Abstract:
:Many intracellular signals, such as host danger-associated molecules and bacterial toxins during infection, elicit inflammasome activation. However, the mechanical environment in tissues may also influence the sensitivity of various inflammasomes to activation. The cellular mechanical environment is determined by the extracellular tissue stiffness, or its inverse, tissue compliance. Tissue stiffness is sensed by the intracellular cytoskeleton through a process termed mechanotransduction. Thus, extracellular compliance and the intracellular cytoskeleton may regulate the sensitivity of inflammasome activation. Control of proinflammatory signaling by tissue compliance may contribute to the pathogenesis of diseases such as ventilator-induced lung injury during bacterial pneumonia and tissue fibrosis in inflammatory disorders. The responsible signaling cascades in inflammasome activation pathways and mechanotransduction crosstalk are not yet fully understood. This rather different immunomodulatory perspective will be reviewed and open questions discussed here.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Joshi H,Morley SCdoi
10.1002/JLB.3MIR1118-417Rsubject
Has Abstractpub_date
2019-07-01 00:00:00pages
119-125issue
1eissn
0741-5400issn
1938-3673journal_volume
106pub_type
杂志文章,评审abstract::Radiation-induced chimeric mice were used to study the origin of pulmonary alveolar macrophages. Unlike in other studies, these radiation chimeras were prepared by using a special fractionated irradiation regimen to minimize the killing of alveolar macrophage colony-forming cells, putative local stem cells. For this s...
journal_title:Journal of leukocyte biology
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journal_title:Journal of leukocyte biology
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pub_type: 杂志文章
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章,评审
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更新日期:2014-09-01 00:00:00
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章
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更新日期:1996-05-01 00:00:00
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章
doi:10.1189/jlb.3A0515-201R
更新日期:2016-03-01 00:00:00
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章,评审
doi:10.1002/JLB.3MIR1218-483RR
更新日期:2019-07-01 00:00:00
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章
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更新日期:2001-03-01 00:00:00
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章,评审
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章
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journal_title:Journal of leukocyte biology
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
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