A direct signaling pathway through tyrosine kinase activation of SH2 domain-containing transcription factors.

abstract：:CD163, a monocyte and macrophage-specific surface glycoprotein, which is increased by interleukin-10 and glucocorticoids, is a scavenger receptor for hemoglobin/haptoglobin complexes. We report a rapid and highly reproducible rise in soluble CD163 in the plasma of human volunteers given intravenous lipopolysaccharide ...

journal_title：Journal of leukocyte biology

authors： Hintz KA,Rassias AJ,Wardwell K,Moss ML,Morganelli PM,Pioli PA,Givan AL,Wallace PK,Yeager MP,Guyre PM

更新日期：2002-10-01 00:00:00

abstract：:An anti-macrophage monoclonal antibody designated TRPM-3 was produced using thioglycollate-elicited rat peritoneal macrophages as immunogen. By the immunoperoxidase method, TRPM-3 was found to be specific for certain macrophage populations, such as marginal zone macrophages and marginal metallophils of the spleen, sin...

journal_title：Journal of leukocyte biology

authors： Takeya M,Hsiao L,Takahashi K

更新日期：1987-03-01 00:00:00

abstract：:To understand the modulation and the behavior of glycocalyx elements during adhesion, we explored one of its components, the CD43 molecule, on human monocytic THP-1 cells exposed to cytokine stimulation and its redistribution during heterotypic adhesion to opsonized erythrocytes. First we demonstrated by immunofluores...

journal_title：Journal of leukocyte biology

authors： Soler M,Merant C,Servant C,Fraterno M,Allasia C,Lissitzky JC,Bongrand P,Foa C

更新日期：1997-05-01 00:00:00

abstract：:Neutrophil extracellular traps (NETs), web-like DNA structures, provide efficient means of eliminating invading microorganisms but can also present a potential threat to its host because it is a likely source of autoantigens or by promoting bystander tissue damage. Therefore, it is important to identify mechanisms tha...

journal_title：Journal of leukocyte biology

authors： Zabieglo K,Majewski P,Majchrzak-Gorecka M,Wlodarczyk A,Grygier B,Zegar A,Kapinska-Mrowiecka M,Naskalska A,Pyrc K,Dubin A,Wahl SM,Cichy J

更新日期：2015-07-01 00:00:00

abstract：:Live, but not dead Bacillus Calmette-Guérin (BCG) is partially protective against infection by Mycobacterium tuberculosis, which causes a disease with high mortality in immune compromised individuals. We have shown that uptake of BCG induces maturation of immature dendritic cells (DCs) regardless of the viability of t...

journal_title：Journal of leukocyte biology

authors： Tsunetsugu-Yokota Y,Tamura H,Tachibana M,Ogata K,Honda M,Takemori T

更新日期：2002-07-01 00:00:00

abstract：:Over 1.4 million Americans have been diagnosed with inflammatory bowel disease (IBD), and ulcerative colitis (UC) makes up approximately half of those diagnoses. As a disease, UC cycles between periods of remission and flare, which is characterized by intense abdominal pain, increased weight loss, intestinal inflammat...

journal_title：Journal of leukocyte biology

authors： Cannon AR,Kuprys PV,Cobb AN,Ding X,Kothari AN,Kuo PC,Eberhardt JM,Hammer AM,Morris NL,Li X,Choudhry MA

更新日期：2018-09-01 00:00:00

abstract：:Fetal alcohol spectrum disorder (FASD), which results from ethanol exposure during pregnancy, and alcohol use disorder (AUD), which includes both binge and chronic alcohol abuse, are strikingly common and costly at personal and societal levels. These disorders are associated with significant pathology, including that ...

journal_title：Journal of leukocyte biology

authors： Kane CJ,Drew PD

更新日期：2016-11-01 00:00:00

abstract：:Aged and protein-malnourished hosts have diminished febrile responses and increased morbidity and mortality from infection that could be due to deficiencies in the production of certain monokines. In this study, the ability of peritoneal macrophages from aged and protein-malnourished rats to produce IL-1 and TNF was e...

journal_title：Journal of leukocyte biology

authors： Bradley SF,Vibhagool A,Kunkel SL,Kauffman CA

更新日期：1989-06-01 00:00:00

abstract：:M-CSF and GM-CSF are mediators involved in regulating the numbers and function of macrophage lineage populations and have been shown to contribute to macrophage heterogeneity. Type I IFN is an important mediator produced by macrophages and can have profound regulatory effects on their properties. In this study, we com...

journal_title：Journal of leukocyte biology

authors： Fleetwood AJ,Dinh H,Cook AD,Hertzog PJ,Hamilton JA

更新日期：2009-08-01 00:00:00

abstract：:We tested several of the functions of macrophages (M phi) in the early phase after allogeneic bone marrow transfer to get information about this important aspect of the nonspecific immune system in the T-cell-deficient recipient. On days 3-5 after transfer, the number of M phi was reduced in the spleen, liver, lungs, ...

