Combinatorial approach to cancer immunotherapy: strength in numbers.

abstract：:Absence of lymph nodes in nonmammalian species, expression of MHCII by APCs in the periphery, and the recent findings that T cells can change their polarization status after presentation in the lymph nodes imply a role for MHCII-mediated presentation outside the organized lymphoid tissue. This study shows that MHCII(+...

journal_title：Journal of leukocyte biology

authors： Inman CF,Singha S,Lewis M,Bradley B,Stokes C,Bailey M

更新日期：2010-09-01 00:00:00

abstract：:In previous studies, macrophages have been shown to influence in vitro colony formation by erythroid progenitors (CFU-E). To determine whether the origin of the macrophages influences their effects on in vitro erythropoiesis, plasma clot cultures of CFU-E were grown over adherent monolayers of macrophages from various...

journal_title：Journal of leukocyte biology

authors： Johnson CS,Furmanski P

更新日期：1984-11-01 00:00:00

abstract：:Modifying the fatty acid composition of macrophages through diet can significantly alter some of their functions, such as tumoricidal capacity and tumor necrosis factor alpha (TNF-alpha) production. The mechanism of that modification, however, is unknown. In this report, we provide evidence that fatty acids added to m...

journal_title：Journal of leukocyte biology

authors： Hubbard NE,Lim D,Somers SD,Erickson KL

更新日期：1993-08-01 00:00:00

abstract：:The transcription factor GATA-2 is expressed in hematopoietic stem and progenitor cells and is functionally implicated in their survival and proliferation. In the present study, we show that GATA-2 exists as an acetylated protein in immature precursor cells, KG1. GATA-2 was acetylated in vitro by p300 and GCN5. We hav...

journal_title：Journal of leukocyte biology

authors： Hayakawa F,Towatari M,Ozawa Y,Tomita A,Privalsky ML,Saito H

更新日期：2004-03-01 00:00:00

abstract：:Radiation-induced chimeric mice were used to study the origin of pulmonary alveolar macrophages. Unlike in other studies, these radiation chimeras were prepared by using a special fractionated irradiation regimen to minimize the killing of alveolar macrophage colony-forming cells, putative local stem cells. For this s...

journal_title：Journal of leukocyte biology

authors： Tarling JD,Lin HS,Hsu S

更新日期：1987-11-01 00:00:00

abstract：:TNF is implicated in the suppression of neutrophil apoptosis during sepsis. Multiple signaling pathways are involved in TNF-mediated antiapoptotic signaling; a role for the MAP kinases (MAPK), ERK1/2, and p38 MAPK has been suggested. Antiapoptotic signaling is mediated principally through TNF receptor-1 (TNFR-1), and ...

journal_title：Journal of leukocyte biology

authors： Kilpatrick LE,Sun S,Mackie D,Baik F,Li H,Korchak HM

更新日期：2006-12-01 00:00:00

abstract：:Epinephrine inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF) production by increasing intracellular cAMP concentrations. Because agents that increase cAMP levels can enhance TNF receptor expression in vitro, granulocyte and monocyte TNF receptors were determined by FACS-analysis in 7 normal humans...

journal_title：Journal of leukocyte biology

authors： van der Poll T,Calvano SE,Kumar A,Coyle SM,Lowry SF

更新日期：1997-02-01 00:00:00

abstract：:TNF is a pleiotropic cytokine involved in a variety of inflammatory processes and immune responses. TNF effects are mediated via two distinct membrane receptors: TNFR1 and TNFR2. Investigations concerning regulation and function of TNFR2 revealed a novel TNFR2 isoform in human and mouse cells, termed icp75TNFR, with m...

journal_title：Journal of leukocyte biology

authors： Bäumel M,Lechner A,Hehlgans T,Männel DN

更新日期：2008-07-01 00:00:00

abstract：:The dynamics of immune cell populations during acute HIV-1 infection are not fully deciphered, especially for non-T cells. In this study, we tested whether specific cellular subsets of the innate arm of the immune response are affected early after HIV-1 infection. Using a cohort of HIV-1-infected individuals, we have ...

journal_title：Journal of leukocyte biology

authors： Centlivre M,Legrand N,Steingrover R,van der Sluis R,Grijsen ML,Bakker M,Jurriaans S,Berkhout B,Paxton WA,Prins JM,Pollakis G

更新日期：2011-05-01 00:00:00

abstract：:This is largely a history of attempts from approximately 1960 until about 1980-81 to understand the mechanisms by which neutrophils are activated by chemotactic factors to induce chemotaxis and granule secretion. As such, it deals with the growth of our knowledge of neutrophil chemotactic factors and their receptors; ...

