Infection of a murine T-cell line with a retrovirus carrying c-myc decreases the interleukin-2 cell dependence by a nonautocrine mechanism.

abstract：:Dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) C-type lectin is almost exclusively expressed at the cell surface of DC. In addition to its normal function facilitating contact of DC with T cells, DC-SIGN has been shown to bind a variety of pathogens, including Mycobacterium bovis, and HIV-1 envelope pro...

journal_title：Journal of leukocyte biology

authors： Yamakawa Y,Pennelegion C,Willcocks S,Stalker A,Machugh N,Burt D,Coffey TJ,Werling D

更新日期：2008-06-01 00:00:00

abstract：:The CD2 receptor on T-lymphocytes plays a major part in mediating adhesive interactions via the LFA-3 ligand and in transducing signals for lymphocyte activation. In this study the expression, function, and internalization of the CD2 receptor was investigated in resting and activated murine T-cells. Surface iodination...

journal_title：Journal of leukocyte biology

authors： Abraham DJ,Bou-Gharios G,Beauchamp JR,Plater-Zyberk C,Maini RN,Olsen I

更新日期：1991-04-01 00:00:00

abstract：:Viral recognition programs DCs to express Signal 3 molecules that promote the differentiation of effector CD8(+) T cells. Besides IL-12, another DC-derived IL-12 family member, IL-27, has been reported to contribute herein, but its specific role is not well understood. Here, we show that whereas IL-12 potently induces...

journal_title：Journal of leukocyte biology

authors： de Groot R,van Beelen AJ,Bakdash G,Taanman-Kueter EW,de Jong EC,Kapsenberg ML

更新日期：2012-09-01 00:00:00

abstract：:Live, but not dead Bacillus Calmette-Guérin (BCG) is partially protective against infection by Mycobacterium tuberculosis, which causes a disease with high mortality in immune compromised individuals. We have shown that uptake of BCG induces maturation of immature dendritic cells (DCs) regardless of the viability of t...

journal_title：Journal of leukocyte biology

authors： Tsunetsugu-Yokota Y,Tamura H,Tachibana M,Ogata K,Honda M,Takemori T

更新日期：2002-07-01 00:00:00

abstract：:Several in vitro functions of neonatal neutrophils (N-PMN) have been reported to be deficient and may be functionally related to the increased susceptibility of the newborn to infection. To evaluate an in vitro event corresponding to one of the early steps in the sequence of inflammation, we used zymosan-activated pla...

journal_title：Journal of leukocyte biology

authors： Zwahlen RD,Slauson DO,Neilsen NR,Clifford CB

更新日期：1987-06-01 00:00:00

abstract：:The aim of this study was to test the hypothesis whether MERTK, which is up-regulated in human DCs treated with immunosuppressive agents, is directly involved in modulating T cell activation. MERTK is a member of the TAM family and contributes to regulating innate immune response to ACs by inhibiting DC activation in ...

journal_title：Journal of leukocyte biology

authors： Cabezón R,Carrera-Silva EA,Flórez-Grau G,Errasti AE,Calderón-Gómez E,Lozano JJ,España C,Ricart E,Panés J,Rothlin CV,Benítez-Ribas D

更新日期：2015-04-01 00:00:00

abstract：:IL-31, a newly identified member of the IL-6 cytokine family, is involved in many pathological conditions, including atopic dermatitis and pruritis. In this study, we investigated how expression of IL-31 is regulated in T cells and mast cells. We observed that expression of IL-31 required a calcium signal and was depe...

journal_title：Journal of leukocyte biology

authors： Park K,Park JH,Yang WJ,Lee JJ,Song MJ,Kim HP

更新日期：2012-02-01 00:00:00

abstract：:Dendritic cells (DCs) are specialized APCs present in all tissues, including tumors. They play a major role in orchestrating immune responses and were shown to occur in various functional states in tumors. In this respect, immunogenic tumor-associated DCs (TADCs) are required to initiate and sustain T cell-dependent a...

journal_title：Journal of leukocyte biology

authors： Keirsse J,Van Damme H,Van Ginderachter JA,Laoui D

更新日期：2017-08-01 00:00:00

abstract：:We investigated the capacity of counterflow-isolated human monocytes to independently synthesize thromboxane B2 (TxB2) and prostaglandin E2 (PGE2) when stimulated with bacterial lipopolysaccharide (LPS). Independent metabolism was confirmed by establishing different specific activities (dpm/ng) of TxB2 and PGE2 releas...

journal_title：Journal of leukocyte biology

authors： Nichols FC,Garrison SW,Davis HW

更新日期：1988-11-01 00:00:00

abstract：:The actual level of circulating estrogen (17β-estradiol, E2) has a serious impact on regulation of diverse immune cell functions, where their classical cytoplasmic receptors, ERα and ERβ, act as nuclear transcriptional regulators of multiple target genes. There is growing evidence, however, for rapid, "non-nuclear" re...