journal_title：Journal of leukocyte biology

authors： Roesler J,Baccarini M,Vogt B,Lohmann-Matthes ML

更新日期：1989-08-01 00:00:00

abstract：:Endotoxin (lipopolysaccharide, LPS) is known to induce inflammatory responses, such as monocyte/macrophage adherence, migration, and accumulation. Recruitment and accumulation of macrophages during infection and inflammation are regulated by integrin-mediated cell-extracellular matrix interactions. In the present repo...

journal_title：Journal of leukocyte biology

authors： Kang YH,Lee CH,Brummel SE,Newball HH,Forrester J

更新日期：1995-04-01 00:00:00

abstract：:Interleukin-1beta is a secreted protein that accumulates in the cytosol as an inactive precursor (pIL-1beta) before processing and release of biologically active protein. To understand the impact of this property on IL-1beta production, we examined the intracellular stability of pIL-1beta in lipopolysaccharide (LPS)-s...

journal_title：Journal of leukocyte biology

authors： Moors MA,Mizel SB

更新日期：2000-07-01 00:00:00

abstract：:Several members of the cytokine network play an important role in controlling the replication of the human immunodeficiency virus (HIV) in several experimental systems. Their effects can be categorized in the following three functional groups: (1) HIV-inductive cytokines; (2) HIV-suppressive cytokines; (3) cytokines w...

journal_title：Journal of leukocyte biology

authors： Vicenzi E,Biswas P,Mengozzi M,Poli G

更新日期：1997-07-01 00:00:00

abstract：:Breaking the long-held paradigm that primary B cells are not phagocytic, several studies have demonstrated recently that B cells from fish, amphibians, and reptilians have a significant phagocytic capacity. Whether such capacity has remained conserved in certain mammalian B cell subsets is presently an enigma. Here, w...

journal_title：Journal of leukocyte biology

authors： Parra D,Rieger AM,Li J,Zhang YA,Randall LM,Hunter CA,Barreda DR,Sunyer JO

更新日期：2012-04-01 00:00:00

abstract：:Immunosuppressive factors, such as vascular endothelial growth factor, transforming growth factor-beta, prostaglandin E2, interleukin (IL)-10, and IL-6, are made frequently by cancer cells. These factors, along with others, can inhibit the development and function of tumor-reactive effector T cells and the clinical re...

journal_title：Journal of leukocyte biology

authors： Spaner DE

更新日期：2004-08-01 00:00:00

abstract：:Fluid-phase endocytosis is stimulated by H-ras-linked growth factor receptors and this stimulation requires activation of rab5. We utilized a GFP-rab5a:wt fusion protein to monitor GFP-rab5a:wt activation in living fibroblasts and in J774 macrophages. Control CHO cells that expressed GFP-rab5a:wt were cultured in seru...

journal_title：Journal of leukocyte biology

authors： Roberts RL,Barbieri MA,Ullrich J,Stahl PD

更新日期：2000-11-01 00:00:00

abstract：:Experimental autoimmune uveoretinitis (EAU) is a T helper type 1 cell-mediated autoimmune disease, which serves as a model of human chronic uveitis. In this model, cells of a monocyte/macrophage lineage and retinal antigen (Ag)-specific T cells infiltrate into the retina and cause inflammatory lesion, where proinflamm...

journal_title：Journal of leukocyte biology

authors： Kitamei H,Iwabuchi K,Namba K,Yoshida K,Yanagawa Y,Kitaichi N,Kitamura M,Ohno S,Onoé K

更新日期：2006-06-01 00:00:00

abstract：:Complex syndromes such as atherosclerosis and type 2 diabetes are disorders that are associated with inflammatory processes involving innate and adaptive immunity. Emerging knowledge about the pathological consequences of immune imbalances in a wide range of disease settings is expected to help to identify novel thera...

journal_title：Journal of leukocyte biology

authors： Rose B,Herder C,Löffler H,Kolb H,Martin S

更新日期：2004-04-01 00:00:00

abstract：:We reported that PARP-1 exhibits differential roles in expression of inflammatory factors. Here, we show that PARP-1 deletion was associated with a significant reduction in inflammatory cell recruitment to mouse airways upon intratracheal administration of LPS. However, PARP-1 deletion exerted little effect in respons...

journal_title：Journal of leukocyte biology

authors： Zerfaoui M,Naura AS,Errami Y,Hans CP,Rezk BM,Park J,Elsegeiny W,Kim H,Lord K,Kim JG,Boulares AH

更新日期：2009-12-01 00:00:00

abstract：:Given the variable protective efficacy provided by Mycobacterium bovis bacillus Calmette-Guérin (BCG), there is an urgent need to develop new vaccines against tuberculosis. As dendritic cells (DC) play a critical role in initiating and regulating a protective T cell response against the pathogens, the comprehension of...

