Trogocytic CD137 transfer causes an internalization of CD137 ligand on murine APCs leading to reduced T cell costimulation.

abstract：:Leukocytes are a central cellular element of innate-immune defense in mammals. In addition to the generation of toxic oxygen radicals and nitric oxide, leukocytes express and secrete a broad array of antimicrobial proteins and peptides. In the study, an antimicrobial polypeptide was isolated and purified from human pe...

journal_title：Journal of leukocyte biology

authors： Feng Y,Huang N,Wu Q,Wang B

更新日期：2005-11-01 00:00:00

abstract：:C1qR(P) is a type I cell surface glycoprotein that has been shown to enhance ingestion of suboptimally opsonized targets by phagocytes in vitro. In this study, we developed and characterized polyclonal antibodies to study the tissue distribution of this receptor targeted to either the N- or C-terminal portion of the m...

journal_title：Journal of leukocyte biology

authors： Fonseca MI,Carpenter PM,Park M,Palmarini G,Nelson EL,Tenner AJ

更新日期：2001-11-01 00:00:00

abstract：:Granulocyte-colony stimulating factor (G-CSF) is an essential cytokine, which contributes to proliferation and differentiation of granulocyte precursor cells in the bone marrow. Despite recent progress in understanding G-CSF signaling events, the mechanisms that underlie the distinct spectrum of biological functions a...

journal_title：Journal of leukocyte biology

authors： Khanna-Gupta A,Sun H,Zibello T,Lozovatsky L,Ghosh PK,Link DC,McLemore ML,Berliner N

更新日期：2006-05-01 00:00:00

abstract：:Bone destruction in inflammatory osteolytic diseases including periodontitis is related to excessive activity of osteoclasts (OC), which originate from precursor cells of the myeloid lineage, termed osteoclast precursors (OCP). In contrast to ample knowledge that we currently have on mature OC, little is known about O...

journal_title：Journal of leukocyte biology

authors： Zhao Y,Li Z,Su L,Ballesteros-Tato A,Katz J,Michalek SM,Feng X,Zhang P

更新日期：2020-10-01 00:00:00

abstract：:The specific binding of human polymorphonuclear leukocytes (PMN) to antibody-coated target cells was characterized by flow cytometry. PMN were labeled with phycoerythrin-E (PE) via a granulocyte-specific monoclonal antibody (leu-M1) and mixed with fluorescein isothiocyanate-labeled K562 tumor cells sensitized with rab...

journal_title：Journal of leukocyte biology

authors： van Kessel KP,van Strijp JA,van der Tol ME,van Kats-Renaud HJ,Thijssen RM,Fluit AC,Verhoef J

更新日期：1989-11-01 00:00:00

abstract：:The recently cloned ligand binding component of the type I human interferon-alpha/beta receptor (IFN-alpha/beta R) and its soluble analogue (p40) were characterized. p40 is a potent inhibitor of type I IFNs and antibodies directed against p40 completely block the activity of type I IFNs in human cells. These antibodie...

journal_title：Journal of leukocyte biology

authors： Novick D,Cohen B,Tal N,Rubinstein M

更新日期：1995-05-01 00:00:00

abstract：:Intravenous administration of lipopolysaccharide (LPS) to rats increased the production of nitric oxide (NO) metabolites (NOx) by blood polymorphonuclear neutrophils (PMN) in vitro. Both dexamethasone and L-NMMA, added in vitro to neutrophil cultures, inhibited the production of NO. On the other hand, the production o...

journal_title：Journal of leukocyte biology

authors： Fierro IM,Nascimento-DaSilva V,Arruda MA,Freitas MS,Plotkowski MC,Cunha FQ,Barja-Fidalgo C

更新日期：1999-04-01 00:00:00

abstract：:CEACAM6 (CD66c) and CEACAM8 (CD66b) are cell-adhesion proteins on neutrophils that belong to the human carcinoembryonic antigen (CEA) family. CEACAM6 reveals homophilic adhesion and heterophilic adhesion to other CEACAM family antigens including CEACAM8, CEACAM1, and CEA, whereas CEACAM8 exhibits only heterophilic adh...

journal_title：Journal of leukocyte biology

authors： Kuroki M,Abe H,Imakiirei T,Liao S,Uchida H,Yamauchi Y,Oikawa S,Kuroki M

更新日期：2001-10-01 00:00:00

abstract：:Proteoglycans (PGs) play a dominant role within the bone marrow (BM), but their role in homing of transplanted hematopoietic progenitor cells (HPC) is unknown. In this study, the role of heparan sulfate (HS) PGs on BM endothelium as adhesive structures was investigated. HPC (primary CD34+ cells and cell line KG-1a) we...

journal_title：Journal of leukocyte biology

authors： Netelenbos T,van den Born J,Kessler FL,Zweegman S,Huijgens PC,Drager AM

更新日期：2003-12-01 00:00:00

abstract：:Six IgG monoclonal antibodies representing the four murine IgG isotypes were active individually in ADCC to T-lymphoma targets mediated by murine macrophages and human blood K cells. The monoclonals were directed against four antigens (Thy-1.2, H-2k, Ly 2.1, Ly 9.2). None was as effective in ADCC as allo-anti-Thy-1.2 ...

