Reperfusion-induced oxidative stress in diabetes: cellular and enzymatic sources.

abstract：:The germinal center (GC) is a dynamic structure formed by proliferating B cells in the follicles of secondary lymphoid organs during T cell-dependent antibody responses to exogenous antigens. GC is composed by a dark zone, enriched in proliferating centroblasts (CBs), and a light zone where CBs migrate and transform i...

journal_title：Journal of leukocyte biology

authors： Ferretti E,Ponzoni M,Doglioni C,Pistoia V

更新日期：2016-11-01 00:00:00

abstract：:Previously, we described a novel glycosylphosphatidyl inositol (GPI)-anchored glycoprotein (designated GPI-80) on human neutrophils and monocytes that may regulate beta(2) integrin-dependent neutrophil adherence and migration. However, the mechanism regulating beta(2) integrin remains to be clarified. To study this, w...

journal_title：Journal of leukocyte biology

authors： Yoshitake H,Takeda Y,Nitto T,Sendo F

更新日期：2002-02-01 00:00:00

abstract：:The in vitro effects of 17 alpha AED, the isomer of 5-androstene-3 beta,17 beta diol (17 beta AED) on the basal growth of murine RAW 264.7, P388D1, and human HL-60 cells were investigated. 17 alpha AED treatment of RAW cells for 48 h reduced total cell number without increasing cell death as detected by trypan blue ex...

journal_title：Journal of leukocyte biology

authors： Huynh PN,Loria RM

更新日期：1997-08-01 00:00:00

abstract：:Expression of phosphatidylserine (PS) on the surface of both macrophages and their apoptotic targets is required for efficient phagocytosis. Monocytes, the precursors of macrophages, do not express PS on their surface and do not efficiently phagocytose apoptotic cells. We report here that PS appears on the surface of ...

journal_title：Journal of leukocyte biology

authors： Callahan MK,Halleck MS,Krahling S,Henderson AJ,Williamson P,Schlegel RA

更新日期：2003-11-01 00:00:00

abstract：:The field of innate immunity is witnessing a paradigm shift regarding "memory" and "programming" dynamics. Past studies of innate leukocytes characterized them as first responders to danger signals with no memory. However, recent findings suggest that innate leukocytes, such as monocytes and neutrophils, are capable o...

journal_title：Journal of leukocyte biology

authors： Lee C,Geng S,Zhang Y,Rahtes A,Li L

更新日期：2017-09-01 00:00:00

abstract：:A wealth of scientific and clinical evidence during the past few years has lent credence to the idea that key components of the host immune effector mechanisms can be targeted to boost current tuberculosis (TB) treatment and control patient relapse. These host-directed strategies not only accelerate the clearance of p...

journal_title：Journal of leukocyte biology

authors： Cheng CY,Böhme J,Singhal A

更新日期：2018-02-01 00:00:00

abstract：:Immune and inflammatory cells play a critical role in the pathogenesis of atherosclerotic plaques. We have demonstrated that A2ARs inhibit foam cell formation and stimulate production of ABCA1, the primary transporter of lipoproteins. We asked whether the effects of A2ARs on foam cell formation in vitro are mediated b...

journal_title：Journal of leukocyte biology

authors： Bingham TC,Fisher EA,Parathath S,Reiss AB,Chan ES,Cronstein BN

更新日期：2010-04-01 00:00:00

abstract：:Protein synthetic patterns of murine peritoneal macrophages were analyzed by two-dimensional polyacrylamide gel electrophoresis (2D PAGE) of 35S methionine-labeled proteins. While the protein synthetic patterns exhibited by resident, inflammatory, and activated macrophages had numerous common features that distinguish...

journal_title：Journal of leukocyte biology

authors： Tannenbaum CS,Nurmi-McKernan L,Largen MT

更新日期：1987-06-01 00:00:00

abstract：:The objective of this study was to find the role of LncRNA SNHG12 in the regulation of hypertensive vascular endothelial injury. LncRNA SNHG12 and miR-25-3p expression were detected by quantitative RT-PCR. Protein levels of Sirtuin 6 (SIRT6), endothelial cell (EC) senescence markers p16 and p21, and EC marker CD31 wer...

journal_title：Journal of leukocyte biology

authors： Qian W,Zheng ZQ,Nie JG,Liu LJ,Meng XZ,Sun H,Xiao FM,Kang T

更新日期：2021-01-19 00:00:00

abstract：:Developmental delays, which impair antibacterial host defense, are present in the neutrophil system of human preterm neonates. We hypothesized that diminished production of interleukin-8 (IL-8), a neutrophil chemotactic peptide, might in part be responsible for these defects. To test this, monocytes from the blood of ...

journal_title：Journal of leukocyte biology

authors： Schibler KR,Trautman MS,Liechty KW,White WL,Rothstein G,Christensen RD

更新日期：1993-04-01 00:00:00

abstract：:Human activated T cells adhere to synovial fibroblast-like cells in vitro. The present study was conducted to investigate the consequences of T cell-synovial fibroblast interactions with regard to induction of adhesion molecules and proinflammatory cytokines. A sensitive Western blot technique, polymerase chain reacti...

