Increased adhesiveness of complement-stimulated neonatal calf neutrophils and its pharmacologic inhibition.

abstract：:This report focuses on the modulatory role of endogenous H(2)O(2) on lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-induced inducible nitric oxide synthase (NOS2) gene expression in rat peritoneal macrophages. Exogenously added H(2)O(2) was initially found to inhibit the synthesis of NOS2, which prompted us to ...

journal_title：Journal of leukocyte biology

authors： Vega A,Chacón P,Monteseirín J,El Bekay R,Alvarez M,Alba G,Conde J,Martín-Nieto J,Bedoya FJ,Pintado E,Sobrino F

更新日期：2004-06-01 00:00:00

abstract：:We studied the tissue distribution of CD6(+) lymphocytes and cells expressing the CD6 ligand (also known as activated leukocyte cell adhesion molecule CD166) in calves by immunohistochemistry using an anti-bovine CD6 monoclonal antibody (mAb), a human CD6 (huCD6)-immunoglobulin G1 fusion protein (huCD6-Ig), and an ant...

journal_title：Journal of leukocyte biology

authors： Konno A,Ahn JS,Kitamura H,Hamilton MJ,Gebe JA,Aruffo A,Davis WC

更新日期：2001-06-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is one of the recently defined damage-associated molecular pattern molecules, passively released from necrotic cells and secreted by activated macrophage/monocytes. Whether cytolytic cells induce HMGB1 release from tumor cells is not known. We developed a highly sensitive method for d...

journal_title：Journal of leukocyte biology

authors： Ito N,DeMarco RA,Mailliard RB,Han J,Rabinowich H,Kalinski P,Stolz DB,Zeh HJ 3rd,Lotze MT

更新日期：2007-01-01 00:00:00

abstract：:Monocytes have been categorized in three main subpopulations based on CD14 and CD16 surface expression. Classical monocytes express the CD14(++)CD16(-)CCR2(+) phenotype and migrate to inflammatory sites by quickly responding to CCL2 signaling. Here, we identified and characterized the expansion of a novel monocyte sub...

journal_title：Journal of leukocyte biology

authors： Gama L,Shirk EN,Russell JN,Carvalho KI,Li M,Queen SE,Kalil J,Zink MC,Clements JE,Kallas EG

更新日期：2012-05-01 00:00:00

abstract：:Thimerosal is an organic mercury compound that is used as a preservative in vaccines and pharmaceutical products. Recent studies have shown a TH2-skewing effect of mercury, although the underlying mechanisms have not been identified. In this study, we investigated whether thimerosal can exercise a TH2-promoting effect...

journal_title：Journal of leukocyte biology

authors： Agrawal A,Kaushal P,Agrawal S,Gollapudi S,Gupta S

更新日期：2007-02-01 00:00:00

abstract：:The switch from fetal to adult hematopoietic stem/progenitor cells (HSPCs) is associated with profound changes in several genetic programs. Although HSPC ageing corresponds to alterations in Wnt signaling, relatively little is known about the relative roles of different Wnt signaling pathways in HSPC ontogeny. We hypo...

journal_title：Journal of leukocyte biology

authors： Kwarteng EO,Hétu-Arbour R,Heinonen KM

更新日期：2018-03-01 00:00:00

abstract：:Neutrophils are important mediators of the innate immune defense and of the host response to a physical trauma. Because aberrant infiltration of injured sites by neutrophils was shown to cause adverse effects after trauma, we investigated how neutrophil infiltration could be modulated at the cellular level. Our data i...

journal_title：Journal of leukocyte biology

authors： Wille C,Eiseler T,Langenberger ST,Richter J,Mizuno K,Radermacher P,Knippschild U,Huber-Lang M,Seufferlein T,Paschke S

更新日期：2018-09-01 00:00:00

abstract：:Initial studies designed to measure the effect of inhibiting RNA synthesis by dactinomycin on macrophage functions revealed that the cells were uniformly killed at concentrations that have been routinely used to inhibit RNA synthesis in other cell types. We, thus, determined the dose curve for the cytotoxicity of dact...

journal_title：Journal of leukocyte biology

authors： Lewis JG,Adams DO,Fan S

更新日期：1995-04-01 00:00:00

abstract：:This short review focuses on the role of central nervous system (CNS) perivascular macrophages as targets of productive infection of the CNS. Data discussed include the importance of these cells as early targets of infection and their productive infection with AIDS. Many of the immune molecules on perivascular macroph...

journal_title：Journal of leukocyte biology

authors： Kim WK,Corey S,Alvarez X,Williams K

更新日期：2003-11-01 00:00:00

abstract：:Elderly humans are more susceptible to bacterial infections because of declining immune status. We have investigated the effect of aging on neutrophil bactericidal responses, comparing neutrophil function in healthy, young (23-35 years) and elderly (>65 years) volunteers. Superoxide generation in response to fMLP was ...

journal_title：Journal of leukocyte biology

authors： Butcher SK,Chahal H,Nayak L,Sinclair A,Henriquez NV,Sapey E,O'Mahony D,Lord JM

