Living on the edge: Pain control by blood leukocytes at the borders of the central nervous system.

abstract：:4-1BB is a member of the TNFR superfamily, which contributes to the activation of signaling pathways required for the survival of activated and memory T cells. We have shown previously that TRAF1, an adaptor protein recruited to 4-1BB, is required for 4-1BB-mediated CD8 T cell survival in vivo. With the use of a prote...

journal_title：Journal of leukocyte biology

authors： Sabbagh L,Andreeva D,Laramée GD,Oussa NA,Lew D,Bisson N,Soumounou Y,Pawson T,Watts TH

更新日期：2013-05-01 00:00:00

abstract：:Increasing the dietary alpha-linolenate (18:3n - 3)/linoleate (18:2n - 6) ratio results in an increase in lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF) production in mouse resident and casein-induced peritoneal macrophages [3]. We found that prostaglandin E2 (PGE2) production is inversely related to ...

journal_title：Journal of leukocyte biology

authors： Watanabe S,Onozaki K,Yamamoto S,Okuyama H

更新日期：1993-02-01 00:00:00

abstract：:Clostridioides difficile (C. difficile) is the major cause of hospital-acquired gastrointestinal infections in individuals following antibiotics treatment. The pathogenesis of C. difficile infection (CDI) is mediated mainly by the production of toxins that induce tissue damage and host inflammatory responses. While in...

journal_title：Journal of leukocyte biology

authors： Hernández Del Pino RE,Barbero AM,Español LÁ,Morro LS,Pasquinelli V

更新日期：2020-08-23 00:00:00

abstract：:Life stress is a major risk factor in the onset and exacerbation of mast cell-associated diseases, including allergy/anaphylaxis, asthma, and irritable bowel syndrome. Although it is known that mast cells are highly activated upon stressful events, the mechanisms by which stress modulates mast cell function and diseas...

journal_title：Journal of leukocyte biology

authors： Ayyadurai S,Gibson AJ,D'Costa S,Overman EL,Sommerville LJ,Poopal AC,Mackey E,Li Y,Moeser AJ

更新日期：2017-12-01 00:00:00

abstract：:Osteopontin is an RGD-containing bone matrix protein with cytokine-like functions that is associated with early stages of Th1-mediated diseases. Although the function of osteopontin in these responses is unknown, it is expressed by activated T cells and macrophages and can costimulate T cell proliferation. Studies hav...

journal_title：Journal of leukocyte biology

authors： O'Regan AW,Hayden JM,Berman JS

更新日期：2000-10-01 00:00:00

abstract：:Human neutrophils generate oxygen reduction products as a consequence of membrane interactions with a number of stimuli. One oxygen-centered free radical (superoxide) has been unequivocally shown to result from this "respiratory burst," and some experimental evidence for another (hydroxyl radical) has been published, ...

journal_title：Journal of leukocyte biology

authors： Britigan BE,Cohen MS,Rosen GM

更新日期：1987-04-01 00:00:00

abstract：:The promoters of the IL-8, MCP-1, and RANTES genes contain binding sites for the redox-responsive transcription factors AP-1 and NF-kappaB, which have been shown to be important for their expression. In this overview, we present evidence from our laboratories that the stimulus-specific regulation of these chemokines b...

journal_title：Journal of leukocyte biology

authors： Roebuck KA,Carpenter LR,Lakshminarayanan V,Page SM,Moy JN,Thomas LL

更新日期：1999-03-01 00:00:00

abstract：:Subcutaneous injection of recombinant human interleukin-2 (rhuIL-2) at 10(2)-10(4) U/mouse induced delayed (48 h) accumulation of mononuclear leukocytes with diffuse granulocytes, including eosinophils. Subcutaneous local infusion of rhuIL-2 or recombinant murine IL-2 (10(2)-10(4) U/mouse) via implanted Alzet miniosmo...

journal_title：Journal of leukocyte biology

authors： Dunn CJ,Hardee MM,Fidler SF,Shields SK,Chosay JG

更新日期：1996-07-01 00:00:00

abstract：:Macrophage activation is associated with increased secretion of monokines, proteases, arachidonic acid metabolites, reactive oxygen, and nitrogen intermediates and yet decreased secretion of apolipoprotein E (apo E). Although the kinetics of apo E down-regulation have been investigated, the mechanism(s) involved remai...

journal_title：Journal of leukocyte biology

authors： Zuckerman SH,O'Neal L

更新日期：1994-06-01 00:00:00

abstract：:ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation. However, in addition to vascular endothelial cells, ICAM-1 expression is also robustly induced on epithelial and immune cells in response to inflammatory sti...

journal_title：Journal of leukocyte biology

authors： Bui TM,Wiesolek HL,Sumagin R

更新日期：2020-09-01 00:00:00

abstract：:Tumor necrosis factor (TNF) and interleukin-1 (IL-1) are cytokines with pleiotropic biological activities, exerting a broad range of overlapping biological functions. The redundancy of TNF and IL-1 activities may be based on the utilization of shared key components of intracellular signaling pathways. Two lipid second...

