Altruistic death: Neutrophil apoptosis maintains gingival health.

abstract：:A combination of diclofenac and glucan administered repeatedly in a protective regimen in the course of repeated gamma irradiation of mice (6 x 2 Gy during 3 weeks) enhanced granulopoiesis and other indices of hematopoietic recovery investigated from 3 to 7 days after the last radiation exposure. Repeated administrati...

journal_title：Journal of leukocyte biology

authors： Hofer M,Pospísil M,Viklická S,Vacek A,Pipalová I,Bartonícková A

更新日期：1993-02-01 00:00:00

abstract：:Neutrophils were classically described as powerful effectors of acute inflammation, and their main purpose was assumed to be restricted to pathogen killing through production of oxidants. As consequence, neutrophils also may lead to significant collateral damage to the healthy tissues, and after performing these tasks...

journal_title：Journal of leukocyte biology

authors： Mattos MS,Lopes ME,de Araujo AM,Alvarenga DM,Nakagaki BN,Mafra K,de Miranda CDM,Diniz AB,Antunes MM,Lopes MAF,Rezende RM,Menezes GB

更新日期：2020-10-01 00:00:00

abstract：:Reactive oxygen metabolites (ROMs) have been implicated in the pathogenesis of the inflammatory response to ischemia/reperfusion (I/R), which is exacerbated in diabetes. This study revealed an increased (P < 0.01) ROMs production in mesenteric tissue (measured using the oxidant-sensitive fluorochrome dihydrorhodamine ...

journal_title：Journal of leukocyte biology

authors： Salas A,Panés J,Elizalde JI,Granger DN,Piqué JM

更新日期：1999-07-01 00:00:00

abstract：:Secretory leukocyte proteinase inhibitor (SLPI) is the main neutrophil elastase (HLE) inhibitor found in the upper airways during pulmonary inflammation. It has been shown to be synthesized and secreted in vitro by epithelial cells and has been localized in tracheal glands and bronchiolar epithelial cells by immunocyt...

journal_title：Journal of leukocyte biology

authors： Sallenave JM,Si Tahar M,Cox G,Chignard M,Gauldie J

更新日期：1997-06-01 00:00:00

abstract：:Dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) C-type lectin is almost exclusively expressed at the cell surface of DC. In addition to its normal function facilitating contact of DC with T cells, DC-SIGN has been shown to bind a variety of pathogens, including Mycobacterium bovis, and HIV-1 envelope pro...

journal_title：Journal of leukocyte biology

authors： Yamakawa Y,Pennelegion C,Willcocks S,Stalker A,Machugh N,Burt D,Coffey TJ,Werling D

更新日期：2008-06-01 00:00:00

abstract：:We examined the relationship of I-A expression by normal murine macrophages to their immunoregulatory role on natural killer cell activity. Macrophages were isolated on the basis of plastic adherence; characterized on the basis of conventional markers such as phagocytic ability, cytoplasmic non-specific esterase activ...

journal_title：Journal of leukocyte biology

authors： Nelson JA,Parhar RS,Scodras JM,Lala PK

更新日期：1990-11-01 00:00:00

abstract：:Dendritic cells (DCs) are specialized APCs present in all tissues, including tumors. They play a major role in orchestrating immune responses and were shown to occur in various functional states in tumors. In this respect, immunogenic tumor-associated DCs (TADCs) are required to initiate and sustain T cell-dependent a...

journal_title：Journal of leukocyte biology

authors： Keirsse J,Van Damme H,Van Ginderachter JA,Laoui D

更新日期：2017-08-01 00:00:00

abstract：:The colony-stimulating factors (CSF) belong to a group of proteins which regulate blood cell production. Human monocytes allowed to adhere express high levels of M-CSF transcripts and secreted protein at 24 h in the presence but not in the absence of indomethacin (Indo), an inhibitor of prostaglandin E (PGE) productio...

journal_title：Journal of leukocyte biology

authors： Lee MT,Kaushansky K,Ralph P,Ladner MB

更新日期：1990-03-01 00:00:00

abstract：:The neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) is a powerful suppressor of inflammation mediated by macrophages, which express at least two receptors, melanocortin 1 and 3 receptors (MC1r and MC3r) that bind alpha-MSH. Albeit, the anti-inflammatory activity of alpha-MSH has been well documented in m...

journal_title：Journal of leukocyte biology

authors： Li D,Taylor AW

更新日期：2008-07-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a multifunctional cytokine that plays a pivotal role in mediating neovascularization as well as other endothelial cell alterations during inflammation. In this study, we demonstrate that human neutrophils are a source of VEGF. We observed that isolated blood neutrophils rel...

journal_title：Journal of leukocyte biology

authors： Taichman NS,Young S,Cruchley AT,Taylor P,Paleolog E

更新日期：1997-09-01 00:00:00

abstract：:We reported that PARP-1 exhibits differential roles in expression of inflammatory factors. Here, we show that PARP-1 deletion was associated with a significant reduction in inflammatory cell recruitment to mouse airways upon intratracheal administration of LPS. However, PARP-1 deletion exerted little effect in respons...