journal_title：Journal of leukocyte biology

authors： Giacomini E,Remoli ME,Gafa V,Pardini M,Fattorini L,Coccia EM

更新日期：2009-03-01 00:00:00

abstract：:Neutrophils kill invading pathogens by AMPs, including cathelicidins, ROS, and NETs. The human pathogen Staphylococcus aureus exhibits enhanced resistance to neutrophil AMPs, including the murine cathelicidin CRAMP, in part, as a result of alanylation of teichoic acids by the dlt operon. In this study, we took advanta...

journal_title：Journal of leukocyte biology

authors： Jann NJ,Schmaler M,Kristian SA,Radek KA,Gallo RL,Nizet V,Peschel A,Landmann R

更新日期：2009-11-01 00:00:00

abstract：:The lymphotoxin signaling pathway plays an important role in the homeostasis and function of peripheral and mucosal dendritic cells, and dendritic cell-intrinsic lymphotoxin β receptor expression is required for optimal responses to opportunistic intestinal bacteria. However, it is unknown whether dendritic cell-intri...

journal_title：Journal of leukocyte biology

authors： Sun T,Rojas OL,Li C,Philpott DJ,Gommerman JL

更新日期：2016-07-01 00:00:00

abstract：:The interaction between CD40 on dendritic cells (DC) and its ligand CD154 has been recognized to be an important feature in the maturation of DC. Here, we were interested in the role of CD44 a surface receptor shown to mediate cell-cell adhesion and binding to Hyaluronic acid (HA). Western blot analysis of human DC st...

journal_title：Journal of leukocyte biology

authors： Termeer C,Johannsen H,Braun T,Renkl A,Ahrens T,Denfeld RW,Lappin MB,Weiss JM,Simon JC

更新日期：2001-11-01 00:00:00

abstract：:The oncogene EVI1 has been implicated in the etiology of AML and MDS. Although AML cells are characterized by accelerated proliferation and differentiation arrest, MDS cells hyperproliferate when immature but fail to differentiate later and die instead. In agreement with its roles in AML and in immature MDS cells, EVI...

journal_title：Journal of leukocyte biology

authors： Konrad TA,Karger A,Hackl H,Schwarzinger I,Herbacek I,Wieser R

更新日期：2009-10-01 00:00:00

abstract：:Brucella abortus is a Gram-negative intracellular bacterial pathogen that causes a zoonosis of worldwide occurrence, leading to undulant fever in humans and abortion in domestic animals. B. abortus is recognized by several pattern-recognition receptors triggering pathways during the host innate immune response. Theref...

journal_title：Journal of leukocyte biology

authors： Gomes MT,Campos PC,Pereira Gde S,Bartholomeu DC,Splitter G,Oliveira SC

更新日期：2016-05-01 00:00:00

abstract：:Murine CD11c(+)CD8alpha(-) and CD11c(+)CD8alpha(+) dendritic cells (DCs) differentially regulate T cell responses. Although specific chemokines that recruit immature (i) or mature (m) CD8alpha(-) DCs have been identified, little is known about the influence of chemokines on CD8alpha(+) DCs. iDCs and mDCs isolated from...

journal_title：Journal of leukocyte biology

authors： Colvin BL,Morelli AE,Logar AJ,Lau AH,Thomson AW

更新日期：2004-02-01 00:00:00

abstract：:The nucleosome, the basic structure of chromatin and normal product of cell apoptosis, plays a pivotal role both in the induction and the pathogenesis of systemic lupus erythematosus (SLE). Nucleosomes have been found to circulate at high levels in patients with SLE and apoptosis of lymphoid cells is increased during ...

journal_title：Journal of leukocyte biology

authors： Laderach D,Bach JF,Koutouzov S

更新日期：1998-12-01 00:00:00

abstract：:Notch signaling plays a preeminent role during development in not only regulating cell fate decisions, but it can also influence growth and survival of progenitor cells. In the immune system, Notch is required for the maintenance of hematopoietic stem cells and in directing T- versus B-lineage commitment. In this revi...

journal_title：Journal of leukocyte biology

authors： Hoyne GF

更新日期：2003-12-01 00:00:00

abstract：:LPS induces dendritic cell (DC) activation, but the precise in vivo mechanism is unclear since DCs express low levels of TLR4. Here, it is shown that DCs can be activated in response to LPS through a bystander mechanism. This result was obtained using chimeric mice reconstituted with LPS-responsive and nonresponsive b...

journal_title：Journal of leukocyte biology

authors： Yadav R,Zammit DJ,Lefrancois L,Vella AT

更新日期：2006-12-01 00:00:00

abstract：:Several in vitro functions of neonatal neutrophils (N-PMN) have been reported to be deficient and may be functionally related to the increased susceptibility of the newborn to infection. To evaluate an in vitro event corresponding to one of the early steps in the sequence of inflammation, we used zymosan-activated pla...

journal_title：Journal of leukocyte biology

authors： Zwahlen RD,Slauson DO,Neilsen NR,Clifford CB

更新日期：1987-06-01 00:00:00