更新日期：2001-12-01 00:00:00

abstract：:Breaking the long-held paradigm that primary B cells are not phagocytic, several studies have demonstrated recently that B cells from fish, amphibians, and reptilians have a significant phagocytic capacity. Whether such capacity has remained conserved in certain mammalian B cell subsets is presently an enigma. Here, w...

journal_title：Journal of leukocyte biology

authors： Parra D,Rieger AM,Li J,Zhang YA,Randall LM,Hunter CA,Barreda DR,Sunyer JO

更新日期：2012-04-01 00:00:00

abstract：:Protein synthetic patterns of murine peritoneal macrophages were analyzed by two-dimensional polyacrylamide gel electrophoresis (2D PAGE) of 35S methionine-labeled proteins. While the protein synthetic patterns exhibited by resident, inflammatory, and activated macrophages had numerous common features that distinguish...

journal_title：Journal of leukocyte biology

authors： Tannenbaum CS,Nurmi-McKernan L,Largen MT

更新日期：1987-06-01 00:00:00

abstract：:HSA preparations for i.v. use are administered in critically ill patients. Although increasing intravascular osmotic pressure seems to be a pathophysiologically orientated treatment, clinical trials do not indicate a benefit for mortality in HSA-treated patients. Instead, there is evidence for inflammatory reactions u...

journal_title：Journal of leukocyte biology

authors： Humpert PM,Lukic IK,Thorpe SR,Hofer S,Awad EM,Andrassy M,Deemer EK,Kasper M,Schleicher E,Schwaninger M,Weigand MA,Nawroth PP,Bierhaus A

更新日期：2009-09-01 00:00:00

abstract：:Endotoxin tolerance is characterized by attenuated macrophage activation to subsequent LPS challenge and can be reversed through nonspecific protein kinase C (PKC) activation, and activation by LPS within naïve cells requires the activation of the cell surface receptors CD14 and TLR4 on lipid rafts. The effect of PKC ...

journal_title：Journal of leukocyte biology

authors： Cuschieri J,Billigren J,Maier RV

更新日期：2006-12-01 00:00:00

abstract：:We have shown that low-dose UVB radiation converts Langerhans cells (LC) from immunogenic to tolerogenic APC. Therefore, we questioned whether low-dose UVB irradiation of bone marrow-derived dendritic cells (DC) alters their APC function, thereby inducing tolerance in T cells. To address this issue, cocultures of DC; ...

journal_title：Journal of leukocyte biology

authors： Denfeld RW,Hara H,Tesmann JP,Martin S,Simon JC

更新日期：2001-04-01 00:00:00

abstract：:Upon exposure to immune or inflammatory stimuli, dendritic cells (DC) migrate from peripheral tissues to lymphoid organs, where they present antigen. The molecular basis for the peculiar trafficking properties of DC is largely unknown. In this study, mouse DC were generated from CD34+ bone marrow precursors and cultur...

journal_title：Journal of leukocyte biology

authors： Vecchi A,Massimiliano L,Ramponi S,Luini W,Bernasconi S,Bonecchi R,Allavena P,Parmentier M,Mantovani A,Sozzani S

更新日期：1999-09-01 00:00:00

abstract：:Eosinophil migration from circulation is controlled, in part, by chemokines through a family of G-protein-coupled chemokine receptors (CCR). Studies of human eosinophils have demonstrated that signaling through CCR3 receptors is a prominent pathway leading to chemotaxis, although several other receptor-ligand interact...

journal_title：Journal of leukocyte biology

authors： Borchers MT,Ansay T,DeSalle R,Daugherty BL,Shen H,Metzger M,Lee NA,Lee JJ

更新日期：2002-06-01 00:00:00

abstract：:The nucleosome, the basic structure of chromatin and normal product of cell apoptosis, plays a pivotal role both in the induction and the pathogenesis of systemic lupus erythematosus (SLE). Nucleosomes have been found to circulate at high levels in patients with SLE and apoptosis of lymphoid cells is increased during ...

journal_title：Journal of leukocyte biology

authors： Laderach D,Bach JF,Koutouzov S

更新日期：1998-12-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) has been shown to induce the production of interstitial collagenase by fibroblasts and chondrocytes. We investigated the role of TNF-alpha in collagenase gene expression by U937 monocyte/macrophage cells. Transcription of the TNF-alpha gene was observed after 0.5 h of phorbol my...

journal_title：Journal of leukocyte biology

authors： Callaghan MM,Lovis RM,Rammohan C,Lu Y,Pope RM

更新日期：1996-01-01 00:00:00

abstract：:Macrophages activated for tumor cell killing by bacterial lipopolysaccharide (LPS) were shown to lose their cytolytic activity if exposed to physiological levels of prostaglandin E2 (PGE2). Increasing the LPS stimulus more than 100-fold over the amount needed to activate the cells did not substantially increase their ...