journal_title：Journal of leukocyte biology

authors： Becker EL

更新日期：1990-04-01 00:00:00

abstract：:Human neutrophils isolated from the blood were incubated in vitro for 30 min with 25 ng/ml of phorbol 12-myristate 13-acetate (PMA), a protein kinase C activator, to study its effect on the fine structure of granulocytes and on the subcellular distribution of lactoferrin (Lf). Flow cytometry analysis of the human neut...

journal_title：Journal of leukocyte biology

authors： Esaguy N,Aguas AP,Vilanova M,Silva MT

更新日期：1991-11-01 00:00:00

abstract：:T helper cell type 1 (Th1)-polarizing cytokines are induced by Legionella pneumophila infection and are suppressed by pretreatment with marijuana cannabinoids (CB). Glucocorticoids and prostaglandin E2(PGE2) are also reported to suppress Th1 polarization and are induced by Delta9-tetrahydrocannabinol (THC), so their r...

journal_title：Journal of leukocyte biology

authors： Newton CA,Lu T,Nazian SJ,Perkins I,Friedman H,Klein TW

更新日期：2004-10-01 00:00:00

abstract：:The neuropathogenesis of HIV-1 encephalitis and its associated dementia revolves around sustained viral replication in cells of mononuclear phagocyte origin (brain macrophages, multinucleated giant cells, and microglia). Macrophage secretory factors play important roles in facilitating monocyte trafficking into the br...

journal_title：Journal of leukocyte biology

authors： Persidsky Y,Gendelman HE

更新日期：1997-07-01 00:00:00

abstract：:Studies of the metabolism and function of the amyloid precursor protein (APP) and its proteolytic fragment A beta in cultured cells, transgenic mice, and post-mortem brain tissue have advanced our understanding of Alzheimer disease (AD). However, the molecular pathogenesis of the disease is still not clear, and we are...

journal_title：Journal of leukocyte biology

authors： Li QX,Fuller SJ,Beyreuther K,Masters CL

更新日期：1999-10-01 00:00:00

abstract：:T-cell recognition of foreign antigen and migration to specific anatomic sites in vivo involves transient adhesive contacts between beta1 integrins expressed on T cells and cell surface proteins or extracellular-matrix components. Engagement of the CD3-T-cell receptor (CD3-TCR) complex initiates a complex signaling ca...

journal_title：Journal of leukocyte biology

authors： Woods ML,Shimizu Y

更新日期：2001-06-01 00:00:00

abstract：:An epithelial cell line, IT-45R1, has been established from a thymus of normal Wistar rat and was found to produce growth factor which stimulated the proliferation of bone marrow cells. This growth factor induced the formation of colonies composed of macrophages, granulocytes, or both, in semi-solid medium and stimula...

journal_title：Journal of leukocyte biology

authors： Nanno M,Takahashi T,Sakata T,Horikawa T,Sako T,Suzuki R,Itoh T,Kumagai K

更新日期：1991-12-01 00:00:00

abstract：:Dendritic cells (DC) are professional antigen-presenting cells that are used in vaccine approaches to cancer. Classically, mature monocyte-derived DC are generated in vitro in the presence of interleukin (IL)-4, granulocyte macrophage-colony stimulating factor, and inflammatory cytokines (G4-DC). Recently, it has been...

journal_title：Journal of leukocyte biology

authors： Breckpot K,Corthals J,Bonehill A,Michiels A,Tuyaerts S,Aerts C,Heirman C,Thielemans K

更新日期：2005-10-01 00:00:00

abstract：:Cytohesin-1 and ARNO are guanine nucleotide-exchange factors (GEFs) for ADP-ribosylation factor (Arf). Here, we show that ARNO is expressed in HL-60 cells and established that granulocytic differentiation induced with Me2SO stimulated cytohesin-1 but not ARNO expression. Cytohesin-1 levels in HL-60 granulocytes were s...

journal_title：Journal of leukocyte biology

authors： Bourgoin SG,Houle MG,Singh IN,Harbour D,Gagnon S,Morris AJ,Brindley DN

更新日期：2002-04-01 00:00:00

abstract：:Potential mechanisms underlying impaired chemotactic responsiveness of neonatal neutrophils were investigated. Two distinct chemoattractants were compared: bacterially derived N-formyl-methionyl-leucyl-phenylalanine (fMLP) and a unique chemotactic monoclonal antibody, designated DL1.2, which binds to a neutrophil anti...

journal_title：Journal of leukocyte biology

authors： Weinberger B,Laskin DL,Mariano TM,Sunil VR,DeCoste CJ,Heck DE,Gardner CR,Laskin JD

更新日期：2001-12-01 00:00:00

abstract：:Prostaglandin J2 metabolite 15-deoxy-delta(12,14)-prostaglandin J2 (15-PGJ2) appears to possess anti-inflammatory properties. Unlike other prostaglandins, it has no known plasma membrane receptor. Its effects have been thought to occur through activation of the nuclear peroxisome proliferator-activated receptor gamma ...

