Abstract:
:HIV is known to subvert cellular machinery to enhance its replication. Recently, HIV has been reported to enhance TC renin expression. We hypothesized that HIV induces and maintains high renin expression to promote its own replication in TCs. Renin enhanced HIV replication in TCs in a dose-dependent manner. (P)RR-deficient TCs, as well as those lacking renin, displayed attenuated NF-κB activity and HIV replication. TCs treated with renin and Hpr displayed activation of the (P)RR-PLZF protein signaling cascade. Renin, HIV, and Hpr activated the PI3K pathway. Both renin and Hpr cleaved Agt (a renin substrate) to Ang I and also cleaved Gag polyproteins (protease substrate) to p24. Furthermore, aliskiren, a renin inhibitor, reduced renin- and Hpr-induced cleavage of Agt and Gag polyproteins. These findings indicate that renin contributes to HIV replication in TCs via the (P)RR-PLZF signaling cascade and through cleavage of the Gag polyproteins.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Chandel N,Ayasolla K,Lan X,Rai P,Mikulak J,Husain M,Malhotra A,McGowan J,Singhal PCdoi
10.1189/JLB.2A0414-192Rsubject
Has Abstractpub_date
2014-10-01 00:00:00pages
601-9issue
4eissn
0741-5400issn
1938-3673pii
JLB.2A0414-192Rjournal_volume
96pub_type
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