journal_title：Journal of leukocyte biology

authors： Schneider AE,Kárpáti E,Schuszter K,Tóth EA,Kiss E,Kulcsár M,László G,Matko J

更新日期：2014-11-01 00:00:00

abstract：:Histone acetylation has an important role in gene regulation, DNA replication, and repair. Because these processes are central to the development of the immune system, we investigated the role of a previously unstudied histone acetyltransferase named KAT7 (also known as Myst2 or HBO1) in the regulation of thymopoiesis...

journal_title：Journal of leukocyte biology

authors： Newman DM,Voss AK,Thomas T,Allan RS

更新日期：2017-04-01 00:00:00

abstract：:Although class A type I/II scavenger receptor (SR-A) is involved in numerous macrophage functions, its signaling ability remains uncertain. We used monoclonal antibodies (mAb) to specifically stimulate receptors on mouse alveolar (AMs) and peritoneal macrophages (PMs). Immobilized anti-SR-A (2F8) and anti-FcgammaR II/...

journal_title：Journal of leukocyte biology

authors： Józefowski S,Kobzik L

更新日期：2004-11-01 00:00:00

abstract：:In the pathogenesis of chronic inflammatory periodontal disease, neutrophils are recognized as a major cellular component from the histopathology of the periodontal lesion around teeth and from clinical cases where absence or dysfunction of neutrophils results in major periodontal destruction. Neutrophils are recruite...

journal_title：Journal of leukocyte biology

authors： Galicia JC,Benakanakere MR,Stathopoulou PG,Kinane DF

更新日期：2009-07-01 00:00:00

abstract：:The immunosuppressive activity of interleukin-10 (IL-10) makes this cytokine a potentially important clinical tool to reduce inflammatory responses in various diseases. Its efficacy as a therapeutic modality is dependent on the responsiveness of immune cells. We report that macrophages from mice chronically infected w...

journal_title：Journal of leukocyte biology

authors： Avdiushko R,Hongo D,Lake-Bullock H,Kaplan A,Cohen D

更新日期：2001-10-01 00:00:00

abstract：:Infection with the opportunistic pathogen Pseudomonas aeruginosa is effectively controlled through tightly coordinated inflammation in healthy individuals. Dysregulated inflammation in cystic fibrosis greatly increases susceptibility to P. aeruginosa and lung damage. Recently, we identified regulator of calcineurin-1,...

journal_title：Journal of leukocyte biology

authors： Pang Z,Junkins RD,MacNeil AJ,McCormick C,Cheng Z,Chen WM,Lin TJ

更新日期：2017-12-01 00:00:00

abstract：:Mucosa represents the main site of pathogen/cell interactions. The two main types of cells forming the epithelial structure [epithelial cells and Langerhans cells (LC)] coordinate the first defense responses to avoid infection. To evaluate the involvement of epithelial cells in the early steps leading to a specific ad...

journal_title：Journal of leukocyte biology

authors： Cremel M,Berlier W,Hamzeh H,Cognasse F,Lawrence P,Genin C,Bernengo JC,Lambert C,Dieu-Nosjean MC,Delézay O

更新日期：2005-07-01 00:00:00

abstract：:It has been reported recently that granulocyte-colony stimulating factor (G-CSF) is degraded upon exposure to human neutrophil elastase (HNE), and this has a negative effect on the ability of the cytokine to promote the in vitro proliferation and maturation of CD34+ cells. This has important implications on the possib...

journal_title：Journal of leukocyte biology

authors： Carter CR,Whitmore KM,Thorpe R

更新日期：2004-03-01 00:00:00

abstract：:The airway epithelial cell of the lower respiratory tract is the primary host target cell for respiratory syncytial virus (RSV) infection. To estimate whether infected epithelial cells contribute to the inflammatory host response observed during the acute infection phase we analyzed the cell surface expression of inte...

journal_title：Journal of leukocyte biology

authors： Arnold R,Konig W

更新日期：1996-12-01 00:00:00

abstract：:4-1BB is a member of the TNFR superfamily, which contributes to the activation of signaling pathways required for the survival of activated and memory T cells. We have shown previously that TRAF1, an adaptor protein recruited to 4-1BB, is required for 4-1BB-mediated CD8 T cell survival in vivo. With the use of a prote...

journal_title：Journal of leukocyte biology

authors： Sabbagh L,Andreeva D,Laramée GD,Oussa NA,Lew D,Bisson N,Soumounou Y,Pawson T,Watts TH

更新日期：2013-05-01 00:00:00

abstract：:It has been shown recently that MCs are required for differential regulation of the immune response by granulocytic versus monocytic MDSCs. Granulocytic MDSCs promoted parasite clearance, whereas monocytic MDSCs enhanced tumor progression; both activities were abrogated in MC-deficient mice. Herein, we demonstrate tha...

journal_title：Journal of leukocyte biology

authors： Martin RK,Saleem SJ,Folgosa L,Zellner HB,Damle SR,Nguyen GK,Ryan JJ,Bear HD,Irani AM,Conrad DH