journal_title：Journal of leukocyte biology

authors： Zerfaoui M,Naura AS,Errami Y,Hans CP,Rezk BM,Park J,Elsegeiny W,Kim H,Lord K,Kim JG,Boulares AH

更新日期：2009-12-01 00:00:00

abstract：:Growth hormone controls somatic growth in mammals by regulating the production of IGF-1, which is predominantly made by the liver. The development of cells within the MPS is controlled by the lineage-specific growth factor M-CSF (CSF-1). In this review, we summarize the role of CSF-1-dependent macrophages in somatic g...

journal_title：Journal of leukocyte biology

authors： Gow DJ,Sester DP,Hume DA

更新日期：2010-09-01 00:00:00

abstract：:Quartz was injected into a hind food of BALB/c and DBA/2 mice and on days 40, 90, and 180 the progressive response ensuing in the draining popliteal lymph node (PLN) was investigated by histopathology and immunohistopathology. The area of silicotic nodules (ASN) was measured by morphometry, and, by this parameter, str...

journal_title：Journal of leukocyte biology

authors： Weirich U,Friemann J,Rehn B,Henkelüdecke U,Lammers T,Sorg C,Bruch J,Gleichmann E

更新日期：1996-02-01 00:00:00

abstract：:In resident mouse peritoneal macrophages, group IVA cytosolic phospholipase A(2) (cPLA(2)alpha) mediates arachidonic acid (AA) release and eicosanoid production in response to diverse agonists such as A23187, phorbol myristate acetate, zymosan, and the enterotoxin, okadaic acid (OA). cPLA(2)alpha is regulated by phosp...

journal_title：Journal of leukocyte biology

authors： Tucker DE,Gijón MA,Spencer DM,Qiu ZH,Gelb MH,Leslie CC

更新日期：2008-09-01 00:00:00

abstract：:We have developed a method that enables the rates of phagocytosis and killing of bacteria by neutrophils to be measured in a single assay. Neutrophils were incubated with bacteria, and at specific intervals were separated from uningested bacteria by low speed centrifugation. Rates of phagocytosis and killing were calc...

journal_title：Journal of leukocyte biology

authors： Hampton MB,Vissers MC,Winterbourn CC

更新日期：1994-02-01 00:00:00

abstract：:Potential mechanisms underlying impaired chemotactic responsiveness of neonatal neutrophils were investigated. Two distinct chemoattractants were compared: bacterially derived N-formyl-methionyl-leucyl-phenylalanine (fMLP) and a unique chemotactic monoclonal antibody, designated DL1.2, which binds to a neutrophil anti...

journal_title：Journal of leukocyte biology

authors： Weinberger B,Laskin DL,Mariano TM,Sunil VR,DeCoste CJ,Heck DE,Gardner CR,Laskin JD

更新日期：2001-12-01 00:00:00

abstract：:Natural killer (NK) cells arise from immature progenitors present in fetal tissues and adult bone marrow, but the factors responsible for driving the proliferation and differentiation of these progenitors are poorly understood. Mouse NK cells had previously been thought not to express interleukin (IL)-2Ralpha chains, ...

journal_title：Journal of leukocyte biology

authors： Toomey JA,Gays F,Foster D,Brooks CG

更新日期：2003-08-01 00:00:00

abstract：:Nitric oxide (NO(.-)) contributes to vascular collapse in septic shock and regulates inflammation. Here, we demonstrate in lipopolysaccharide (LPS)-stimulated human THP-1 cells and monocytes that NO(.-) regulates interleukin (IL)-8 and tumor necrosis factor alpha (TNF-alpha) by distinct mechanisms. Dibutyryl-cyclic gu...

journal_title：Journal of leukocyte biology

authors： Ma P,Cui X,Wang S,Zhang J,Nishanian EV,Wang W,Wesley RA,Danner RL

更新日期：2004-07-01 00:00:00

abstract：:Colostrum plays an important role in protecting newborn infants against acute gastrointestinal and respiratory infections. IgA antibodies have been considered the major effector component; however, the role of their receptors on colostral phagocytes, especially neutrophils, has not been studied. Here, we demonstrate t...

journal_title：Journal of leukocyte biology

authors： Honorio-França AC,Launay P,Carneiro-Sampaio MM,Monteiro RC

更新日期：2001-02-01 00:00:00

abstract：:Radioprotective 105 kDa (CD180) is an unusual TLR that lacks an intracellular Toll-IL-1R signaling domain and exhibits unconventional homodimerization behavior. Differential expression and functions of radioprotective 105 kDa have been associated with immune-mediated pathologies, including infection, chronic inflammat...

journal_title：Journal of leukocyte biology

authors： Schultz TE,Blumenthal A

更新日期：2017-01-01 00:00:00

abstract：:Blood leukocyte count alterations induced by PAF-acether in anesthetized and nonanesthetized rats were investigated. Intravenous injection of increasing amounts of PAF-acether (1.5-8 micrograms/kg) in nonanesthetized animals induced dose-dependent hemoconcentration and leukocytosis. The former was apparent within 10 m...