journal_title：Journal of leukocyte biology

authors： Schütze S,Machleidt T,Krönke M

更新日期：1994-11-01 00:00:00

abstract：:Emerging evidence has revealed that noradrenaline (NA), the main neurotransmitter of the sympathetic nervous system (SNS), regulates a variety of immune functions via binding to adrenergic receptors present on immune cells. In this study, we examined the role of NA in the regulation of neutrophil functions. Neutrophil...

journal_title：Journal of leukocyte biology

authors： Nicholls AJ,Wen SW,Hall P,Hickey MJ,Wong CHY

更新日期：2018-02-01 00:00:00

abstract：:A murine model of allergic bronchopulmonary aspergillosis (ABPA), developed by exposure to Aspergillus fumigatus antigens, demonstrated eosinophilia of peripheral blood (PB), bone marrow (BM), and lung. The eosinophilia was abrogated by monoclonal anti-interleukin-5 (IL-5) antibody (TRFK-5) and not by an isotype contr...

journal_title：Journal of leukocyte biology

authors： Murali PS,Kumar A,Choi H,Banasal NK,Fink JN,Kurup VP

更新日期：1993-03-01 00:00:00

abstract：:The magnitude and efficacy of CD8(+) T cell memory may notably regress, especially if immune induction occurs in the absence of adequate CD4(+) help. This report demonstrates that this CD8(+) memory malfunction could be remedied if a source of cognate antigen-recognizing helper cells were provided during recall. The i...

journal_title：Journal of leukocyte biology

authors： Kumaraguru U,Banerjee K,Rouse BT

更新日期：2005-10-01 00:00:00

abstract：:LPS has been widely used to induce inflammatory pain, attributing to production of inflammatory cytokines and sensitization of nociceptors. Paeoniflorin (PF) possesses anti-nociceptive property, but its effect on LPS-induced inflammatory pain has not been investigated. In this study, we aimed to investigate the analge...

journal_title：Journal of leukocyte biology

authors： Yin N,Gao Q,Tao W,Chen J,Bi J,Ding F,Wang Z

更新日期：2020-07-01 00:00:00

abstract：:Macrophages play major roles in the onset of immune responses and inflammation by inducing a variety of cytokines such as TNF and IFN-beta. The pathogen-associated molecular pattern, polyinosinic-polycytidylic acid [poly(I:C)], and LPS were used to study type-I IFN and TNF responses in human macrophages. Additionally,...

journal_title：Journal of leukocyte biology

authors： Reimer T,Brcic M,Schweizer M,Jungi TW

更新日期：2008-05-01 00:00:00

abstract：:Alveolar macrophages from chronic obstructive pulmonary disease patients and cigarette smokers are deficient in their ability to phagocytose apoptotic bronchial epithelial cells (efferocytosis). We hypothesized that the defect is mediated via inhibition of sphingosine kinases and/or their subcellular mislocalization i...

journal_title：Journal of leukocyte biology

authors： Tran HB,Barnawi J,Ween M,Hamon R,Roscioli E,Hodge G,Reynolds PN,Pitson SM,Davies LT,Haberberger R,Hodge S

更新日期：2016-07-01 00:00:00

abstract：:2-Arachidonoyl-glycerol (2-AG) and arachidonyl-ethanolamide (AEA) are endocannabinoids that have been implicated in many physiologic disorders, including obesity, metabolic syndromes, hepatic diseases, pain, neurologic disorders, and inflammation. Their immunomodulatory effects are numerous and are not always mediated...

journal_title：Journal of leukocyte biology

authors： Turcotte C,Chouinard F,Lefebvre JS,Flamand N

更新日期：2015-06-01 00:00:00

abstract：:The oxidative metabolic burst of stimulated human polymorphonuclear leukocytes (PMNs) has been evaluated by the measurement of oxygen consumption, chemiluminescence, and oxygen radicals (O2-, H2O2, OH-) derived from activation of the hexose monophosphate shunt (HMPS). PMNs from patients with chronic granulomatous dise...

journal_title：Journal of leukocyte biology

authors： Hassan NF,Campbell DE,Douglas SD

更新日期：1988-04-01 00:00:00

abstract：:Absence of lymph nodes in nonmammalian species, expression of MHCII by APCs in the periphery, and the recent findings that T cells can change their polarization status after presentation in the lymph nodes imply a role for MHCII-mediated presentation outside the organized lymphoid tissue. This study shows that MHCII(+...

