Abstract:
:A murine interleukin-2 (IL-2)-dependent T-cell line, CTLL-2, was infected with a retrovirus carrying the mouse c-myc cDNA and the Tn-5 neogene. Transduced cells were selected in the presence of Geneticin sulfate (G418); these cells were shown to express both the endogenous and the transduced c-myc genes. The IL-2 requirement of these cells was then found to be significantly reduced. The cells did not express IL-2 mRNA nor did they produce an activity mitogenic for CTLL-2 cells. This suggests that the reduction of IL-2 dependence observed following retroviral transduction of c-myc is caused by a nonautocrine mechanism.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Shapiro IM,Winberg G,Stefanescu I,Wigzell H,Menezes Jdoi
10.1002/jlb.44.6.559subject
Has Abstractpub_date
1988-12-01 00:00:00pages
559-65issue
6eissn
0741-5400issn
1938-3673journal_volume
44pub_type
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