Abstract:
:Bacterial and viral infections cause high rates of morbidity and mortality in premature newborns. In the setting of viral infection, pDCs play a key role as strong producers of IFN-α upon TLR9 activation. We analyzed pDC frequency, phenotype, morphology, and function in CB of preterm and term newborns in comparison with adults. Whereas all age groups show similar pDC numbers, BDCA-2, CD123, and TLR9 levels, the expression of BDCA-4 and capacity to produce IFN-α upon TLR9 challenge were decreased significantly in preterm neonates. Furthermore, we show by means of electron microscopy that pDCs from preterm newborns exhibit a distinct, "immature" morphology. Taken together, these findings suggest decreased functionality of pDCs in the premature newborn. The reduced capacity to produce IFN-α is likely to render such infants more susceptible to viral infections.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Schüller SS,Sadeghi K,Wisgrill L,Dangl A,Diesner SC,Prusa AR,Klebermasz-Schrehof K,Greber-Platzer S,Neumüller J,Helmer H,Husslein P,Pollak A,Spittler A,Förster-Waldl Edoi
10.1189/jlb.1011525subject
Has Abstractpub_date
2013-05-01 00:00:00pages
781-8issue
5eissn
0741-5400issn
1938-3673pii
jlb.1011525journal_volume
93pub_type
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