journal_title：Journal of leukocyte biology

authors： Russell SW,Pace JL

更新日期：1984-03-01 00:00:00

abstract：:Pulmonary alveolar macrophages (AMphis) are incompetent to phagocytose unopsonized Pseudomonas aeruginosa, but ingestion by other macrophage phenotypes (i.e., peritoneal macrophages) occurs efficiently. The purpose of this study was to explore factors that might control such phenotypic differences. Our laboratory has ...

journal_title：Journal of leukocyte biology

authors： Heale JP,Speert DP

更新日期：2001-01-01 00:00:00

abstract：:The scavenger receptor CD163 is exclusively expressed by monocyte/macrophages and is shed by matrix metalloproteinases (MMPs) and neutrophil elastase (ELA2) as soluble CD163 (sCD163). Monocyte phenotype is altered in diabetes, but the relationship among monocyte CD163, sCD163, and diabetic complications is not known a...

journal_title：Journal of leukocyte biology

authors： Min D,Brooks B,Wong J,Aamidor S,Seehoo R,Sutanto S,Harrisberg B,Yue DK,Twigg SM,McLennan SV

更新日期：2016-12-01 00:00:00

abstract：:Compared with CD4+25+ regulatory T cells (Tregs), the mechanisms for natural, polyclonal CD8+25+ Treg immune suppression have been significantly less studied. We previously showed that polyclonal T cells can acquire antigen-specific targeting activity through arming with exosomal peptide-MHC (pMHC). In this study, we ...

journal_title：Journal of leukocyte biology

authors： Mu C,Zhang X,Wang L,Xu A,Ahmed KA,Pang X,Chibbar R,Freywald A,Huang J,Zhu Y,Xiang J

更新日期：2017-05-01 00:00:00

abstract：:Immunosuppressive factors, such as vascular endothelial growth factor, transforming growth factor-beta, prostaglandin E2, interleukin (IL)-10, and IL-6, are made frequently by cancer cells. These factors, along with others, can inhibit the development and function of tumor-reactive effector T cells and the clinical re...

journal_title：Journal of leukocyte biology

authors： Spaner DE

更新日期：2004-08-01 00:00:00

abstract：:RA is a chronic autoimmune disease characterized by accumulation of inflammatory cells within synovial joints. RA is associated with a failure of apoptosis of infiltrating leukocytes, thought to be a result of overexpression of prosurvival Bcl-2 proteins. Overexpression of Bcl-2 in hematopoietic cells can result in sp...

journal_title：Journal of leukocyte biology

authors： Lawlor KE,van Nieuwenhuijze A,Parker KL,Drake SF,Campbell IK,Smith SD,Vince JE,Strasser A,Wicks IP

更新日期：2013-04-01 00:00:00

abstract：:Leukocytes are a central cellular element of innate-immune defense in mammals. In addition to the generation of toxic oxygen radicals and nitric oxide, leukocytes express and secrete a broad array of antimicrobial proteins and peptides. In the study, an antimicrobial polypeptide was isolated and purified from human pe...

journal_title：Journal of leukocyte biology

authors： Feng Y,Huang N,Wu Q,Wang B

更新日期：2005-11-01 00:00:00

abstract：:The human polyomavirus JCV lytically infects oligodendrocytes of immunosuppressed individuals leading to the fatal demyelinating disease termed progressive multifocal leukoencephalopathy (PML). Dementia, hemiparesis, and hemianopsia are the predominant presenting signs of PML. Asymptomatic JCV infection is common worl...

journal_title：Journal of leukocyte biology

authors： Jensen PN,Major EO

更新日期：1999-04-01 00:00:00

abstract：:In the present study, we investigated the expression of human CD1d antigen on activated mature T cells. Expression of this glycoprotein was found to be highly regulated and dependent on PHA stimulation. Flow cytometry studies using the NOR3.2 antibody, which recognized CD1d under denaturing conditions, showed a clear ...

journal_title：Journal of leukocyte biology

authors： Salamone MC,Rabinovich GA,Mendiguren AK,Salamone GV,Fainboim L

更新日期：2001-02-01 00:00:00

abstract：:IL-17 has been associated with selected inflammatory and autoimmune diseases. We characterized the expression of this proinflammatory cytokine following HSV-1 corneal infection and investigated whether IL-17R signaling modulated the host response to the viral pathogen at early time-points postinfection. IL-17 was elev...

journal_title：Journal of leukocyte biology

authors： Molesworth-Kenyon SJ,Yin R,Oakes JE,Lausch RN

更新日期：2008-02-01 00:00:00

abstract：:Studies of the metabolism and function of the amyloid precursor protein (APP) and its proteolytic fragment A beta in cultured cells, transgenic mice, and post-mortem brain tissue have advanced our understanding of Alzheimer disease (AD). However, the molecular pathogenesis of the disease is still not clear, and we are...

journal_title：Journal of leukocyte biology

authors： Li QX,Fuller SJ,Beyreuther K,Masters CL

更新日期：1999-10-01 00:00:00