Regulation by dietary essential fatty acid balance of tumor necrosis factor production in mouse macrophages.

abstract：:We have characterized the beta-adrenergic receptor binding site and the beta-adrenergic cAMP response of the HL-60 cell. The hydrophilic ligand [3H]-(-)-CGP-12177 was specifically and reversibly bound to one single class of binding sites (Kd 220 pM and Bmax 1,970 sites/cell). The adrenergic agonists inhibited the spec...

journal_title：Journal of leukocyte biology

authors： Sager G,Bang BE,Pedersen M,Aarbakke J

更新日期：1988-07-01 00:00:00

abstract：:A combination of diclofenac and glucan administered repeatedly in a protective regimen in the course of repeated gamma irradiation of mice (6 x 2 Gy during 3 weeks) enhanced granulopoiesis and other indices of hematopoietic recovery investigated from 3 to 7 days after the last radiation exposure. Repeated administrati...

journal_title：Journal of leukocyte biology

authors： Hofer M,Pospísil M,Viklická S,Vacek A,Pipalová I,Bartonícková A

更新日期：1993-02-01 00:00:00

abstract：:CD11c, a member of the leukointegrin family, is expressed prominently on tissue macrophages and dendritic cells and binds to complement fragment (iC3b), provisional matrix molecules (fibrinogen), and the Ig superfamily cell adhesion molecule, ICAM-1. CD11c has been proposed to function in phagocytosis, cell migration,...

journal_title：Journal of leukocyte biology

authors： Sadhu C,Ting HJ,Lipsky B,Hensley K,Garcia-Martinez LF,Simon SI,Staunton DE

更新日期：2007-06-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a potent natural adjuvant, commonly used to amplify Th1 responses. Here, we report that systemic immunization using LPS generates large numbers of specific Th17 cells in murine small intestinal lamina propria. The priming of these Th17 cells required IL-23p19 production by bone marrow-deriv...

journal_title：Journal of leukocyte biology

authors： McAleer JP,Liu B,Li Z,Ngoi SM,Dai J,Oft M,Vella AT

更新日期：2010-07-01 00:00:00

abstract：:Postnatal stem cells regulate the homeostasis of the majority of our tissues. They continuously generate new progenitors and mature, functional cells to replace old cells, which cannot assume the tissue function anymore and are eliminated. Blood, skin, gut mucosa, muscle, cartilage, nerves, cornea, retina, liver, and ...

journal_title：Journal of leukocyte biology

authors： Kindler V

更新日期：2005-10-01 00:00:00

abstract：:Myeloperoxidase aids in clearance of microbes by generation of peroxidase-mediated oxidants that kill leukocyte-engulfed pathogens. In this review, we will examine 1) strategies for in vitro evaluation of myeloperoxidase function and its inhibition, 2) ways to monitor generation of certain oxidant species during infla...

journal_title：Journal of leukocyte biology

authors： Huang J,Milton A,Arnold RD,Huang H,Smith F,Panizzi JR,Panizzi P

更新日期：2016-04-01 00:00:00

abstract：:Hepatic Macs, consisting of resident KCs and infiltrating monocytes/IMs, are thought to play an important role in the pathogenesis of ALD. Previous work has focused on KCs or studied hepatic Macs as one cell population. The aim of the current study is to distinguish IMs from KCs and to compare their phenotypes and fun...

journal_title：Journal of leukocyte biology

authors： Wang M,You Q,Lor K,Chen F,Gao B,Ju C

更新日期：2014-10-01 00:00:00

abstract：:Resting microglia comprise up to 13% of the cells in human central nervous system (CNS) white matter. Their large number and dendritic morphology make them ideally suited to survey the CNS for noxious stimuli. Upon activation microglia gradually lose dendritic processes and transform into typical phagocytic macrophage...

journal_title：Journal of leukocyte biology

authors： Ulvestad E,Williams K,Bjerkvig R,Tiekotter K,Antel J,Matre R

更新日期：1994-12-01 00:00:00

abstract：:Because myotonic dystrophy (MD) is an autosomal dominant multisystemic disorder affecting plasma membrane, we have studied the oxidative burst of PMNs. The PMA and fMet-Leu-Phe-stimulated superoxide generation is defective in the patient group as compared to controls: the response is both delayed and low. The kinetic ...

journal_title：Journal of leukocyte biology

authors： Mege JL,Pouget J,Capo C,Andre P,Benoliel AM,Serratrice G,Bongrand P

更新日期：1988-09-01 00:00:00

abstract：:Mycobacterium avium complex (MAC) is a significant cause of opportunistic infection in patients with acquired immunodeficiency syndrome. Although the major route of entry of MAC is via the gastrointestinal tract, MAC can infect humans through the respiratory tract and eventually encounter alveolar macrophages within t...

