Abstract:
:The rapid and efficient expansion of CD8(+) memory T cells after the second encounter with a pathogen constitutes a hallmark trait of adaptive immunity. Yet, the contribution of CD4(+) T cells to the expansion of memory CD8(+) T cells remains the subject of controversy. Here, we show that, antigen-specific CD4(+) T cells, once activated by dendritic cells (DC) in vitro, have the capacity to stimulate expansion of memory CD8(+) T cells in vivo. The memory CD8(+) T cell expansion triggered by active CD4(+) T cells are mediated through DC-derived MHC I/peptide complexes and CD80 molecules displayed on the active CD4(+) T cells, with the involvement of IL-2 secreted by the active CD4(+) T cells. These results highlight a previously undescribed role of active CD4(+) T cells in triggering expansion of memory CD8(+) T cells.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Shi M,Hao S,Chan T,Xiang Jdoi
10.1189/jlb.0506321subject
Has Abstractpub_date
2006-12-01 00:00:00pages
1354-63issue
6eissn
0741-5400issn
1938-3673pii
jlb.0506321journal_volume
80pub_type
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