journal_title：Journal of leukocyte biology

authors： Ralph P,Nakoinz I

更新日期：1984-01-01 00:00:00

abstract：:To understand the modulation and the behavior of glycocalyx elements during adhesion, we explored one of its components, the CD43 molecule, on human monocytic THP-1 cells exposed to cytokine stimulation and its redistribution during heterotypic adhesion to opsonized erythrocytes. First we demonstrated by immunofluores...

journal_title：Journal of leukocyte biology

authors： Soler M,Merant C,Servant C,Fraterno M,Allasia C,Lissitzky JC,Bongrand P,Foa C

更新日期：1997-05-01 00:00:00

abstract：:Mast cells and MDSCs are increased by parasitic infection and tumor growth. We previously demonstrated that enhanced MDSC development in ADAM10 transgenic mice yielded resistance to Nb infection and that coculturing MDSCs and mast cells enhanced cytokine production. In the current work, we show that MDSC-mast cell coc...

journal_title：Journal of leukocyte biology

authors： Morales JK,Saleem SJ,Martin RK,Saunders BL,Barnstein BO,Faber TW,Pullen NA,Kolawole EM,Brooks KB,Norton SK,Sturgill J,Graham L,Bear HD,Urban JF Jr,Lantz CS,Conrad DH,Ryan JJ

更新日期：2014-04-01 00:00:00

abstract：:Cellular lysates from PPD+ donors have been reported to transfer tuberculin reactivity to naïve recipients, but not diphtheria reactivity, and vice versa. A historically controversial topic, the terms "transfer factor" and "DLE" were used to characterize the reactivity-transferring properties of lysates. Intrigued by ...

journal_title：Journal of leukocyte biology

authors： Myles IA,Zhao M,Nardone G,Olano LR,Reckhow JD,Saleem D,Break TJ,Lionakis MS,Myers TG,Gardina PJ,Kirkpatrick CH,Holland SM,Datta SK

更新日期：2017-01-01 00:00:00

abstract：:Successful remodeling of the uterine spiral arteries is essential for a complication-free pregnancy and is best described in terms of its morphologic features. The molecular mediators and cellular sources of spiral artery remodeling are not known, although a role for uterine leukocytes has been proposed. Immunohistoch...

journal_title：Journal of leukocyte biology

authors： Lash GE,Pitman H,Morgan HL,Innes BA,Agwu CN,Bulmer JN

更新日期：2016-08-01 00:00:00

abstract：:Interleukin-15 (IL-15) is a cytokine that possesses interesting, potential therapeutic properties. However, based on several parameters including activation of neutrophils, it is also recognized as a proinflammatory cytokine. The mechanisms by which IL-15 activates human neutrophil functions are not fully understood. ...

journal_title：Journal of leukocyte biology

authors： Ratthé C,Girard D

更新日期：2004-07-01 00:00:00

abstract：:Glucosamine, an amino monosaccharide naturally occurring in the connective and cartilage tissues, contributes to maintaining the strength, flexibility, and elasticity of these tissues. In recent years, glucosamine has been used widely to treat osteoarthritis in humans and animal models. Neutrophils, which usually func...

journal_title：Journal of leukocyte biology

authors： Hua J,Sakamoto K,Nagaoka I

更新日期：2002-04-01 00:00:00

abstract：:Myeloperoxidase aids in clearance of microbes by generation of peroxidase-mediated oxidants that kill leukocyte-engulfed pathogens. In this review, we will examine 1) strategies for in vitro evaluation of myeloperoxidase function and its inhibition, 2) ways to monitor generation of certain oxidant species during infla...

journal_title：Journal of leukocyte biology

authors： Huang J,Milton A,Arnold RD,Huang H,Smith F,Panizzi JR,Panizzi P

更新日期：2016-04-01 00:00:00

abstract：:The immune system in early life is regarded as immature. However, the IL-12 family member IL-23 is highly produced upon TLR stimulation by neonatal DCs. Human adult Vγ9Vδ2 T cells can be stimulated specifically via their TCR by phosphoantigens (as the pathogen-derived HMB-PP) or agents and infections that lead to thei...

journal_title：Journal of leukocyte biology

authors： Moens E,Brouwer M,Dimova T,Goldman M,Willems F,Vermijlen D

更新日期：2011-05-01 00:00:00

abstract：:The role of NOD2 and RIP2 in inflammatory disease has been paradoxical. Whereas loss-of-function NOD2 polymorphisms cause CD, a granulomatous disease of the gastrointestinal tract, gain-of-function mutations cause EOS-a granulomatous disease primarily affecting the skin, joints, and eyes. Thus, gain-of-function mutati...

