Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163.

abstract：:Overexpression of CD95 (Fas/Apo-1) ligand (CD95L) has been shown to induce T cell tolerance but also, neutrophilic inflammation and rejection of allogeneic tissue. We explored the capacity of dendritic cells (DCs) genetically engineered to overexpress CD95L to induce an antitumor response. We first found that DCs over...

journal_title：Journal of leukocyte biology

authors： Buonocore S,Haddou NO,Moore F,Florquin S,Paulart F,Heirman C,Thielemans K,Goldman M,Flamand V

更新日期：2008-09-01 00:00:00

abstract：:The toxicity of guanosine and deoxyguanosine in the presence or absence of the purine nucleoside phosphorylase inhibitor, 8-aminoguanosine, for malignant lymphoid cell lines and mitogen-stimulated peripheral blood lymphocytes has been studied. Deoxyguanosine inhibited the proliferation of lymphoid cells more strongly ...

journal_title：Journal of leukocyte biology

authors： van der Kraan PM,van Zandvoort PM,De Abreu RA,Bakkeren JA

更新日期：1988-07-01 00:00:00

abstract：:Patients with head and neck squamous cell carcinoma (HNSCC) have increased levels of immune-suppressive peripheral blood CD34+ cells. This study showed that the peripheral blood CD34+ cells of HNSCC patients are capable of differentiating into dendritic cells. Because CD34+ cells can differentiate through several path...

journal_title：Journal of leukocyte biology

authors： Lathers DM,Lubbers E,Wright MA,Young MR

更新日期：1999-05-01 00:00:00

abstract：:In this report, the construction of a functional, immunocompetent, full-thickness skin equivalent (SE) is described, consisting of an epidermal compartment containing keratinocytes, melanocytes, and human LCs derived from the MUTZ-3 cell line (MUTZ-LC) and a fibroblast-populated dermal compartment. The CD1a(+)Langerin...

journal_title：Journal of leukocyte biology

authors： Ouwehand K,Spiekstra SW,Waaijman T,Scheper RJ,de Gruijl TD,Gibbs S

更新日期：2011-11-01 00:00:00

abstract：:The interaction between CD40 on dendritic cells (DC) and its ligand CD154 has been recognized to be an important feature in the maturation of DC. Here, we were interested in the role of CD44 a surface receptor shown to mediate cell-cell adhesion and binding to Hyaluronic acid (HA). Western blot analysis of human DC st...

journal_title：Journal of leukocyte biology

authors： Termeer C,Johannsen H,Braun T,Renkl A,Ahrens T,Denfeld RW,Lappin MB,Weiss JM,Simon JC

更新日期：2001-11-01 00:00:00

abstract：:Several members of the cytokine network play an important role in controlling the replication of the human immunodeficiency virus (HIV) in several experimental systems. Their effects can be categorized in the following three functional groups: (1) HIV-inductive cytokines; (2) HIV-suppressive cytokines; (3) cytokines w...

journal_title：Journal of leukocyte biology

authors： Vicenzi E,Biswas P,Mengozzi M,Poli G

更新日期：1997-07-01 00:00:00

abstract：:Hepatic lymphocytes are enriched in NK and NKT cells that play important roles in antiviral and antitumor defenses and in the pathogenesis of chronic liver disease. In this review, we discuss the differential distribution of NK and NKT cells in mouse, rat, and human livers, the ultrastructural similarities and differe...

journal_title：Journal of leukocyte biology

authors： Gao B,Radaeva S,Park O

更新日期：2009-09-01 00:00:00

abstract：:Dysregulated Ca(2+) handling is prevalent during sepsis and postulated to perpetuate the aberrant inflammation underlying subsequent organ dysfunction and death. The signal transduction cascades mediating these processes are unknown. Here, we identify that CaMKIα mediates the Mϕ response to LPS in vitro and the inflam...

journal_title：Journal of leukocyte biology

authors： Zhang X,Guo L,Collage RD,Stripay JL,Tsung A,Lee JS,Rosengart MR

更新日期：2011-08-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) has been shown to induce the production of interstitial collagenase by fibroblasts and chondrocytes. We investigated the role of TNF-alpha in collagenase gene expression by U937 monocyte/macrophage cells. Transcription of the TNF-alpha gene was observed after 0.5 h of phorbol my...

journal_title：Journal of leukocyte biology

authors： Callaghan MM,Lovis RM,Rammohan C,Lu Y,Pope RM

更新日期：1996-01-01 00:00:00

abstract：:It is well established that the cytokine IL-12 and the transcription factor STAT4, an essential part of the IL-12 signaling pathway, are critical components of the Th1 differentiation process in T cells. In response to pathogenic stimuli, this process causes T cells to proliferate rapidly and secrete high amounts of t...

journal_title：Journal of leukocyte biology

authors： Schaller M,Ito T,Allen RM,Kroetz D,Kittan N,Ptaschinski C,Cavassani K,Carson WF 4th,Godessart N,Grembecka J,Cierpicki T,Dou Y,Kunkel SL