更新日期：2014-07-01 00:00:00

abstract：:Granulocyte apoptosis and subsequent clearance by phagocytes are critical for the resolution of inflammation. However, no studies have addressed how the resolution proceeds in the inflammatory site. We studied the time course of neutrophil apoptosis and the following ingestion by mononuclear leukocytes in rat carragee...

journal_title：Journal of leukocyte biology

authors： Murai N,Nagai K,Fujisawa H,Hatanaka K,Kawamura M,Harada Y

更新日期：2003-04-01 00:00:00

abstract：:In vivo, dendritic cells (DC) form a network comprising different populations. In particular, Langerhans cells (LC) appear as a unique population of cells dependent on transforming growth factor beta(TGF-beta) for its development. In this study, we show that endogenous TGF-beta is required for the development of both ...

journal_title：Journal of leukocyte biology

authors： Caux C,Massacrier C,Dubois B,Valladeau J,Dezutter-Dambuyant C,Durand I,Schmitt D,Saeland S

更新日期：1999-11-01 00:00:00

abstract：:During B-cell differentiation, the gene expression of B-cell differentiation-related transcription factors must be strictly controlled by epigenetic mechanisms including histone acetylation and deacetylation, to complete the differentiation pathway. GCN5, one of the most important histone acetyltransferases, is involv...

journal_title：Journal of leukocyte biology

authors： Kikuchi H,Nakayama M,Kuribayashi F,Imajoh-Ohmi S,Nishitoh H,Takami Y,Nakayama T

更新日期：2014-03-01 00:00:00

abstract：:The ability of neutrophils to sense and migrate toward damaged tissue is a vital component of the innate immune response. Paradoxically, this same migration serves as the hallmark of a number of inflammatory conditions, including ischemic reperfusion injury, atherosclerosis, arthritis, and Crohn's disease. More recent...

journal_title：Journal of leukocyte biology

authors： Maher BM,Dhonnchu TN,Burke JP,Soo A,Wood AE,Watson RW

更新日期：2009-01-01 00:00:00

abstract：:The success of using immune checkpoint inhibitors to treat cancers implies that inhibiting an immunosuppressive cytokine, such as TGF-β2, could be a strategy to develop novel adjuvants for microbial vaccines. To develop nucleic acid based TGF-β2 inhibitors, we designed three antisense oligonucleotides, designated as T...

journal_title：Journal of leukocyte biology

authors： Tu L,Sun X,Yang L,Zhang T,Zhang X,Li X,Dong B,Liu Y,Yang M,Wang L,Yu Y

更新日期：2020-11-01 00:00:00

abstract：:Both humoral and cellular immune responses are inducible by inoculation of naked plasmid DNA encoding a polypeptide antigen. This new vaccination protocol, known as genetic immunization, has been used to initiate protective immunity against a variety of infectious pathogens and tumors in experimental animals. Dendriti...

journal_title：Journal of leukocyte biology

authors： Takashima A,Morita A

更新日期：1999-08-01 00:00:00

abstract：:The absence or reduction of CFTR function causes CF and results in a pulmonary milieu characterized by bacterial colonization and unresolved inflammation. The ineffectiveness at controlling infection by species such as Pseudomonas aeruginosa suggests defects in innate immunity. Macrophages, neutrophils, and DCs have a...

journal_title：Journal of leukocyte biology

authors： Bonfield TL,Hodges CA,Cotton CU,Drumm ML

更新日期：2012-11-01 00:00:00

abstract：:Radiation-induced chimeric mice were used to study the origin of pulmonary alveolar macrophages. Unlike in other studies, these radiation chimeras were prepared by using a special fractionated irradiation regimen to minimize the killing of alveolar macrophage colony-forming cells, putative local stem cells. For this s...

journal_title：Journal of leukocyte biology

authors： Tarling JD,Lin HS,Hsu S

更新日期：1987-11-01 00:00:00

abstract：:Mycoplasmas and mycoplasma membranes have been shown to induce the production of inflammatory cytokines, including tumor necrosis factor alpha and interleukin-6, as well as nitric oxide, by mouse macrophages and rat brain astrocytes. Luminol-enhanced chemiluminescence was used as a sensitive method to show that Mycopl...

journal_title：Journal of leukocyte biology

authors： Avron A,Gallily R

更新日期：1995-02-01 00:00:00

abstract：:T cell-mediated immunity against Chlamydia in mice is mediated at least in part by T cell-derived interferon-gamma (IFN-gamma) induction of the nitric oxide synthase (iNOS) system in infected epithelial cells. Although IFN-gamma alone could stimulate nitric oxide (NO) production from epithelial cells and inhibit the i...

journal_title：Journal of leukocyte biology

authors： Igietseme JU,Uriri IM,Hawkins R,Rank RG

更新日期：1996-05-01 00:00:00