time measured, intact and 180-kDa fibronectin supported significantly larger quantities of cell-associated gelatin than contro...

journal_title：Journal of leukocyte biology

authors： Penc SF,Blumenstock FA,Kaplan JE

更新日期：1995-11-01 00:00:00

abstract：:Prostaglandins function as down regulators of immune responses probably by increasing the concentration of intracellular cAMP. Phosphodiesterase inhibitors, which prevent the breakdown of cAMP, also increase the intracellular levels of cAMP. Prostaglandins and phosphodiesterase inhibitors have both been shown to suppr...

journal_title：Journal of leukocyte biology

authors： Ellis NK,Duffie GP,Young MR,Wepsic HT

更新日期：1990-04-01 00:00:00

abstract：:Angiogenesis is essential in many physiological and pathological processes and can be stimulated by many different factors. To better understand and to manipulate this process more effectively, it would be beneficial to identify molecules common to the signaling pathways stimulated by different classes of angiogenic f...

journal_title：Journal of leukocyte biology

authors： Yao M,Zhou RH,Petreaca M,Zheng L,Shyy J,Martins-Green M

更新日期：2006-09-01 00:00:00

abstract：:Neutrophil accumulation and plasma leakage induced in rabbit skin by neutrophil-activating peptide-1 (NAP-1, a 72 amino acid peptide produced by monocytes and a variety of tissue cells), E. coli endotoxin, and interleukin-1 (IL-1) were compared. Neutrophil accumulation at sites injected with NAP-1 was intense, rapid, ...

journal_title：Journal of leukocyte biology

authors： Colditz IG,Zwahlen RD,Baggiolini M

更新日期：1990-08-01 00:00:00

abstract：:Throughout evolution, mammals have developed an elaborate network of positive and negative regulatory mechanisms, which provide balance between defensive measures against bacterial and viral pathogens and protective measures against unwarranted destruction of the host by the activated immune system. Kinases and phosph...

journal_title：Journal of leukocyte biology

authors： Salojin K,Oravecz T

更新日期：2007-04-01 00:00:00

abstract：:Leukocyte trafficking from the blood into the tissues represents a key process during inflammation and requires multiple steps mediated by adhesion molecules and chemoattractants. Inflammation has a detrimental role in several diseases, and in such cases, the molecular mechanisms controlling leukocyte migration are po...

journal_title：Journal of leukocyte biology

authors： Rossi B,Angiari S,Zenaro E,Budui SL,Constantin G

更新日期：2011-04-01 00:00:00

abstract：:The viral CC chemokines MC148, encoded by the poxvirus molluscum contagiosum, and viral macrophage inflammatory protein (vMIP)-I and vMIP-II, encoded by human herpesvirus 8, were probed on the murine CC receptor (CCR) 8 in parallel with human CCR8. In calcium mobilization assays, vMIP-I acted as a high-affinity agonis...

journal_title：Journal of leukocyte biology

authors： Lüttichau HR,Gerstoft J,Schwartz TW

更新日期：2001-08-01 00:00:00

abstract：:In a DNA immunization against Herpes simplex virus (HSV), we examined the ability of plasmid-encoded interleukin-15 (pIL-15) to induce and maintain the mucosal B and T cell immune response. pIL-15 generated memory CD8(+) T cell responses that were threefold higher and mainly maintained in the spleen, but high levels o...

journal_title：Journal of leukocyte biology

authors： Toka FN,Rouse BT

更新日期：2005-07-01 00:00:00

abstract：:TLRs are a class of pattern recognition receptors (PRRs) that detect invading microbes by recognizing pathogen-associated molecular patterns (PAMPs). Upon PAMP engagement, TLRs activate a signaling cascade that leads to the production of inflammatory mediators. The localization of TLRs, either on the plasma membrane o...

journal_title：Journal of leukocyte biology

authors： Marongiu L,Gornati L,Artuso I,Zanoni I,Granucci F

更新日期：2019-07-01 00:00:00

abstract：:Azurocidin is a multifunctional endotoxin-binding serine protease homolog synthesized during the promyelocytic stage of neutrophil development. To characterize the biosynthesis and processing of azurocidin, cDNA encoding human preproazurocidin was stably transfected to the rat basophilic leukemia cell line RBL-1 and t...

journal_title：Journal of leukocyte biology

authors： Lindmark A,Garwicz D,Rasmussen PB,Flodgaard H,Gullberg U

更新日期：1999-10-01 00:00:00

abstract：:Healthy donors infused with high doses of glucocorticoids [GCs; methyl-prednisolone (MP); 500 mg/day for 3 days] suffer a selective depletion of the CD14(+)CD16(+) monocytes such that these cells are reduced by 95% on day 5. In vitro studies revealed that at 11 h of culture in the presence of 10(-)(5) M MP, no depleti...

journal_title：Journal of leukocyte biology

authors： Dayyani F,Belge KU,Frankenberger M,Mack M,Berki T,Ziegler-Heitbrock L

更新日期：2003-07-01 00:00:00