journal_title：Journal of leukocyte biology

authors： Guyton K,Bond R,Reilly C,Gilkeson G,Halushka P,Cook J

更新日期：2001-04-01 00:00:00

abstract：:Previous work has demonstrated that bleomycin can directly stimulate alveolar macrophage secretion of fibroblast growth factors and monocyte chemotactic factors. In this study, rat alveolar macrophages obtained by bronchoalveolar lavage were examined for the presence of bleomycin binding sites, which might mediate thi...

journal_title：Journal of leukocyte biology

authors： Denholm EM,Phan SH

更新日期：1990-12-01 00:00:00

abstract：:Interleukin-15 (IL-15) is a cytokine that possesses interesting, potential therapeutic properties. However, based on several parameters including activation of neutrophils, it is also recognized as a proinflammatory cytokine. The mechanisms by which IL-15 activates human neutrophil functions are not fully understood. ...

journal_title：Journal of leukocyte biology

authors： Ratthé C,Girard D

更新日期：2004-07-01 00:00:00

abstract：:Endocytic proteolysis represents a major functional component of the major histocompatibility complex class II antigen-presentation machinery. Although transport and assembly of class II molecules in the endocytic compartment are well characterized, we lack information about the pattern of endocytic protease activity ...

journal_title：Journal of leukocyte biology

authors： Lautwein A,Kraus M,Reich M,Burster T,Brandenburg J,Overkleeft HS,Schwarz G,Kammer W,Weber E,Kalbacher H,Nordheim A,Driessen C

更新日期：2004-05-01 00:00:00

abstract：:CXC chemokines, which induce angiogenesis, have glutamine-leucine-arginine amino acid residues (ELR motif) in the amino terminus and bind CXCR2 and the Duffy antigen chemokine-binding protein. Duffy, a seven transmembrane protein that binds CXC and CC chemokines, has not been shown to couple to trimeric G proteins or ...

journal_title：Journal of leukocyte biology

authors： Du J,Luan J,Liu H,Daniel TO,Peiper S,Chen TS,Yu Y,Horton LW,Nanney LB,Strieter RM,Richmond A

更新日期：2002-01-01 00:00:00

abstract：:Prostaglandins function as down regulators of immune responses probably by increasing the concentration of intracellular cAMP. Phosphodiesterase inhibitors, which prevent the breakdown of cAMP, also increase the intracellular levels of cAMP. Prostaglandins and phosphodiesterase inhibitors have both been shown to suppr...

journal_title：Journal of leukocyte biology

authors： Ellis NK,Duffie GP,Young MR,Wepsic HT

更新日期：1990-04-01 00:00:00

abstract：:Mycobacterium avium complex (MAC) is a significant cause of opportunistic infection in patients with acquired immunodeficiency syndrome. Although the major route of entry of MAC is via the gastrointestinal tract, MAC can infect humans through the respiratory tract and eventually encounter alveolar macrophages within t...

journal_title：Journal of leukocyte biology

authors： Lopez JP,Clark E,Shepherd VL

更新日期：2003-10-01 00:00:00

abstract：:Treatment of mice with a monoclonal antibody (mAb) designated NIMP-R10, directed against the CD11b polypeptide of the CD18/CD11b heterodimeric type 3 complement receptor (CR3), exacerbates listeriosis by preventing myelomonocytic cells from focusing at sites of infected hepatocytes in the liver. Under these conditions...

journal_title：Journal of leukocyte biology

authors： Conlan JW,North RJ

更新日期：1992-07-01 00:00:00

abstract：:MRL/fas(lpr) mice, which undergo a systemic autoimmune disease with similarities to systemic lupus erythematosus (SLE), display reduced pathology and prolonged survival if rendered deficient in ICAM-1. However, it remains unclear whether this is a result of the ability of ICAM-1 to promote the immune response or media...

journal_title：Journal of leukocyte biology

authors： Norman MU,James WG,Hickey MJ

更新日期：2008-07-01 00:00:00

abstract：:Previously, we demonstrated the stimulus-specific ability of platelet lysate or release products to inhibit neutrophil functions in response to f-met-leu-phe (fMLP) or phorbol myristate acetate (PMA). The present study further characterizes these activities and identifies one of the platelet inhibitors of neutrophil s...

journal_title：Journal of leukocyte biology

authors： McGarrity ST,Stephenson AH,Hyers TM,Webster RO

更新日期：1988-11-01 00:00:00

abstract：:Monocytes and macrophages differentiate from progenitor cells under the influence of colony-stimulating factors. Genome-scale data have enabled the identification of the set of genes that distinguishes macrophages from other cell types and the ways in which thousands of genes are regulated in response to pathogen chal...

journal_title：Journal of leukocyte biology

authors： Hume DA

更新日期：2012-09-01 00:00:00