journal_title：Journal of leukocyte biology

authors： Inman CF,Singha S,Lewis M,Bradley B,Stokes C,Bailey M

更新日期：2010-09-01 00:00:00

abstract：:Constitutive expression of cell-associated, but not secreted, interleukin-1alpha (IL-1alpha) by oncogene-transformed fibrosarcoma cells induced regressing tumors in mice, a phenomenon that was abrogated by the IL-1 inhibitor, the IL-1 receptor antagonist (IL-1Ra). On the contrary, non-IL-1alpha-expressing tumor cells ...

journal_title：Journal of leukocyte biology

authors： Dvorkin T,Song X,Argov S,White RM,Zoller M,Segal S,Dinarello CA,Voronov E,Apte RN

更新日期：2006-07-01 00:00:00

abstract：:Autoreactive CD4+ and CD8+ T cells directed against CNS autoantigens may play a role in the development of multiple sclerosis (MS). Identical twins share the same genetic background but not the TCR repertoire that is shaped by the encounter with self or foreign antigens. To gain insights into the interplay between MS ...

journal_title：Journal of leukocyte biology

authors： Somma P,Ristori G,Battistini L,Cannoni S,Borsellino G,Diamantini A,Salvetti M,Sorrentino R,Fiorillo MT

更新日期：2007-03-01 00:00:00

abstract：:Mice with a naturally occurring Csfm(op)/Csfm(op) (op/op) gene mutation lack functional macrophage-colony stimulating factor (M-CSF) and are deficient of M-CSF-derived macrophages. They are severely monocytopenic, and their remaining M-CSF-independent macrophages were shown to differ in differentiation and distinct fu...

journal_title：Journal of leukocyte biology

authors： Schönlau F,Schlesiger C,Ehrchen J,Grabbe S,Sorg C,Sunderkötter C,Ehrehen J

更新日期：2003-05-01 00:00:00

abstract：:We examined the relationship of I-A expression by normal murine macrophages to their immunoregulatory role on natural killer cell activity. Macrophages were isolated on the basis of plastic adherence; characterized on the basis of conventional markers such as phagocytic ability, cytoplasmic non-specific esterase activ...

journal_title：Journal of leukocyte biology

authors： Nelson JA,Parhar RS,Scodras JM,Lala PK

更新日期：1990-11-01 00:00:00

abstract：:The pathogenesis of CRC remains to be further understood. This study was designed to elucidate the role of Foxp3+IL-17+ T cells in the pathogenesis of CRC. Surgically removed CRC tissue was collected from 12 patients with CRC. The frequency and cytokine profile of Foxp3+IL-17+ T cells in CRC were examined by flow cyto...

journal_title：Journal of leukocyte biology

authors： Yang S,Wang B,Guan C,Wu B,Cai C,Wang M,Zhang B,Liu T,Yang P

更新日期：2011-01-01 00:00:00

abstract：:Resting microglia comprise up to 13% of the cells in human central nervous system (CNS) white matter. Their large number and dendritic morphology make them ideally suited to survey the CNS for noxious stimuli. Upon activation microglia gradually lose dendritic processes and transform into typical phagocytic macrophage...

journal_title：Journal of leukocyte biology

authors： Ulvestad E,Williams K,Bjerkvig R,Tiekotter K,Antel J,Matre R

更新日期：1994-12-01 00:00:00

abstract：:Discussion on targeting LXR and PPAR agonists as therapeutic alternatives to ustekinumab therapy in LAD-1. ...

journal_title：Journal of leukocyte biology

authors： Cooper KN,Bagaitkar J

更新日期：2020-11-01 00:00:00

abstract：:Epinephrine inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF) production by increasing intracellular cAMP concentrations. Because agents that increase cAMP levels can enhance TNF receptor expression in vitro, granulocyte and monocyte TNF receptors were determined by FACS-analysis in 7 normal humans...

journal_title：Journal of leukocyte biology

authors： van der Poll T,Calvano SE,Kumar A,Coyle SM,Lowry SF

更新日期：1997-02-01 00:00:00

abstract：:This study investigated the expression of MUC5B by AMs in the lungs of cigarette smokers and nonsmokers. We analyzed MUC5B expression by measuring the levels of apomucin and mRNA in human BALF cells from 50 subjects (20 nonsmokers, 17 patients with CB, and 13 patients with COPD). apoMUC5B was observed in BALF mononucl...

journal_title：Journal of leukocyte biology

authors： Sepper R,Prikk K,Metsis M,Sergejeva S,Pugatsjova N,Bragina O,Marran S,Fehniger TE

更新日期：2012-08-01 00:00:00

abstract：:Mono-Mac-6 (MM6) human monocytes ingest IgG-opsonized particles better than other human cell lines. We compared the phagocytic signaling pathway in MM6 with human monocytes. MM6 expressed FcgammaRI at levels similar to monocytes, whereas FcRgammaII expression was approximately double. MM6 ingested IgG-opsonized erythr...

journal_title：Journal of leukocyte biology

authors： Karimi K,Gemmill TR,Lennartz MR

更新日期：1999-06-01 00:00:00