更新日期：2015-10-01 00:00:00

abstract：:During inflammation the balance between cell activation and cell death is determined by the tight regulation of multiple intracellular enzyme cascades. Key regulatory steps often involve protein kinases. We show that the prototypical pro-inflammatory molecule, bacterial lipopolysaccharide, activates multiple protein k...

journal_title：Journal of leukocyte biology

authors： Lee J,Mira-Arbibe L,Ulevitch RJ

更新日期：2000-12-01 00:00:00

abstract：:The dynamics of immune cell populations during acute HIV-1 infection are not fully deciphered, especially for non-T cells. In this study, we tested whether specific cellular subsets of the innate arm of the immune response are affected early after HIV-1 infection. Using a cohort of HIV-1-infected individuals, we have ...

journal_title：Journal of leukocyte biology

authors： Centlivre M,Legrand N,Steingrover R,van der Sluis R,Grijsen ML,Bakker M,Jurriaans S,Berkhout B,Paxton WA,Prins JM,Pollakis G

更新日期：2011-05-01 00:00:00

abstract：:The human polyomavirus JCV lytically infects oligodendrocytes of immunosuppressed individuals leading to the fatal demyelinating disease termed progressive multifocal leukoencephalopathy (PML). Dementia, hemiparesis, and hemianopsia are the predominant presenting signs of PML. Asymptomatic JCV infection is common worl...

journal_title：Journal of leukocyte biology

authors： Jensen PN,Major EO

更新日期：1999-04-01 00:00:00

abstract：:We studied the effect of exogenous nitric oxide (NO) on migration of rabbit peritoneal neutrophils. Exogenous NO enhanced random migration of neutrophils in a concentration-dependent way. An optimally stimulatory effect was observed with 0.5 microM NO, whereas at higher NO concentrations the enhancing effect decreased...

journal_title：Journal of leukocyte biology

authors： VanUffelen BE,de Koster BM,Van den Broek PJ,VanSteveninck J,Elferink JG

更新日期：1996-07-01 00:00:00

abstract：:Deoxycytidyl-deoxyguanosine [(CpG)3] oligodeoxynucleotides (ODNs) signal through TLR9 to induce type-I IFN (IFN-alphabeta) and IFN-alphabeta-dependent MHC-I cross-presentation of exogenous antigens by dendritic cells (DCs). A puzzle was presented by our observation that three ODN classes, CpG-A, CpG-B, and CpG-C, had ...

journal_title：Journal of leukocyte biology

authors： Gray RC,Kuchtey J,Harding CV

更新日期：2007-04-01 00:00:00

abstract：:Initial studies designed to measure the effect of inhibiting RNA synthesis by dactinomycin on macrophage functions revealed that the cells were uniformly killed at concentrations that have been routinely used to inhibit RNA synthesis in other cell types. We, thus, determined the dose curve for the cytotoxicity of dact...

journal_title：Journal of leukocyte biology

authors： Lewis JG,Adams DO,Fan S

更新日期：1995-04-01 00:00:00

abstract：:Matrix metalloproteinases-2 and -9 (MMP-2/9) are critically involved in degradation of extracellular matrix, and their inhibition is discussed as a promising strategy against hepatic ischemia-reperfusion (I/R) injury. Here, we analyzed the role of MMP-2 and -9 for leukocyte migration and tissue injury in sham-operated...

journal_title：Journal of leukocyte biology

authors： Khandoga A,Kessler JS,Hanschen M,Khandoga AG,Burggraf D,Reichel C,Hamann GF,Enders G,Krombach F

更新日期：2006-06-01 00:00:00

abstract：:A murine interleukin-2 (IL-2)-dependent T-cell line, CTLL-2, was infected with a retrovirus carrying the mouse c-myc cDNA and the Tn-5 neogene. Transduced cells were selected in the presence of Geneticin sulfate (G418); these cells were shown to express both the endogenous and the transduced c-myc genes. The IL-2 requ...

journal_title：Journal of leukocyte biology

authors： Shapiro IM,Winberg G,Stefanescu I,Wigzell H,Menezes J

更新日期：1988-12-01 00:00:00

abstract：:The engagement of activating NK receptors (aNKR) stimulates NK cell activity, provided that interactions between inhibitory NK receptors (iNKR) with their HLA ligands do not override them. Abs bound to target cells can also activate NK cells by engaging the CD16 aNKR. NK cell education status is an important factor fo...

journal_title：Journal of leukocyte biology

authors： Lisovsky I,Kant S,Tremblay-McLean A,Isitman G,Kiani Z,Dupuy FP,Gilbert L,Bruneau J,Shoukry NH,Lebouché B,Bernard NF

更新日期：2019-03-01 00:00:00

abstract：:Emerging evidence has revealed that noradrenaline (NA), the main neurotransmitter of the sympathetic nervous system (SNS), regulates a variety of immune functions via binding to adrenergic receptors present on immune cells. In this study, we examined the role of NA in the regulation of neutrophil functions. Neutrophil...