journal_title：Journal of leukocyte biology

authors： Bombara MP,Webb DL,Conrad P,Marlor CW,Sarr T,Ranges GE,Aune TM,Greve JM,Blue ML

更新日期：1993-11-01 00:00:00

abstract：:In inflammatory diseases, circulating neutrophils are recruited to sites of injury. Attractant signals are provided by many different chemotactic molecules, such that blockade of one may not prevent neutrophil recruitment effectively. The Slit family of secreted proteins and their transmembrane receptor, Robo, repel a...

journal_title：Journal of leukocyte biology

authors： Tole S,Mukovozov IM,Huang YW,Magalhaes MA,Yan M,Crow MR,Liu GY,Sun CX,Durocher Y,Glogauer M,Robinson LA

更新日期：2009-12-01 00:00:00

abstract：:An immunoglobulin M (IgM) monoclonal antibody, My43, specific for IgA Fc receptor (Fc alpha R) on human monocytes, bound to human polymorphonuclear neutrophils (PMNs) and inhibited their ability to bind IgA but not IgG. It was observed that the PMN oxidative burst was induced by both polymeric IgA and aggregated IgG, ...

journal_title：Journal of leukocyte biology

authors： Shen L

更新日期：1992-04-01 00:00:00

abstract：:Monocyte chemoattractant protein-1 (MCP-1, CCL2) is a mediator of inflammation that has been implicated in the pathogenesis of a wide variety of human diseases. CCR2, a heterotrimeric G-coupled receptor, is the only known receptor that functions at physiologic concentrations of MCP-1. Despite the importance of CCR2 in...

journal_title：Journal of leukocyte biology

authors： Schecter AD,Berman AB,Yi L,Ma H,Daly CM,Soejima K,Rollins BJ,Charo IF,Taubman MB

更新日期：2004-06-01 00:00:00

abstract：:mRNAs encoding inflammatory chemokines that recruit neutrophils frequently exhibit short half-lives that serve to limit their expression under inappropriate conditions but are often prolonged to ensure adequate levels during inflammatory response. Extracellular stimuli that modulate the stability of such mRNAs may be ...

journal_title：Journal of leukocyte biology

authors： Hamilton T,Li X,Novotny M,Pavicic PG Jr,Datta S,Zhao C,Hartupee J,Sun D

更新日期：2012-03-01 00:00:00

abstract：:Microorganisms interact with the immune system in multiple ways. In an interaction between a microorganism and its host, the defense of the host does not go unchallenged. Microorganisms have for decades been suspected of possessing the capabilities of hiding from and escaping the consequences of immune surveillance. E...

journal_title：Journal of leukocyte biology

authors： Kotwal GJ

更新日期：1997-10-01 00:00:00

abstract：:We report the systematic use of large-scale cDNA microarrays to study the gene expression profiles of primary human peripheral blood monocytes (MONO) in comparison with in vitro-differentiated, M-CSF-induced MONO-derived macrophages (MAC) and primary human alveolar MAC (AM), obtained by bronchoalveolar lavage from the...

journal_title：Journal of leukocyte biology

authors： Li J,Pritchard DK,Wang X,Park DR,Bumgarner RE,Schwartz SM,Liles WC

更新日期：2007-01-01 00:00:00

abstract：:Neutrophils, an essential component of the innate immune system, are produced at a rate 10(11) cells/day and are consequently the most abundant leukocyte in the blood. These granulocytes have a relatively short half-life (6-8 h) in the blood, and as a result of the cytotoxic nature of their contents, it is critical th...

journal_title：Journal of leukocyte biology

authors： Rankin SM

更新日期：2010-08-01 00:00:00

abstract：:Alcohol-induced neuroinflammation is mediated by proinflammatory cytokines, including IL-1β. IL-1β production requires caspase-1 activation by inflammasomes-multiprotein complexes that are assembled in response to danger signals. We hypothesized that alcohol-induced inflammasome activation contributes to increased IL-...

journal_title：Journal of leukocyte biology

authors： Lippai D,Bala S,Petrasek J,Csak T,Levin I,Kurt-Jones EA,Szabo G

更新日期：2013-07-01 00:00:00

abstract：:T cell-mediated immunity against Chlamydia in mice is mediated at least in part by T cell-derived interferon-gamma (IFN-gamma) induction of the nitric oxide synthase (iNOS) system in infected epithelial cells. Although IFN-gamma alone could stimulate nitric oxide (NO) production from epithelial cells and inhibit the i...

