Abstract:
:mRNAs encoding inflammatory chemokines that recruit neutrophils frequently exhibit short half-lives that serve to limit their expression under inappropriate conditions but are often prolonged to ensure adequate levels during inflammatory response. Extracellular stimuli that modulate the stability of such mRNAs may be the same as the transcriptional activator, as is the case with TLR ligands, or may cooperate with independent transcriptional stimuli, as with IL-17, which extends the half-life of TNF-induced transcripts. These different stimuli engage independent signaling pathways that target different instability mechanisms distinguished by dependence on different regulatory nucleotide sequence motifs within the 3'UTRs, which involve that action of different mRNA-binding proteins. The selective use of these pathways by different stimuli and in distinct cell populations provides the potential for tailoring of chemokine expression patterns to meet specific needs in different pathophysiologic circumstances.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Hamilton T,Li X,Novotny M,Pavicic PG Jr,Datta S,Zhao C,Hartupee J,Sun Ddoi
10.1189/jlb.0811404subject
Has Abstractpub_date
2012-03-01 00:00:00pages
377-83issue
3eissn
0741-5400issn
1938-3673pii
jlb.0811404journal_volume
91pub_type
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