journal_title：Journal of leukocyte biology

authors： Nicholls AJ,Wen SW,Hall P,Hickey MJ,Wong CHY

更新日期：2018-02-01 00:00:00

abstract：:Apoptosis of polymorphonuclear leukocytes (PMNs) is a critical step in the resolution of tissue inflammation. PMN apoptosis has been studied extensively in vitro, and diverse inflammatory mediators have been shown to modulate the process. The reported effects of interleukin-6 (IL-6) on PMN apoptosis are inconsistent; ...

journal_title：Journal of leukocyte biology

authors： Biffl WL,Moore EE,Moore FA,Barnett CC Jr

更新日期：1995-11-01 00:00:00

abstract：:This study tested the hypothesis that eotaxins (CCL11, CCL24, and CCL26) and IL-5 contribute to eosinophil recruitment to the intestine in UC and that intestinal macrophages are important producers of CCL11 in this disease. Peripheral blood and rectal biopsy samples were obtained from patients with active (n=18) and q...

journal_title：Journal of leukocyte biology

authors： Lampinen M,Waddell A,Ahrens R,Carlson M,Hogan SP

更新日期：2013-11-01 00:00:00

abstract：:Vascular occlusion is the main cause of the morbidity and mortality observed in patients with sickle cell disease (SCD). Increasing evidence indicates that (activated) neutrophils could play an important role in the initiation and propagation of vaso-occlusive processes in SCD. In this study, the activation state of n...

journal_title：Journal of leukocyte biology

authors： Lard LR,Mul FP,de Haas M,Roos D,Duits AJ

更新日期：1999-09-01 00:00:00

abstract：:Interferons (IFN) and lipopolysaccharide (LPS) cause multiple changes in isoprenoid-modified proteins in murine macrophages, the most dramatic being the expression of a prenyl protein of 65 kDa. The guanylate binding proteins (GBPs) are IFN-inducible GTP-binding proteins of approximately 65 kDa that possess a CaaX mot...

journal_title：Journal of leukocyte biology

authors： Nantais DE,Schwemmle M,Stickney JT,Vestal DJ,Buss JE

更新日期：1996-09-01 00:00:00

abstract：:A simple and rapid method for the purification of morphologically and functionally intact eosinophils from human blood of both normal and eosinophilic subjects is described. The method is based on a single centrifugation of total blood leukocytes suspended in Percoll with specific gravity 1.0853 g/ml, after erythrocyt...

journal_title：Journal of leukocyte biology

authors： Cramer R,Dri P,Zabucchi G,Patriarca P

更新日期：1992-09-01 00:00:00

abstract：:Neutrophil activation is a multistep process. In vitro activation of neutrophils with semiphysiological activators is optimal only after preactivation or priming with cytokines, chemotaxins, and/or bacterial products. Until now, no antibodies have been developed that can distinguish between resting and (cytokine) prim...

journal_title：Journal of leukocyte biology

authors： Koenderman L,Kanters D,Maesen B,Raaijmakers J,Lammers JW,de Kruif J,Logtenberg T

更新日期：2000-07-01 00:00:00

abstract：:An immunoglobulin M (IgM) monoclonal antibody, My43, specific for IgA Fc receptor (Fc alpha R) on human monocytes, bound to human polymorphonuclear neutrophils (PMNs) and inhibited their ability to bind IgA but not IgG. It was observed that the PMN oxidative burst was induced by both polymeric IgA and aggregated IgG, ...

journal_title：Journal of leukocyte biology

authors： Shen L

更新日期：1992-04-01 00:00:00

abstract：:The restriction of herpes simplex virus type 1 (HSV-1) gene expression in nonpermissive murine resident peritoneal macrophages (ResPMO) was analyzed at the level of transcription. Using nuclear run-on assays, we established that transcription of a representative gene from each HSV-1 kinetic class was initiated in both...

journal_title：Journal of leukocyte biology

authors： Wu L,Morahan PS,Leary K

更新日期：1993-01-01 00:00:00

abstract：:Polymorphonuclear granulocytes (PMNs) are known to contribute to reperfusion injury of the heart. However, whether PMNs compromise myocardial function of hearts exposed to a low-flow ischemia has not been determined. Moreover, not much is known about deleterious effects of PMNs at different times during ischemia and r...

journal_title：Journal of leukocyte biology

authors： Seligmann C,Bock A,Leitsch T,Schimmer M,Simsek Y,Schultheiss HP

更新日期：2001-05-01 00:00:00

abstract：:Structurally, the monocyte chemotactic proteins MCP-1, -2, and -3 form a subfamily of the C-C or beta-chemokines. Like other chemokines, MCPs are produced by a variety of cells on stimulation with cytokines (interleukin-1, tumor necrosis factor-alpha, interferon-gamma), bacterial and viral products or mitogens. MCP-1 ...

journal_title：Journal of leukocyte biology

authors： Proost P,Wuyts A,Van Damme J

更新日期：1996-01-01 00:00:00