journal_title：Journal of leukocyte biology

authors： Jun JC,Cominelli F,Abbott DW

更新日期：2013-11-01 00:00:00

abstract：:Lymphocyte development is initiated from hematopoietic stem cells and can be divided into multiple phenotypically distinct stages. Transcription factors play important roles in programming the developmental process of lymphocytes. Recent studies have identified key roles of several orphan nuclear receptors in T lympho...

journal_title：Journal of leukocyte biology

authors： He YW

更新日期：2002-09-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) encodes the MHC class I-like molecule UL18, which binds with high affinity to the leukocyte Ig-like receptor-1 (LIR-1), an inhibitory receptor commonly expressed on myeloid cells and subsets of NK and T cells. The exact role of UL18 is not known, in particular in relation to its proposed r...

journal_title：Journal of leukocyte biology

authors： Wagner CS,Walther-Jallow L,Buentke E,Ljunggren HG,Achour A,Chambers BJ

更新日期：2008-01-01 00:00:00

abstract：:Introduction of alloantigens into the AC induces a form of immune tolerance known as ACAID, which induces antigen-specific CD8+ Tregs, contributing to ocular immune privilege by down-regulating immune responses. Recent evidence suggests IFN-γ is needed for the suppressive function of CD8+ ACAID Tregs. This study teste...

journal_title：Journal of leukocyte biology

authors： Paunicka K,Chen PW,Niederkorn JY

更新日期：2012-03-01 00:00:00

abstract：:The seven transmembrane G protein-coupled receptor EBV-induced gene 2 (EBI2), also known as GPR183, is expressed in particular in immune cells. Activated by its endogenous ligands, which are a group of oxysterols, it functions as a chemo-attractant receptor, mediating cell migration. In coordination with other recepto...

journal_title：Journal of leukocyte biology

authors： Barington L,Wanke F,Niss Arfelt K,Holst PJ,Kurschus FC,Rosenkilde MM

更新日期：2018-08-01 00:00:00

abstract：:RelB is one of the more unusual members of the NF-κB family. This family, arguably the best known group of transcription regulators, regulates an astonishing array of cell types and biological processes. This includes regulation of cell growth, differentiation and death by apoptosis, and the development and function o...

journal_title：Journal of leukocyte biology

authors： Millet P,McCall C,Yoza B

更新日期：2013-11-01 00:00:00

abstract：:Engagement of 2B4 (CD244) with CD48 results in activation, costimulation, or inhibition of NK cell activities, depending on the cell types and the stage of differentiation. In vivo, 2B4+ NK cells can interact with CD48+ NK cells and also with surrounding CD48+ hematopoietic cells. Similarly, CD48+ NK cells may be trig...

journal_title：Journal of leukocyte biology

authors： Kim EO,Kim N,Kim TJ,Kim K,Kim TW,Kumar V,Lee KM

更新日期：2010-10-01 00:00:00

abstract：:In previous studies, macrophages have been shown to influence in vitro colony formation by erythroid progenitors (CFU-E). To determine whether the origin of the macrophages influences their effects on in vitro erythropoiesis, plasma clot cultures of CFU-E were grown over adherent monolayers of macrophages from various...

journal_title：Journal of leukocyte biology

authors： Johnson CS,Furmanski P

更新日期：1984-11-01 00:00:00

abstract：:To elucidate the differentiation mechanisms of macrophages in the murine omentum, we studied the repopulation of these cells and the expression of macrophage colony-stimulating factor (M-CSF) in the milky spots and omental tissues in mice depleted of macrophages following administration of liposome-encapsulated dichlo...

journal_title：Journal of leukocyte biology

authors： Zhu H,Naito M,Umezu H,Moriyama H,Takatsuka H,Takahashi K,Shultz LD

更新日期：1997-04-01 00:00:00

abstract：:Endotoxin (lipopolysaccharide, LPS) is known to induce inflammatory responses, such as monocyte/macrophage adherence, migration, and accumulation. Recruitment and accumulation of macrophages during infection and inflammation are regulated by integrin-mediated cell-extracellular matrix interactions. In the present repo...

journal_title：Journal of leukocyte biology

authors： Kang YH,Lee CH,Brummel SE,Newball HH,Forrester J

更新日期：1995-04-01 00:00:00

abstract：:Alcohol use has been shown to decrease monocyte antigen presentation capacity and inflammatory cytokine production, thereby increasing susceptibility to infections. Here, we demonstrate that in vitro acute treatment of normal monocytes with pharmacological doses of ethanol can decrease superantigen [Staphylococcus ent...

journal_title：Journal of leukocyte biology

authors： Szabo G,Mandrekar P,Catalano D

更新日期：1995-09-01 00:00:00

abstract：:Role of IL-18 on proliferation and survival of CD8+ T cells, activated by immobilized anti-CD3 antibody (anti-CD3), was examined. Proliferation and survival of activated T cells, especially that of CD8+ T cells, were impaired by IL-18 deficiency [IL-18 knockout (KO)]. After 3 days of culture with anti-CD3, the number ...

journal_title：Journal of leukocyte biology

authors： Li W,Kashiwamura S,Ueda H,Sekiyama A,Okamura H

更新日期：2007-07-01 00:00:00