journal_title：Journal of leukocyte biology

authors： Bozza PT,Silva PM,Castro-Faria-Neto HC,Martins MA,Cordeiro RS

更新日期：1992-02-01 00:00:00

abstract：:Eosinophils are generally linked to innate host defense against helminths, as well as the pathologies associated with allergic diseases, such as asthma. Nonetheless, the activities of eosinophils remain poorly understood, which in turn, has prevented detailed definitions of their role(s) in health and disease. Homolog...

journal_title：Journal of leukocyte biology

authors： Doyle AD,Jacobsen EA,Ochkur SI,Willetts L,Shim K,Neely J,Kloeber J,Lesuer WE,Pero RS,Lacy P,Moqbel R,Lee NA,Lee JJ

更新日期：2013-07-01 00:00:00

abstract：:Thrombin has receptor-mediated effects on a variety of cell types. A recently cloned platelet thrombin receptor exerts its effects by a tethered-ligand mechanism. A similar receptor was shown in at least two nonplatelet cell types, fibroblasts and endothelial cells. Thrombin has biologically important effects on leuko...

journal_title：Journal of leukocyte biology

authors： Hoffman M,Church FC

更新日期：1993-08-01 00:00:00

abstract：:Insight into molecular and cellular mechanisms of innate immunity is critical to understand viral pathogenesis and immunopathology and might be exploited for therapy. Whereas the molecular mechanisms of the IFN defense are well established, cellular mechanisms of antiviral immunity are only emerging, and their pharmac...

journal_title：Journal of leukocyte biology

authors： Li S,Starckx S,Martens E,Dillen C,Lamerant-Fayel N,Berghmans N,Gouwy M,van Pel M,Heremans H,Kieda C,Fibbe WE,Billiau A,Van Damme J,Opdenakker G

更新日期：2010-11-01 00:00:00

abstract：:Genomic, transcriptomic and proteomic databases indicate that the N-terminal 322 residues encoded by the presumptive LOC100996504 gene, which is adjacent to the ARHGEF18 guanine nucleotide exchange factor gene on chromosome 19, constitute the N-terminal portion of a 1361-residue isoform of ARHGEF18, dubbed LOCGEF-X3. ...

journal_title：Journal of leukocyte biology

authors： Turton KB,Wilkerson EM,Hebert AS,Fogerty FJ,Schira HM,Botros FE,Coon JJ,Mosher DF

更新日期：2018-07-01 00:00:00

abstract：:The receptor for urokinase plasminogen activator (uPAR; CD87) is a 50- to 65-kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed by leukocytes and tumor cells where it facilitates uPA-dependent, plasmin-mediated pericellular proteolysis during cellular invasion. Because uPAR is inducibly shed into c...

journal_title：Journal of leukocyte biology

authors： Mizukami IF,Todd RF 3rd

更新日期：1998-08-01 00:00:00

abstract：:Exposure of lymphocytes from guinea pigs sensitized to keyhole limpet hemocyanin and of macrophages from nonsensitized animals to noncytotoxic doses of lidocaine (10(-4) to 10(-6) M) resulted in the inhibition of the production of macrophage migration inhibitory factor and of macrophage motility. The inhibition of bot...

journal_title：Journal of leukocyte biology

authors： Dickstein RA,Kiremidjian-Schumacher L,Stotzky G

更新日期：1984-11-01 00:00:00

abstract：:The preferential association of some chemokine receptors with human Th1 or Th2 cells has recently been reported. In this study, the expression of CCR3, CCR5, CXCR3, and CXCR4 were analyzed by flow cytometry in three distinct in vitro models of Th1/Th2 polarization, activated naive and memory T cells, and T-cell clones...

journal_title：Journal of leukocyte biology

authors： Annunziato F,Cosmi L,Galli G,Beltrame C,Romagnani P,Manetti R,Romagnani S,Maggi E

更新日期：1999-05-01 00:00:00

abstract：:2-Arachidonoyl-glycerol (2-AG) and arachidonyl-ethanolamide (AEA) are endocannabinoids that have been implicated in many physiologic disorders, including obesity, metabolic syndromes, hepatic diseases, pain, neurologic disorders, and inflammation. Their immunomodulatory effects are numerous and are not always mediated...

journal_title：Journal of leukocyte biology

authors： Turcotte C,Chouinard F,Lefebvre JS,Flamand N

更新日期：2015-06-01 00:00:00

abstract：:Lymphocyte development is initiated from hematopoietic stem cells and can be divided into multiple phenotypically distinct stages. Transcription factors play important roles in programming the developmental process of lymphocytes. Recent studies have identified key roles of several orphan nuclear receptors in T lympho...

journal_title：Journal of leukocyte biology

authors： He YW

更新日期：2002-09-01 00:00:00