journal_title：Journal of leukocyte biology

authors： Lopez JP,Clark E,Shepherd VL

更新日期：2003-10-01 00:00:00

abstract：:CD163 is the monocyte/macrophage-specific receptor for haptoglobin-hemoglobin (Hp-Hb) complexes. The cytoplasmic tail of human CD163 exists as a short tail variant and two long tail variants. Reverse transcriptase-polymerase chain reaction analysis indicated that all three CD163 variants are substantially expressed in...

journal_title：Journal of leukocyte biology

authors： Nielsen MJ,Madsen M,Møller HJ,Moestrup SK

更新日期：2006-04-01 00:00:00

abstract：:We have shown previously that the cellular proteins 47b and 71/73 could be used to construct phenotypes that distinguish among bone marrow culture-derived (BMCD) macrophages that were either unstimulated or primed by gamma interferon or fully activated for tumor cell killing by gamma interferon in combination with lip...

journal_title：Journal of leukocyte biology

authors： MacKay RJ,Russell SW

更新日期：1987-09-01 00:00:00

abstract：:Signaling through chemokine receptor, C-X-C chemokine receptor type 4 (CXCR4) regulates essential processes in normal physiology, including embryogenesis, tissue repair, angiogenesis, and trafficking of immune cells. Tumors co-opt many of these fundamental processes to directly stimulate proliferation, invasion, and m...

journal_title：Journal of leukocyte biology

authors： Luker GD,Yang J,Richmond A,Scala S,Festuccia C,Schottelius M,Wester HJ,Zimmermann J

更新日期：2020-10-26 00:00:00

abstract：:We have shown that low-dose UVB radiation converts Langerhans cells (LC) from immunogenic to tolerogenic APC. Therefore, we questioned whether low-dose UVB irradiation of bone marrow-derived dendritic cells (DC) alters their APC function, thereby inducing tolerance in T cells. To address this issue, cocultures of DC; ...

journal_title：Journal of leukocyte biology

authors： Denfeld RW,Hara H,Tesmann JP,Martin S,Simon JC

更新日期：2001-04-01 00:00:00

abstract：:Emerging evidence has revealed that noradrenaline (NA), the main neurotransmitter of the sympathetic nervous system (SNS), regulates a variety of immune functions via binding to adrenergic receptors present on immune cells. In this study, we examined the role of NA in the regulation of neutrophil functions. Neutrophil...

journal_title：Journal of leukocyte biology

authors： Nicholls AJ,Wen SW,Hall P,Hickey MJ,Wong CHY

更新日期：2018-02-01 00:00:00

abstract：:Many tumor cells are resistant to Fas-mediated killing, which has been primarily used as a mechanism to evade immune attack. In this study, we found a new action of Fas on tumors where activation of the Fas signal may force tumor cells to produce survival factors for neutrophils. Human peripheral circulating neutrophi...

journal_title：Journal of leukocyte biology

authors： Hor WS,Huang WL,Lin YS,Yang BC

更新日期：2003-03-01 00:00:00

abstract：:To become competent killer cells, CD8(+) T cells require stimulation through signal transduction pathways associated with the T-cell receptor, costimulatory molecules such as CD28, and cytokine receptors such as the interleukin (IL)-2 receptor. We used wortmannin and LY294002, two inhibitors of phosphatidylinositol 3-...

journal_title：Journal of leukocyte biology

authors： Phu T,Haeryfar SM,Musgrave BL,Hoskin DW

更新日期：2001-05-01 00:00:00

abstract：:Recent advances have led to the identification and characterization of an array of transmembrane proteases that mediate the proteolysis of various substrates (including bioactive peptides, components of the extracellular matrix, and integral proteins) and cell-cell or cell-matrix adhesion. The membrane proteases known...

journal_title：Journal of leukocyte biology

authors： Bauvois B

更新日期：2001-07-01 00:00:00

abstract：:Engagement of 2B4 (CD244) with CD48 results in activation, costimulation, or inhibition of NK cell activities, depending on the cell types and the stage of differentiation. In vivo, 2B4+ NK cells can interact with CD48+ NK cells and also with surrounding CD48+ hematopoietic cells. Similarly, CD48+ NK cells may be trig...

journal_title：Journal of leukocyte biology

authors： Kim EO,Kim N,Kim TJ,Kim K,Kim TW,Kumar V,Lee KM

更新日期：2010-10-01 00:00:00

abstract：:Eosinophils are generally linked to innate host defense against helminths, as well as the pathologies associated with allergic diseases, such as asthma. Nonetheless, the activities of eosinophils remain poorly understood, which in turn, has prevented detailed definitions of their role(s) in health and disease. Homolog...

journal_title：Journal of leukocyte biology

authors： Doyle AD,Jacobsen EA,Ochkur SI,Willetts L,Shim K,Neely J,Kloeber J,Lesuer WE,Pero RS,Lacy P,Moqbel R,Lee NA,Lee JJ

