Abstract:
:Recently, several studies, including those with respiratory syncytial virus, mouse pneumovirus, and simian virus 5, have reported that virus-specific CD8+ effector cells entering the lung as a result of respiratory infection undergo significant loss of function. The impaired function in these cells has been proposed to be the result of infection-induced changes in the lung. Although virus-specific effects may contribute to regulation of T cells in the lung, the findings from this study provide evidence that the basal lung environment is sufficient to promote loss of function in effector cells. Loss of function occurs within 48 h of entry into the lung and is most evident in cells residing in the lung parenchyma. These findings suggest an additional paradigm for the immunoregulation of effector cells that enter the lung as a result of virus infection.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Arimilli S,Palmer EM,Alexander-Miller MAdoi
10.1189/jlb.0407215subject
Has Abstractpub_date
2008-03-01 00:00:00pages
564-74issue
3eissn
0741-5400issn
1938-3673pii
jlb.0407215journal_volume
83pub_type
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