journal_title：Journal of leukocyte biology

authors： Igietseme JU,Uriri IM,Hawkins R,Rank RG

更新日期：1996-05-01 00:00:00

abstract：:The effects of the carbocyclic nucleoside MDL 201,112 and the purine nucleoside adenosine on the interferon-gamma (IFN-gamma)-induced priming of macrophages (m phi s) for the respiratory burst and major histocompatibility class II (MHC class II) Ia+ antigen expression were compared. Priming of purified, peritoneal m p...

journal_title：Journal of leukocyte biology

authors： Edwards CK 3rd,Watts LM,Parmely MJ,Linnik MD,Long RE,Borcherding DR

更新日期：1994-08-01 00:00:00

abstract：:Stromal cell-derived factor 1alpha (SDF-1alpha) is the exclusive ligand for the chemokine receptor CXCR4. This receptor plays a pivotal role in immune responses, the pathogenesis of infection such as HIV, and cellular trafficking. However, the signaling mechanisms regulating SDF-driven T cell migration are not well de...

journal_title：Journal of leukocyte biology

authors： Shahabi NA,McAllen K,Sharp BM

更新日期：2008-03-01 00:00:00

abstract：:CD8(+) T cells play an important role in immune regulation and effective immune responses against tumor cells, viral infection, and intracellular pathogens. In this report, using tiger or 10BiT mice, we defined a population of IL-10-producing CD8(+) T cells that were induced by IL-4. These IL-10(+)CD8(+) T cells posse...

journal_title：Journal of leukocyte biology

authors： Zhao Y,Zhao H,Sun Y,Hao J,Qi X,Zhou X,Wu Z,Wang P,Kaech SM,Weaver CT,Flavell RA,Zhao L,Yao Z,Yin Z

更新日期：2013-12-01 00:00:00

abstract：:We have identified three distinct cell phenotypes with respect to the conditions under which cells became susceptible to TNF-mediated lysis. These conditions include: 1) treatment with the protein synthesis inhibitor, cycloheximide; 2) contact with activated macrophages, and 3) infection with vaccinia virus. Whereas v...

journal_title：Journal of leukocyte biology

authors： Woods KM,Chapes SK

更新日期：1993-01-01 00:00:00

abstract：:HIV infection of mononuclear phagocytes (MP), mostly as tissue macrophages, is a dominant feature in the pathogenesis of HIV disease and its progression to AIDS. Although the general mechanism of infection is not dissimilar to that of CD4+ T lymphocytes occurring via interaction of the viral envelope with CD4 and a ch...

journal_title：Journal of leukocyte biology

authors： Cassol E,Alfano M,Biswas P,Poli G

更新日期：2006-11-01 00:00:00

abstract：:Human skin mast cells (HSMC) in situ were examined by electron microscopy of surgical biopsy specimens obtained from a wide variety of circumstances. From these studies, it is apparent that the general ultrastructural morphology of normal HSMC is similar to that of human mast cells from other sites, except that the mo...

journal_title：Journal of leukocyte biology

authors： Dvorak AM,Kissell S

更新日期：1991-02-01 00:00:00

abstract：:Osteoclasts are large, multinucleated cells, which originate from the fusion of macrophages. They play a central role in bone development and remodeling via the resorption of bone and are thus important mediators of bone loss, which leads to osteoporosis. IL-1R-associated kinase (IRAK)-M is a pseudokinase, which acts ...

journal_title：Journal of leukocyte biology

authors： Soares-Schanoski A,Gómez-Piña V,del Fresno C,Rodríguez-Rojas A,García F,Glaría A,Sánchez M,Vallejo-Cremades MT,Baos R,Fuentes-Prior P,Arnalich F,López-Collazo E

更新日期：2007-09-01 00:00:00

abstract：:Previously we had determined that neonatal neutrophils had decreased interaction with monolayers expressing P-selectin compared to adult cells. In this study we examined the function of neonatal P-selectin glycoprotein ligand-1 (PSGL-1). A rabbit polyclonal antibody directed against the amino terminus of human PSGL-1 ...

journal_title：Journal of leukocyte biology

authors： Tcharmtchi MH,Smith CW,Mariscalco MM

更新日期：2000-01-01 00:00:00

abstract：:Live, but not dead Bacillus Calmette-Guérin (BCG) is partially protective against infection by Mycobacterium tuberculosis, which causes a disease with high mortality in immune compromised individuals. We have shown that uptake of BCG induces maturation of immature dendritic cells (DCs) regardless of the viability of t...

journal_title：Journal of leukocyte biology

authors： Tsunetsugu-Yokota Y,Tamura H,Tachibana M,Ogata K,Honda M,Takemori T

更新日期：2002-07-01 00:00:00

abstract：:The switch from fetal to adult hematopoietic stem/progenitor cells (HSPCs) is associated with profound changes in several genetic programs. Although HSPC ageing corresponds to alterations in Wnt signaling, relatively little is known about the relative roles of different Wnt signaling pathways in HSPC ontogeny. We hypo...

journal_title：Journal of leukocyte biology

authors： Kwarteng EO,Hétu-Arbour R,Heinonen KM

更新日期：2018-03-01 00:00:00