更新日期：2013-07-01 00:00:00

abstract：:The colony-stimulating factors (CSF) belong to a group of proteins which regulate blood cell production. Human monocytes allowed to adhere express high levels of M-CSF transcripts and secreted protein at 24 h in the presence but not in the absence of indomethacin (Indo), an inhibitor of prostaglandin E (PGE) productio...

journal_title：Journal of leukocyte biology

authors： Lee MT,Kaushansky K,Ralph P,Ladner MB

更新日期：1990-03-01 00:00:00

abstract：:During inflammatory and immunological responses, leukocytes respond to external stimuli by altering the stability of cytokine and cytokine receptor messages. Change in message stability is an effective mechanism for rapidly regulating steady state levels of mRNA. Cytokine messages containing A-U-rich elements located ...

journal_title：Journal of leukocyte biology

authors： Xu L,Rahimpour R,Ran L,Kong C,Biragyn A,Andrews J,Devries M,Wang JM,Kelvin DJ

更新日期：1997-11-01 00:00:00

abstract：:Neutrophil apoptosis leads to macrophage ingestion of intact senescent neutrophils. This may represent a neutrophil removal mechanism that is important both in the control of inflammatory tissue injury and for the normal resolution processes of inflammation. Because apoptosis is likely to be a key control process in c...

journal_title：Journal of leukocyte biology

authors： Lee A,Whyte MK,Haslett C

更新日期：1993-10-01 00:00:00

abstract：:Extracellular histones have been implicated as a cause of tissue inflammatory injury in a variety of disorders including sepsis, lung, and liver diseases. However, little is known about their interactions with neutrophils and how this might contribute to injury. Here, it is shown that histone H4 acts as neutrophil act...

journal_title：Journal of leukocyte biology

authors： Hsieh IN,Deluna X,White MR,Hartshorn KL

更新日期：2020-08-17 00:00:00

abstract：:Constitutive expression of cell-associated, but not secreted, interleukin-1alpha (IL-1alpha) by oncogene-transformed fibrosarcoma cells induced regressing tumors in mice, a phenomenon that was abrogated by the IL-1 inhibitor, the IL-1 receptor antagonist (IL-1Ra). On the contrary, non-IL-1alpha-expressing tumor cells ...

journal_title：Journal of leukocyte biology

authors： Dvorkin T,Song X,Argov S,White RM,Zoller M,Segal S,Dinarello CA,Voronov E,Apte RN

更新日期：2006-07-01 00:00:00

abstract：:Severe injury can initiate an exaggerated systemic inflammatory response and multiple organ failure (MOF) if a subsequent immune stimulus, "second hit", occurs. Using a mouse thermal injury model, we tested whether changes in innate immune cell reactivity following injury can contribute to the development of heightene...

journal_title：Journal of leukocyte biology

authors： Murphy TJ,Paterson HM,Kriynovich S,Zang Y,Kurt-Jones EA,Mannick JA,Lederer JA

更新日期：2005-01-01 00:00:00

abstract：:Besides their growth-inhibiting and differentiation-inducing properties, retinoids have been shown to exert immunomodulatory and anti-inflammatory functions by mechanisms that are not well understood. Tumor necrosis factor-alpha (TNF), a cytokine produced by mononuclear phagocytes, has been shown to be an important me...

journal_title：Journal of leukocyte biology

authors： Mehta K,McQueen T,Tucker S,Pandita R,Aggarwal BB

更新日期：1994-03-01 00:00:00

abstract：:We tested several of the functions of macrophages (M phi) in the early phase after allogeneic bone marrow transfer to get information about this important aspect of the nonspecific immune system in the T-cell-deficient recipient. On days 3-5 after transfer, the number of M phi was reduced in the spleen, liver, lungs, ...

journal_title：Journal of leukocyte biology

authors： Roesler J,Baccarini M,Vogt B,Lohmann-Matthes ML

更新日期：1989-08-01 00:00:00

abstract：:TNFR-associated periodic syndrome is an autoinflammatory disorder caused by autosomal-dominant mutations in TNFRSF1A, the gene encoding for TNFR superfamily 1A. The lack of knowledge in the field of TNFR-associated periodic syndrome biology is clear, particularly in the context of control of immune self-tolerance. We ...

journal_title：Journal of leukocyte biology

authors： Pucino V,Lucherini OM,Perna F,Obici L,Merlini G,Cattalini M,La Torre F,Maggio MC,Lepore MT,Magnotti F,Galgani M,Galeazzi M,Marone G,De Rosa V,Talarico R,Cantarini L,Matarese G

更新日期：2016-05-01 00:00:00

abstract：:How regulatory T (TR) cells dampen T cell responses remains unclear. Multiple modes of action have been proposed, including cell contact-dependent and/or cytokine-dependent mechanisms. Suppression may involve direct contact between TR cells and responder T cells. Alternatively, TR cells may act on dendritic cells to r...

journal_title：Journal of leukocyte biology

authors： Bodor J,Fehervari Z,Diamond B,Sakaguchi S

更新日期：2007-01-01 00:00:00